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阳光中的紫外线能杀死或抑制皮肤表面的细菌,促进皮肤中的脱氢胆固醇转化为维生素D,还能增强人体的抗病能力,促进人体的新陈代谢,对人体的生长发育有重要作用。另一方面,紫外线对人体皮肤和头发有伤害作用。紫外辐射(UV)能引起皮肤灼伤和红斑,促使皮肤过早老化,引起角膜及,压缩机内氟里昂(CFC)的泄漏量也在不断增加,从而使臭氧层产生的空洞加剧,地面受到紫外辐射的强度有增高的趋势。因此对紫外线、防晒剂及其制品的研究也得到了众多学者的关注。1紫外线及其对人体的影响1.1紫外线阳光由电磁波谱的许多波长组成。当阳光穿透地球大气层,其… 相似文献
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重金属是环境中一类很难降解的无机污染物,并且具有较强的生物富集性,可以通过各种途径进入人体内并在体内长期积累,最终对人体健康造成危害。主要对人体头发中重金属的正常参考值进行总结,对不同地区、不同居民头发中重金属的含量值进行系统阐述,分析其原因及影响因素,并就存在的问题和发展趋势进行了总结。 相似文献
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纳米氧化锌在防晒剂中的广泛应用,使得其安全性成为近年来研究的热点.总结了防晒剂中纳米氧化锌人体暴露的主要途径及人体吸收的情况,分析了纳米氧化锌的细胞毒性、基因毒性及光毒性,认为防晒剂中的纳米氧化锌不经正常皮肤吸收,对人体安全性无明确的影响,不失为一种高效、安全的防晒剂.但应进一步研究纳米氧化锌在受损皮肤吸收的情况以及经... 相似文献
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目前检测皮质醇主要的方法是通过检测血液、唾液以及尿液中的皮质醇浓度,但这只能反映人体的应激压力,而头发皮质醇含量则可以反映人体慢性压力。建立了一种定量检测头发皮质醇含量的方法,比较了一步法与四步法测定头发皮质醇含量的差异,探讨了磷酸盐缓冲液(PBS)体积、样品放置时间等因素对测定结果的影响。结果表明,四步法比一步法更加有利于充分提取出头发中的皮质醇;溶解5 mg头发皮质醇的最佳PBS体积为170μL;皮质醇溶液放置7 d后,会随时间的延长而降解,对最终检测结果造成影响。使用该方法对20例头发样本中的皮质醇含量进行了测定,结果表明儿童中女生头发皮质醇含量比男生高,成人中男性头发皮质醇含量比女性高。 相似文献
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Time-Course Expression Profiles of Hair Cycle-Associated Genes in Male Mini Rats after Depilation of Telogen-Phase Hairs 总被引:1,自引:0,他引:1
Aya Umeda-Ikawa Isao Shimokawa Kunio Doi 《International journal of molecular sciences》2009,10(5):1967-1977
Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a growth hormone (GH)-deficient transgenic rat. The hair cycle in the dorsal skin of male Mini rats enters a long-lasting telogen phase after eights weeks of age, but depilation can induce a transient hair cycle again. In this study, a time-course profiling of genes expression was done on the dorsal skin of male Mini rats along the progression of depilation-induced hair cycle using DNA microarray analysis. As a result, 1,215 probe sets including 1,171 hair cycle-related ones showed more than 3-fold changes in expression compared with that in before-depilation telogen phase. The present data will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents. 相似文献
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To simulate temperature rise of human skin and to predict burn injury during radiant heat exposure, the traditional method is to use a sensor to simulate skin surface and use a numerical model to simulate heat transfer in inner skin. However, the numerical models of skin burns are based on few experimental data of nude skin and some simplifications of human skin characteristics. In this study, a new multi‐layered skin simulant is presented for low radiant heat exposures up to 15 kW/m2. The skin simulant has implanted thermocouples into layered polydimethylsiloxane (PDMS) materials with controlled thermal properties and thicknesses of the skin layers. The multi‐layered skin simulant developed in this study has a good reproducibility for temperature measurements with similar temperature rise profiles compared with human skin except at skin surface. For burn injury prediction, the results of our PDMS skin model can be linearly corrected using ASTM model as a reference. Our developed skin simulant provides an advanced method to directly simulate the heat transfer inside human skin in a multi‐layered structure rather than using the combined physical sensor‐numerical model in the traditional way. 相似文献
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Gink N. Yang Parinaz Ahangar Xanthe L. Strudwick Zlatko Kopecki Allison J. Cowin 《International journal of molecular sciences》2021,22(15)
Epidermal progenitor cells divide symmetrically and asymmetrically to form stratified epidermis and hair follicles during late embryonic development. Flightless I (Flii), an actin remodelling protein, is implicated in Wnt/β-cat and integrin signalling pathways that govern cell division. This study investigated the effect of altering Flii on the divisional orientation of epidermal progenitor cells (EpSCs) in the basal layer during late murine embryonic development and early adolescence. The effect of altering Flii expression on asymmetric vs. symmetric division was assessed in vitro in adult human primary keratinocytes and in vivo at late embryonic development stages (E16, E17 and E19) as well as adolescence (P21 day-old) in mice with altered Flii expression (Flii knockdown: Flii+/−, wild type: WT, transgenic Flii overexpressing: FliiTg/Tg) using Western blot and immunohistochemistry. Flii+/− embryonic skin showed increased asymmetrical cell division of EpSCs with an increase in epidermal stratification and elevated talin, activated-Itgb1 and Par3 expression. FliiTg/Tg led to increased symmetrical cell division of EpSCs with increased cell proliferation rate, an elevated epidermal SOX9, Flap1 and β-cat expression, a thinner epidermis, but increased hair follicle number and depth. Flii promotes symmetric division of epidermal progenitor cells during murine embryonic development. 相似文献
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Yu Ri Woo Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim 《International journal of molecular sciences》2022,23(3)
Skin cancer is the most common type of cancer in the US with an increasing prevalence worldwide. While ultraviolet (UV) radiation is a well-known risk factor, there is emerging evidence that the microbiota may also contribute. In recent years, the human microbiota has become a topic of great interest, and its association with inflammatory skin diseases (i.e., atopic dermatitis, acne, rosacea) has been explored. Little is known of the role of microbiota in skin cancer, but with the recognized link between microbial dysbiosis and inflammation, and knowledge that microbiota modulates the effect of UV-induced immunosuppression, theories connecting the two have surfaced. In this paper, we provide a comprehensive review of the key literature on human microbiota, especially the skin microbiota, and skin cancer (i.e., non-melanoma skin cancer, melanoma, cutaneous T cell lymphoma). Also, mechanistic perspectives as to how our microbiota influence skin cancer development and treatment are offered. 相似文献
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Synthetic skin as an ideal human‐tissue substitute is needed for the research and assessment of hair‐ and skin‐care products. In this study, a systematic study was carried out of the surface, tribological, and mechanical properties of two synthetic skins and rat skin with and without skin‐cream treatment with scanning electron microscopy, atomic force microscopy, and a nanoindenter. The film thickness, adhesive force, coefficient of friction, surface roughness, and contact angle of the two synthetic skins and rat skin were comparable. The hardness of one synthetic skin was more similar to rat skin. After treatment with skin cream, the trends of the properties of the two synthetic skins and rat skin were similar. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 相似文献