The structure of psychological distress and well-being in general populations.

Describes the development of the Mental Health Inventory (MHI), a 38-item measure of psychological distress and well-being, developed for use in general populations. The MHI was fielded in 4 large samples (N?=?5089) of Ss aged 13–69 yrs. One data set was used to explore the MHI's factor structure, and confirmatory factor analyses were used for cross validation. Results support a hierarchical factor model composed of a general underlying psychological distress vs well-being factor; a higher order structure defined by 2 correlated factors—Psychological Distress and Well-Being; and 5 correlated lower order factors—Anxiety, Depression, Emotional Ties, General Positive Affect, and Loss of Behavioral Emotional Control. Summated rating scales produced high internal consistency estimates and substantial stability over a 1-yr interval. Results provide strong psychometric support for a hierarchical model and scoring options ranging from 5 distinct constructs to reliance on 1 summary index. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A prospective study of positive psychological well-being and coronary heart disease.

Objective: Research suggests that positive psychological well-being is associated with cardiovascular health. However, much of this research uses elderly samples and has not determined the pathways by which psychological well-being influences cardiovascular disease or whether effects are similar for men and women. This study investigates the association between two aspects of well-being (emotional vitality and optimism) and coronary heart disease (CHD) in a sample of middle-aged men and women, and considers potential mediating factors. Method: Between 1991 and 1994, well-being and coronary risk factors were assessed among 7,942 individuals without a prior cardiovascular event from the Whitehall II cohort. Incident CHD (fatal CHD, first nonfatal myocardial infarction, or first definite angina) was tracked during 5 person-years of follow-up. Results: Positive psychological well-being was associated with reduced risk of CHD with an apparent threshold effect. Relative to people with the lowest levels of well-being, those with the highest levels had minimally adjusted hazard ratios of 0.74, 95% confidence interval [0.55, 0.98] for emotional vitality and 0.73, 95% confidence interval [0.54, 0.99] for optimism. Moreover, the association was strong for both genders and was only weakly attenuated when accounting for ill-being. Neither health-related behaviors nor biological factors explained these associations. Conclusions: Positive psychological well-being was associated with a modest, but consistent reduced risk of incident CHD. The relationship was comparable for men and women, and was maintained after controlling for cardiovascular risk factors and ill-being. Additional research is needed to identify underlying mechanisms and investigate whether interventions to increase well-being may enhance cardiovascular health. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Some research issues and findings in the study of psychological well-being in the aged.

This review of the 1956–1977 literature concerning psychological well-being in the aged is limited to multidimensional approaches to the construct. The major research issues include the diverse conceptualizations of well-being by various experimenters, the differences in the experimental procedures employed by such investigators, and the relationship between well-being and a host of related variables such as activity level, personality, and health. It is concluded that a narrow conceptualization of well-being in terms of "current happiness" and the use of longitudinal as opposed to cross-sectional studies would lead to a better understanding of the relationship between well-being and other variables affecting the well-being of the aged. (58 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mind machines: a controlled study on the effects of electromagnetic and optic-acoustic stimulation on general well-being, electrodermal activity, and exceptional psychological experiences

Structural brain repair has become a possibility with the identification and characterization of persistent neuronal progenitor cells in both the neonatal and adult brain. However, despite recent advances in the identification, propagation and expansion of these cells, they will not be useful therapeutically until methods are available for directing or delivering them to sites of need. As a result, the natural history and induction of neuronal migration into adult brain tissue has assumed new importance in clinical neurobiology. In this review we consider the cellular and molecular bases of neuronal migration into the postnatal forebrain. In particular, we discuss two natural paradigms of postnatal neuronal recruitment: radial-cell-directed neuronal migration to the songbird neostriatum, and neurophilic migration to the rodent olfactory bulb. In each, we will focus on the dynamic interactions between the migrants, their cellular guides and the local environment, and the effect of those interactions on migrational success.     

A longitudinal study of the relations between parent-adolescent conflict and adolescent psychological well-being

The enzyme glutaryl-7-ACA acylase from Pseudomonas sp. NCIMB 40474, produced by a recombinant Escherichia coli host, was purified to homogeneity. The enzyme is a tetramer composed of two couples of asymmetric dimers, each of them constituted of two subunits of mol wt 18 and 52 kDa, respectively. It was found that glutaric acid, one of the products of the substrate hydrolysis, is an effective acylase inhibitor. Between pH 6.0 and pH 10.0, the enzymatic activity is almost constant, but below pH 6.0 it progressively declines. The acylase activity decreased sharply as a function of guanidine HCl concentration. The loss is significant even at concentrations of denaturant lower than those causing unfolding, as suggested by UV spectroscopy and fluorescence emission studies. In these conditions (low denaturant concentration and low pH) the inactivation of the enzyme is caused by the tetramer dissociation into dimers. The lability of the quaternary structure of the enzyme is a key feature that must be taken into account for the improvement of the catalyst stability.     

Effects of customer entitlement on service workers' physical and psychological well-being: A study of waitstaff employees.

This exploratory study examines the nature of customer entitlement and its impact on front-line service employees. In an open-ended qualitative inquiry, 56 individuals with waitstaff experience described the types of behaviors entitled customers engage in and the kinds of service-related “perks” these individuals feel deserving of. Participants explained how they responded to entitled customers, how and when managers became involved, and how their dealings with these patrons influenced their subjective physical and psychological well-being. We found that the behaviors of entitled customers negatively impacted waitstaff employees. Participants reported physiological arousal, negative affect, burnout, and feelings of dehumanization as a result of dealing with these patrons. While respondents drew on a variety of strategies to manage their encounters with entitled customers, they indicated workplace support was often informal and described feeling abandoned by management in dealing with this workplace stressor. Approaching customer entitlement as a form of microaggression, we offer recommendations for practice and suggest new directions for future research. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Impact of employment-related experiences on immigrants' psychological well-being and adaptation to Canada.

Examined the process of acculturation with a specific emphasis on the impact of economic integration on psychological well-being and adaptation. 110 Turkish immigrants (aged 20–70 yrs) living in Montreal were surveyed through questionnaires. Despite high educational attainments, two-thirds of the sample were either unemployed or underemployed. Inability to fully integrate into the labor force in the 1st 6 mo in Canada was attributed mainly to lack of competence in both official languages, difficulty in getting credentials and accreditations recognized in Canada, and lack of Canadian work experience. In time, these barriers were overcome. In their place, market conditions (e.g., economic recession) delayed full participation in the work force. The model developed and tested through LISREL 8 demonstrated that adversity experienced in employment life, such as status loss, unemployment, and underemployment, had a negative impact on both psychological well-being and adaptation to Canada. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Direct and moderating effects of community context on the psychological well-being of African American women.

The effects of community characteristics on well-being were examined among 709 African American women. Direct and moderating effects of neighborhood characteristics on distress were tested. Aggregate-level ratings of neighborhood cohesion and disorder were significantly related to distress, although the relation between cohesion and distress became nonsignificant when individual risk factors were statistically controlled. Aggregate-level neighborhood variables interacted significantly with individual risk and resource variables in the prediction of distress, consistent with trait-situation interaction theories (D. Magnusson & N. S. Endler, 1977). Community cohesion intensified the benefits of a positive life outlook. Community disorder intensified both the benefits of personal resources and the detrimental effects of personal risk factors. Results showed evidence of resilience among African American women. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Individual and common components of the social environment at work and psychological well-being.

Interpretations of correlational research on the social origins of psychological well-being are limited by the possibility of reciprocal influences between persons and their social situations and by respondent bias. These issues are addressed in a study of the relation between the social environment at work and mental health. Two components of a social environment were measured: a common social environment, the social climate shared by employees in the same work setting, and an individual social environment, the social space surrounding one individual in the setting. The study related (a) averaged co-workers' ratings and individuals' own ratings of the social environment to (b) individuals' self-reported psychological well-being. A group of 37 bank branches represented work environments, and nonmanagerial personnel in the branches served as participants. Results indicated that the quality of the social environment at work is related to the mental health of employees. More important, the relation was confirmed with an independent measure of the social environment. Aggregate co-worker ratings of the common social environment were significantly correlated with individual depression and anxiety. However, an individual's perceptions appeared to mediate the social environment's impact. As hypothesized, well-being was more closely tied to the proximal individual social environment than to the more distal common social environment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of social interaction and children's relative inputs on older women's psychological well-being.

Sampled 719 White females, ages 60–75 yrs; half of the Ss were widows and half were currently married, living with a spouse. For each marital-status group, half were childless and half had living children. Results reveal that contact with relatives, friends, and associates was more important for Ss' well-being than contact with children and that well-being was enhanced by quality of interaction. Perceived quality of child contact appeared to be influenced by Ss' perceptions of other social relationships. Weak support for equity theory explanations of relationship satisfaction was found. For Ss with children the amount of interaction appeared unimportant whereas for childless Ss the amount and quality of contact with others was positively related to well-being. (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Experimenter outcome-orientation and the results of the psychological experiment.

This review considers evidence bearing on the question of whether an E's orientation (expectations and wishes) toward the results of his research may partially determine those results. The evidence is drawn from everyday life, medicine, clinical psychology, survey research, and experimental behavioral research. (43 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of racial and sexual harassment on work and the psychological well-being of African American women.

Research on workplace harassment has typically examined either racial or sexual harassment, without studying both simultaneously. As a result, it remains unknown whether the co-occurrence of racial and sexual harassment or their interactive effects account for unique variance in work and psychological well-being. In this study, hierarchical linear regression analyses were used to explore the influence of racial and sexual harassment on these outcomes among 91 African American women involved in a sexual harassment employment lawsuit. Results indicated that both sexual and racial harassment contributed significantly to the women's occupational and psychological outcomes. Moreover, their interaction was statistically significant when predicting supervisor satisfaction and perceived organizational tolerance of harassment. Using a sample of African American women employed in an organizational setting where harassment was known to have occurred and examining sexual and racial harassment concomitantly makes this study unique. As such, it provides novel insights and an important contribution to an emerging body of research and underscores the importance of assessing multiple forms of harassment when examining organizational stressors, particularly among women of color. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

主干课程群“项目课程”改革的研究与实践

把典型的工作任务或工作项目作为课程的内容,在教师的指导下,学生自主完成由计划到实施的全过程,这样可以有效的完成综合职业知识的教学,同时还能够很好的培养学生的职业能力,这是现代职业教育的一个方向。文章针对包头钢铁职业技术学院的实际,选择了一个专业的主干课程群进行先行的探索,使教学团队建设、理实一体化教室建设、自编教材开发、教学方法和手段创新等一系列环节得以有效融合,创新了理论和实践教学的模式,提高了学生学习的积极性。     

The PEGASUS project--a prospective cohort study for the investigation of drug use in pregnancy. PEGASUS Study Group

Since the thalidomide disaster, it is well accepted that drugs can have adverse effects on the developing human being. Although numerous studies show that medication during pregnancy is wide-spread, there still is a serious lack of comprehensive and valid data concerning the risks of drug use during pregnancy. One objective of the PEGASUS project, a population-based cohort study focusing on Munich, is to prospectively record information on drug exposure during pregnancy, to evaluate these data with regard to teratogenic properties, and to contribute to the quality assurance of medical treatment in pregnancy. The results of PEGASUS confirm that drug utilization during pregnancy is rather common--84% of the women use at least one preparation. The most frequent groups are minerals (mainly magnesium), iodide, and iron preparations. Although randomized studies have shown that periconceptional folic acid supplementation considerably reduces the risk of neural tube defects, only very few women in the PEGASUS project recorded folic acid intake during the critical period and in sufficient dosage. Moreover, only 42% of the pregnant women apply iodide prophylaxis in the recommended dosage.     

Reproducibility of drug efficacy predictions by Holter monitoring in the electrophysiologic study versus electrocardiographic monitoring (ESVEM) trial. ESVEM Investigators

The effect of a newly developed free radical scavenger (OPC-15161) on the progression of nephrotoxic serum (NTS) nephritis was evaluated. NTS nephritis rats were sacrificed immediately before and 1, 2, 3, 6, and 24 h and 13 and 19 days after intravenous injection of NTS. The tissue content of phosphatidylcholine hydroperoxide, the activity of superoxide, the activity of superoxide dismutase in the renal cortex, and the serum malondialdehyde levels were measured. The phosphatidylcholine hydroperoxide content in the renal cortex of OPC-15161-treated NTS nephritis rats was lower than that in the control rats 24 h after NTS injection. The activity of superoxide dismutase in OPC-15161-treated rats was sustained in contrast to the decrease in this activity in the control rats 6 h after injection of NTS. The effects of OPC-15161, dipyridamole, and prednisolone on NTS nephritis rats were investigated. OPC-15161 (20 mg/kg p.o.) showed a potent inhibitory effect on the urinary protein excretion, whereas dipyridamole (30 and 100 mg/kg p.o.) and prednisolone (2 mg/kg p.o.) had less suppressive effects. In view of these results, we conclude that OPC-15161 notably ameliorated the urinary protein excretion by way of the suppression of lipid peroxidation in the renal tissue of NTS nephritis rats.     

Colchicine versus prednisone in the treatment of idiopathic pulmonary fibrosis. A randomized prospective study. Members of the Lung Study Group

Calcium (Ca) stimulates proliferation of osteoblasts in vitro, an effect proposed to be mediated by IGF I. Addition of 1 mM Ca or of 1 nM IGF I to the medium (0.3 mM Ca) of a rat bone-derived cell line, PyMS, stimulated not only DNA synthesis but also sodium-dependent (Nad) phosphate (Pi) uptake, the latter, within 2 h. These cells barely express and produce IGF I. IGF binding protein-3 which inhibits IGF action decreased neither basal nor Ca-stimulated but IGF I-stimulated NadPi transport and DNA synthesis, indicating that Ca stimulated NadPi transport and DNA synthesis independently of IGF I. The effects of Ca and IGF I on DNA synthesis were additive. 1 microM nifedipine blocked IGF I- and Ca-stimulated DNA synthesis but not NadPi transport, suggesting that Ca influx is not mediating the NadPi transport-enhancing IGF I signal but is required for IGF I-induced osteoblast proliferation.     

Happiness is everything, or is it? Explorations on the meaning of psychological well-being.

Reigning measures of psychological well-being have little theoretical grounding, despite an extensive literature on the contours of positive functioning. Aspects of well-being derived from this literature (i.e., self-acceptance, positive relations with others, autonomy, environmental mastery, purpose in life, and personal growth) were operationalized. Three hundred and twenty-one men and women, divided among young, middle-aged, and older adults, rated themselves on these measures along with six instruments prominent in earlier studies (i.e., affect balance, life satisfaction, self-esteem, morale, locus of control, depression). Results revealed that positive relations with others, autonomy, purpose in life, and personal growth were not strongly tied to prior assessment indexes, thereby supporting the claim that key aspects of positive functioning have not been represented in the empirical arena. Furthermore, age profiles revealed a more differentiated pattern of well-being than is evident in prior research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Racial identity, academic achievement, and the psychological well-being of economically disadvantaged adolescents.

The relation between racial identity and personal psychological functioning was examined within the framework of the "racelessness" construct proposed by Fordham and Ogbu (S. Fordham, 1988; S. Fordham & J. U. Ogbu, 1986). These researchers have proposed that academically successful African American students achieve their success by adopting behaviors and attitudes that distance them from their culture of origin, resulting in increased feelings of depression, anxiety, and identity confusion. Studies 1 and 2 describe the development of the Racelessness Scale (RS) designed to test these assumptions. Study 2 also investigated Race?×?Achievement level differences in students' responses to the RS. In Study 3, correlations between the RS and measures of depression, self-efficacy, anxiety, alienation, and collective self-esteem were assessed. The pattern of results in Study 2 suggest that the behaviors and attitudes described by Fordham and Ogbu are common to high-achieving adolescents and not specific to African Americans. However, racial differences in the pattern of associations between the RS and measures of depression suggest that racelessness may have important psychological consequences for African American adolescents. (PsycINFO Database Record (c) 2010 APA, all rights reserved)