The EphB6 Receptor: Kinase-Dead but Very Much Alive

The Eph receptor tyrosine kinase member EphB6 is a pseudokinase, and similar to other pseudoenzymes has not attracted an equivalent amount of interest as its enzymatically-active counterparts. However, a greater appreciation for the role pseudoenzymes perform in expanding the repertoire of signals generated by signal transduction systems has fostered more interest in the field. EphB6 acts as a molecular switch that is capable of modulating the signal transduction output of Eph receptor clusters. Although the biological effects of EphB6 activity are well defined, the molecular mechanisms of EphB6 function remain enigmatic. In this review, we use a comparative approach to postulate how EphB6 acts as a scaffold to recruit adaptor proteins to an Eph receptor cluster and how this function is regulated. We suggest that the evolutionary repurposing of EphB6 into a kinase-independent molecular switch in mammals has involved repurposing the kinase activation loop into an SH3 domain-binding site. In addition, we suggest that EphB6 employs the same SAM domain linker and juxtamembrane domain allosteric regulatory mechanisms that are used in kinase-positive Eph receptors to regulate its scaffold function. As a result, although kinase-dead, EphB6 remains a strategically active component of Eph receptor signaling.     

引入更多的膜分离装置推动氯碱工业技术进步

介绍了采用纳滤膜去除盐水中SO42-,采用超滤和反渗透相结合处理废水并回用,采用在活性污泥处理中引入超滤提高处理后废水的质量等。建议引入更多的膜分离装置以推动氯碱工业的发展。     

Nickel and Lanthanum Hydroxide Nanocomposites with Much Improved Electrochemical Performance for Supercapacitors

By developing a facile low temperature hydrothermal process, we demonstrate the direct growth of nickel and lanthanum hydroxide nanocomposites on Ni‐foam substrate. The hydroxide nanocomposites thus derived show much enhanced overall electrochemical capacitance and improved stability of the alpha nickel hydroxide phase in alkaline solution. By adjusting the initial molar ratio between nickel and lanthanum nitrates from 1:0 to 1:2, the electrochemical behavior, such as specific capacitance, shows a dramatic change, while the nickel hydroxide phase evolves from beta nickel hydroxides (1:0) to alpha nickel hydroxide (1:2). Lanthanum hydroxide is not expected to contribute to the pseudocapacitance as it only shows a capacitance of <10 F/g. The specific capacitance is increased from 970 F/g (Ni:La = 1:0) to 1874 F/g (Ni: La = 1:2) at the discharging current of 1 A/g. At high discharging currents (e.g. 10 A/g), the Ni:La = 1:2 sample can retain a capacitance of 1055 F/g. An excellent cycling performance is demonstrated for the Ni:La = 1:2 nanocomposite sample upon 2000 cycles at the discharging current density of 2 A/g, where the stability of alpha nickel hydroxide in the alkaline solution is improved. The low temperature hydrothermal method compares favorably to other previously documented preparation processes, such as chemical coprecipitation and electrochemical deposition, for lanthanum‐doped nickel hydroxides, where the specific capacitance is typically less than 1000 F/g (1 A/g).     

DVD光盘规格太多光驱市场难成气候

对于数据保来说,目前普通CD-R光盘的容量是650MB或者700MB,而擦写型DVD光盘则为4.7GB。但是,写入型DVD光驱却并没有象当初预想的那样得以普及。写入型DVD光驱之所以普及缓慢的一个重要原因是由于写入型DVD光盘有多种规格,因此用户不知道应该选择支持哪种规格的光驱。     

多汽源高温差分汽缸泄漏原因分析

从某厂一分汽缸破裂泄漏情况入手,对裂纹原因进行分析研究,其原因由于两个汽源温差太大,受到压力波动影响,内部介质剧烈运动,筒体内部材料受到很大的温度应力,为典型的热疲劳破坏。     

Two Catalytic Technologies of Much Influence on Progress in Chemical Process Development in Japan

A tremendous number of new catalytic chemical processes have been established and commercialized in Japan in recent years [l, 21. Table 1 shows typical Japanese-made technologies and processes from 1957, about which time the petrochemical industry started in Japan. In those days almost all processes adopted were either fully licensed from foreign companies in Western Europe and the U.S. or completed in Japan as a practical technology using basic and original ones discovered by the foreign companies. In 18 years, from 1957 to 1974, when the Japanese petrochemical industry matured and rapidly magnified its scale, 22 new technologies and processes were accomplished in Japan; however, some of them are not intrinsically Japanese for the reason already mentioned—they derived from foreign companies—and some others were only the first in Japan but not the first in the world. The next 17 years (1975-1992), which included two oil embargoes and were regarded as the time the industry entered the age of a low growth rate present striking contrasts, however, in that a considerable number, 29, of new technologies adopted in this period were Japanese originals. They were not only the first in Japan but also the first in the world.     

先天性多发性肺囊肿的CT诊断与鉴别诊断

目的了解先天性多发性肺囊肿在CT表现上的特征。方法 100例经病理证实的多发性肺囊肿。男64例,女36例,年龄4～60岁,平均年龄32岁。行CT平扫、增强及高分辨扫描,造影剂总量80mL。结果左肺58例,右肺30例,双肺12例。形态均为多发环形透光区,均可见含气的、含液的及含气液的囊肿。结论多发性肺囊肿的CT表现有其特征性,应作为常规检查。     

MTP装置精制系统带水问题的解决方案

MTP装置精制系统带水严重,导致丙烯产品含水含量过高而致使产品不合格,同时还导致精制系统深冷管线发生冻堵现象,原因为进精制系统进料液烃中含水量过高。通过液烃干燥器前增加聚结器、压缩机四段分离罐增加脱水罐的改造措施,显著降低了精制系统进料液烃中的含水量,保证了后续系统的稳定运行。     

综合利用粉煤灰生产墙体材料值得重视的问题

1　引言利用粉煤灰作为原料生产墙体材料 ,在国内已有几十年历史和经验 ,先后用其研制和生产了泡沫混凝土制品、蒸养粉煤灰中型密实砌块、粉煤灰小型空心砌块、蒸养蒸压粉煤灰砖、蒸养蒸压加气混凝土制品、粉煤灰烧结陶粒等。为了处理工业固体废物粉煤灰 ,保护环境 ,早在5 0年代中后期 ,国内就开展了大量利用粉煤灰的研究 ,首先生产了粉煤灰泡沫混凝土。六十年代初 ,粉煤灰中型密实砌块普遍用在上海市公共住宅建筑 ,在上海城市建设中发挥了重大作用。后因块型大、太重、施工麻烦而逐渐改产、停产。在蒸压灰砂砖在我国开发成功、普遍推广的基…     

Developing Soil Microbial Inoculants for Pest Management: Can One Have Too Much of a Good Thing?

Soil microbes present a novel and cost-effective method of increasing plant resistance to insect pests and thus create a sustainable opportunity to reduce current pesticide application. However, the use of microbes in integrated pest management programs is still in its infancy. This can be attributed primarily to the variations in microbial inoculum performance under laboratory and field conditions. Soil inoculants containing single, indigenous microbial species have shown promising results in increasing chemical defenses of plants against foliar feeding insects. Conversely, commercial inoculants containing multiple species tend to show no effects on herbivore infestation in the field. We present here a simple model that endeavours to explain how single and multiple species in microbial inoculants differentially govern insect population dynamics via changes in plant chemical profiles. We discuss further how this knowledge can be applied to manipulate soil microbial species and develop ‘tailored’ microbial inoculants that could be used in plant protection against antagonists.     

From “Strong” to “Much Stronger”: Utilization of Green Tea Extract Dispersant for SWCNT‐Reinforced Polymer Composites

PVA is reinforced with SWCNTs using green tea extract as a dispersant to achieve good dispersion of the SWCNTs in an organic solvent and finally high‐performance composite fibers. A combination of green tea extract/DMSO/SWCNT/PVA is found to disperse larger aggregates of SWCNTs to individual or thin bundles of a few nanotubes. Incorporation of 0.5 wt% SWCNTs into PVA fibers yields a tensile strength of 2.42 GPa, a Young's modulus of 46 GPa, toughness of 105 J · g^?1 at a failure strain of 11%, and a loop strength of 245 MPa, much higher than the values of commercial PVA fibers. The incorporation of highly dispersed SWCNTs suppresses the fibrillation tendency of the PVA fibers. The applied load is effectively transferred from the matrix to the SWCNTs.