Automatic breast cancer detection based on optimized neural network using whale optimization algorithm

Breast cancer is the second deadliest type of cancer. Early detection of breast cancer can considerably improve the effectiveness of treatment. A significant early sign of breast cancer is the mass. However, separating the cancerous masses from the normal portions of the breast tissue is usually a challenge for radiologists. Recently, because of the availability of high‐accuracy computing, computer‐aided detection systems based on image processing have become capable of accurately diagnosing the various types of cancers. The main purpose of this study is to utilize a powerful image segmentation method for the diagnosis of cancerous regions through mammography, based on a new configuration of the multilayer perceptron (MLP) neural network. The most popular method for minimizing the errors in an MLP neural network is backpropagation. However, this method has certain drawbacks, such as a low convergence speed and becoming trapped at the local minimum. In this study, a new training algorithm based on the whale optimization algorithm is proposed for the MLP network. This algorithm is capable of solving various problems toward the current algorithms for the analyzed systems. The proposed method is validated on the Mammographic Image Analysis Society database, which contains 322 digitized mammography images, and the Digital Database for Screening Mammography, which contains approximately 2500 digitized mammography images. To assess the detection performance of the proposed system, the correct detection rate, percentage of identification with false acceptance, and percentage of identification with false rejection were evaluated and compared using various methods. The results indicate that the proposed method is highly efficient and yields significantly better accuracy compared with other methods.     

Breast cancer diagnosis from mammographic images using optimized feature selection and neural network architecture

Breast cancer is one of the deadly diseases in women that have raised the mortality rate of women. An accurate and early detection of breast cancer using mammogram images is still a complex task. Hence, this article proposes a novel breast cancer detection model, which included five major phases: (a) preprocessing, (b) segmentation, (c) feature extraction, (d) feature selection, and (e) classification. The input mammogram image is initially preprocessed using contrast limited adaptive histogram equalization (CLAHE) and median filtering. The preprocessed image is then subjected to segmentation via the region growing algorithm. Subsequently, geometric features, texture features and gradient features are extracted from the segmented image. Since the length of the feature vector is large, it is essential to select the optimal features. Here, the selection of optimal features is done by a hybrid optimization algorithm. Once the optimal features are selected, they are subjected to the classification process involving the neural network (NN) classifier. As a novelty, the weight of NN is selected optimally to enhance the accuracy of diagnosis (benign and malignant). The optimal feature selection as well as the weight optimization of NN is accomplished by merging the Lion algorithm (LA) and particle swarm optimization (PSO), named as velocity updated lion algorithm (VU‐LA). Finally, a performance‐based evaluation is carried out between VU‐LA and the existing models like, whale optimization algorithm (WOA), gray wolf optimization (GWO), firefly (FF), PSO, and LA.     

具有分割健壮性的超声图像分类方法探索

在早期癌症的发病表现中,肿块和微小钙化点是重要的特征和诊断依据.然而,病变可疑区域与正常组织区域之间的差别很小,并且肿块的边界和内部结构在超声图像上形态不一,与周围组织的差别也很细微,很难用人眼检查到,这样使得早期确诊变得比较困难.本文采用一种基于模糊数学理论的乳腺超声图像增强算法,经过增强处理之后,原先由于图像的模糊而隐藏的信息能够清晰的观察到,这也后后面的肿瘤的分割与分类打好基础.     

Fused and Modified Evolutionary Optimization of Multiple Intelligent Systems Using ANN,SVM Approaches

The Fused Modified Grasshopper Optimization Algorithm has been proposed, which selects the most specific feature sets from images of the disease of plant leaves. The Proposed algorithm ensures the detection of diseases during the early stages of the diagnosis of leaf disease by farmers and, finally, the crop needed to be controlled by farmers to ensure the survival and protection of plants. In this study, a novel approach has been suggested based on the standard optimization algorithm for grasshopper and the selection of features. Leaf conditions in plants are a major factor in reducing crop yield and quality. Any delay or errors in the diagnosis of the disease can lead to delays in the management of plant disease spreading and damage and related material losses. Comparative new heuristic optimization of swarm intelligence, Grasshopper Optimization Algorithm was inspired by grasshopper movements for their feeding strategy. It simulates the attitude and social interaction of grasshopper swarm in terms of gravity and wind advection. In the decision on features extracted by an accelerated feature selection algorithm, popular approaches such as ANN and SVM classifiers had been used. For the evaluation of the proposed model, different data sets of plant leaves were used. The proposed model was successful in the diagnosis of the diseases of leaves the plant with an accuracy of 99.41 percent (average). The proposed biologically inspired model was sufficiently satisfied, and the best or most desirable characteristics were established. Finally, the results of the research for these data sets were estimated by the proposed Fused Modified Grasshopper Optimization Algorithm (FMGOA). The results of that experiment were demonstrated to allow classification models to reduce input features and thus to increase the precision with the presented Modified Grasshopper Optimization Algorithm. Measurement and analysis were performed to prove the model validity through model parameters such as precision, recall, f-measure, and precision.     

Multi-Index Image Retrieval Hash Algorithm Based on Multi-View Feature Coding

In recent years, with the massive growth of image data, how to match the image required by users quickly and efficiently becomes a challenge. Compared with single-view feature, multi-view feature is more accurate to describe image information. The advantages of hash method in reducing data storage and improving efficiency also make us study how to effectively apply to large-scale image retrieval. In this paper, a hash algorithm of multi-index image retrieval based on multi-view feature coding is proposed. By learning the data correlation between different views, this algorithm uses multi-view data with deeper level image semantics to achieve better retrieval results. This algorithm uses a quantitative hash method to generate binary sequences, and uses the hash code generated by the association features to construct database inverted index files, so as to reduce the memory burden and promote the efficient matching. In order to reduce the matching error of hash code and ensure the retrieval accuracy, this algorithm uses inverted multi-index structure instead of single-index structure. Compared with other advanced image retrieval method, this method has better retrieval performance.     

Cell-type based semantic segmentation of histopathological images using deep convolutional neural networks

Histopathological whole-slide image (WSI) analysis is still one of the most important ways to identify regions of cancer risk. For cancer in which early diagnosis is vital, pathologists are at the center of the decision-making process. Thanks to the widespread use of digital pathology and the development of artificial intelligence methods, automatic histopathological image analysis methods help pathologists in their decision-making process. In this process, rather than producing labels for whole-slide image patches, semantic segmentation is very useful, which facilitates the pathologists’ interpretation. In this study, automatic semantic segmentation based on cell type is proposed for the first time in the literature using novel deep convolutional networks structure (DCNN). We presents semantic information on four classes, including white areas in the whole-slide image, tissue without cells, tissue with normal cells and tissue with cancerous cells. This visual information presented to the pathologist is an easy-to-understand picture of the status of the cells and their implications for the spread of cancerous cells. A new DCNN architecture is created, inspired by the residual network and deconvolution network architecture. Our network is trained end-to-end manner with histopathological image patches for cell structures to be more discriminative. The proposed method not only produces more successful results than other state-of-art semantic segmentation algorithms with 9.2% training error and 88.89% F-score for test, but also has the most important advantage in that it has the ability to generate automatic information about the cancer and also provides information that pathologists can quickly interpret.     

基于最近邻搜索耦合近邻损耗聚类的图像伪造检测算法

目的为了解决当前图像伪造检测算法在对图像进行伪造检测时,主要依靠全局搜索的方式来完成特征点匹配,导致其检测效率较低,且在对复杂伪造图像进行检测时,易出现检测精度不高和检测错误的不足。方法提出基于最近邻搜索耦合近邻损耗聚类的图像伪造检测算法。首先引入积分图像的方法,对图像进行预处理,借助Hessian矩阵行列式来提取特征点。利用特征点构建圆形区域,通过求取圆形区域内Haar小波响应获取特征点的特征描述符。然后通过特征描述符建立KD树索引,利用最近邻搜索方法代替SURF中全局搜索的方法,对SURF进行改进,完成特征点的匹配。最后,利用特征点间的近邻关系求取近邻函数值,通过近邻函数值对特征点进行聚类,完成图像的伪造检测。结果实验结果显示,与当前图像伪造检测算法相比,所提算法具有更高的检测效率以及更高的检测正确度。结论所提算法具备较高的检测精度,在印刷防伪与信息安全等领域具有较好的应用价值。     

Computer aided brain tumor detection system using watershed segmentation techniques

Magnetic Resonance Imaging (MRI) is an advanced medical imaging technique that has proven to be an effective tool in the study of the human brain. In this article, the brain tumor is detected using the following stages: enhancement stage, anisotropic filtering, feature extraction, and classification. Histogram equalization is used in enhancement stage, gray level co‐occurrence matrix and wavelets are used as features and these extracted features are trained and classified using Support Vector Machine (SVM) classifier. The tumor region is detected using morphological operations. The performance of the proposed algorithm is analyzed in terms of sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV). The proposed system achieved 0.95% of sensitivity rate, 0.96% of specificity rate, 0.94% of accuracy rate, 0.78% of PPV, and 0.87% of NPV, respectively. © 2015 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 25, 297–301, 2015     

Automated Deep Learning Empowered Breast Cancer Diagnosis Using Biomedical Mammogram Images

Biomedical image processing is a hot research topic which helps to majorly assist the disease diagnostic process. At the same time, breast cancer becomes the deadliest disease among women and can be detected by the use of different imaging techniques. Digital mammograms can be used for the earlier identification and diagnostic of breast cancer to minimize the death rate. But the proper identification of breast cancer has mainly relied on the mammography findings and results to increased false positives. For resolving the issues of false positives of breast cancer diagnosis, this paper presents an automated deep learning based breast cancer diagnosis (ADL-BCD) model using digital mammograms. The goal of the ADL-BCD technique is to properly detect the existence of breast lesions using digital mammograms. The proposed model involves Gaussian filter based pre-processing and Tsallis entropy based image segmentation. In addition, Deep Convolutional Neural Network based Residual Network (ResNet 34) is applied for feature extraction purposes. Specifically, a hyper parameter tuning process using chimp optimization algorithm (COA) is applied to tune the parameters involved in ResNet 34 model. The wavelet neural network (WNN) is used for the classification of digital mammograms for the detection of breast cancer. The ADL-BCD method is evaluated using a benchmark dataset and the results are analyzed under several performance measures. The simulation outcome indicated that the ADL-BCD model outperforms the state of art methods in terms of different measures.     

提高时域乳腺光学层析成像质量的方法

时域乳腺光学层析成像技术可以有效重建乳腺组织的光学参数,实现乳腺癌的早期检测.为了提高重建图像的性能,针对图像重建过程中吸收系数和约化散射系数的雅克比矩阵间的量级差异,提出了一种有效的雅克比矩阵标定方法;为了克服不适定性因素对重建图像质量的影响,引入了图像分割技术实现对雅克比矩阵有效降维.实验数据的相关验证表明,上述两种方法可有效提高重建图像的质量.     

基于不变矩特征模型耦合相似度量规则的图像匹配算法

目的为了解决当前图像匹配算法因主要利用特征点之间的距离来实现特征匹配,从而忽略了特征点的结构特征,导致算法存在较多的漏匹配点以及错误匹配点等不足的问题。方法提出基于不变矩特征模型耦合相似度量规则的图像匹配算法。通过对待检测像素点构造的邻域圆上的点进行分类,制定检测规则,对FAST算子进行改进,利用改进的FAST算子快速、精准地检测图像的特征点。随后,构造不变矩特征模型,取代SIFT算法中获取特征向量的方法,生成低维度的特征描述符。通过Euclidean模型和SSIM建立相似度量规则,对特征点之间的相似度进行度量,完成图像的特征匹配。最后,引入随机抽样一致性(RANSAC)算法剔除错误匹配点,完成图像的匹配。结果仿真结果显示,相较于当前的图像匹配算法,所提算法具有更高的匹配正确度和鲁棒性,其查全率最高可达95%左右,且匹配效率较快,约为3.75 s。结论所提匹配方法具备良好的匹配精度,在图像信息安全、包装条码识别与拼接等领域具有一定的参考价值。     

基于L1范数优化路径的视频稳像算法

目的 为解决外包装行业对产品外观进行检测时,采集视频图像存在抖动失真的问题.方法 提出一种基于L1范数优化路径的视频稳像算法,采用SURF算法和FREAK算法对视频序列帧中的特征点进行检测和描述;然后,使用KNN算法和RANSAC算法对相邻帧间的特征点进行匹配和筛选;最后,通过L1范数优化算法对序列帧进行校正和去黑边处理,得到稳像视频.结果 在处理前景无运动和前景有运动的2类视频时,稳像前后视频的平均PSNR值分别提升了5.094 dB和4.273 dB,并且相对于常用的特征匹配算法,文中算法能显著降低相机路径的主动平滑因子.结论 文中算法能够有效地解决视频抖动失真的问题,提高抖动视频的质量,具有一定的鲁棒性.     

基于Harris与Sift算法的图像匹配方法

采用 Harris 角点检测算法进行图像特征检测, 采用 Sift 算法中的特征描述方法进行图像特征描述, 之后将图像特征点划分为多对多匹配对, 根据特征描述值的支持强度不同建立精确的一对一匹配关系. 该算法有效地避免了图像特征分布均匀时的 Sift 匹配效率较低的问题.     

An approach for classification of malignant and benign microcalcification clusters

The only reliable and successful treatment of breast cancer is its detection through mammography at initial stage. Clusters of microcalcifications are important signs of breast cancer. Manual interpretation of mammographic images, in which the suspicious regions are indicated as areas of varying intensities, is not error free due to a number of reasons. These errors can be reduced by using computer-aided diagnosis systems that result in reduction of either false positives or true negatives. The purpose of the study in this paper is to develop a methodology for distinguishing malignant microcalcification clusters from benign microcalcification clusters. The proposed approach first enhances the region of interest by using morphological operations. Then, two types of features, cluster shape features and cluster texture features, are extracted. A Support Vector Machine is used for classification. A new set of shape features based on the recursive subsampling method is added to the feature set, which improves the classification accuracy of the system. It has been found that these features are capable of differentiating malignant and benign tissue regions. To investigate the performance of the proposed approach, mammogram images are taken from Digital Database for Screening Mammography database and an accuracy of 94.25% has been achieved. The experiments have shown that the proposed classification system minimizes the classification errors and is more efficient in correct diagnosis.     

Investigation of absorbed radiation dose in refraction-enhanced breast tomosynthesis by a Laue case analyser

An early diagnosis system for breast cancer using refraction-enhanced breast tomosynthesis is under development. Tomograms of breast specimens based on refraction-contrast were demonstrated using the simplest shift-and-add tomosynthesis algorithm. Raw projection image data of breast specimens for tomosynthesis were acquired for a total of 51 views over an angle of 50°, in increments of 1°, by rotating the object. The incident X ray was monochromatic synchrotron radiation with 20 keV. The purpose of this study was to estimate the absorbed dose of a new X-ray imaging method. As breast cancer almost always arises in glandular breast tissue, the average absorbed dose in such glandular tissue should be measured to estimate the radiation risk associated with mammography. The absorbed dose of the mammary gland due to monochromatic X rays was calculated by the Monte Carlo method, and the optimal X ray energy range for refraction-enhanced breast tomosynthesis was investigated through actual measurements. Compared with the conventional method, it was found to be below one-sixth per inspection.     

基于组合图像特征与分层节点搜索的回环检测方法

目的 文中通过提出一种新的回环解决方案,平衡回环检测系统的高准确率与高运行效率。方法 提出一种利用组合图像特征与分层节点搜索的新方法。首先,计算一种原始图像的下采样二值化全局特征和经过改进的ORB(oriented FAST and rotated BRIEF)局部特征,将其存入图像特征数据库。其次,引入一种分层节点搜索算法,在数据库中搜索与当前图像特征最相似的全局特征作为回环候选。最后,利用改进的ORB特征进行局部特征匹配,验证候选图像,确定回环检测结果。结果 使用该算法在3个不同的数据集上进行验证,测试中每次回环检测的平均处理时间仅需19 ms。结论 实验结果表明,该算法在运行效率、准确率、召回率等方面均达到了领域内的先进水平。     

Research on Multi-View Image Reconstruction Technology Based on Auto-Encoding Learning

Traditional three-dimensional (3D) image reconstruction method, which highly dependent on the environment and has poor reconstruction effect, is easy to lead to mismatch and poor real-time performance. The accuracy of feature extraction from multiple images affects the reliability and real-time performance of 3D reconstruction technology. To solve the problem, a multi-view image 3D reconstruction algorithm based on self-encoding convolutional neural network is proposed in this paper. The algorithm first extracts the feature information of multiple two-dimensional (2D) images based on scale and rotation invariance parameters of Scale-invariant feature transform (SIFT) operator. Secondly, self-encoding learning neural network is introduced into the feature refinement process to take full advantage of its feature extraction ability. Then, Fish-Net is used to replace the U-Net structure inside the self-encoding network to improve gradient propagation between U-Net structures, and Generative Adversarial Networks (GAN) loss function is used to replace mean square error (MSE) to better express image features, discarding useless features to obtain effective image features. Finally, an incremental structure from motion (SFM) algorithm is performed to calculate rotation matrix and translation vector of the camera, and the feature points are triangulated to obtain a sparse spatial point cloud, and meshlab software is used to display the results. Simulation experiments show that compared with the traditional method, the image feature extraction method proposed in this paper can significantly improve the rendering effect of 3D point cloud, with an accuracy rate of 92.5% and a reconstruction complete rate of 83.6%.     

Meta-heuristics for Feature Selection and Classification in Diagnostic BreastCancer

One of the most common kinds of cancer is breast cancer. The early detection of it may help lower its overall rates of mortality. In this paper, we robustly propose a novel approach for detecting and classifying breast cancer regions in thermal images. The proposed approach starts with data preprocessing the input images and segmenting the significant regions of interest. In addition, to properly train the machine learning models, data augmentation is applied to increase the number of segmented regions using various scaling ratios. On the other hand, to extract the relevant features from the breast cancer cases, a set of deep neural networks (VGGNet, ResNet-50, AlexNet, and GoogLeNet) are employed. The resulting set of features is processed using the binary dipper throated algorithm to select the most effective features that can realize high classification accuracy. The selected features are used to train a neural network to finally classify the thermal images of breast cancer. To achieve accurate classification, the parameters of the employed neural network are optimized using the continuous dipper throated optimization algorithm. Experimental results show the effectiveness of the proposed approach in classifying the breast cancer cases when compared to other recent approaches in the literature. Moreover, several experiments were conducted to compare the performance of the proposed approach with the other approaches. The results of these experiments emphasized the superiority of the proposed approach.     

Brain tumour segmentation from MRI image using genetic algorithm with fuzzy initialisation and seeded modified region growing (GFSMRG) method

Segmentation is an important aspect of medical image processing. For improving the accuracy in the detection of tumour and improving the speed of execution in segmentation, a new genetic-based genetic algorithm with fuzzy initialisation and seeded modified region growing (GFSMRG) method with back propagation neural network (BPNN) is proposed and presented in this paper. The proposed system consists of four steps: pre-processing, segmentation, feature extraction and classification. The GFSMRG method and its components, feature extraction and classification are explained in detail. The performance analysis of the GFSMRG method with respect to accuracy and time complexity are also discussed. The performance of this method has been validated both quantitatively and qualitatively by using the performance metrics such as Similarity Index, Jaccard Index, Sensitivity, Specificity and Accuracy.     

Fitness adaptive deer hunting-based region growing and recurrent neural network for melanoma skin cancer detection

This proposal aims to enhance the accuracy of a dermoscopic skin cancer diagnosis with the aid of novel deep learning architecture. The proposed skin cancer detection model involves four main steps: (a) preprocessing, (b) segmentation, (c) feature extraction, and (d) classification. The dermoscopic images initially subjected to a preprocessing step that includes image enhancement and hair removal. After preprocessing, the segmentation of lesion is deployed by an optimized region growing algorithm. In the feature extraction phase, local features, color morphology features, and morphological transformation-based features are extracted. Moreover, the classification phase uses a modified deep learning algorithm by merging the optimization concept into recurrent neural network (RNN). As the main contribution, the region growing and RNN improved by the modified deer hunting optimization algorithm (DHOA) termed as Fitness Adaptive DHOA (FA-DHOA). Finally, the analysis has been performed to verify the effectiveness of the proposed method.