Characterization and comparison of diblock and triblock amphiphilic copolymers of poly(δ‐valerolactone)

Three types of pegylated amphiphilic copolymers of poly(δ‐valerolactone) (PVL) were copolymerized with methoxy poly(ethylene glycol) (MePEG) and poly(ethylene glycol) (PEG₄₀₀₀ and PEG_10,000), respectively. Pegylation of PVL allowed copolymers possessing amphiphilic property and efficiently self‐assembled to form micelles with a low critical micelle concentration (CMC) in the range of 10^?7–10^?8M. The average molecular weight of copolymers was in the range of 10,000–20,000 Da, and the polydispersity of copolymers was about 1.7–1.8. Higher mobility of low molecular weight PEG (i.e., MePEG and PEG₄₀₀₀) than high molecular weight PEG_10,000 allowed valerolactone ring opening more efficient in terms of PVL/MePEG and PVL/PEG₄₀₀₀ copolymers possessing longer chain length in hydrophobic domain. Pegylated PVL with low CMC and triblock structure was preferred to encapsulate drug during micelle formation. Although all of these amphiphilic copolymers exhibited controlled release character, the micelles formed by triblock copolymer possessed a more stable core‐shell conformation than that by diblock copolymer, and resulted in the release of drug from triblock micelles slower than that from diblock micelles. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 1836–1841, 2006     

Preparation of stealth micellar nanoparticles of novel biodegradable and biocompatible brush copolymers with cholesteryl-modified PLA and PEG side chains

Novel amphiphilic brush copolymers, P(CPLAMA)-co-P(PEGMA), of cholesteryl poly(l-lactic acid) (CPLA) and poly(ethylene glycol) monomethyl ether (PEG) with determined hydrophobic/hydrophilic ratios were synthesized by the methacrylate (MA) macromonomer copolymerization method. Brush copolymers were prepared via both free radical polymerization (FRP) and atom transfer radical polymerization (ATRP). The copolymer compositions were determined by ¹H NMR spectroscopy. The synthesized copolymers were used to prepare the micellar nanoparticles with hydrophobic CPLA and hydrophilic PEG forming the core and shell, respectively. The critical micelle concentration (CMC) values of the samples produced by FRP (brush copolymer 1) and ATRP (brush copolymer 2) were estimated to be approximately 0.9 and 0.7 mg/L in aqueous solution by a fluorescence probe technique, respectively. The transmission electron microscopy (TEM) images of micelles of the brush copolymers 1 and 2 showed that micelles were spherical in shape with a mean diameter of 111 and 32 nm, respectively. The results showed that the size of micelles became larger with the increase of the molecular weight of polymer and the relative content of the hydrophilic PEG as well. The drug loading efficiency and drug-releasing properties of the micelles were investigated by using naproxen as a hydrophobic model drug. The in vitro release of naproxen-loaded micelles with about 85–89 % loading efficiency and 17–18 % loading capacity was studied by a using dialysis method in phosphate-buffered solution at 37 °C. The drug-releasing characteristics exhibited a phase of slow release. On the basis of the results obtained, the proposed brush copolymers may be useful in various targeted drug delivery applications, especially those involving hydrophobic drugs.     

新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征

Methoxy poly （ethylene glycol） -poly （D, L-lactide） block copolymers （PEG-PLA） were prepared through ring-opening polymerization. The oil in water suspension method was used to prepare block copolymer micelles. The critical micelle concentration （CMC） by fluorescence spectroscopy was 0. 0056 mg· ml^- 1. The physical state of the inner core region of micelles was characterized with ^1 HNMR. The size of indomethacin （IMC） loaded micelles measured by dynamic light scattering （DLS） showed narrow monodisperse size distribution and the average diameters were less than 50 nm. In addition, the nanoparticles with relatively high drug loading content （DLC） were obtained.     

Amphiphilic biodegradable poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) triblock copolymers: synthesis, characterization and their use as drug carriers for folic acid

Amphiphilic biodegradable poly(ε-caprolactone)-poly(ethylene glycol)-poly (ε-caprolactone) (PCEC) triblock copolymers have been successfully synthesized by the ring-opening polymerization of ε-caprolactone (ε-CL) employing SnOct as catalyst and double-hydroxyl capped PEG (DHPEG) as macro-initiator. The triblock structure and copolymer composition were conformed by FT-IR, ¹H-NMR, and GPC. Using a membrane dialysis method, PCEC micelles were prepared with a core–shell type. The critical micelle concentration (CMC) of PCEC triblock copolymers was determined by fluorescence technique using pyrene as probe, and CMC values decreased with the increase of PCL chain length. From the observation of transmission electron microscopy (TEM), the morphology of polymer micelles was spherical in shape. Micelles size measured by dynamic light scattering (DLS) exhibited a narrow size distribution. Folic acid (FA) was then used as a model drug to incorporate into PCEC micelles. The diameter, drug loading, and drug release rate of PCEC micelles were influenced by the feed weight ratio of FA and copolymer, and polymer composition. In addition, in vitro release experiments of the drug-loaded PCEC micelles exhibited sustained release behavior without any burst effects and the release behavior was also affected by the pH of release media.     

Polymeric micelles formed by polypeptide graft copolymer and its mixtures with polypeptide block copolymer

Polymeric micelles based on poly(γ-benzyl-l-glutamate)-poly(ethylene glycol) graft copolymer (PBLG-g-PEG) with various degrees of grafting and the mixtures composed of PBLG-g-PEG and poly(γ-benzyl-l-glutamate)-poly(ethylene glycol) block copolymer (PBLG-b-PEG) were prepared by the dialysis method in deionized water. Fluorescence spectroscopy and transmission electron microscope (TEM) have been used to study the self-assembly behavior. The experimental results revealed that the degree of grafting exerts marked effect on the critical micelle concentration (CMC) and the morphology of the micelle formed by PBLG-g-PEG. With increasing the degree of grafting, the CMC value becomes larger and the morphology of formed micelle changes from irregular shape to spindle. It was also found that mixtures of PBLG-g-PEG/PBLG-b-PEG can associate into hybrid polymeric micelle with various shapes.     

Self-assembled micelles of well-defined pentaerythritol-centered amphiphilic A4B8 star-block copolymers based on PCL and PEG for hydrophobic drug delivery

Biodegradable star-shaped poly(?-caprolactone) (PCL) with four arms were synthesized by ring-opening polymerization (ROP) from a symmetric pentaerythritol core via the ‘‘core-first’’ strategy. Subsequently, two samples of the amphiphilic A₄B₈ star-block copolymers with symmetrical topologies [4s(PCL-b-2sPEG)] were synthesized by a macromolecular coupling reaction between carboxyl-terminated poly(ethylene glycol) (PEG) and 4-arm star-shaped PCL macromers with eight -OH end groups. The latter was prepared by attaching 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid (HHMPA) to 4sPCL using a simple two-step reaction sequence. The in vitro cytotoxicity test indicated no apparent cytotoxicity. The amphiphilic star-block copolymers are capable of self-assembling into spherical micelles in water at room temperature, and they possess low critical micelle concentrations (CMCs) of 2∼8 mg/L in aqueous solution which was determined by fluorescence spectroscopy using pyrene as a probe. Transmission electron microscopy (TEM) measurement demonstrated that the micelles exhibit a spherical shape with a size range of 30∼50 nm in diameter. In addition, the hydrophobic and anticancer drug, quercetin, is loaded effectively in the polymeric micelles, suggesting that these new materials are appropriate candidates as hydrophobic drug nanocarriers.     

Poly(methyl methacrylate)/poly(ethylene glycol)/poly(ethylene glycol dimethacrylate) micelles: Preparation,characterization, and application as doxorubicin carriers

A crosslinked amphiphilic copolymer [poly(ethylene glycol) (PEG)–poly(methyl methacrylate) (PMMA)–ethylene glycol dimethacrylate (EGDM)] composed of PMMA, PEG, and crosslinking units (EGDM) was synthesized by atom transfer radical polymerization to develop micelles as carriers for hydrophobic drugs. By adjusting the molar ratio of methyl methacrylate and EGDM, three block copolymer samples (P0, P1, and P2) were prepared. The measurement of gel permeation chromatography and ¹H‐NMR indicated the formation of crosslinked structures for P1 and P2. Fluorescence spectroscopy measurement indicated that PEG–PMMA–EGDM could self‐assemble to form micelles, and the critical micelle concentration values of the crosslinked polymer were lower than those of linear ones. The prepared PEG–PMMA–EGDM micelles were used to load doxorubicin (DOX). The drug‐loading efficiencies of P1 and P2 were higher than that of P0 because the crosslinking units enhanced the micelles' stability. With increasing drug‐loading contents, DOX release from the micelles in vitro was decreased, and in the crosslinked formulations, the release rate was also slower. An in vitro release study indicated that DOX release from the micelles for the linear samples was faster than that for crosslinked micelles. The drug feeding amount increased and resulted in an increase in the drug‐loading content, and the loading efficiency decreased. These PEG–PMMA–EGDM micelles did not show toxicity in vitro and could reduce the cytotoxicity of DOX in the micelles; this suggested that they are good candidates as stable drug carriers. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 39623.     

Self‐assembled micelles prepared from poly(ɛ‐caprolactone)–poly(ethylene glycol) and poly(ɛ‐caprolactone/glycolide)–poly(ethylene glycol) block copolymers for sustained drug delivery

A series of poly(?‐caprolactone)–poly(ethylene glycol) (PCL‐PEG) and poly(?‐caprolactone/glycolide)–poly(ethylene glycol) [P(CL/GA)‐PEG] diblock copolymers were prepared by ring‐opening polymerization of ?‐caprolactone or a mixture of ?‐caprolactone and glycolide using monomethoxy PEG (mPEG) as macroinitiator and Sn(Oct)₂ as catalyst. The resulting copolymers were characterized using ¹H‐NMR, gel permeation chromatography, differential scanning calorimetry, and wide‐angle X‐ray diffraction. Copolymer micelles were prepared using the nanoprecipitation method. The morphology of the micelles was spherical or worm‐like as revealed by transmission electron microscopy, depending on the copolymer composition and the length of the hydrophobic block. Introduction of the glycolide component, even in small amounts (CL/GA = 10), disrupted the chain structure and led to the formation of spherical micelles. Interestingly, the micelle size decreased with the encapsulation of paclitaxel. Micelles prepared from mPEG5000‐derived copolymers exhibited better drug loading properties and slower drug release than those from mPEG2000‐derived copolymers. Drug release was faster for copolymers with shorter PCL blocks than for those with longer PCL chains. The introduction of glycolide moieties enhanced drug release, but the overall release rate did not exceed 10% in 30 days. In contrast, drug release was enhanced in acidic media. Therefore, these bioresorbable micelles and especially P(CL/GA)‐PEG micelles with excellent stability, high drug loading content, and prolonged drug release could be promising for applications as drug carriers. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 45732.     

Synthesis and micellization of a new amphiphilic star-shaped poly(D,L-lactide)/polyphosphoester block copolymer

A new amphiphilic 4-arm star-shaped poly(D,L-lactide)/poly(ethyl ethylene phosphate) (ssPLA-b-PEEP) block copolymer was synthesized by ring-opening polymerization of ethyl ethylene phosphate (EEP) with hydroxyl terminated 4-arm star-shaped poly(D,L-lactide) (ssPLA) as a macroinitiator, which was prepared by ring-opening polymerization of D,L-lactide (LA) initiated by pentaerythrite using stannous octoate as catalyst. The structures of the block copolymers were confirmed by IR, ¹H-NMR and GPC analysis. Fluorescence measurements were applied to determine the critical micelle concentration (CMC) of the copolymer micelle solutions. The diameter and the distribution of micelles were characterized by dynamic light scattering (DLS) and the shape was perceived by transmission electron microscopy (TEM). The results indicated those copolymers formed nano-micelles in aqueous solution with hydrophobic poly(D,L-lactide) core and hydrophilic poly(ethyl ethylene phosphate) shell. The CMC of the copolymer solutions increased with the increments of the proportion of PEEP segments. TEM images demonstrated that all micelles were spherical.     

Preparation and Characterization of Copolymer Micelles Formed by Poly(ethylene glycol)-Polylactide Block Copolymers as Novel Drug Carriers

Diblock copolymer poly(ethylene glycol) methyl ether-polylactide (MePEG-PLA) micelles were prepared by dialysis against water. Indomethacin (IMC) as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration (CMC) of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEG-PLA micelles and IMC loaded MePEG-PLA micelles in number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. Transmission electron microscope and scanning electron microscope observation showed that the appearance of MePEG-PLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18 wt.%. The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed.     

Synthesis of double‐hydrophilic poly(methylacrylic acid)–poly(ethylene glycol)–poly(methylacrylic acid) triblock copolymers and their micelle formation

The aim of the work reported was to synthesize a series of double‐hydrophilic poly(methacrylic acid)‐block‐poly(ethylene glycol)‐block‐poly(methacrylic acid) (PMAA‐b‐PEG‐b‐PMAA) triblock copolymers and to study their self‐assembly behavior. These copolymeric self‐assembly systems are expected to be potential candidates for applications as carriers of hydrophilic drugs. Bromo‐terminated difunctional PEG macroinitiators were used to synthesize well‐defined triblock copolymers of poly(tert‐butyl methacrylate)‐block‐poly(ethylene glycol)‐block‐poly(tert‐butyl methacrylate) via reversible‐deactivation radical polymerization. After the removal of the tert‐butyl group by hydrolysis, double‐hydrophilic PMAA‐b‐PEG‐b‐PMAA triblock copolymers were obtained. pH‐sensitive spherical micelles with a core–corona structure were fabricated by self‐assembly of the double‐hydrophilic PMAA‐b‐PEG‐b‐PMAA triblock copolymers at lower solution pH. Transmission electron microscopy and laser light scattering studies showed the micelles were of nanometric scale with narrow size distribution. Solution pH and micelle concentration strongly influenced the hydrodynamic radius of the spherical micelles (48–310 nm). A possible reason for the formation of the micelles is proposed. Copyright © 2010 Society of Chemical Industry     

Synthesis and micellization behavior of amphiphilic graft copolymer with 1‐octene as hydrophobic moiety

Two new kinds of amphiphilic copolymers were synthesized in this work. Poly(1‐octene‐co‐acrylic acid) copolymers were prepared through the copolymerization of 1‐octene and tert‐butyl acrylate, and the hydrolysis of tert‐butyl acrylate units. Poly(1‐octene‐co‐acrylic acid)‐g‐poly (ethylene glycol) copolymers were obtained from the esterification reaction between poly(1‐octene‐co‐acrylic acid) and poly(ethylene glycol) monomethyl ether. They were characterized by means of ¹H‐NMR, ¹³C‐NMR, GPC, and FTIR. These amphiphilic copolymers can form stable micelles in aqueous solutions. The critical micelle concentration was determined by fluorescence spectroscopy. The micellar morphology and size distribution were investigated by transmission electron microscopy and dynamic light scattering. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010     

pH-responsive PMAA-b-PEG-b-PMAA triblock copolymer micelles for prednisone drug release and release kinetics

pH-sensitive hydrophilic poly(methacrylic acid)-b-poly(ethylene glycol)-b-poly(methacrylic acid) (PMAA-b-PEG-b-PMAA) triblock copolymers were synthesized through atom transfer radical polymerization, and were characterized by FT-IR, ¹H NMR, and GPC. The as-synthesized polymers can self-assemble into stable and almost spherical nanomicelles in aqueous solution with an average size range from 18 to 89?nm, depending on the micellar concentrations, while they assumed well-defined spherical morphologies in PBS solutions. The micellization behavior in different media was investigated by a fluorescence spectroscopy technique, UV–Vis transmittance, and dynamic light scattering measurements. The critical micelle concentration and size of the micelles decrease with the increasing the length or molecular weights of PEG and PMAA chains. A pH-dependent phase transition behavior produces at a pH value of about 5.2, and the stable pH micellization behavior varied within a narrow pH range from ca. 4.8 to 7.4. These triblock copolymers are generally low cytotoxicity at a micellar concentration below 400?mg?L^?1, as revealed by the MTT assay. The prednisone release and release kinetics studies disclosed that these pH-sensitive polymeric micelles are good carriers for the drug delivery.     

Synthesis and characterization of brush copolymers based on methoxy poly(ethylene glycol) and poly(ε‐caprolactone)

Brush copolymers composed of methoxy poly(ethylene glycol) (MPEG) and poly(ε‐caprolactone) (PCL) have been synthesized by the ring‐opening polymerization of ε‐caprolactone initiated by hydroxyl function of thermally esterified MPEG‐citrate in presence of stannous octoate. Citric acid (CA) acts as spacer between brush‐like MPEG and the long chain of PCL. Existence of hydrophobic domains as cores of the micelles were characterized by ¹H NMR spectroscopy and further confirmed with fluorescence technique using pyrene as a probe. Critical micelle concentration (CMC) of the synthesized copolymer decreased from 0.019 to 0.0031 mg/mL on increasing the fraction of PCL. Along with the physicochemical study, the brush copolymers were explored for the preparation of nanoparticles by nanoprecipitation technique. The morphology and geometry of micelles were investigated by using DLS, AFM, and TEM. Hydrodyanamic dimensions of micelles were around 118 and 178 nm with the core size of 8–10 nm, which further aggregated to form secondary micelle of 60–90 nm. Such assembled polymeric micelles with its flexible dendritic MPEG corona could hold a promise for the immobilization (encapsulation) of hydrophobic drugs and subsequently promote sustained release so that it can be a good vehicle for anti‐cancer drug deliverance. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009     

Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells

Diblock copolymers of poly(ethylene glycol) (PEG) and poly(?-caprolactone) (PCL) bearing a tumor-targeting ligand, folate, were self-assembled into micelles. Superparamagnetic iron oxide (SPIO) nanoparticles and an anticancer drug doxorubicin (DOX) were coencapsulated within the micelles less than 100 nm in diameters. These SPIO-DOX-loaded micelles were superparamagnetic at room temperature, but turned ferrimagnetic at 10 K, consistent with magnetic properties of primary SPIO nanoparticles. Cell culture experiments demonstrated the potential of these polymeric micelles as an effective dual targeting nanoplatform for the delivery of anticancer drugs. Folate attachment to micelles resulted in the recognition of the micelles by tumor cells over-expressing folate receptors, leading to facilitation in cellular uptake of micelles, and the transport efficiency of the SPIO-loaded and folate-functionalized micelles into the tumor cells can be further enhanced by applying an external magnetic field to the cells.     

Synthesis and characterization of biodegradable polymers composed of 3,4-dihydroxycinnamic acid and poly(ethylene glycol)

A novel series of biodegradable copolymers were synthesized by the thermal polycondensation of 3,4-dihydroxycinnamic acid (DHCA) and poly(ethylene glycol) (PEG). The copolymers were characterized by ¹H-NMR, Fourier transform infrared spectroscopy, and gel permeation chromatography. It was found that the incorporation of PEG reduced the glass-transition temperature (T_g) of the copolymers, and T_g decreased with increasing amount of PEG in the compositions. The fluorescence spectroscopy revealed that the homopolymer and copolymers of DHCA gave a higher fluorescence emission intensity than that of DHCA monomer, of which the strongest fluorescence emission peak occurred in the copolymers containing a small amount of PEG. X-ray diffraction spectra demonstrated that poly(3,4-dihydroxycinnamic acid) and copolymer were amorphous; this indicated the facile biodegradability of the copolymers. Furthermore, copolymer micelles formed by self-assembly were investigated. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012     

Effects of micelle structures formed in selective solvents on crystallization behaviors of poly(ethylene glycol)-b-poly(styrene) copolymers

Well-defined amphiphilic block copolymers, poly(ethylene glycol) methyl ether-b-poly(styrene) (mPEG-b-PS), in which the PS blocks had different molecular weights, were synthesized by atom transfer radical polymerization (ATRP). Through introduction of selective solvents for the blocks, crystalline and amorphous blocks were self-assembled into different micelle structures in solutions. Atomic force microscopy (AFM) was used to characterize the micelle structures. It was observed that spherical micelles were always formed, whereas lamellar aggregates appeared only in the PS-selective solvent when the molecular weight of the PS block in mPEG-b-PS was low. The crystallizable mPEG blocks were self-assembled into either the core or corona of the micelles formed. The effects of the self-assembled structures on the crystallization behavior of mPEG blocks were then investigated with differential scanning calorimeter (DSC). When the PS molecular weight was much larger than that of mPEG, the result showed that the crystallinity of the mPEG block was lower when mPEG blocks crystallized in the corona than that in the core of the micelles. In this case, when mPEG blocks crystallized in micelle coronae, the micelle core formed by insoluble PS blocks was very big, so mPEG chains had to distribute sparsely in the micelle coronae. It was hard for mPEG chains in one micelle or among different micelles to gather together to crystallize. However, when the PS molecular weight was lower than that of mPEG, the crystallinity of mPEG was higher when the mPEG chains crystallized in the micelle corona, as the core formed by insoluble PS was small and the mPEG chains in the corona were easy to aggregate and crystallize.     

Nanosized micelles self-assembled from amphiphilic poly(citric acid)–poly(ε-caprolactone)–poly(citric acid) copolymers

In this study, novel ABA-type amphiphilic copolymers consisting of poly(citric acid) (PCA) (A) as hydrophilic segment and poly(ε-caprolactone) (PCL) (B) as hydrophobic block were prepared by an approach in the following two steps: (1) ring-opening polymerization (ROP) of ε-caprolactone with 1,5-pentanediol initiator to obtain a hydroxyl telechelic PCL; (2) melt polycondensation reaction of hydroxyl telechelic PCL and citric acid molecules. The prepared copolymers are capable of self-assembling into nanosized micelles in aqueous solution. The influence of the copolymer composition on the micelle dimensions was investigated. The critical micellar concentration of the copolymers is in the range of 5–6.3 × 10^?2 mg/mL which is determined by the fluorescence probe technique using pyrene. Also the results indicate that CMC of self assembled micelles is influenced by the hydrophilicity of PCA–PCL–PCA copolymers depending on the CA/CP ratio, and these micelles may find great potential as drug carriers in biomedical fields.     

Biodegradable depsipeptide–PDO–PEG-based block copolymer micelles as nanocarriers for controlled release of doxorubicin

Nowadays, biodegradable amphiphilic block copolymers with stable performance and adjustable structure have attracted the interests of researchers in the field of drug delivery. In this work, the triblock copolymer, P(SBMD-co-PDO)-b-PEG-b-P(SBMD-co-PDO), was successfully synthesized by ring-opening polymerization of 3(S)-sec-butyl-morpholine-2,5-dione (SBMD) and p-dioxanone (PDO) with poly(ethylene glycol) (PEG) as the initiator. In phosphate buffered solution (PBS), these copolymers could self-assemble into nano-sized micelles that have a hydrophobic P(SBMD-co-PDO) core surrounded by a hydrophilic PEG shell. Because of the strong hydrogen bonding and hydrophobic interactions, doxorubicin (DOX) was loaded into the micelles with high loading capacity (LC, up to 28.4%) and encapsulation efficiency (EE, up to 62.5%). The drug-loaded micelles showed sustained-release of DOX along with the hydrolytic degradation of the micelles in PBS. Therefore, these amphiphilic triblock copolymers have potential as drug matrix for controlled release.     

两亲性无规共聚物MAA-SMA-PEGMA的表面活性研究

利用功能性单体甲基丙烯酸(MAA)、甲基丙烯酸十八烷基酯(SMA)和聚乙二醇甲基丙烯酸酯(PEG-MA)通过自由基共聚,合成了两亲性共聚物Poly(MAA-SMA-PEGMA)。研究了其结构、临界胶束浓度(CMC)和表面张力,探讨了由共聚物与低分子表面活性剂组成的复配体系。结果表明高低分子表面活性剂复配体系在质量比为5∶5后,体系的表面张力和临界胶束浓度都有所降低,接近于低分子表面活性剂。