Prospective study of fluoxetine treatment and suicidal behavior in affectively ill subjects

A complementary DNA clone preferentially expressed in the gastrointestinal tract was obtained from a rat stomach library. The protein coded by the clone had a single carbohydrate recognition domain having conserved motifs for beta-galactoside binding and showed 67% amino acid identity with human galectin-2. The recombinant protein synthesized in Escherichia coli could bind to an asialofetuin column and was eluted with beta-galactopyranoside. From these observations, we named the protein rat galectin-2 coded by the cDNA. The rat galectin-2 was predominantly expressed in the epithelial cells of stomach. Thus this protein may form a mucin layer cross-linking with the beta-galactoside moiety of glycoproteins.     

The relationship between anxiety disorders and age

OBJECTIVES: To review the major community-based epidemiological studies that have reported data on anxiety disorders in individuals aged 65 and over and to examine age-related changes in their prevalence and incidence. DATA SOURCES AND STUDY SELECTION: All English language entries relating to anxiety in the BIDS, EMBASE, Medline and PsychLit computerized databases, together with a search of relevant citations. DATA SYNTHESIS: The prevalence of phobic disorders in the population aged 65 or over lies between 0.7% and 12% over a 1-6-month period. As the rates for social phobia, 1%, and simple phobia, 4%, are fairly consistent, much of this variation is due to agoraphobia, whose prevalence lies between 1.4% and 7.9%. The prevalence of obsessive-compulsive disorder is 0.1-0.8%, panic disorder 0.1% and generalized anxiety 4%. Women do have a higher prevalence of anxiety disorders than men but this difference diminishes with increasing age, as does the apparent prevalence of all anxiety disorders apart from generalized anxiety, measured without hierarchical rules, which appears to be maintained or increase. The relative importance of various explanations for this apparent reduction is discussed, including the three that are of greatest public health and clinical importance: cohort effects, anxiety-related mortality and comorbidity between anxiety and cognitive impairment. A tri-dimensional approach (psychic, somatic and behavioural) to anxiety measurement is advocated in order to facilitate future studies of age-related changes which may lead to a reappraisal of the status of generalized anxiety as a 'residual category'.     

The use of homework in behavior therapy for anxiety disorders.

In this article, the authors discuss the role of homework in behavior therapy for the anxiety disorders. First, the authors describe the essential components of behavior therapy that include exposure to feared consequences and cessation of all avoidance behaviors. Then, the authors briefly review the literature on the relationship between homework compliance and treatment outcome. Next, the authors discuss the way that homework is used in terms of self-monitoring and exposure exercises during the course of treatment. Finally, the authors discuss the practicalities of encouraging homework compliance and managing noncompliance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Lifetime comorbidity among anxiety disorders and between anxiety disorders and other mental disorders in adolescents

We examine the lifetime comorbidity among anxiety disorders, and between anxiety disorders and other mental disorders, in a large (n = 1,507) community sample of high school students on whom extensive diagnostic data were available. Three diagnostic groups were formed: those with a lifetime anxiety disorder (n = 134); those with a nonanxiety disorder (n = 510); and those who had never met criteria for a mental disorder (n = 863). The intra-anxiety comorbidity rate was relatively low (18.7%), and was strongly associated with being female (92%). The lifetime comorbidity between anxiety and other mental disorders (primarily MDD) was substantial (73.1%) and was not associated with being female.     

Relationships between suicidal behavior and personality types

This study examined the hypotheses that introversion in general and the introverted-intuitive-feeling-perceiving (INFP) type as measured by the Meyers-Briggs Type Indicator are related to suicidal ideation and behaviors. Analyses of data from 330 university students found four interactive suicidal behavior risk models: introverted-perceiving (IP) (females); introverted-sensing-feeling (ISF) (males); introverted-intuitive-perceiving (INP) (males); extraverted-intuitive-judging (ENJ) (males). Study findings were interpreted in terms of implications for risk assessment and intervention.     

Cerebrospinal fluid corticotropin-releasing factor concentrations in patients with anxiety disorders and normal comparison subjects

A simple immunosensor based on a conductivity method was developed for determination of methamphetamine (MA, a stimulant drug) in urine. Anti-MA antibody was immobilized onto the surface of a pair of platinum electrodes. The reaction of MA with the antibody causes a decrease in the conductivity of the anti-MA immobilized layer between the electrodes. A linear relationship was obtained between the conductivity and MA concentration in the range of 1-10 micrograms/ml. The method requires the sample to be rinsed with water on the electrodes after the immunoreaction. This detection system was applied to the determination of MA in urine and proved to be a useful and a simple detection technique of MA in forensic science in comparison with a gas chromatography-mass spectrometry method.     

The relationship between maladaptive cognitions and social anxiety.

Used the cognitive theories of A. Beck (see PA, Vol 56:8303) and A. Ellis (see PA, Vol 37:1437) to identify cognitive phenomena thought to be related to social anxiety. Their constructs, risk appraisal and irrational beliefs, were operationalized for the present study. Both discriminated between a clinical sample of 46 anxious men and a group of 18 competent daters (18–26 yrs). Together they accounted for 35% of the variance in social anxiety for a mixed sample of high, moderate, and low confident men. Ss were administered the Irrational Beliefs Test, Survey of Heterosexual Interactions, and Situational Expectancies Inventory. Results are discussed in terms of their clinical significance and implications for cognitive assessment of social anxiety. (7 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The relationship between anxiety and oral word association performance.

To test the comparative validity of 2 theories of anxiety (Sarason's interfering response and Spence and Taylor's drive theory), associations to word stimuli were analyzed. According to drive theory, anxiety should interfere with the number of different associations to the same word. Words that stimulate few associations should result in short reaction times and few disturbance of responsiveness and rare responses. According to interference theory there should be an effect upon association without an interaction between the degree of association value of the word and anxiety level of S. The results were interpreted as supporting Sarason's theory. From Psyc Abstracts 36:04:4HK68G. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The relationship between level of self-esteem and suicidal ideation with stability of self-esteem as moderator.

131 undergraduate university students (aged 18-24 yrs) participated in a study of the relationship between suicidal ideation and level and (in)stability of self-esteem, while controlling for the possible effect of depression. Level of self-esteem and (in)stability of self-esteem, suicidal ideation, and depression were measured using M. Rosenberg's (1965) Self-Esteem Scale, the scale for Suicidal Ideation, and the Beck Depression Inventory (A. T. Beck et al., 1961), respectively. Results of correlation analyses and an analysis of covariance show that suicidal ideation was significantly related to level of self esteem, but not to (in)stability of self-esteem. An interaction effect shows that for individuals with high self-esteem, variation in self-esteem stability did not have a significant moderating influence, whereas for those with low self-esteem, stable self-esteem appeared to be a protective factor. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comorbidity of substance use disorders with mood and anxiety disorders: results of the International Consortium in Psychiatric Epidemiology

This article reports the results of a cross-national investigation of patterns of comorbidity between substance use and psychiatric disorders in six studies participating in the International Consortium in Psychiatric Epidemiology. In general, there was a strong association between mood and anxiety disorders as well as conduct and antisocial personality disorder with substance disorders at all sites. The results also suggest that there is a continuum in the magnitude of comorbidity as a function of the spectrum of substance use category (use, problems, dependence), as well as a direct relationship between the number of comorbid disorders and increasing levels of severity of substance use disorders (which was particularly pronounced for drugs). Finally, whereas there was no specific temporal pattern of onset for mood disorders in relation to substance disorders, the onset of anxiety disorders was more likely to precede that of substance disorders in all countries. These results illustrate the contribution of cross-national data to understanding the patterns and risk factors for psychopathology and substance use disorders.     

Platelet monoamine oxidase activity in mental disorders: 2. Affective psychoses and suicidal behavior

A case of permanent atrial standstill is described in a 10-month-old dog with ascites as a presenting complaint. The patient had absence of P waves in all leads in numerous ECG's and had a regular idioventricular rhythm. Pathologically, the patient had multiple areas of atrial and ventricular myocardial necrosis and fibrosis, with chronic active myocarditis and obliteration of the SA and AV node and AV bundle.     

The relationship between oral contraceptives and adolescent sexual behavior

The AAMD Adaptive Behavior Scale, Public School Revision, was administered to 2,618 elementary-school children from 7 to 13 years of age. The sample of children included White, Black, and Spanish-surname groups from regular and special-education classes. Factor analyses of domain scores indicated four dimensions of adaptive behavior: Functional Autonomy, Interpersonal Adjustment, Social Responsibility, and Intrapersonal Adjustment. Comparison of factor structure across school classification and age groups revealed the same four dimensions for all groups. Implications for the assessment of adaptive behavior were discussed.     

The relationship between opioid use and laxative use in terminally ill cancer patients

BACKGROUND AND OBJECTIVES: Functional pacemaker interference by mobile telephones has been described with analogical systems and with possible greater influence, digital systems, including inhibition and inadequate pacing. The influence of both system has not been extensively studied in patients with implantable cardioverter defibrillators (ICD). PATIENTS AND METHODS: We studied the influence of mobile phones, both digital and analogic network, on the performance of several models of defibrillators, in a standardised test set up designed to provide high sensitivity. The purpose of our study was to establish whether there are any influences on ICD functions, both in in vivo and in in vitro models. Several mobile phones, with different transmission powers, were moved towards the defibrillator and the electrode, under continuous documentation of defibrillator sensing and interrogation afterwards. The experimental model was performed with the aid of an arrhythmia simulator (Intersim) and demo-defibrillators. The tests were repeated both in and out of a solution of saline water with an impedance within normal human limits. RESULTS: Partial loss of telemetry was found in 14 patients, 8 with analogical phones and 6 with digital phones. Fourteen patients showed alterations only on the surface electrocardiogram channel and five on the intracavitary channel. The same results were reproduced in the in vitro model. However, the in vitro test allowed us to simulate multiple ventricular arrhythmias, and demonstrate the normal sensing and functioning of the defibrillator during a "spontaneous" arrhythmia. After testing, we demonstrate that no real oversensing/undersensing was documented in any device. There was no evidence of ICD reprogramming or pacing inhibition. In particular, no inadequate therapies were delivered. CONCLUSIONS: a) in our series, we have not demonstrated clinically significant electromagnetic interferences with mobile phones of digital or analogical networks: b) the in vitro model allowed us to conclude that even if a spontaneous arrhythmia appears, the function of the defibrillator is not altered; c) the use of mobile phones seems to be safe for defibrillator patients, and d) however, some basic rules, such as to maintain the phone at least 15 cm away from the defibrillator, are advised.     

The relationship between discontinuous yielding and cyclic behavior in polycrystalline molybdenum

The fatigue properties of polycrystalline molybdenum at room temperature have been determined by axial tension-compression tests in both stress and strain control modes to give lives of up to 10⁶ cycles. Under the appropriate conditions, the endurance limit can be considerably reduced,e.g., the stress to cause failure in 10⁶ cycles decreases from ～42,000 psi at 5 cps to ～28,000 psi at 0.5 cps. The fatigue resistance as assessed by either strain control or by stress control is discussed in relation to the tensile and creep behavior, and it is concluded that the reduction in the long life fatigue resistance with decrease in the cyclic frequency is due to the time dependent generation of a mobile dislocation population. The previously accepted value of 0.6 for the ratioFL/UTS for bcc metals can be attributed to this frequency effect. A lower value for this ratio, 0.4, can be derived from the high frequency data by the use of an extrapolation technique. This lower value is confirmed by long life, low frequency tests, in agreement with the value for fcc metals. The importance of obtaining fatigue data under comparable states of mobile dislocation density is emphasized, particularly for materials exhibiting pronounced tensile yield points, in order that meaningful comparisons can be made between different materials.     

Social anxiety in children with anxiety disorders: relation with social and emotional functioning

BACKGROUND: Oxygen radicals have been implicated as important mediators in the early pathogenesis of acute pancreatitis, but the mechanism by which they produce pancreatic tissue injury remains unclear. We have, therefore, investigated the effects of oxygen radicals on isolated rat pancreatic acinar cells as to the ultrastructure, cytosolic Ca2+ concentration and energy metabolism. METHODS: Acinar cells were exposed to an oxygen radical-generating system consisting of xanthine oxidase, hypoxanthine and chelated iron ions. Cell injury was assessed by LDH release and electron microscopy. Cytosolic Ca2+ levels and mitochondrial membrane potential were determined by flow cytometry; adenine nucleotide concentrations by HPLC. Mitochondrial dehydrogenase activity was measured by spectrophotometric assay. RESULTS: Oxygen radicals damaged the plasma membrane as shown by a 6-fold LDH increase in the incubation medium within 180 min. At the ultrastructural level, mitochondria were the most susceptible to oxidative stress. In correlation to the pronounced mitochondrial damage, the mitochondrial dehydrogenase activity declined by 70%, whereas the mitochondrial membrane potential was enhanced by 27% after 120 min. Together this may cause the 85% decrease in the ATP concentration and the corresponding increase in ADP/AMP observed in parallel. In addition, an immediate 26% increase in cytosolic Ca2+ was found, a change which could be inhibited by BAPTA, reducing cellular damage. CONCLUSION: Cytosolic Ca2+ synergizes with oxygen radicals causing alterations of the ultrastructure and energy metabolism of acinar cells which might contribute to the cellular changes found in early stages of acute pancreatitis.     

Social anxiety, sexual behavior, and contraceptive use.

170 female and 90 male college students completed a questionnaire that provided information regarding their sexual experience, knowledge, and attitudes; their self-evaluations on dimensions related to sexuality; and their level of heterosocial anxiety (anxiety experienced in social interactions with members of the other sex). Compared with Ss low in heterosocial anxiety, highly anxious Ss were less sexually experienced, engaged in sexual activity less frequently, had fewer sexual partners, were less likely to have engaged in oral sex, expressed a higher degree of apprehension about sex, and had a somewhat higher incidence of sexual dysfunctions. In addition, low socially anxious women tended to use the pill, whereas highly anxious women preferred the condom. High and low heterosocially anxious Ss also differed on self-ratings related to their sexuality but did not differ in their attitudes or knowledge regarding sex. Results are discussed in terms of the cognitive, behavioral, and affective concomitants of social anxiety. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Some relations between speech behavior and anxiety level.

The relationships between certain formal aspects of speech behavior and anxiety level, as defined by score on the Taylor Scale of Manifest Anxiety, are investigated. Interpretations of TAT cards for two groups of Ss, one "high anxious" and the other "low anxious" as determined by the Taylor scale, are scored for verb/adjective quotient, number of adjectives per 100 words, total number of words, latency, and number of words per minute. For all five measures, the "high anxious" groups showed higher scores; however, only the predicted difference in total word count, and the predicted difference in latent time, approached statistical significance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

For suicidal young adults with comorbid depressive and anxiety disorders, probem-solving treatment may be better than treatment as usual.

Practicing psychologists face many complexities and challenges in caring for suicidal patients who have comorbid mood and anxiety disorders. Not only must suicidal crises be addressed, but co-occurring depressive and anxiety symptoms compete for attention as well and are associated with relatively poor clinical prognosis in usual treatments. The current study compared problem-solving treatment to treatment as usual among depression–anxiety comorbid versus noncomorbid clinically suicidal young adults. Suicidal patients with mood and anxiety disorders were randomized to the 2 treatments and followed over time. Comorbid suicidal patients, in particular, experienced notable symptom improvements from the problem-solving treatment. Features of the problem-solving treatment are described for use in clinical practice. (PsycINFO Database Record (c) 2010 APA, all rights reserved)