A Learning Based Brain Tumor Detection System

Brain tumor is one of the most dangerous disease that causes due to uncontrollable and abnormal cell partition. In this paper, we have used MRI brain scan in comparison with CT brain scan as it is less harmful to detect brain tumor. We considered watershed segmentation technique for brain tumor detection. The proposed methodology is divided as follows: pre-processing, computing foreground applying watershed, extract and supply features to machine learning algorithms. Consequently, this study is tested on big data set of images and we achieved acceptable accuracy from K-NN classification algorithm in detection of brain tumor.     

Improved fuzzy entropy clustering algorithm for MRI brain image segmentation

Magnetic resonance imaging (MRI) brain image segmentation is essential at preliminary stage in the neuroscience research and computer‐aided diagnosis. However, presence of noise and intensity inhomogeneity in MRI brain images leads to improper segmentation. The fuzzy entropy clustering (FEC) is often used to deal with noisy data. One major disadvantage of the FEC algorithm is that it does not consider the local spatial information. In this article, we have proposed an improved fuzzy entropy clustering (IFEC) algorithm by introducing a new fuzzy factor, which incorporates both local spatial and gray‐level information. The IFEC algorithm is insensitive to noise, preserves the image detail during clustering, and is free of parameter selection. The efficacy of IFEC algorithm is demonstrated by comparing it quantitatively with the state‐of‐the‐art segmentation approaches in terms of similarity index on publically available real and simulated MRI brain images.     

MRI brain image enhancement using brightness preserving adaptive fuzzy histogram equalization

In this article, fuzzy logic based adaptive histogram equalization (AHE) is proposed to enhance the contrast of MRI brain image. Medical image plays an important role in monitoring patient's health condition and giving an effective diagnostic. Mostly, medical images suffer from different problems such as poor contrast and noise. So it is necessary to enhance the contrast and to remove the noise in order to improve the quality of a various medical images such as CT, X‐ray, MRI, and MAMOGRAM images. Fuzzy logic is a useful tool for handling the ambiguity or uncertainty. Brightness Preserving Adaptive Fuzzy Histogram Equalization technique is proposed to improve the contrast of MRI brain images by preserving brightness. Proposed method comprises of two stages. First, fuzzy logic is applied to an input image and then it's output is given to AHE technique. This process not only preserves the mean brightness and but also improves the contrast of an image. A huge number of highly MRI brain images are taken in the proposed method. Performance of the proposed method is compared with existing methods using the parameters namely entropy, feature similarity index, and contrast improvement index and the experimental results show that the proposed method overwhelms the previous existing methods.     

A novel brain image segmentation using intuitionistic fuzzy C means algorithm

A process of splitting the image into pixel bands is the image segmentation. As medical imaging contain uncertainties, there are difficulties in classification of images into homogeneous regions. There is a need for segmentation algorithm for removing the noise from the medical image segmentation. The very popular algorithm is Fuzzy C‐Means (FCM) algorithm used for image segmentation. Fuzzy sets, rough sets, and the combination of fuzzy and rough sets play a prominent role in formalizing uncertainty, vagueness, and incompleteness in diagnosis. But it will use intensity values only which will be highly sensitive to noise. In this article, an Intuitionistic FCM (IFCM) algorithm is presented for clustering. Intuitionistic fuzzy (IF) sets are generalized sets and their elements are characterized by a membership value as well as nonmembership value. This IFCM has an uncertainty parameter which is called hesitation degree and a new objective function is integrated in the standard FCM based on IF entropy. The IFCM will provide better performance than FCM for image segmentation.     

Multi-resolution fuzzy clustering approach for image-based particle characterization for particle systems

Online characterization of particles is an important step for maintaining desired product quality in particulate processes. Direct real-time image analysis is a promising method for monitoring particle systems, and is becoming increasingly more attractive due to availability of high speed imaging devices and equally powerful computers. Performing image segmentation (separation of objects (particles) within one image) accurately becomes a key issue in particle image analysis. This paper presents a novel technique based on combining wavelet transform and Fuzzy C-means Clustering (FCM) for particle image segmentation. Through performing wavelet transform on images, the noise and high frequency components of images can be eliminated and the textures and features can be obtained. FCM is then used to divide data into two clusters to separate touching objects. To quantitatively evaluate this method, a case study involving a particle image is investigated. The procedure of selecting optimum wavelet function and decomposition level for this image is presented. ‘Fuzzy range’ is used as a derived feature for segmentation. The number of particles, particle equivalent diameters, and size distribution before and after partition are discussed. The results show that this method is effective and reliable.     

A machine learning approach for brain image enhancement and segmentation

In brain MRI analysis, image segmentation is commonly used for measuring and visualizing the brain's anatomical structures, for surgical planning, etc. However, due to presence of noise and uncertainty between different tissues in the brain image, the segmentation of brain is a challenging task. This problem is rectified in this article using two stages. In the first stage an enhancement technique called contrast limited fuzzy adaptive histogram equalization (CLFAHE) which is a combination of CLAHE and fuzzy enhancement is used to improve the contrast of MRI Brain images. Contrast of the image is controlled using contrast intensification operator (Clip limit). The second stage deals with the segmentation of enhanced image. The enhanced brain images are segmented using new level‐set method which has the property of both local and global segmentation. Signed pressure force (SPF) function is also used here which stops the contours at weak and blurred edged efficiently.     

Compatible abnormality detection technique for CT and MRI brain images

Abstract

An automated computerised tomography (CT) and magnetic resonance imaging (MRI) brain images are used to perform an efficient classification. The proposed technique consists of three stages, namely, pre-processing, feature extraction and classification. Initially, pre-processing is performed to remove the noise from the medical MRI images. Then, in the feature extraction stage, the features that are related with MRI and CT images are extracted and these extracted features which are given to the Feed Forward Back-propagation Neural Network (FFBNN) is exploited in order to classify the brain MRI and CT images into two types: normal and abnormal. The FFBNN is well trained by the extracted features and uses the unknown medical brain MRI images for classification in order to achieve better classification performance. The proposed method is validated by various MRI and CT scan images. A classification with an accomplishment of 96% and 70% has been obtained by the proposed FFBNN classifier. This achievement shows the effectiveness of the proposed brain image classification technique when compared with other recent research works.     

Fuzzy generalized fast marching method for 3D segmentation of brain structures

The aim of this work is to develop a new model for segmentation of brain structures in medical brain MR images. Brain segmentation is a challenging task due to the complex anatomical structure of brain structures as well as intensity nonuniformity, partial volume effects and noise. Generally the structures of interest are of relatively complicated size and have significant shape variations, the structures boundaries may be blurry or even missing, and the surrounding background is full of irrelevant edges. Segmentation methods based on fuzzy models have been developed to overcome the uncertainty caused by these effects. In this study, we propose a robust and accurate brain structures segmentation method based on a combination of fuzzy model and deformable model. Our method breaks up into two great parts. Initially, a preliminary stage allows to construct the various information maps, in particular a fuzzy map, used as a principal information source, constructed using the Fuzzy C‐means method (FCM). Then, a deformable model implemented with the generalized fast marching method (GFMM), evolves toward the structure to be segmented, under the action of a normal force defined from these information maps. In this sense, we used a powerful evolution function based on a fuzzy model, adapted for brain structures. Two extensions of our general method are presented in this work. The first extension concerns the addition of an edge map to the fuzzy model and the use of some rules adapted to the segmentation process. The second extension consists of the use of several models evolving simultaneously to segment several structures. Extensive experiments are conducted on both simulated and real brain MRI datasets. Our proposed approach shows promising and achieves significant improvements with respect to several state‐of‐the‐art methods and with the three practical segmentation techniques widely used in neuroimaging studies, namely SPM, FSL, and Freesurfer.     

MRI brain segmentation in combination of clustering methods with Markov random field

Medical image segmentation is a preliminary stage of inclusion in identification tools. The correct segmentation of brain Magnetic Resonance Imaging (MRI) images is crucial for an accurate detection of the disease diagnosis. Due to in‐homogeneity, low distinction and noise the segmentation of the brain MRI images is treated as the most challenging task. In this article, we proposed hybrid segmentation, by combining the clustering methods with Hidden Markov Random Field (HMRF) technique. This aims to decrease the computational load and improves the runtime of segmentation method, as MRF methodology is used in post‐processing the images. Its evaluation has performed on real imaging data, resulting in the classification of brain tissues with dice similarity metric. These results indicate the improvement in performance of the proposed method with various noise levels, compared with existing algorithms. In implementation, selection of clustering method provides better results in the segmentation of MRI brain images.     

Online variational learning of finite inverted Beta-Liouville mixture model for biomedical analysis

Image segmentation is widely applied for biomedical image analysis. However, segmentation of medical images is challenging due to many image modalities, such as, CT, X-ray, MRI, microscopy among others. An additional challenge to this is the high variability, inconsistent regions with missing edges, absence of texture contrast, and high noise in the background of biomedical images. Thus, many segmentation approaches have been investigated to address these issues and to transform medical images into meaningful information. During the past decade, finite mixture models have been revealed to be one of the most flexible and popular approaches in data clustering. In this article, we propose a statistical framework for online variational learning of finite inverted Beta-Liouville mixture model for clustering medical images. The online variational learning framework is used to estimate the parameters and the number of mixture components simultaneously, thus decreasing the computational complexity of the model. To this end, we evaluated our proposed algorithm on five different biomedical image data sets including optic disc detection and localization in diabetic retinopathy, digital imaging in melanoma lesion detection and segmentation, brain tumor detection, colon cancer detection and computer aid detection (CAD) of Malaria. Furthermore, we compared the proposed algorithm with three other popular algorithms. In our results, we analyze that the proposed online variational learning of finite IBL mixture model algorithm performs accurately on multiple modalities of medical images. It detects the disease patterns with high confidence. Computational and statistical approaches like the one presented in this article hold a significant impact on medical image analysis and interpretation in both clinical applications and scientific research. We believe that the proposed algorithm has the capacity to address multi modal biomedical image data sets and can be further applied by researchers to analyze correct disease patterns.     

Fully automatic method for segmentation of brain tumor from multimodal magnetic resonance images using wavelet transformation and clustering technique

Fully automatic brain tumor segmentation is one of the critical tasks in magnetic resonance imaging (MRI) images. This proposed work is aimed to develop an automatic method for brain tumor segmentation process by wavelet transformation and clustering technique. The proposed method using discrete wavelet transform (DWT) for pre‐ and post‐processing, fuzzy c‐means (FCM) for brain tissues segmentation. Initially, MRI images are preprocessed by DWT to sharpen the images and enhance the tumor region. It assists to quicken the FCM clustering technique and classified into four major classes: gray matter (GM), white matter (WM), cerebrospinal fluid (CSF), and background (BG). Then check the abnormality detection using Fuzzy symmetric measure for GM, WM, and CSF classes. Finally, DWT method is applied in segmented abnormal region of images respectively and extracts the tumor portion. The proposed method used 30 multimodal MRI training datasets from BraTS2012 database. Several quantitative measures were calculated and compared with the existing. The proposed method yielded the mean value of similarity index as 0.73 for complete tumor, 0.53 for core tumor, and 0.35 for enhancing tumor. The proposed method gives better results than the existing challenging methods over the publicly available training dataset from MICCAI multimodal brain tumor segmentation challenge and a minimum processing time for tumor segmentation. © 2016 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 26, 305–314, 2016     

Automatic Segmentation of Liver from Abdominal Computed Tomography Images Using Energy Feature

Liver Segmentation is one of the challenging tasks in detecting and classifying liver tumors from Computed Tomography (CT) images. The segmentation of hepatic organ is more intricate task, owing to the fact that it possesses a sizeable quantum of vascularization. This paper proposes an algorithm for automatic seed point selection using energy feature for use in level set algorithm for segmentation of liver region in CT scans. The effectiveness of the method can be determined when used in a model to classify the liver CT images as tumorous or not. This involves segmentation of the region of interest (ROI) from the segmented liver, extraction of the shape and texture features from the segmented ROI and classification of the ROIs as tumorous or not by using a classifier based on the extracted features. In this work, the proposed seed point selection technique has been used in level set algorithm for segmentation of liver region in CT scans and the ROIs have been extracted using Fuzzy C Means clustering (FCM) which is one of the algorithms to segment the images. The dataset used in this method has been collected from various repositories and scan centers. The outcome of this proposed segmentation model has reduced the area overlap error that could offer the intended accuracy and consistency. It gives better results when compared with other existing algorithms. Fast execution in short span of time is another advantage of this method which in turns helps the radiologist to ascertain the abnormalities instantly.     

Automated brain tumour segmentation techniques— A review

Automatic segmentation of brain tumour is the process of separating abnormal tissues from normal tissues, such as white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). The process of segmentation is still challenging due to the diversity of shape, location, and size of the tumour segmentation. The metabolic process, psychological process, and detailed information of the images, are obtained using positron emission tomography (PET) image, Computer Tomography (CT) image and Magnetic Resonance Image (MRI). Multimodal imaging techniques (such as PET/CT and PET/MRI) that combine the information from many imaging techniques contribute more for accurate brain tumour segmentation. In this article, a comprehensive overview of recent automatic brain tumour segmentation techniques of MRI, PET, CT, and multimodal imaging techniques has been provided. The methods, techniques, their working principle, advantages, their limitations, and their future challenges are discussed in this article. © 2017 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 27, 66–77, 2017     

A Novel Deep Neural Network for Intracranial Haemorrhage Detection and Classification

Data fusion is one of the challenging issues, the healthcare sector is facing in the recent years. Proper diagnosis from digital imagery and treatment are deemed to be the right solution. Intracerebral Haemorrhage (ICH), a condition characterized by injury of blood vessels in brain tissues, is one of the important reasons for stroke. Images generated by X-rays and Computed Tomography (CT) are widely used for estimating the size and location of hemorrhages. Radiologists use manual planimetry, a time-consuming process for segmenting CT scan images. Deep Learning (DL) is the most preferred method to increase the efficiency of diagnosing ICH. In this paper, the researcher presents a unique multi-modal data fusion-based feature extraction technique with Deep Learning (DL) model, abbreviated as FFE-DL for Intracranial Haemorrhage Detection and Classification, also known as FFEDL-ICH. The proposed FFEDL-ICH model has four stages namely, preprocessing, image segmentation, feature extraction, and classification. The input image is first preprocessed using the Gaussian Filtering (GF) technique to remove noise. Secondly, the Density-based Fuzzy C-Means (DFCM) algorithm is used to segment the images. Furthermore, the Fusion-based Feature Extraction model is implemented with handcrafted feature (Local Binary Patterns) and deep features (Residual Network-152) to extract useful features. Finally, Deep Neural Network (DNN) is implemented as a classification technique to differentiate multiple classes of ICH. The researchers, in the current study, used benchmark Intracranial Haemorrhage dataset and simulated the FFEDL-ICH model to assess its diagnostic performance. The findings of the study revealed that the proposed FFEDL-ICH model has the ability to outperform existing models as there is a significant improvement in its performance. For future researches, the researcher recommends the performance improvement of FFEDL-ICH model using learning rate scheduling techniques for DNN.     

Modified transform-based gamma correction for MRI tumor image denoising and segmentation by optimized histon-based elephant herding algorithm

Medical image processing is typically performed to diagnose a patient's brain tumor prior to surgery. In this study, a technique in denoising and segmentation was developed to improve medical image processing. The proposed approach employs multiple modules. In the first module, the noisy brain tumor image is transformed into multiple low- and high-pass tetrolet coefficients. In the second module, multiple low-pass tetrolet coefficients are applied through a modified transform-based gamma correction method. Generalized cross-validation is used on multiple high-pass tetrolet coefficients to obtain the best threshold value. In the third module, all enhanced coefficients are applied to the partial differential equation method. In the final module, the denoised image is applied to Atanassov's intuitionistic fuzzy set histon-based fuzzy clustering method with centroid optimization using an elephant herding method. Accordingly, the tumor part is segmented from the nontumor part in the magnetic resonance imaging brain images. The method was assessed in terms of peak signal-to-noise ratio, mean square error, specificity, sensitivity, and accuracy. The experimental results showed that the suggested method is superior to traditional methods.     

Denoising and segmentation of MR images using fourth order non-linear adaptive PDE and new convergent clustering

At present, digital image processing plays a vital role in medical imaging areas and specifically in magnetic resonance imaging (MRI) of brain images such as axial and coronal sections. This article mainly focused on the MRI brain images. The existing methods such as total variation (MC), parallel MRI, modified pyramidal dual-tree direction filter, adaptive dictionary selection algorithm, classifier methods, and fuzzy clustering techniques are poor in image eminence and precision. Thus, this article presents a novel approach consisting of denoising followed by segmentation. The objective of these proposed methods was visual eminence improvement of medical images to examine tumor extent using an adaptive partial differential equation (APDE)-based analysis with soft threshold function in denoising. The fourth order, nonlinear APDE was used to denoise the image depending on gradient and Laplacian operators associated with the new adaptive Haar-type wavelet transform. A second approach was the new convergent K-means clustering for segmentation. The convergent K-means procedure diminishes the summation of the squared deviations of structures in a cluster from the center. The significance of these proposed methods was to compute their performances in terms of mean squared error, peak signal-to-noise ratio, structure similarity, segmentation accuracy, false hit, missed-term, and elapsed time. The results were analyzed with the MATLAB software.     

Computer aided automated detection and classification of brain tumors using CANFIS classification method

The development of abnormal cells in human brain leads to the formation of tumors. This article proposes an efficient approach for brain tumor detection and segmentation using image fusion and co-active adaptive neuro fuzzy inference system (CANFIS) classification method. The brain MRI images are fused and the dual tree complex wavelet transform is applied on the fused image. Then, the statistical features, local ternary pattern features and gray level co-occurrence matrix features. These extracted features are classified using CANFIS classification approach for the classification of source brain MRI image into either normal or abnormal. Further, morphological operations are applied on the abnormal brain MRI image for segmenting the tumor regions. The proposed methodology is evaluated with respect to the performance metrics sensitivity, specificity, positive predictive value, negative predictive value, tumor segmentation accuracy with detection rate. The proposed image fusion based brain tumor detection and classification methodology stated in this article achieves 96.5% of average sensitivity, 97.7% of average specificity, 87.6% of positive predictive value, 96.6% of negative predictive value, and 98.8% of average accuracy.     

Robust brain MRI denoising and segmentation using enhanced non‐local means algorithm

Image denoising is an integral component of many practical medical systems. Non‐local means (NLM) is an effective method for image denoising which exploits the inherent structural redundancy present in images. Improved adaptive non‐local means (IANLM) is an improved variant of classical NLM based on a robust threshold criterion. In this paper, we have proposed an enhanced non‐local means (ENLM) algorithm, for application to brain MRI, by introducing several extensions to the IANLM algorithm. First, a Rician bias correction method is applied for adapting the IANLM algorithm to Rician noise in MR images. Second, a selective median filtering procedure based on fuzzy c‐means algorithm is proposed as a postprocessing step, in order to further improve the quality of IANLM‐filtered image. Third, different parameters of the proposed ENLM algorithm are optimized for application to brain MR images. Different variants of the proposed algorithm have been presented in order to investigate the influence of the proposed modifications. The proposed variants have been validated on both T1‐weighted (T1‐w) and T2‐weighted (T2‐w) simulated and real brain MRI. Compared with other denoising methods, superior quantitative and qualitative denoising results have been obtained for the proposed algorithm. Additionally, the proposed algorithm has been applied to T2‐weighted brain MRI with multiple sclerosis lesion to show its superior capability of preserving pathologically significant information. Finally, impact of the proposed algorithm has been tested on segmentation of brain MRI. Quantitative and qualitative segmentation results verify that the proposed algorithm based segmentation is better compared with segmentation produced by other contemporary techniques.     

Unsupervised learning-based clustering approach for smart identification of pathologies and segmentation of tissues in brain magnetic resonance imaging

Human-made/developed algorithms provide automatic identification and segmentation of the tissues, lesions and tumor regions available in brain magnetic resonance scan images, which invocates predicaments such as high computational cost and low accuracy rate. Such hassles are reconciled with the utilization of an unsupervised approach in combination with clustering techniques. Initially, static features are chosen from the input image, which is fed to the self-organizing map (SOM), where the algorithm employs the dimensionality reduction of input images. Consecutively, the reduced SOM prototype of data is clustered by the modified fuzzy K-means (MFKM) algorithm. The MFKM algorithm can be modified in terms of membership variables because it operates with spatial information and converges quickly, and this would be of greater benefit to radiologists as they reduce the wrong predictions and voluminous time that normally occur owing to human involvement. The proposed algorithm provides 98.77% sensitivity and 97.5% specificity, which are better than any other traditional algorithms mentioned in this article.     

Hierarchical fuzzy segmentation of brain MR images

In brain magnetic resonance (MR) images, image segmentation and 3D visualization are very useful tools for the diagnosis of abnormalities. Segmentation of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is the basic process for 3D visualization of brain MR images. Of the many algorithms, the fuzzy c‐means (FCM) technique has been widely used for segmentation of brain MR images. However, the FCM technique does not yield sufficient results under radio frequency (RF) nonuniformity. We propose a hierarchical FCM (HFCM), which provides good segmentation results under RF nonuniformity and does not require any parameter setting. We also generate Talairach templates of the brain that are deformed to 3D brain MR images. Using the deformed templates, only the cerebrum region is extracted from the 3D brain MR images. Then, the proposed HFCM partitions the cerebrum region into WM, GM, and CSF. © 2003 Wiley Periodicals, Inc. Int J Imaging Syst Technol 13, 115–125, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ima.10035