Light scattering studies of aqueous solution of polyvinylpyrrolidone (author''s transl)

The investigations were done in a group of 100 patients with migraine, 50 patients with chronic diseases of various organs and 50 healthy subjects. EEG investigations in patients with migraine were carried out several times, in controls only once. The records were interpreted according to strictly defined criteria separating normal from pathological (slightly, moderately and severely) records. In 35% of migrainous patients slight or moderate changes were found. The frequency of these changes was significantly increased in relation to healthy subjects and approached the frequency found in non-neurological cases. EEG changes in migrainous patients failed to demonstrate any specific features and failed to correlate with clinical findings. The analysis of 330 EEG records in 100 cases of migraine demonstrated that some records changed in time and that the number of records showing deterioration was greater than that of records showing improvement.     

Hallucinantion and illusion (author''s transl)

The value of an anaesthetic attachment during the first two postgraduate years is considered under three major headings, the value to the recent graduate, the value to the specialty, and the value to the community. The anaesthetic attachment offers all recent graduates an opportunity to perfect practical skills which should from part of the armamentarium of all doctors, and for some there is the option to acquire the ability to administer a safe anaesthetic. Exposure to the specialty at this time is important for recruitment to the specialist ranks.     

Angiography in coxarthrosis (author''s transl)

The preparation of 125I-labelled tracer for digoxin radioimmunoassay (125I monoiodinated 3-succinyl digoxigenin-1-tyrosine) is described, and its performance in radioimmunoassay of plasma samples is compared with that obtained with tritiated digoxin. The accuracy levels were assessed through the evaluation of different potential sources of systematic errors, such as interference from digoxin-related molecules and plasma proteins and methodological artefacts possibly associated with the immunocomplex instability, and through a series of checks including the recovery and parallelism tests and the correspondence of results obtained with the two tracers. The slope and the repeatability with time of the calibration curves and the spread of replicate estimates were taken into consideration to assess the assay precision. An essential equivalence in terms of reliability of measurement was proved for the two methodological variants, so that practical aspects and economic factors remain the main criteria to evaluate the relative merits: from this point of view, the advantages of using 125I-labelled tracer, as an alternative to tritiated digoxin, are discussed.     

Serum folic acid in anticonvulsant long term therapy (author''s transl)

Forty Holstein heifer calves were assigned at random among four dietary treatments: 1) an all-concentrate ration; 2) a pelleted complete ration of 20% alfalfa and 80% concentrate; 3) concentrate and alfalfa pellets fed separately, free-choice; and 4) concentrate and long-stem alfalfa hay fed separately, free-choice. Treatment diets were continued for 12 wk. Calves fed the concentrate only had reduced weight gains, feed intakes, and poorer feed efficiencies compared to treatments 2 and 4. Calves fed long-stem alfalfa hay as a roughage consumed more feed and had larger weight gains than calves fed alfalfa pellets as a roughage free-choice. The pelleted complete ration containing 20% alfalfa was comparable to a ration containing long-stem alfalfa hay free-choice for weight gains and feed efficiencies. The digestibility of dry matter and crude protein of the pelleted complete feed was similar to the digestibility of equal amounts and proportions of concentrate and alfalfa pellets fed separately. Thus, when fed free choice to early-weaned calves, pelleted alfalfa is inferior to long-stem hay for stimulating intake of dry matter. However, increasing the proportion of alfalfa pellets in a complete ration compensates for its partial loss of efficacy for elevating feed intake and growth rates.     

The study on the aqueous extract of Pueraiae radix. III. On the formation of diacetonamine from choline-reineckate in acetone (author''s transl)

Mature female rats were given U11,555A and U11,100A on orally on Day 2 of pregnancy and the number of implantations counted on Day 9. Using doses which reduced the implantation number to approximately 40% that of the controls, it was shown that the reduced number was not due to an effect on egg transport or to a delay of implantation.     

Antibacterial activity of the derivatives of cholic acid (author''s transl)

Serum and urinary myo-inositol and urinary glucose were estimated by means of gas-liquid chromatography in 54 patients with glomerulonephritis with and without renal failure. myo-Inositol clearance was calculated and an index was formulated which reflected changes in glomerular filtration, tubular reabsorption and catabolism of myo-inositol by the kidney. Serum and urinary myo-inositol levels were increased in glomerulonephritis with a close correlation to the degree of renal failure. In advanced forms of glomerulonephritis, glomerular filtration, tubular reabsorption and catabolism of myo-inositol were shown to be markedly deranged. Evidence obtained showed further that a derangement of tubular reabsorption and catabolism of myo-inositol also accompany milder forms of glomerulonephritis without decreased glomerular filtration. The myo-inositol index value, especially, was increased in patients with signs of disease activity as indicated by a histological examination of the kidney tissue. The index can also be regarded as a highly sensitive test of renal failure. Low grade glucosuria was shown to be frequently associated with glomerulonephritis with renal failure. Evidence was produced which suggested that the tubular reabsorption of myo-inositol was deranged earlier than glucose reabsorption in glomerulonephritis, although they may share a common step in the reabsorption process. The data suggest that the estimation of serum and urinary myo-inositol has advantages in the evaluation of kidney function.     

Effect of dexamethasone on erosette formation by lymphoid cells (author''s transl)

The corpora lutea (CL) of the hamster secrete progesterone on days 1 and 2 of the oestrous cycle before marked regression at pro-oestrus (day 4) virtually eliminates them from the ovary. Luteal protein and RNA reached their maximum values on day 2 and declined up to day 4. DNA was constant throughout the cycle substantiating the importance of cellular hypertrophy rather than hyperplasia in the growth of the CL. Concentrations of cholesterol and its esters were unchanged between days 1 and 3 but almost doubled in concentration on day 4. Glucose-6-phosphate dehydrogenase activity was maximal on days 2 and 4, apparently associated on these days with steroidogenesis and lipid metabolism, respectively. A significant increase in acid phosphatase activity occurred on day 3 reaching maximal values on day 4, probably accounting for the rapid regression of the CL. The maximal concentration of 3beta-hydroxysteroid dehydrogenase in CL was on day 1, with a gradual decline over the next 3 days.     

Smell in human sexuality (author''s transl)

The authors present the results of family investigations carried out in a healthy man whose serum contained anti-IDBH alloantibodies. In the erythrocytes of the propositus and one of his brothers defects in ID and IS components were found. At the same time increased expression of IT component was observed in both these men and in their brother. In the erythrocytes of the remaining family members no abnormalities in the components of I complex was found. The authors stress the importance of detection of these defects in the practice of transfusiology in patients with autoimmunohaemolytic anaemia.     

Flocculation-deflocculation behavior of chloramphenicol in aqueous solutions of polyvinylpyrrolidone/ionic surfactants (author''s transl)

Certain impressive epidemiological evidence appearing in the last few years leads to the conclusion that some males are more prone to have a spouse with squamous cancer of the cervix than others. Advances in knowledge in other fields, especially at the molecular biological level, enable speculation on reasons for this curious conclusion. These readily testable theories, together with an outline of the evidence on which they rest, form the substance of this hypothesis.     

Spondylitis in typhoid fever (author''s transl)

Obstructing esophageal food impaction was successfully relieved in 3 patients by the administration of intravenous glucagon. Since proteolytic enzyme digestion of bolus impaction carries a clear risk of fatal esophageal perforation, early therapeutic administration of glucagon during initial esophagography affords a safe and effective acute-care radiologic adjunct. Advantages include immediate diagnosis and therapy, effectiveness in meat and vegetable impactions, and safety for repeated doses. A glucagon-papain combination is suggested as a routine regimen during standard efforts at enzymatic disimpaction.     

Prophylactic psychotherapy of addiction (author''s transl)

In a cohort of 50,282 pregnancies 19 children with cardiovascular defects were born to 1042 women who received female hormones during early pregnancy (18.2 per 1000). Among 49,240 children not exposed in utero to these agents there were 385 with cardiovascular malformations (7.8 per 1000). Six children with cardiovascular defects were born to a sub-group of 278 women who used oral contraceptives during early pregnancy (21.5 per 1000). After the data were controlled for a wide variety of potentially confounding factors by multivariate methods, the association between in utero exposure to female hormones and cardiovascular birth defects was statistically significant.     

Spectrophotometrical determination of paprika-pigments (author''s transl)

3-Methyl-4-thia-cyclohexylsulfamic acid was synthesized, the degree of sweetness of its sodium salt was measured, and compared with that of the sodium salts of 3-methyl-cyclohexylsulfamic acid, 4-thia-cyclohexylsulfamic acid, and cyclohexylsulfamic acid.     

Investigation of ninhydrin reaction (author''s transl)

Nineteen individuals with inordinate fear of dental treatment are presented and discussed with respect to their psychopathology and those aspects of their fear involving feelings of confinement and helplessness in the dental chair, and a negative relationship with the dentist. This material is part of a comprehensive investigation previously reported by the authors into the components and factors contributing to this kind of fear, and the personality and emotional reactions of the individuals suffering from it. The data presented are based on single structured interviews of each patient. Analysis of the patient population suggests division into four major categories: those in whom fear of dental treatment was associated with feelings of inferiority in bodily appearance or function (the largest category); those in whom the fear was associated with neurotic disturbances in which disturbance in body image is not apparent; those in whom the fear was a reflection of a schizophrenic or schizoid process; and those in whom no overt psychopathology was found. The patients in the first category were those who tended most to be afraid of dental treatment due to feelings of confinement or helplessness in the dental chair, or due to a negative relationship with the dentist.     

Treatment of pneumonia in childhood (author''s transl)

It is necessary to start with antibiotic treatment in infections of the lower respiratory system, especially pneumonias. The finding of the infectious agent is difficult and without security. With simple investigations, as sedimentation rate, white blood cell count and cell differentiation there is a possibility of 80% to get a diagnosis of bacterial infection. In 25 patients aged 1 1/2 to 9 years with x-ray diagnosis of pneumonia the results of treatment with cephacetril (100 mg/kg/d) are given. Clinical symptoms disappeared after 5 days, the average time of illness was 12 days. One patient got a severe pleural effusion.