共查询到20条相似文献，搜索用时 15 毫秒
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L. Dong A. K. Agarwal D. J. Beebe H. Jiang 《Advanced materials (Deerfield Beach, Fla.)》2007,19(3):401-405
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Y. Mei D. J. Thurmer F. Cavallo S. Kiravittaya O. G. Schmidt 《Advanced materials (Deerfield Beach, Fla.)》2007,19(16):2124-2128
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M.&#x;S. Hahn J.&#x;S. Miller J.&#x;L. West 《Advanced materials (Deerfield Beach, Fla.)》2005,17(24):2939-2942
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E. Delamarche D. Juncker H. Schmid 《Advanced materials (Deerfield Beach, Fla.)》2005,17(24):2911-2933
This review is an account of our efforts to develop a versatile and flexible microfluidic technology for surface‐processing applications and miniaturizing biological assays. The review is presented in the context of current trends in microfluidic technology and addresses some of the major challenges for confining chemical and biochemical processes on surfaces: the sealing of a microchannel with a surface, the world‐to‐chip interface, the displacement of liquids in small conduits, the sequential delivery of multiple solutions, the accurate patterning of surfaces, the coincident detection of various analytes, and the detection of analytes in a small and dilute sample. Our solutions to these problems include the use of reversible sealing, capillary phenomena for powering and controlling liquid transport, and non‐contact microfluidics for spotting and drawing (on surfaces) with flow conditions. These solutions offer many advantages over conventional techniques for handling minute amounts of liquids and may find applications in lithography, biopatterning (e.g., the patterning of biomolecules), diagnostics, drug discovery, and also cellular assays. 相似文献
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E. Han I. In S.‐M. Park Y.‐H. La Y. Wang P. F. Nealey P. Gopalan 《Advanced materials (Deerfield Beach, Fla.)》2007,19(24):4448-4452
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M. Zourob J.&#x;E. Gough R.&#x;V. Ulijn 《Advanced materials (Deerfield Beach, Fla.)》2006,18(5):655-659
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A polymer hydrogel platform for peptide arrays compatible with both solid‐phase peptide synthesis conditions and the aqueous environment essential for biological assays is reported on p. 655 by Ulijn and co‐workers. Micropatterning followed by multiple‐step peptide synthesis produces the peptide‐functionalized poly(ethylene glycol)–polyamide “biochips” shown schematically on the cover. On‐chip biological assays involving cells and enzymes provide proof‐of‐concept. 相似文献
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N.&#x;A. Peppas J.&#x;Z. Hilt A. Khademhosseini R. Langer 《Advanced materials (Deerfield Beach, Fla.)》2006,18(11):1345-1360
Hydrophilic polymers are the center of research emphasis in nanotechnology because of their perceived “intelligence”. They can be used as thin films, scaffolds, or nanoparticles in a wide range of biomedical and biological applications. Here we highlight recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for these applications. Natural, biohybrid, and synthetic hydrophilic polymers and hydrogels are analyzed and their thermodynamic responses are discussed. In addition, examples of the use of hydrogels for various therapeutic applications are given. We show how such systems' intelligent behavior can be used in sensors, microarrays, and imaging. Finally, we outline challenges for the future in integrating hydrogels into biomedical applications. 相似文献
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J.‐Y. Miao Z.‐L. Xu X.‐Y. Zhang N. Wang Z‐Y. Yang P. Sheng 《Advanced materials (Deerfield Beach, Fla.)》2007,19(23):4234-4237
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