Three-year clinical evaluation of the Clearfil Liner Bond system

Modern dental adhesive systems have improved the bond of restorative materials to mineralized tooth structures. The purpose of this study was to evaluate the clinical performance of composite restorations placed in abrasion and erosion lesions using the Clearfil Liner Bond dental adhesive system. Following ADA clinical guidelines for dentin and enamel adhesive materials, 62 facial class 5 smooth surface erosion or abrasion lesions with no undercuts and involving primarily root surfaces were restored in 25 adult male and female patients. The teeth were restored without preparations using Clearfil Liner Bond and Clearfil Photo Anterior composite resin. The clinical performance of the restorations was assessed by two examiners at baseline, 6 months, 1, 2, and 3 years using the following evaluative parameters: color match, marginal discoloration, and marginal integrity according to modified Ryge criteria; the presence or absence of recurrent decay; pre- and postoperative sensitivity; and restoration failure due to loss of retention or other causes. At the end of 3 years, four of the 55 restorations remaining in the study failed due to lack of retention (92.7% retention rate). The evaluations of the other clinical parameters demonstrated excellent performance by this system.     

The role of adhesion molecules in the immunopathogenesis of atherosclerosis

Advances in the studies on the structure and role of adhesive particles make possible putting forward of the hypothesis that they may also play a significant role in the immunopathogenesis of atherosclerosis. It was demonstrated that in the earliest phase of atherosclerosis development, increased adhesion occurred of monocytes to the vascular endothelium, while autopsy examinations showed the presence of monocytes and T-cells within atherosclerotic lesions. The present studies concentrate on the role of individual adhesive particles as determinants of the above phenomena.     

Splenic irradiation for hairy cell leukaemia

In vitro studies show that the adhesive amalgam technique is superior to the nonadhesive technique. Also, early clinical results indicate that the adhesive technique can eliminate the microspace between amalgam and tooth. And, it can retain amalgam on unprepared occlusal surfaces of molars and premolars, sealing the fissures. Moreover, amalgam can be retained in preparations without undercuts. Early results indicate in traditional preparations, the adhesive technique appears to be at least equivalent to nonadhesive technique.     

A method for testing denture adhesives

An in vitro test is described that simulates the in vivo fate of a denture adhesive, namely destruction, dilution, and dissolution of the adhesive, by repeated measurement of tensile bond strength for the adhesive in isotonic saline over time. The bond strengths were measured under two different settings of the testing machine. The main compositions of three denture adhesive pastes, Fittydent, Fixodent, and Super Poli-Grip and one powder adhesive, Super Wernet's, were determined by infrared spectroscopy. The tensile bond strengths of these adhesives and those of pure tragacanth gum were subjected to a three-way analysis of variance. The Fittydent and Super Poli-Grip adhesives exhibited the best results over time. The most appropriate of the described methods for testing denture adhesives seem useful; however, when seen in relation to the results of a published clinical study where the patients were asked to evaluate the retention and the duration of some of these adhesives, there are indications that the clinical validity of the method might be improved if paste adhesives are tested at temperatures above 35 degrees C.     

Tactile extinction following unilateral lesions in the rat anteromedial cortex: Effects of a contralateral cue.

Following unilateral lesions of the anteromedial cortex (AMC) or the caudal forelimb representation (CFL), rats prefer to remove an adhesive patch placed on the forelimb ipsilateral to the lesion before removing a simultaneously applied contralateral patch (i.e., ipsilateral asymmetry). The present experiment was designed to investigate the possibility that attention has some role in these asymmetries. Specifically, the researchers investigated whether a contralateral tactile cue presented before the simultaneous presentation of bilateral tactile stimuli would neutralize the ipsilateral asymmetry. In 14 male rats with AMC lesions, the contralateral cue neutralized the ipsilateral bias, whereas the cue had no effect on 6 male rats with CFL lesions. These data suggest that the ipsilateral bias observed in AMC-damaged rats may reflect an impairment in attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adhesive systems for tooth-colored restorations. A review

The quality, longevity and the esthetic appearance of tooth-colored restorations are primarily dependent upon the integrity of the bond of the restoration with the enamel and dentin. Consequently, the enamel and dentin adhesives which are increasingly combined in the so-called adhesive systems play key roles in restorative dentistry. This paper describes the components, the clinical technique, the importance of the systems and the relevant adhesive mechanisms.     

Saint's triade presenting as volvulus of the gallbladder

Saint's triade of hiatus hernia, colonic diverticula, and cholelithiasis presenting with volvulus of the gallbladder is a unique occurrence. Possible etiology of volvulus of the gallbladder involves kyphosis, viceroptosis, cholelithiasis, and in this case adhesive bands. Laparoscopic decompression of the gallbladder, division of the adhesive bands, detorsion of the volvulus, and finally laparoscopic cholecystectomy successfully resolved this uncommon clinical problem. We describe a case and review the literature.     

Tooth fragment reattachment: an alternative for restoration of fractured anterior teeth

The development of advanced adhesive systems has made it possible to bond various substrates, e.g., composite resin and vital or nonvital tooth structures. The management of coronal and coronoradicular fractures in the maxillary region with these adhesive materials is easier, safer, and more efficacious than the use of traditional treatment alternatives that involve the use of posts and cores and/or other mechanical devices to obtain retention. Ability to bond the dislocated segment of the fractured tooth constitutes a significant step forward in the management of this clinical condition.     

Adhesive crowns and fixed partial dentures fabricated of ceromer/FRC: clinical and laboratory procedures

Ceramic optimized polymer and fiber-reinforced composite materials represent a significant development in prosthetic dentistry. When utilized in conjunction with adhesive luting techniques, exceptionally conservative crown and bridge restorations may be achieved. This article discusses utilization of these materials in inlay and onlay restorations, as well as clinical and laboratory procedures for fabrication, preparation, and seating of adhesive crown and bridge restorations. The initial results of restorations utilizing these innovative materials are presented.     

Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats

A clinical trial was undertaken to assess the value of incorporating fluoride released from a commercially available bonding adhesive (Rely-a-Bond) to determine the extent of any protection provided against enamel decalcification. Fifty patients undergoing fixed appliance therapy were included in the trial. Contralateral quadrants were used as controls where no fluoride was present in the adhesive. Enamel decalcification after treatment and bond failure rates during treatment were investigated. A total of 366 experimental and 371 control teeth were included in the study. The results showed that 50 per cent of patients and 13.5 per cent of teeth exhibited post-treatment decalcification. The addition of fluoride to the adhesive did not significantly reduce the incidence of enamel decalcification. Bond failure rates were satisfactory for both experimental and control teeth (all under 5 per cent).     

Maximizing aesthetics of debilitated maxillary central incisors: a clinical case

With the advent of true "adhesive dentistry," practitioners have at their disposal new multi-purpose adhesive agents which bond to most dental substrates. These new adhesives have a high affinity for roughened or "microetched" surfaces, penetrating and wetting the surfaces to increase the bonding strength. The improved adhesion has altered treatment plans from previous years and has enabled clinicians to practice more constructive dentistry and replace only defective or missing tooth structure. The objective of this article is to present a case report to illustrate the utilization of one of the new bonding agents in an especially difficult clinical situation.     

Marginal integrity and postoperative sensitivity in Class 2 resin composite restorations in vivo

INTRODUCTION: Problems that may arise in resin composite Class 2 restorations include microleakage and postoperative sensitivity. However, limited in-vivo research is conducted to evaluate these processes. AIM: The aim of this study was to assess postoperative sensitivity, microleakage and the pooling of adhesives in relation to Class 2 box-type composite restorations placed in vivo using various adhesive systems and application techniques. MATERIALS AND METHODS: One hundred and forty-four Class 2 box restorations were placed in the mesial and distal surfaces of 72 premolar teeth in-vivo using one of three combinations of adhesive systems and three filling techniques. After 6 weeks of clinical service postoperative sensitivity was recorded. The teeth were then extracted, immersed in a dye solution and sectioned. Microleakage and pooling of the adhesive was recorded. Statistical analysis involved logistic regression and chi2 tests to identify differences between groups at p < 0.05. RESULTS: Of the 144 restorations, 65 showed minimal cervical leakage in enamel, 5 suffered leakage into dentin and 74 were free of microleakage. No statistically significant differences were found in cervical microleakage between the adhesive systems or between filling procedures. Occlusal microleakage in the enamel was present in 16 of the 160 restorations. Liner Bond 2 restorations leaked significantly more at the occlusal surface (p < 0.05). Pooling of the adhesive was significantly less when PhotoBond was used. No spontaneous postoperative sensitivity was reported. Twenty-eight restorations were sensitive to loading. Postoperative sensitivity was significantly less in patients with Liner Bond 2 restorations. CONCLUSIONS: The adhesive systems used in this study showed minimal leakage into dentin in vivo. Using Liner Bond 2, restorations exhibited more occlusal leakage but were significantly less sensitive to loading.     

Adhesive luting cements--classes, criteria, and usage

Clinical studies have shown that recurrent decay and lack of retention are the major causes of traditional crown and bridge failure. Optimal marginal accuracy and preparation retention form are important pre-requisites for longevity, as well as good patient oral hygiene. In an effort to provide improved clinical success, new classes of luting agents with improved physical properties and new therapeutic capabilities have been developed. Conventional glass ionomer cements provide fluoride release and adhesive properties. Recently introduced resin-modified glass ionomer luting materials add the potential for increased resistance to dissolution and improved physical and biological attributes. The resin luting cements are more difficult to use but provide greatly increased bonding capabilities and are necessary for strength requirements of all-ceramic restorations. This article describes the three classes of adhesive luting materials, provides a comparison of biological and physical properties, describes the indications and limitations of each class, and makes recommendations for clinical usage.     

Clinical-morphological aspects of the adhesive disease progress in children]

The results of treatment of 60 children with complete adhesive ileus (CAI), occurring from 6 mo till 10 yrs after appendectomy conduction, were analyzed. Complex biochemical and immunological examination was conducted in 30 patients. There were 10 biopsies of parietal peritoneum examined. The obtained clinical, biochemical, immunological and morphological features may be applied for reliable prognostication of the CAI occurrence, complications course and outcome. Long observation and rehabilitational measures conduction is indicated in the patients with high risk of the peritoneal adhesive disease occurrence.     

Expression of types I, II, and III TGF-beta receptors in human glomerulonephritis

Protein and mRNA expression of transforming growth factor-beta (TGF-beta) receptor type I (TbetaRI), type II (TbetaRII), and type III (TbetaRIII) were studied in serial sections of kidney samples obtained from patients with glomerulonephritis. In minimal change disease, weak expression of TbetaRI and TbetaRII was observed mainly in glomerular endothelial cells, peritubular capillaries, and interstitial arteriolar endothelial cells, whereas TbetaRIII expression was found mainly in the interstitium. Expression of all three TGF-beta receptors (TbetaR) was increased remarkably in glomerular and Bowman's capsular cells comprising the tuft adhesions to Bowman's capsules in glomerulonephritis with increased matrix accumulation, including IgA nephropathy, lupus nephritis, focal and segmental glomerulosclerosis, myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis, and membranoproliferative glomerulonephritis. Increased expression of the three TbetaR was also seen in glomerular epithelial cells in the vicinity of glomerulosclerotic lesions, in crescent cells, and in some tubules and infiltrative mononuclear cells found in the periglomerular and tubulointerstitial lesions with increased matrix deposition. In contrast, no remarkable TbetaRII expression was noted in mesangial proliferative lesions in IgA nephropathy, lupus nephritis, and membranoproliferative glomerulonephritis. These data suggest that distinctive modulation of TbetaR expression may be involved in the development of adhesive, sclerotic, and proliferative renal lesions in human glomerulonephritis.     

Macrophage apoptosis in muscle tissue in experimental autoimmune myasthenia gravis

BACKGROUND: In adhesive small bowel obstruction, the early recognition of complications such as strangulation or volvulus is essential to choose between surgical or conservative initial treatment. The objective of this study was to determine prospectively the contribution of computed tomography (CT) to decision making in the management of these patients. METHODS: Patients with suspected adhesive small bowel obstruction had CT at admission. Patients with CT signs of volvulus or strangulation and/or clinical signs of peritoneal irritation underwent urgent surgery; other patients had conservative initial treatment. RESULTS: Fifty-four patients were evaluated. CT demonstrated signs of strangulation or volvulus in 19 patients, including three with signs of peritoneal irritation. Within this group, urgent laparotomy was performed in 17 patients and confirmed the CT diagnosis in 16. Thirty-seven patients without clinical or CT signs of complications had initial conservative treatment; among them, seven of 12 with a distal obstruction determined by CT required a delayed operation for persisting obstruction, compared with two of 25 patients with a proximal obstruction (P < 0.01). CONCLUSION: CT is useful for the evaluation of adhesive small bowel obstruction, to detect accurately patients with complications who require urgent operation and to determine the location of the adhesion, which represents a significant prognostic factor for success of conservative treatment.     

Endoesthetics. Rehabilitation of the endodontically treated tooth

This article discusses the restoration of the endodontically-treated tooth as it relates to infrastructure and superstructure. Like any structure, it is only as sound as the base upon which it rests. The combination of endodontics and sophisticated developments in adhesive dentistry are considered in the attainment of predictable clinical success.     

Posterior composite resin restorations: operative innovations

The adhesive revolution is alleviating reservations regarding posterior composite resin restorations, established by past experience with outdated materials and techniques. Improved materials, instrumentation, and placement techniques have enhanced the performance of current formulations of posterior composite resins over their predecessors. However, it is a clinician's operative skill that ultimately determines the quality of a restorative option. The learning objective of this article is to share the author's experience in attaining adhesive excellence with posterior tooth-colored restorations as well as aesthetic anatomic form, minimal postoperative sensitivity, and a bond which can weather the true test of success-durability. Optimal applications, dental dam requirement, importance of the first increment of composite resin, restitution of occlusal morphology, and the clinical application are discussed.     

Acquired Glanzmann's thrombasthenia associated with Hodgkin's lymphoma: a case report and review of the literature

BACKGROUND: Acquired Glanzmann's thrombasthenia is a rare hemorrhagic diathesis resulting from impaired adhesive function of the platelet receptor GPIIb/IIIa (alpha(IIb)beta3). Typically, this disorder develops during adulthood, with patients manifesting fluctuating clinical and laboratory findings. To date, the underlying defect of most if not all cases of acquired Glanzmann's thrombasthenia results from an autoantibody or plasma protein inhibitor directed toward a demonstrably normal GPIIb/IIIa glycoprotein. METHODS: In this report, a patient with a history of treated Hodgkin's lymphoma presented with a severe hemorrhagic diathesis characterized by mild thrombocytopenia, a prolonged bleeding time, and defective platelet aggregation. RESULTS: Examination of the patient's platelet GPIIb/IIIa by Western blot analysis revealed no abnormality. Mixing studies demonstrated a non-immunoglobulin G plasma inhibitory factor, whereas flow cytometry analysis revealed elevated platelet-associated immunoglobulin (Ig) M. After an emergency colectomy for severe hemorrhage, the patient's qualitative and quantitative platelet parameters significantly improved. Pathology of the resected colonic segment demonstrated atypical lymphoid hyperplastic lesions. CONCLUSIONS: To the authors' knowledge, this is the first reported case of acquired Glanzmann's thrombasthenia associated with a putative IgM autoantibody. Furthermore, this report verifies the association of acquired thrombasthenia with lymphoproliferative disease. Although rare, awareness of this hemorrhagic diathesis as a possible sequelae of active or treated lymphoid disorders should encourage clinical vigilance of these patients.