Heavy drinking occasions and the occurrence of sexual activity.

With the advent of the AIDS epidemic, research on the relationship of drinking to sexual activity takes on increased importance. Although several studies have investigated the characteristics of sexual encounters that do and do not involve alcohol, few studies have examined drinking incidents that may or may not result in sexual activity. Respondents (N?=?1,110) in 3 surveys were asked about the circumstances of a recent heavy drinking occasion. Approximately one third of the Ss reported having sex during this maximum consumption episode, and the likelihood of having sex was a significant positive linear function of the amount of alcohol consumed. Ss who drank more heavily in the episode were slightly more likely to have sex with a new or casual partner. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stress, drinking, and the adverse consequences of drinking in two samples of young adults.

This study examined the relationships between stress and both alcohol use and alcohol problems, in addition to testing the possibility that social support and coping styles significantly moderate these relationships. Two samples of men and women in their 20s and 30s were studied. Findings showed that stress was unrelated to alcohol consumption in 1 sample, and, although there were significant associations in the 2nd sample, the overall percentage of variance explained was small. Stress appeared to be more highly related to alcohol problems, with some stress measures showing a protective relationship vis á vis alcohol problems and others acting in ways that can put people at risk for alcohol problems. Coping styles and social support interacted significantly with some measures of life stress (e.g., daily hassles, negative life events), but only in some circumstances. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The impact of maternal drinking during and after pregnancy on the drinking of adolescent offspring

OBJECTIVE: The impact of prenatal maternal drinking on alcohol consumption in adolescent offspring was examined among boys and girls separately. METHOD: A prospective longitudinal sample of 185 mother-firstborn child dyads was used to examine the impact of maternal self-reported alcohol consumption during pregnancy on adolescent self-reported lifetime and current drinking, controlling for potential confounding factors. RESULTS: In this representative general population sample, maternal drinking during pregnancy, particularly continuous moderate to heavy consumption, had a significant positive effect on adolescent daughters' current drinking, but a slight negative effect on sons' lifetime drinking. The sex-specific prenatal effect on current drinking persisted with controls for prenatal maternal cigarette smoking, current maternal drinking, child-rearing practices (i.e., maternal-child closeness, monitoring and a rule against drinking) and the adolescent's problem behaviors in childhood. Prenatal maternal smoking was also associated with elevated rates of adolescent drinking, particularly current drinking. Of the child-rearing variables, only a rule against drinking decreased adolescent drinking. CONCLUSIONS: Selected prenatal factors may constitute risks for alcohol consumption among adolescent daughters. The results are discussed in light of animal models that document increased vulnerability among female offspring to the deleterious effects of gestational alcohol exposure. Implications for understanding the risk factors associated with adolescent alcohol use are discussed.     

Drug and environmental factors associated with adverse pregnancy outcomes. Part II: Improvement with folic acid

OBJECTIVE: To provide a comprehensive review of periconceptional folic acid supplementation and factors affecting folate supplementation trials. DATA SOURCES: A MEDLINE search was conducted through December 1997. Additional sources were obtained from Current Contents and citations from the references obtained. Search terms included folate, folic acid, neural tube defect, spina bifida, and anencephaly. STUDY SELECTION: Relevant animal and human studies examining the effects of folate were reviewed. DATA EXTRACTION: Data collected included: type of study, folate dosing, dietary folate intake, serum and red blood cell folate concentrations, type of defect(s) studied, vitamin usage, parental risk factors, factors affecting trial results. DATA SYNTHESIS: Nine key factors have been identified that affect outcomes of folic acid supplementation trials. Daily doses of 0.8 mg decreased the occurrence and doses of 4 mg decreased the recurrence of neural tube defects in randomized clinical trials. Since lower folic acid doses were effective in nonrandomized trials, research is needed to determine the lowest effective dosage. Other benefits involving pregnancy outcome are suggested. CONCLUSIONS: Women of childbearing age should take a daily folic acid supplement to reduce the risk of pregnancies resulting in infants with a neural tube defect and other potential adverse pregnancy outcomes. Further health benefits from folic acid supplementation are reviewed in Part III of this series.     

Lithium therapy and drinking water

ain causes of failure and giving up in psychotropic lithiotherapics because of instable lithiemy to the same patient or functional acute renal insufficiency, are principaly mistaken diets, those mistaken concerning the amount, the quality and the way of taking drinking water and other beverages. Lithium salt, taken either in two times, morning and evening, or in one, must be absorbed at the end of a solid meal with at least 25 cl. of water. The patient must absorb at least 1.5 l. of water per day, and up to 3 l. in case of physical efforts or heat. The pH of this water and it ionic compound should be stable, as close as possible to the plasma's, without additives that could change its taste. This includes cooking water and infusions. Physicopharmacological explanations.     

Intragastric water and the acquisition of schedule-induced drinking

A case of multiple neonatal haemangiomatosis is described. A short course of steroid therapy produced rapid and marked improvement of cutaneous lesions, without any effect on testicular involvement. The authors emphasize the value of an early treatment with steroids.     

Severity of homelessness and adverse birth outcomes.

Predictors and the prevalence of adverse birth outcomes among 237 homeless women interviewed at 78 shelters and meal programs in Los Angeles in 1997 were assessed. It was hypothesized that they would report worse outcomes than national norms, that African Americans would report the worst outcomes because of their greater risk in the general population, and that homelessness severity would independently predict poorer outcomes beyond its association with other adverse conditions. Other predictors included reproductive history, behavioral and health-related variables, psychological trauma and distress, ethnicity, and income. African Americans and Hispanics reported worse outcomes than are found nationally, and African Americans reported the worst outcomes. In a predictive structural equation model, severity of homelessness significantly predicted low birth weight and preterm births beyond its relationship with prenatal care and other risk factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol expectancies, problem drinking, and adverse health consequences

This study evaluated a measure of positive and negative expected effects of alcohol and their subjective evaluation in the identification of college freshmen at high risk for problem drinking and associated morbidities. It was hypothesized that greater expectations of positive outcomes and fewer negative evaluations of negative outcomes would be associated with reports of heavier drinking and more alcohol-related health problems. College freshmen (n = 328) completed a standardized measure of expectations and subjective evaluations of positive and negative outcomes associated with drinking, and a questionnaire assessing drinking patterns and common alcohol-related health problems. Fifty-two percent of students were male and the mean age was 17.9 years (SD = 0.5). Students' expectations of positive outcomes and their subjective evaluations of both positive and negative outcomes from drinking were significantly correlated with drinking and alcohol-related health problems indices (p < 0.001). Gender, expectation of positive outcomes, and evaluation of negative outcomes explained 29% of the variance in drinking and 15% of the variance in alcohol-related health problems indices. Heavier-drinking students and those reporting more health problems expected more positive effects on their sociability and sexuality (p < 0.03) and were less concerned about cognitive and behavioral impairment as a result of drinking (p < 0.001). Students with more health problems were less concerned that drinking would lead to risk-taking or aggressive behavior (p < 0.003). Positive and negative outcome expectancies and their subjective evaluations accounted for a significant portion of the variability in drinking and alcohol-related health problems.(ABSTRACT TRUNCATED AT 250 WORDS)     

Predicting the occurrence of adverse events after coronary artery bypass surgery

Approximately 15% of patients with mitral valve disease will experience left atrial thrombosis and its consequences. The etiology and diagnosis of left atrial thrombosis are reviewed, stressing the importance of blood stagnation as the most important etiologic factor. Atrial fibrillation, a left atrial diameter greater than 60 mm and absence of significant mitral regurgitation are predictors of left atrial thrombosis in mitral stenosis. Left atrial thrombus can be detected in 50% of patients with all three factors; all influence blood stagnation. Smoke-like echoes in the left atrium, detected by echocardiography, provide a semi-quantitative assessment of left atrial blood stagnation. The incidence of thrombi in patients with well marked smoke-like echoes is 60%, while in those without this echocardiographic finding it is only 9%. Smoke-like echoes provide an early warning system of conditions in the left atrium likely to lead to thrombosis unless the patient is anticoagulated.     

Relation between negligent adverse events and the outcomes of medical-malpractice litigation

BACKGROUND: We have previously shown that in New York State the initiation of malpractice suits correlates poorly with the actual occurrence of adverse events (injuries resulting from medical treatment) and negligence. There is little information on the outcome of such lawsuits, however. To assess the ability of malpractice litigation to make accurate determinations, we studied 51 malpractice suits to identify factors that predict payment to plaintiffs. METHODS: Among malpractice claims that we reviewed independently in an earlier study, we identified 51 litigated claims and followed them over a 10-year period to determine whether the malpractice insurer had closed the case. We obtained detailed summaries of the cases from the insurers and reviewed the litigation files if the outcome of a case differed from the outcome predicted in our original review. RESULTS: Of the 51 malpractice cases, 46 had been closed as of December 31, 1995. Among these cases, 10 of 24 that we originally identified as involving no adverse event were settled for the plaintiffs (mean payment, $28,760), as were 6 of 13 cases classified as involving adverse events but no negligence (mean payment, $98,192) and 5 of 9 cases in which adverse events due to negligence were found in our assessment (mean payment, $66,944). Seven of eight claims involving permanent disability were settled for the plaintiffs (mean payment, $201,250). In a multivariate analysis, disability (permanent vs. temporary or none) was the only significant predictor of payment (P=0.03). There was no association between the occurrence of an adverse event due to negligence (P = 0.32) or an adverse event of any type (P=0.79) and payment. CONCLUSIONS: Among the malpractice claims we studied, the severity of the patient's disability, not the occurrence of an adverse event or an adverse event due to negligence, was predictive of payment to the plaintiff.     

The effect of water pipelines on the quality of drinking water

Examined whether marital discord over childrearing contributes to child behavior problems after taking into account general marital adjustment, and if child age moderates associations between child behavior problems and either general marital adjustment or marital discord over childrearing. Participants were 146 two-parent families seeking services for their child's (4 to 9 years of age) conduct problems. Data on marital functioning and child behavior problems were collected from both parents. Mothers' and fathers' reports of marital discord over childrearing related positively to child externalizing problems after accounting for general marital adjustment. Child age moderated associations between fathers' reports of general marital adjustment and both internalizing and externalizing child problems, with associations being stronger in families with younger children. The discussion highlights the role that developmental factors may play in understanding the link between marital and child behavior problems in clinic-referred families.     

A prospective study of spontaneous abortion: relation to amount and source of drinking water consumed in early pregnancy

Turcot's syndrome (TS) is a rare disorder associated with the development of both brain and colon neoplasms. Because of the very low incidence of the disease, its molecular basis remains unclear. Presented is a TS case of a 30-year-old Japanese male with a histopathologically confirmed diagnosis of both brain tumor (glioblastoma multiforme) and colon tumor (well-differentiated adenocarcinoma). Germline mutations of the p53 gene, somatic mutations of the Ki-ras, p53 and APC genes, and microsatellite instability (MSI) was examined using polymerase chain reaction (PCR)-single strand conformation polymorphism analysis, followed by PCR-direct sequencing, and sequencing after subcloning. No germline mutations of the p53 gene were found. Somatic mutations of Ki-ras and APC genes were found in the colon adenocarcinoma but not in the brain tumor. No somatic mutation of the p53 gene was present in either colon or brain tumors. Microsatellite instability of both colon and brain tumors was positive in two of four loci. These results indicate that the colon tumor of the TS patient carries the Ki-ras and APC gene mutations. The finding of MSI in both the brain and the colon tumors may support the hypothesis that alterations of DNA repair genes are involved in the tumor development of the TS patient.     

Stressors and adverse outcomes for female construction workers.

The authors examined the impact of a number of job stressors, including sexual harassment and gender-based discrimination, on female construction workers' level of job satisfaction and psychological and physical health. Results from a telephone survey with 211 female laborers indicated that having responsibility for others' safety and having support from supervisors and male coworkers was related to greater job satisfaction. Increased reported psychological symptoms were also related to increased responsibility, as well as skill underutilization, experiencing sexual harassment and gender-based discrimination from supervisors and coworkers, and having to overcompensate at work. Perceptions of overcompensation at work and job certainty were positively associated with self-reports of insomnia. Finally, sexual harassment and gender discrimination were positively related to reports of increased nausea and headaches. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Calcium supplementation of hen drinking water

Two experiments with White Leghorn hens (42 and 56 wk old, respectively) examined the effects of calcium supplementation through drinking water in the presence of adequate and inadequate dietary calcium. Each experiment was of 28 d duration with six replicate pens of five individually caged hens in each treatment. Treatments were a combination of either 2.25 or 3.5% dietary calcium coupled with tap water or water supplemented with .2% calcium from calcium lactate. In both studies, specific gravity of eggs was significantly improved when low dietary calcium was supplemented with .2% calcium in the drinking water. Egg production and egg weight were not influenced by waterborne calcium. Daily water intake was reduced by calcium lactate in all cases. Feed consumption was also depressed by waterborne calcium in both studies when 3.5% dietary calcium was given, and in Experiment 1 when 2.25% was fed. Waterborne calcium as calcium lactate was found to be effectively utilized for eggshell quality improvement when dietary sources were inadequate.