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Mojtaba Abbasian Parvaneh Bighlari Farideh Mahmoodzadeh Metin Hayri Acar Mehdi Jaymand 《应用聚合物科学杂志》2019,136(41):48037
A de novo formulation of metformin (MET) was developed through the physical loading of drug into a chitosan-grafted-[poly(acryl amide)-block-poly(acrylic acid)] [CS-g-(PAAm-b-PAA)] terpolymer. For this purpose, CS was functionazed with phthalic anhydride followed by 4-cyano, 4-[(phenylcarbothioyl)sulfanyl]pentanoic acid to produc a macro-RAFT agent (CS-CTA). Afterward, acryl amide and acrylic acid monomers were graft and block copolymerized onto the synthesized CS-CTA through a reversible addition–fragmentation chain transfer (RAFT) polymerization technique to afford CS-g-PAAm copolymer and CS-g-(PAAm-b-PAA) terpolymer, respectively. The fabricated CS-g-(PAAm-b-PAA) terpolymer was loaded with MET as an anti-diabetic drug, and its drug release behavior was evaluated in the body simulated environment. As results, it was concluded that the fabricated CS-g-(PAAm-b-PAA) nanosystem has high potential as de novo drug delivery system (DDS) for diabetes therapy, mainly due to controlled drug release profile in comparison with conventional formulations of MET. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 48037. 相似文献
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A new pH- sensitive thiol-ended amphiphilic triblock copolymer was synthesized by reversible addition fragmentation chain transfer polymerization. The critical micelle concentration (CMC) value for the synthesized PAA-b-PDMAEMAQ-b-PCL-SH triblock copolymer was determined to be 0.0079?g?L-1 using fluorescence probe technique. The average sizes of PAA-b-PDMAEMAQ-b-PCL-SH micelles was obtained to be 30?±?5?nm using TEM observation. It is expected that the synthesized PAA-b-PDMAEMAQ-b-PCL-SH triblock copolymer considered as a prospective candidate in nanomedicine applications such as chemo-photothermal therapy and drug delivery, mainly due to the strong affinity of thiol-ended group toward gold nanoparticle and its excellent micellization behavior. 相似文献
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A facile thermoresponsive injectable hydrogel is prepared from stearyl methacrylate (SMA) and N-isopropyl acrylamide (NIPAM) copolymers via reversible addition-fragmentation chain-transfer (RAFT) emulsion polymerization method. By regulating the content of the oil phase, emulsions with divergent properties are obtained. The yield stress and the viscosity results of the emulsions increase evidently as the initial content of the oil phase increase from 10 to 40%. The microstructures of 10% oil content sample (SN10) is seen as a dispersed particle whereas 20, 30, and 40% oil content samples (SN20, SN30, and SN40) appear as aggregated particles in a dilute solution that shows the microscopical phase transitions of the emulsions. Increasing the temperature from 15 to 45 °C, phase separation takes place, the emulsions contract to squeeze the water. A sharp decrease in particle size is noticed when the temperature increase from 30 to 35 °C. In this point, hydrophilic drug procaine is loaded and release experiments are conducted using thermoresponsive injectable hydrogel. The drug loading and release results are evaluated using the Weibull distribution model and the Fick's law of diffusion that precisely works out. A thermoresponsive injectable hydrogel offers an efficient, cost-effective, and scalable approach towards controlled release of drugs. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 137, 48669. 相似文献
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由磷脂和嵌段共聚物组成囊泡结合脂质体和多聚体优点,同时克服各自不足。该研究以聚甲基丙烯酸胆固醇酯-嵌段-聚甲基丙烯酸二甲氨基乙酯共聚物(pCMA-b-pDMAEMA)和磷脂为原料组装磷脂-嵌段共聚物杂化囊泡。磷脂-嵌段共聚物杂化囊泡的形貌特点、尺寸大小和Zeta-电位等性质被检测,此外,使用RAW 264.7小鼠巨噬细胞测定磷脂-嵌段共聚物杂化囊泡细胞毒性和内化作用。A3和A8分别与巨噬细胞共培养后的细胞存活率为93.4±1.1%和92.1±0.8%,它们的数值均高于其它样品,因此聚合物P2比P1更适合制备磷脂-嵌段共聚物杂化囊泡作为药物载体。通过荧光强度测试,A18比A16更易被巨噬细胞吸收,用其搭载抗癌药物DOX对人肾癌细胞（OS-RC-2）进行治疗实验,当DOX终浓度为3.00 μmol/L时其对OS-RC-2癌细胞抑制率为75±1.1%。 相似文献
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K. C. Remant Bahadur Santosh Aryal Shanta Raj Bhattarai Myung Seob Khil Hak Yong Kim 《应用聚合物科学杂志》2007,103(4):2695-2702
Amphiphilic triblock copolymers composed of poly(p‐dioxanone) (PPDO) and poly(ethylene glycol) (PEG) were synthesized by ring opening polymerization of PDO initiated through dihydroxyl‐terminated PEG in the presence of stannous 2‐ethylhexanoate [Sn(oct)2] as a catalyst. Polymeric nanoparticles were prepared in an aqueous medium (triple distilled water and phosphate buffer pH 7.4) by cosolvent evaporation technique at room temperature (25°C). Stability of nanoparticles was significantly enough in triple distilled water when compared with the phosphate buffer. Core‐shell geometry of polymeric nanoparticles was characterized by 1H‐NMR spectroscopy and further confirmed by spectrophotometric analysis using pyrene as a probe. Variation in physicochemical characteristics of polymeric nanoparticles with the fraction of PPDO was investigated through the analysis of microscopic, spectroscopic, and light scattering techniques. Critical micelle concentration of polymer in triple distilled water decreased from 2.3 × 10?3 to 4.7 × 10?3. Atomic force microscopic observation revealed that polymeric nanoparticles were spherical and uniform with smooth textured of around 50–68 nm diameter. Dynamic light scattering and electrophoretic light scattering measurements showed a mono‐disperse size distribution of around 113–171 nm hydrodynamic diameters and negative zeta (ζ)‐potential (?4.00 to ?5.87 mV), respectively. The investigation showed a significant effect of polymeric composition on the physicochemical characteristic of polymeric nanoparticles. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2695–2702, 2007 相似文献
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纳米药物作为一种新兴技术,为肿瘤的精确定位和早期诊断、靶向、长效和联合治疗提供了重要的研发平台,为克服传统药物非特异性靶向和非选择性损伤机体组织的瓶颈问题提供了可能。近年来研究者基于量子点、纳米金、纳米介孔硅等无机纳米药物载体设计合成了大量可用于肿瘤诊疗的纳米药物,主要通过“核-壳”结构设计、表面修饰等方法提高纳米药物性能。综述了无机纳米材料作为纳米药物载体在肿瘤诊疗中的应用,详细介绍了纳米药物的设计策略和肿瘤诊疗作用机制,并对未来进行无机纳米药物在肿瘤诊疗中的临床应用进行了展望。 相似文献
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A block copolymer based on poly(γ‐benzyl‐L ‐glutamate) (PBLG) as the hydrophobic part and poly(ethylene oxide) (PEO) as the hydrophilic part was synthesized and characterized. PBLG/PEO/PBLG (GEG) block copolymer nanoparticles were prepared using the dialysis technique. Fluorescence spectroscopy measurement suggested that GEG block copolymers were associated in water to form polymeric micelles and the critical micelle concentration (CMC) value of the GEG‐50 block copolymer was 0.0084 g/L. Particle‐size distribution of the GEG‐50 block copolymer based on the number average was 34.9 ± 17.6 nm. Also, the particle size and drug‐loading contents of GEG nanoparticles were significantly changed with the initial solvent used. From transmission electron microscope (TEM) observations, the GEG polymeric micelle was a nice spherical shape and the sizes ranged from approximately 20–60 nm in diameter. Results from assessing the drug‐loading contents against the initial solvent showed that the use of tetrahydrofuran (THF) or 1,4‐dioxane as the initial solvent resulted in higher drug‐loading contents than those of other solvents. In the drug‐release studies, the higher the molecular weight of the polymer and drug‐loading contents, the slower the drug release. Also, the initial solvent used was significantly affected not only in the drug‐loading contents but also in the drug‐release kinetics. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 75: 1115–1126, 2000 相似文献
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嵌段共聚物的表面活性行为及其应用 总被引：3，自引：0，他引：3
综述了嵌段共聚物在选择性溶剂中的胶束性质和在气/液界面、液/液界面以及固/液界面的界面行为 ,并介绍了嵌段共聚物胶束在药物输送、分离和释放等方面的应用。 相似文献
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Zhifang YANG Jingao WU Yingkui YANG Xingping ZHOU Xiaolin XIE 《Frontiers of Chemical Engineering in China》2008,2(1):85-88
The self-assembly behaviors of the rod-coil-rod (PANI)98−(PEG)136−(PANI)98 triblock copolymer are investigated in different solvents, such as N-methyl-2-pyrrolidone (NMP), dimethyl formamide (DMF), ethanol and water. The effects of solvents, concentration and ultrasonic irradiation on self-assembly are discussed. The results indicate that the triblock copolymer forms particles, rods, fiber, networks and fiber bands in the above solvents, respectively. Especially, the triblock copolymer can form a multi-layer, tri-dimensional fibrous network and a petaline structure from the mono-layer fibrous network with the increase of its concentration in ethanol. Also, the ultrasonic irradiation has a great effect on the self-assembly of the triblock copolymer. __________ Translated from Journal of Functional Materials, 2007, 38(2): 289–291 [译自: 功能材料] 相似文献
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采用原子转移自由基聚合（ATRP）方法合成了两亲性嵌段共聚物PSt-b-PAA。用1H NMR和GPC等手段对活性聚合进行了确认,对嵌段共聚物的结构进行了表征。两亲性嵌段共聚物在离子液体1-丁基-3-甲基咪唑六氟磷酸盐（[BM IM][PF6]）中形成胶束溶液。用透射电子显微镜（TEM）观察聚合物在离子液体中形成胶束的纳米结构。当疏水链长固定时,胶束的自组装形状主要依赖于亲水链的长度。两亲性共聚物在离子液体中可自组装成可控制结构的纳米胶束,这种纳米胶束可应用在很多领域。 相似文献
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Lifu Ma Weijiao Liu Jianjun Yi Hongli Wang Qigu Huang Kejing Gao Wantai Yang 《应用聚合物科学杂志》2011,120(6):3171-3179
The copolymerization of styrene with ethylene was promoted by CpTiCl3/BDGE/Zn/MAO catalyst system combining free radical polymerization with coordination polymerization via sequential monomer addition strategy in one‐pot. The effect of polymerization conditions such as temperature, time, ethylene pressure, and Al/Ti molar ratio on the polymerization performance was investigated. The hydroxy‐functionalized aPS‐b‐random copolymer‐b‐PE triblock copolymer was obtained by solvent extraction and determined by GPC, DSC, WAXD, and 13C‐NMR. The DSC result indicated that the aPS‐b‐random copolymer‐b‐PE had a Tg at 87°C and a Tm at 119°C which attributed to the Tg of aPS segment and the Tm of PE segment, respectively. The microstructure of the hydroxy‐functionalized aPS‐b‐random copolymer‐b‐PE was further confirmed by WAXD, 13C‐NMR, and 1H‐NMR analysis; and these results demonstrated that the obtained block copolymer consisted of aPS segment, S‐E random copolymer segment, and crystalline PE segment. The connection polymerization of the hydroxy‐functionalized aPS with random copolymer‐b‐PE was revealed by GPC results. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 相似文献
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A new class of PLGA‐based materials suitable for the production of biodegradable NPs via free‐radical polymerization is proposed. ROP of lactide and glycolide using HEMA is carried out; macromonomers (HEMA‐LxGyA) with short PLGA chain ends are successfully produced. Afterwards, monomer‐starved semi‐batch emulsion polymerization of these HEMA‐LxGyA macromonomers is performed to obtain NPs with a low polydispersity index and a controlled size. The stability and degradability of NPs is confirmed from degradation studies that verify the possibility of tuning the degradation time by changing macromonomer characteristics such as chain length and composition.
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A poly(ethylene oxide)‐block‐poly(dimethylamino ethyl methacrylate) block copolymer (PEO‐b‐PDMAEMA) bearing an amino moiety at the PEO chain end was synthesized by a one‐pot sequential oxyanionic polymerization of ethylene oxide (EO) and dimethylamino ethyl methacrylate (DMAEMA), followed by a coupling reaction between its PEO amino and a biotin derivative. The polymers were charac terized with 1H NMR spectroscopy and gel permeation chromatography. Activated biotin, biotin‐NHS (N‐hydroxysuccinimide), was used to synthesize biotin‐PEO‐PDMAEMA. In aqueous media, the solubility of the copolymer was temperature‐ and pH‐sensitive. The particle size of the micelle formed from functionalized block copolymers was determined by dynamic light scattering. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 3552–3558, 2006 相似文献
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Remant Bahadur KC Shanta Raj Bhattarai Santosh Aryal Narayan Bhattarai Byoung Min Lee Hak Yong Kim 《Polymer International》2007,56(4):518-524
A series of amine‐functionalized block copolymers, poly(caprolactone)‐block‐poly(ethylene glycol) (PCL‐b‐PEG), were synthesized by ring‐opening bulk polymerization (ROP) of ε‐caprolactone (ε‐CL) initiated through the hydroxyl end of the amino poly(ethylene glycol) (PEG) used as a macroinitiator in the presence of stannous 2‐ethylhexonoate [Sn(Oct)2]. The polymerization and end functionality of the polymer were studied by different physicochemical techniques (1H NMR, Fourier transform infrared and X‐ray photoelectron spectroscopy, gel permeation chromatography and thermogravimetric analysis). Thermal, crystalline and mechanical properties of the polymer were thoroughly analyzed using differential scanning calorimetry, wide‐angle X‐ray diffractometry and tensile testing, respectively. The results showed a linear improvement in crystallinity and mechanical properties of the polymer with the content of PEG. Thus the synthesized functional polymers can be used as excellent biomaterials for the delivery of polyanions, as well as macroinitiators for the synthesis of A–B–C‐type block copolymers. Copyright © 2006 Society of Chemical Industry 相似文献
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Diem-Huong Nguyen Tran Thi Hiep Nguyen Thanh Nguyet Nguyen Vo Linh Phuong Tran Pham Do Minh Hoang Vo Cuu Khoa Nguyen Long Giang Bach Dai Hai Nguyen 《应用聚合物科学杂志》2019,136(20):47544
Curcumin (CUR) is a natural active ingredient that attracted much attention for its chemotherapeutic activity against tumors without causing toxicity in healthy cells. However, it has certain limitations for being used in chemotherapy such as low aqueous solubility and hydrolytic instability in the physiological environment. In this study, self-assembled poly(ethylene glycol) methyl ether-grafted gelatin (Gel-mPEG) nanogels were fabricated as delivery systems to improve the applicability of CUR in cancer treatment. CUR-loaded Gel-mPEG nanogels exhibited desired size range, relatively colloidal stability, and provided enhanced CUR stability in aqueous solutions. Especially, they showed significant high CUR loading capacity and better anticancer activity than free CUR as compared to previously reported CUR-loaded nanogels according to the best of our knowledge. Moreover, the in vitro release of CUR from the nanogels was controlled and prolonged up to 96 h. These results demonstrated that Gel-mPEG nanogels are the promising modality for the efficient delivery of CUR in cancer treatment. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47544. 相似文献