共查询到20条相似文献,搜索用时 15 毫秒
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Cyanidin‐3‐glucoside and its phenolic acid metabolites attenuate visible light‐induced retinal degeneration in vivo via activation of Nrf2/HO‐1 pathway and NF‐κB suppression 下载免费PDF全文
Yong Wang Yazhen Huo Liang Zhao Feng Lu Ou Wang Xue Yang Baoping Ji Feng Zhou 《Molecular nutrition & food research》2016,60(7):1564-1577
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Che‐yi Chao Mei‐chin Mong Kung‐chi Chan Mei‐chin Yin 《Molecular nutrition & food research》2010,54(3):388-395
Protective effects of caffeic acid (CA) and ellagic acid (EA) in kidney of diabetic mice were examined. CA or EA at 2.5 and 5% was mixed in diet and supplied to diabetic mice for 12 wk. Results showed that the intake of CA or EA increased renal content of these compounds, alleviated body weight loss, decreased urine output, increased plasma insulin and decreased blood glucose levels at weeks 6 and 12 (p<0.05). The intake of these compounds dose dependently reduced plasma blood urea nitrogen and elevated creatinine clearance (p<0.05). CA or EA at 5% significantly decreased the levels of plasma HbA1c, urinary glycated albumin, renal carboxymethyllysine, pentosidine, sorbitol and fructose (p<0.05), and significantly diminished renal activity of aldose reductase and sorbitol dehydrogenase, as well as suppressed renal aldose reductase mRNA expression (p<0.05). CA or EA dose dependently lowered renal levels of IL‐6, IL‐1β, tumor necrosis factor (TNF)‐α and monocyte chemoattractant protein 1 (MCP‐1) (p<0.05). Furthermore, CA or EA dose dependently down‐regulated tumor necrosis factor‐α and monocyte chemoattractant protein‐1 mRNA expression in kidney (p<0.05). Based on the observed anti‐glycative and anti‐inflammatory effects, the supplement of CA or EA might be helpful for the prevention or attenuation of diabetic kidney diseases. 相似文献
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Green tea extract provides extensive Nrf2‐independent protection against lipid accumulation and NFκB pro‐ inflammatory responses during nonalcoholic steatohepatitis in mice fed a high‐fat diet 下载免费PDF全文
Jinhui Li Teryn N. Sapper Eunice Mah Swetha Rudraiah Kevin E. Schill Chureeporn Chitchumroonchokchai Meredith V. Moller Joshua D. McDonald Philip R. Rohrer José E. Manautou Richard S. Bruno 《Molecular nutrition & food research》2016,60(4):858-870
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Ru‐Huei Fu Shih‐Ping Liu Ching‐Liang Chu Ya‐Hsien Lin Yu‐Chen Ho Shao‐Chih Chiu Wei‐Yong Lin Woei‐Cherng Shyu Shinn‐Zong Lin 《Journal of the science of food and agriculture》2013,93(1):76-84
BACKGROUND: Myricetin is a naturally occurring flavonoid that is found in many fruits, vegetables, teas and medicinal herbs. It has been demonstrated to have anti‐inflammatory properties, but, to date, no studies have described the immunomodulatory effects of myricetin on the functions of dendritic cells (DCs). The aim of this study was to evaluate the potential for myricetin to modulate lipopolysaccharide (LPS)‐stimulated activation of mouse bone marrow‐derived DCs. RESULTS: Our experimental data showed that treatment with myricetin up to 10 µg mL−1 does not cause cytotoxicity in cells. Myricetin significantly decreased the secretion of tumour necrosis factor‐α, interleukin‐6 and interleukin‐12p70 by LPS‐stimulated DCs. The expression of LPS‐induced major histocompatibility class II, CD40 and CD86 on DCs was also inhibited by myricetin, and the endocytic and migratory capacity of LPS‐stimulated DCs was blocked by myricentin. In addition, LPS‐stimulated DC‐elicited allogeneic T‐cell proliferation was reduced by myricetin. Moreover, our results confirmed that myricetin attenuates the responses of LPS‐stimulated activation of DCs via suppression of IκB kinase/nuclear factor‐κB and mitogen‐activated protein kinase‐dependent pathways. CONCLUSION: Myricetin has novel immunopharmacological activity, and modulation of DCs by myricetin may be an attractive strategy for the treatment of inflammatory and autoimmune disorders, and for transplantation. Copyright © 2012 Society of Chemical Industry 相似文献
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