Effect of BCG and cyclophosphamide on the antitumor activity of mouse peritoneal macrophages

Peritoneal macrophages activated by BCG and cyclophosphamide were unable to complete elimination of small numbers of tumour cells in spite of high level of cytotoxicity and cytostatic activity of these cells. It is appeared useful to evaluate the influence of new immunomodulators and combinations of immunomodulators with chemotherapeutic drugs not only on the cytotoxic and cytostatic, but also on the "feeder" activity of macrophages.     

Effect of the combined use of BCG, PPD, a protein-containing preparation from allogenic tissue and cyclophosphamide in the development of methylcholanthrene-induced tumors

The organism resistance to the appearance of 20-methylcholanthrene-induced tumours may be enhanced by application of different immunologic factors (BCG, PPD, low-molecular allogenic protein) in combination with a single administration of cyclophosphane (CPh). The positive effect was observed both when CPh was applied prior to the immunologic impact (3 or 7 days before) and after it (3 or 8 days later). In the last case the effect was more stable.     

90°转向复合延迟器件的研制

为实现延迟器件出射光束的90°转向功能,提出了一种新的设计,利用一等腰直角菱体延迟器和一平板延迟器的组合,使光束在菱体延迟器上发生全反射而转向90°,同时使器件具有延迟功能。测试表明,实际制作的器件的误差完全在允许范围内,说明这一设计是合理的。     

孕期微量染镉对雄性胎鼠性腺分化发育影响的研究

目的：探讨孕期微量染镉对胎鼠睾丸分化发育的影响及作用机制。方法：SD孕鼠16只,随机分为镉组（A组）、己烯雌酚组（B组）、镉加他莫静酚组（C组）和正常对照组（D组）,每组4只。A组于孕期第9、11、13天腹腔注射氯化镉1．5H影（kg．d）,B组于妊娠第9至17天皮下注射已烯雌酚10％g／（kg．d）,C组注射氯化镉的同时给予雌激素受体拮抗剂他莫昔酚50mg／（kg．d）,D组注射与镉等体积生理盐水。妊娠第18天,削商产取雄性胎鼠睾丸作光、电镜观察;免疫组化测定各组胎鼠睾丸间质细胞类固醇激素合成急性调节蛋白（StAR）表达水平;RT—PCR法测定曲勒氏管抑制物（MIS）表达量。结果：光镜下A组和B组睾丸生精小管内支持细胞排列紊乱,间质成分增生,C组未见明显的形态学改变;电镜下A组和B组均可见支持细胞、生殖母细胞及间质细胞线粒体肿胀、内质网扩张以及间质细胞内脂滴堆积,C组超微结构退变轻于A组和B组;A组和B组间质细胞中StAR阳性产物表达均显著低于D组（P〈0．01）,C组StAR阳性产物表达虽低于D组,其差异没有统计学意义（P〉0．05）,但却明明显高于A组（P〈0．05）;各组间MIS表达差异无统计学意义（P〉0．05）。结论：孕期微量镉暴露可影响雄性胎鼠性腺的分化与发育,且镉具有雌激素样作用．     

Effect of vaccination of mice with endogenous retrovirus on the development of tumors induced by gamma-irradiation or 7,12-dimethylbenz[a]anthracene

Mouse vaccination with alive endogenous N-tropic virus OA-3 inhibited and decreased the development of the Rauscher leukemia in C57B1/6 mice (B-type) and SWR mice (N-type) as well as the development 7,12-dimethyl benzanthracene (DMBA)-induced tumours in mouse hybrids (neither N-, nor B-types). The effect of vaccination was DMBA- or MLV-P-dose-dependent. Vaccination with the same virus did not affect the incidence of gamma-irradiation-induced leukemia in CBA mice (N-type) and C57B1/6 mice while it increased twice the incidence of radiation leukemia in DBA mice (N-type). However, the incidence of thymomas lowered in radiation leukemia-bearing vaccinated mice of all the 3 strains, which may result from inhibition of murine thymotropic endogenous virus reproduction. The data obtained indicate the participation of murine own endogenous viruses in DMBA- or gamma-irradiation induced carcinogenesis.     

Effect of oblique incidence on bistability of nonlinear microcavity

Based on the nonlinear medium transfer theory, optical bistability of nonlinear microcavity is investigated at oblique incidence. It is found that the critical frequency of incident light inducing bistability phenomenon is related to the polarization and incident angle. The critical frequency increases with the incident angle. Increasing the incident angle can make bistability happen easier for focusing Kerr medium, but will hinder bistability for defocusing Kerr medium. The bistability switch threshold of TE mode is significantly lower than that of TM mode at a large incident angle.     

Effect of correcting liver function on the development of DMBA-induced mammary gland tumors and the metabolism of sex steroid hormones in rats

The tumours of mammary glands in Wistar rat females were induced by threefold intravenous administration of 7,12-dimethylbenz (a) anthracene (DMBA). The application of pharmacological preparations contributing to the liver function correction (PCLF) in the process of carcinogenesis and during the surgical treatment of mammary tumours leads to prolongation of the first tumour latent period after DMBA administration and of recurrent tumours after the operation. The lowering of the frequency, multiplicity and the rate of mammary tumours growth were also observed. The use of PCLF exerted a normalizing effect on the level of sex steroid hormones in rats.     

阜阳市儿童预防接种信息系统数字化预防接种门诊试点效果评价

目的：了解依托儿童预防接种信息化系统建立的数字化接种门诊对预防接种工作流程中发挥的效果。方法：采用现况调查和自身前后对照的方法,收集和分析资料。结果：数字化接种门诊实施前后接种流程中各个阶段,差异有统计学意义（t=14.611、t =6.964、t =12.704、t =10.418、t =28.673、t =31.138,P＜0.05）,数字化后的患儿家属满意度高于数字化前,差异有统计学意义（χ2=80.954、χ2=103.156、χ2=4.536、χ2=64.737,P＜0.05）。结论：数字化预防接种门诊能够明显缩短疫苗接种效率并提高儿童家长的满意度。     

Effect of ethanol on the hepatocarcinogenic action of N-nitrosodiethylamine in rats

It is shown that the administration of ethanol to male Wistar rats (3 g/kg by gastric tube 3 times a week for 2 months) before or at the beginning of the N-nitrosodiethylamine (NDEA) treatment (2.5 mg/kg 6 times a week in drinking water) reduces the hepatocarcinogenicity of NDEA. This was expressed macroscopically by less important neoplastic changes and biochemically by the higher glucose-6-phosphatase and lower glucose-6-phosphate dehydrogenase activities in the liver.     

Snapback应力对90nm nMOSFET栅氧化层完整性的影响

基于测试对snapback应力引起的栅氧化层损伤特性和损伤位置进行了研究．研究发现应力期间产生的损伤引起器件特性随应力时间以近似幂指数的关系退化．应力产生的氧化层陷阱将会引起应力引起的泄漏电流增加，击穿电荷减少，也会造成关态漏泄漏电流的退化．栅氧化层损伤不仅在漏区一侧产生，而且也会在源区一侧产生．热空穴产生的三代电子在指向衬底的电场作用下向Si-SiO2界面移动，这解释了源区一侧栅氧化层损伤的产生原因．     

Effect of androgens on the development of leukemia in AKR-strain mice

A possibility of the androgen's correction of spontaneous and transplanted leukogenesis has been investigated in AKR mice. Prolongation of life was observed in the animals treated with the hormone at early stages of the leukemia development. The obtained results may be related to the stem hemopoietic precursors differentiation change under the testosterone influence manifested by erythropoiesis stimulation and the reduction of granulocytic colonies determined by the growth in the cellulose-acetate membranes (CFUcam).     

Effect of Electromigration on Interfacial Reactions in 90Sn-10Sb Pb-Free Solder Joints

The electromigration effect on interfacial reactions in Cu/90Sn-10Sb/Cu Pb-free solder joints was investigated under electric current stressing. The growth of the Cu₃Sn and Cu₆Sn₅ intermetallic compound (IMC) layers was enhanced at the anode but inhibited at the cathode, compared with the no-current case. The growth of the IMC at the anode followed a parabolic law. Upon increasing the temperature to about 140°C, the thickness of the Cu₆Sn₅ IMC at the anode increased significantly. Sn₃Sb₂ IMC coarsened in the Cu₆Sn₅ IMC at the anode and in the β-Sn at the cathode. The possible mechanism of the electromigration effect is discussed.     

护理干预对糖尿病前期人群的影响

目的探讨护理干预对糖尿病前期人群2型糖尿病发生率的影响。方法对糖尿病高危人群行口服葡萄糖耐量试验(OGTT),按1999年WHO的诊断标准,对筛选出的165例糖耐量减低(IGT)患者进行1年6个月前瞻性观察。初访时随机分为对照组(口服药物组)和护理干预组,每半年进行OGTT复查。结果1年6个月末,对照组和护理干预组空腹血糖(FPG)及餐后2h血糖(2hPG)均有明显下降,平均每年对照组糖尿病发生率为3.3%,护理干预组糖尿病发病率为4%。结论护理干预与口服药物对糖尿病前期人群减少糖尿病发生作用相当。     

Effect of ascorbic acid on the hepatocarcinogenic action of N-nitrosodiethylamine in rats

It is shown that the ascorbic acid (AA) administration to Wistar male rats (50 mg per animal intraperitoneally 3 times a week) accelerates hepatocarcinogenesis induced by N-nitrosodiethylamine (2.5 mg/kg 6 times a week in drinking water). In this case the activity of glucose-6-phosphate dehydrogenase in liver increases, while that of glucose-6-phosphatase decreases.     

入射光椭圆度对晶体微粒旋转角速度的影响

光致旋转技术在微机械和微生物等领域的应用越来越广泛。利用光束自旋角动量可以导致晶体微粒光致旋转的机理,从理论上分析了入射光椭圆度对晶体微粒旋转角速度的影响。通过MATLAB对不同激光功率下,光束的椭圆度与晶体微粒旋转角速度的关系进行数值模拟。结果表明:在实际对晶体微粒光致旋转操作中,晶体微粒能否旋转起来取决于光束椭圆度与微粒厚度之间的关系;在同一激光功率下,光束椭圆度与晶体微粒旋转角速度呈正旋曲线变化。因此,通过调节光束的椭圆度和较高的激光功率可以提高晶体微粒的旋转角速度。该结论对光驱动微机械马达的优化设计有一定的指导意义。     

Effect of intravascular pressure changes on the induction of bone neoplasms in rats

The development of bone tumours induced by 3,4-benzpyrene in rats with arterial hypotension and venous congestion was studied. Six months after, osteogenous sarcomas were detected in 36% of animals with normal pressure, in 10%--with arterial hypotension and in 58%--with venous congestion. The differences in the antitumor tissue resistance under chemical blastomogenesis, as well as in cases of transplanted tumours, are supposed to depend on the character of compensatory rearrangements in the microcirculatory bed in response to the intravascular pressure change.     

糖皮质激素对大鼠睾丸血睾屏障的影响

糖皮质激素是肾上腺皮质分泌的一种甾体类激素 ,参与机体的代谢、免疫、以及生长发育的调控 ,对于维持机体的内稳态起着重要的作用[1] ,临床上常用于抗炎及免疫治疗 ,但由于糖皮质激素是一种作用广泛的激素 ,几乎对机体的每一个器官都有作用[2 ] ,因此糖皮质激素对机体各个器官的影响不容忽视 ,为此我们研究了糖皮质激素对睾丸超微结构的影响 ,以期为糖皮质激素与睾丸的关系研究及临床用药提供一些依据。材料与方法1 .动物分组和给药　雄性 SD大鼠 8只 ,体重 2 5 0～ 2 80 g,由河北省实验动物中心提供。随机分为 2组 ,每组 4只 :正常对照组…     

Dependence of the incidence of the occurrence of ovarian and uterine tumors in rats on the irradiation dosage from accelerated particles and gamma rays

The incidence rate of ovarian and uterine tumours in rats after irradiation by protons with the energy of 645 MeV, 9 GeV and He2+ has been studied. The tumour rate is shown to increase with the radiation dose. The character of the dose-response for tumours of two sites is different. A relative risk of ovarian tumour incidence after He2+ exposure is twice as high as after other types of radiation.     

Effect of cryodestruction of Lewis lung carcinoma in mice on the development of metastases

The effect of the primary tumour cryodestruction on a degree of metastatic spreading in the lungs was investigated in experiments with C57B1/6 mice with Lewis carcinoma of the lungs. It is found that after the tumour cryosurgery there was a less quantity of metastases as compared with operated animals (surgical removal of the tumour or amputation of the limb with the tumour) or with untreated animals. A regular correlation is observed between the degree of metastatic spreading and the efficiency of the primary tumour treatment. The relapse after cryosurgery or surgical removal of the tumour led to an increase in the quantity of pulmonary metastases.     

Effect of staphylococcal enterotoxin A on the development of Lewis lung carcinoma in mice

The effect of Staphylococcus aureus enterotoxin A (SEA) was studied for its effect on the development of the Lewis carcinoma in mice. It was shown that administration of SEA immediately after the appearance of the primary node in mice after transplantation of tumour cells led to insignificant inhibition of the node growth and a slight decrease of tumour metastasizing into the lungs. Inoculation of mice after the appearance of the primary node with 1/microgram of SEA 5 times a week significantly increased their survival rate. The lack of the marked effect of SEA appears to be associated with the disturbance of the immune interferon system functioning in tumour-bearing mice, since the production of serum interferon induced by SEA in mice with tumours was considerably lower than in the intact ones.