A deep learning approach to the classification of 3D CAD models简

Model classification is essential to the management and reuse of 3D CAD models. Manual model classification is laborious and error prone. At the same time, the automatic classification methods are scarce due to the intrinsic complexity of 3D CAD models. In this paper, we propose an automatic 3D CAD model classification approach based on deep neural networks. According to prior knowledge of the CAD domain, features are selected and extracted from 3D CAD models first, and then pre-processed as high dimensional input vectors for category recognition. By analogy with the thinking process of engineers, a deep neural network classifier for 3D CAD models is constructed with the aid of deep learning techniques. To obtain an optimal solution, multiple strategies are appropriately chosen and applied in the training phase, which makes our classifier achieve better per-formance. We demonstrate the efficiency and effectiveness of our approach through experiments on 3D CAD model datasets.     

A fuzzy classification model for myocardial infarction risk assessment

The use of data mining approaches for analyzing patients trace in different medical databases has become an important research field especially with the evolution of these methods and their contributions in medical decision support. In this paper, we develop a new clinical decision support system (CDSS) to diagnose Coronary Artery Diseases (CAD). According to CAD experts, Angiography is most accurate CAD diagnosis technique. However, it has many aftereffects and is very costly. Existing studies showed that CAD diagnosis requires heterogeneous patients traces from medical history while applying data mining techniques to achieve high accuracy. In this paper, an automatic approach to design CDSS for CAD assessment is proposed. The proposed diagnosis model is based on Random Forest algorithm, C5.0 decision tree algorithm and Fuzzy modeling. It consists of two stages: first, Random Forest algorithm is used to rank the features and a C5.0 decision tree based approach for crisp rule generation is developed. Then, we created the fuzzy inference system. The generation of fuzzy weighted rules is carried out automatically from the previous crisp rules. Moreover, a critical issue about the CDSS is that some values of the features are missing in most cases. A new method to deal with the problem of missing data, which allows evaluating the similarity despite the missing information, was proposed. Finally, experimental results underscore very promising classification accuracy of 90.50% while optimizing training time using UCI (the University of California at Irvine) heart diseases datasets compared to the previously reported results.     

Intensity-based statistical features for classification of lungs CT scan nodules using artificial intelligence techniques

A computer-aided diagnostic (CAD) system for effective and accurate pulmonary nodule detection is required to detect the nodules at early stage. This paper proposed a novel technique to detect and classify pulmonary nodules based on statistical features for intensity values using support vector machine (SVM). The significance of the proposed technique is, it uses the nodules features in 2D & 3D and also SVM for the classification that is good to classify the nodules extracted from the image. The lung volume is extracted from Lung CT using thresholding, background removal, hole-filling and contour correction of lung lobe. The candidate nodules are extracted and pruned using the rules based on ground truth of nodules. The statistical features for intensity values are extracted from candidate nodules. The nodule data are up-samples to reduce the biasness. The classifier SVM is trained using data samples. The efficiency of proposed CAD system is tested and evaluated using Lung Image Consortium Database (LIDC) that is standard data-set used in CAD Systems for Lungs Nodule classification. The results obtained from proposed CAD system are good as compare to previous CAD systems. The sensitivity of 96.31% is achieved in the proposed CAD system.     

Breast cancer classification using deep belief networks

Over the last decade, the ever increasing world-wide demand for early detection of breast cancer at many screening sites and hospitals has resulted in the need of new research avenues. According to the World Health Organization (WHO), an early detection of cancer greatly increases the chances of taking the right decision on a successful treatment plan. The Computer-Aided Diagnosis (CAD) systems are applied widely in the detection and differential diagnosis of many different kinds of abnormalities. Therefore, improving the accuracy of a CAD system has become one of the major research areas. In this paper, a CAD scheme for detection of breast cancer has been developed using deep belief network unsupervised path followed by back propagation supervised path. The construction is back-propagation neural network with Liebenberg Marquardt learning function while weights are initialized from the deep belief network path (DBN-NN). Our technique was tested on the Wisconsin Breast Cancer Dataset (WBCD). The classifier complex gives an accuracy of 99.68% indicating promising results over previously-published studies. The proposed system provides an effective classification model for breast cancer. In addition, we examined the architecture at several train-test partitions.     

Deep feature extraction and classification of breast ultrasound images

Controlled despeckling (structure/edges/feature preservation with smoothing the homogeneous areas) is a desired pre-processing step for the design of computer-aided diagnostic (CAD) systems using ultrasound images as the presence of speckle noise masks diagnostically important information making interpretation difficult even for experienced radiologist. For efficiently classifying the breast tumors, the conventional CAD system designs use hand-crafted features. However, these features are not robust to the variations in size, shape and orientation of the tumors resulting in lower sensitivity. Thus deep feature extraction and classification of breast ultrasound images have recently gained attention from research community. The deep networks come with an advantage of directly learning the representative features from the images. However, these networks are difficult to train from scratch if the representative training data is small in size. Therefore transfer learning approach for deep feature extraction and classification of medical images has been widely used. In the present work the performance of four pre-trained convolutional neural networks VGG-19, SqueezeNet, ResNet-18 and GoogLeNet has been evaluated for differentiating between benign and malignant tumor types. From the results of the experiments, it is noted that CAD system design using GoogLeNet architecture for deep feature extraction followed by correlation based feature selection and fuzzy feature selection using ANFC-LH yields highest accuracy of 98.0% with individual class accuracy value of 100% and 96% for benign and malignant classes respectively. For differentiating between the breast tumors, the proposed CAD system design can be utilized in routine clinical environment.

     

Automated breast cancer detection and classification using ultrasound images: A survey

Breast cancer is the second leading cause of death for women all over the world. Since the cause of the disease remains unknown, early detection and diagnosis is the key for breast cancer control, and it can increase the success of treatment, save lives and reduce cost. Ultrasound imaging is one of the most frequently used diagnosis tools to detect and classify abnormalities of the breast. In order to eliminate the operator dependency and improve the diagnostic accuracy, computer-aided diagnosis (CAD) system is a valuable and beneficial means for breast cancer detection and classification. Generally, a CAD system consists of four stages: preprocessing, segmentation, feature extraction and selection, and classification. In this paper, the approaches used in these stages are summarized and their advantages and disadvantages are discussed. The performance evaluation of CAD system is investigated as well.     

Ensemble feature selection and classification methods for machine learning-based coronary artery disease diagnosis

Coronary artery disease (CAD) is a condition in which the heart is not fed sufficiently as a result of the accumulation of fatty matter. As reported by the World Health Organization, around 32% of the total deaths in the world are caused by CAD, and it is estimated that approximately 23.6 million people will die from this disease in 2030. CAD develops over time, and the diagnosis of this disease is difficult until a blockage or a heart attack occurs. In order to bypass the side effects and high costs of the current methods, researchers have proposed to diagnose CADs with computer-aided systems, which analyze some physical and biochemical values at a lower cost. In this study, for the CAD diagnosis, (i) seven different computational feature selection (FS) methods, one domain knowledge-based FS method, and different classification algorithms have been evaluated; (ii) an exhaustive ensemble FS method and a probabilistic ensemble FS method have been proposed. The proposed approach is tested on three publicly available CAD data sets using six different classification algorithms and four different variants of voting algorithms. The performance metrics have been comparatively evaluated with numerous combinations of classifiers and FS methods. The multi-layer perceptron classifier obtained satisfactory results on three data sets. Performance evaluations show that the proposed approach resulted in 91.78%, 85.55%, and 85.47% accuracy for the Z-Alizadeh Sani, Statlog, and Cleveland data sets, respectively.     

A computer aid for early diagnostic classification of jaundice (the COMIP program)

We describe the Computer Icterus Program (COMIP), a computer-assisted diagnosis (CAD) program which is designed to facilitate the early choice of a diagnostic strategy in cases of jaundice. To anticipate transfer to other centres, the COMIP program offers facilities to make local adjustments for relative disease incidences and for laboratory data. This is a useful extension for CAD systems.     

Pneumonia classification using quaternion deep learning

Pneumonia is an infection in one or both the lungs because of virus or bacteria through breathing air. It inflames air sacs in lungs which fill with fluid which further leads to problems in respiration. Pneumonia is interpreted by radiologists by observing abnormality in lungs in case of fluid in Chest X-Rays. Computer Aided Detection Diagnosis (CAD) tools can assist radiologists by improving their diagnostic accuracy. Such CAD tools use neural networks which are trained on Chest X-Ray dataset to classify a Chest X-Ray into normal or infected with Pneumonia. Convolution neural networks have shown remarkable performance in object detection in an image. Quaternion Convolution neural network (QCNN) is a generalization of conventional convolution neural networks. QCNN treats all three channels (R, G, B) of color image as a single unit and it extracts better representative features and which further improves classification. In this paper, we have trained Quaternion residual network on a publicly available large Chest X-Ray dataset on Kaggle repository and obtained classification accuracy of 93.75% and F-score of .94. We have also compared our performance with other CNN architectures. We found that classification accuracy was higher with Quaternion Residual network when we compared it with a real valued Residual network.

     

Attention-based VGG-16 model for COVID-19 chest X-ray image classification

Applied Intelligence - Computer-aided diagnosis (CAD) methods such as Chest X-rays (CXR)-based method is one of the cheapest alternative options to diagnose the early stage of COVID-19 disease...     

Tree-based modelling for the classification of mammographic benign and malignant micro-calcification clusters

Multimedia Tools and Applications - Computer Aided Detection (CAD) systems are being developed to assist radiologists in diagnosis. For breast cancer the emphasis is shifting from detection to...     

Representation and classification of 3-D objects

This paper addresses the problem of generic object classification from three-dimensional depth or meshed data. First, surface patches are segmented on the basis of differential geometry and quadratic surface fitting. These are represented by a modified Gaussian image that includes the well-known shape index. Learning is an interactive process in which a human teacher indicates corresponding patches, but the formation of generic classes is unaided. Classification of unknown objects is based on the measurement of similarities between feature sets of the objects and the generic classes. The process is demonstrated on a group of three-dimensional (3-D) objects built from both CAD and laser-scanned depth data.     

Automated classification of patients with coronary artery disease using grayscale features from left ventricle echocardiographic images

Coronary Artery Disease (CAD), caused by the buildup of plaque on the inside of the coronary arteries, has a high mortality rate. To efficiently detect this condition from echocardiography images, with lesser inter-observer variability and visual interpretation errors, computer based data mining techniques may be exploited. We have developed and presented one such technique in this paper for the classification of normal and CAD affected cases. A multitude of grayscale features (fractal dimension, entropies based on the higher order spectra, features based on image texture and local binary patterns, and wavelet based features) were extracted from echocardiography images belonging to a huge database of 400 normal cases and 400 CAD patients. Only the features that had good discriminating capability were selected using t-test. Several combinations of the resultant significant features were used to evaluate many supervised classifiers to find the combination that presents a good accuracy. We observed that the Gaussian Mixture Model (GMM) classifier trained with a feature subset made up of nine significant features presented the highest accuracy, sensitivity, specificity, and positive predictive value of 100%. We have also developed a novel, highly discriminative HeartIndex, which is a single number that is calculated from the combination of the features, in order to objectively classify the images from either of the two classes. Such an index allows for an easier implementation of the technique for automated CAD detection in the computers in hospitals and clinics.     

用户自定义特征库分类模型研究*

针对传统CAD系统中用户自定义特征库分类不支持特征共享的问题,提出了基于有向无环图的用户自定义特征库分类模型。通过将特征信息作为公共子节点附加到分类树中形成有向无环图,实现了特征的分类和共享,并利用中性的XML文档实现了模型的存储,提高了模型的移植性;最后给出了模型的建立过程。实例表明,该模型简单灵活,极大地提高了用户自定义特征库的分类和共享能力。     

Integrating discretization and association rule-based classification for Alzheimer’s disease diagnosis

This paper shows a computer aided diagnosis (CAD) combining continuous attribute discretization and association rule mining for the early diagnosis of Alzheimer’s disease (AD) based on emission computed tomography images. A mask is obtained from the mean control images by an image histogram segmentation. 3D voxels centered in mask coordinates are selected by equal-width binning-based discretization of the mean intensity. These Regions of Interest (ROIs) are then used as input for the Association Rule (AR)-mining using control subject images to fully characterize the normal pattern of the image. Minimum support and confidence are fixed to the maximum values in order to obtain the highest predictive power rules for each discretization level (or combination of levels). Finally, classification is carried out by comparing the number of ARs verified by each subject under test. The proposed system is evaluated using two different databases of single photon emission computed tomography (SPECT) and positron emission tomography (PET) images from the Alzheimer Disease Neuroimaging Initiative (ADNI) yielding an accuracy up to 96.91% (for SPECT) and 92% (for PET), thus outperforming the baseline (the so called continuous AR-based method) and other recently reported CAD methods.     

A comprehensive review of computer-aided whole-slide image analysis: from datasets to feature extraction,segmentation, classification and detection approaches

With the development of Computer-aided Diagnosis (CAD) and image scanning techniques, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital histopathology. Since 2004, WSI has been used widely in CAD. Since machine vision methods are usually based on semi-automatic or fully automatic computer algorithms, they are highly efficient and labor-saving. The combination of WSI and CAD technologies for segmentation, classification, and detection helps histopathologists to obtain more stable and quantitative results with minimum labor costs and improved diagnosis objectivity. This paper reviews the methods of WSI analysis based on machine learning. Firstly, the development status of WSI and CAD methods are introduced. Secondly, we discuss publicly available WSI datasets and evaluation metrics for segmentation, classification, and detection tasks. Then, the latest development of machine learning techniques in WSI segmentation, classification, and detection are reviewed. Finally, the existing methods are studied, and the application prospects of the methods in this field are forecasted.

     

Computer-aided detection and classification of microcalcifications in mammograms: a survey

Breast cancer continues to be a significant public health problem in the world. Approximately, 182,000 new cases of breast cancer are diagnosed and 46,000 women die of breast cancer each year in the United States. Even more disturbing is the fact that one out of eight women in US will develop breast cancer at some point during her lifetime. Primary prevention seems impossible since the causes of this disease still remain unknown. Early detection is the key to improving breast cancer prognosis. Mammography is one of the reliable methods for early detection of breast carcinomas. There are some limitations of human observers, and it is difficult for radiologists to provide both accurate and uniform evaluation for the enormous number of mammograms generated in widespread screening. The presence of microcalcification clusters (MCCs) is an important sign for the detection of early breast carcinoma. An early sign of 30–50% of breast cancer detected mammographically is the appearance of clusters of fine, granular microcalcification, and 60–80% of breast carcinomas reveal MCCs upon histological examinations. The high correlation between the appearance of the microcalcification clusters and the diseases show that the CAD (computer aided diagnosis) systems for automated detection/classification of MCCs will be very useful and helpful for breast cancer control. In this survey paper, we summarize and compare the methods used in various stages of the computer-aided detection systems (CAD). In particular, the enhancement and segmentation algorithms, mammographic features, classifiers and their performances are studied and compared. Remaining challenges and future research directions are also discussed.     

Visual learning and classification of human epithelial type 2 cell images through spontaneous activity patterns

Identifying the presence of anti-nuclear antibody (ANA) in human epithelial type 2 (HEp-2) cells via the indirect immunofluorescence (IIF) protocol is commonly used to diagnose various connective tissue diseases in clinical pathology tests. As it is a labour and time intensive diagnostic process, several computer aided diagnostic (CAD) systems have been proposed. However, the existing CAD systems suffer from numerous shortcomings due to the selection of features, which is commonly based on expert experience. Such a choice of features may not work well when the CAD systems are retasked to another dataset. To address this, in our previous work, we proposed a novel approach that learns a set of filters from HEp-2 cell images. It is inspired by the receptive fields in the mammalian's vision system, since the receptive fields can be thought as a set of filters for similar shapes. We obtain robust filters for HEp-2 cell classification by employing the independent component analysis (ICA) framework. Although, this approach may be held back due to one particular problem; ICA learning requires a sufficiently large volume of training data which is not always available. In this paper, we demonstrate a biologically inspired solution to address this issue via the use of spontaneous activity patterns (SAP). The spontaneous activity patterns, which are related to the spontaneous neural activities initialised by the chemical release in the brain, are found as the typical stimuli for the visual cell development of newborn animals. In the classification system for HEp-2 cells, we propose to model SAP as a set of small image patches containing randomly positioned Gaussian spots. The SAP image patches are generated and mixed with the training images in order to learn filters via the ICA framework. The obtained filters are adopted to extract the set of responses from a HEp-2 cell image. We then employ regions from this set of responses and stack them into “cubic regions”, and apply a classification based on the correlation information of the features. We show that applying the additional SAP leads to a better classification performance on HEp-2 cell images compared to using only the existing patterns for training ICA filters. The improvement on classification is particularly significant when there are not enough specimen images available in the training set, as SAP adds more variations to the existing data that makes the learned ICA model more robust. We show that the proposed approach consistently outperforms three recently proposed CAD systems on two publicly available datasets: ICPR HEp-2 contest and SNPHEp-2.     

Automatic classification of Human Epithelial type 2 cell Indirect Immunofluorescence images using Cell Pyramid Matching

This paper describes a novel system for automatic classification of images obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial type 2 (HEp-2) cells using the Indirect Immunofluorescence (IIF) protocol. The IIF protocol on HEp-2 cells has been the hallmark method to identify the presence of ANAs, due to its high sensitivity and the large range of antigens that can be detected. However, it suffers from numerous shortcomings, such as being subjective as well as time and labour intensive. Computer Aided Diagnostic (CAD) systems have been developed to address these problems, which automatically classify a HEp-2 cell image into one of its known patterns (e.g., speckled, homogeneous). Most of the existing CAD systems use handpicked features to represent a HEp-2 cell image, which may only work in limited scenarios. We propose a novel automatic cell image classification method termed Cell Pyramid Matching (CPM), which is composed of regional histograms of visual words coupled with the Multiple Kernel Learning framework. We present a study of several variations of generating histograms and show the efficacy of the system on two publicly available datasets: the ICPR HEp-2 cell classification contest dataset and the SNPHEp-2 dataset.     

Approaches for automated detection and classification of masses in mammograms

Breast cancer continues to be a significant public health problem in the world. Early detection is the key for improving breast cancer prognosis. Mammography has been one of the most reliable methods for early detection of breast carcinomas. However, it is difficult for radiologists to provide both accurate and uniform evaluation for the enormous mammograms generated in widespread screening. The estimated sensitivity of radiologists in breast cancer screening is only about 75%, but the performance would be improved if they were prompted with the possible locations of abnormalities. Breast cancer CAD systems can provide such help and they are important and necessary for breast cancer control. Microcalcifications and masses are the two most important indicators of malignancy, and their automated detection is very valuable for early breast cancer diagnosis. Since masses are often indistinguishable from the surrounding parenchymal, automated mass detection and classification is even more challenging. This paper discusses the methods for mass detection and classification, and compares their advantages and drawbacks.