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头孢克肟,即第三代口服头孢菌素类抗生素,其具有通过对细胞分裂时细胞壁合成进行抑制的杀菌作用。且由于具有能够稳定的对多数B-内酰胺酶产生作用,广谱抗菌并且具有较长的半衰期、疗效好、适应症广、用药剂量小的优点而在临床中广泛运用。通过对头孢克肟的合成工艺进行研究。 相似文献
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本文重点就头孢克肟的中间体合成工艺的改进和完善进行了研究,实践发现,此工艺较传统合成工艺不仅收效得到了有效提高,而且大大简化了工艺操作过程: 相似文献
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头孢克肟是第三代口服头孢菌素,是一种重要的抗生素原料药,该药品是“十五”推荐研究开发的重要的头孢菌素品种,并被列入国家级化学医药新产品指南。 相似文献
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以脂肪醛与丙二酸为原料,通过Knoevenagel反应制备了(E)-3-烷烯羧酸,反应以二甲苯为溶剂,在回流条件下进行。考察了哌啶、吡啶及4-二甲氨基吡啶(DMAP)对反应产物的影响。结果表明,采用哌啶催化时,反应产率最高,可达70%左右,(E)-3-烷烯羧酸与副产物α,β-不饱和羧酸的摩尔比可达12/1以上;DMAP作催化剂,产率较低,在60%左右,反应选择性略高于哌啶;吡啶作催化剂时产率最低,反应选择性也最差,(E)-3-烷烯羧酸与副产物α,β-不饱和羧酸的摩尔比只有3/1。 相似文献
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We report the synthesis of 7,10-dihydroxy-8(E)-octadecenoic acid (DOD), which has recently also been reported from bioconversion of oleic acid. One hydroxyl of 1,7-heptanediol
was protected as tetrahydropyranyl ether, and the other hydroxyl was used for chain extension by two carbonsvia Wittig reaction to give ethyl 9-tetrahydropyranyloxy-2(E)-nonenoate, an α,β-unsaturated ester, which on Dibal-H reduction offered allylic alcohol. The epoxidation at the double bond
followed by conversion of the hydroxyl group to chloro gave 9-tetrahydropyranyloxy-2,3-oxirane-1-chlorononane. Treatment of
this epoxy nonyl chloride with excess of LiNH2/liquid NH3; followed by addition of 1-nonanal, gave 18-tetrahydropyranyloxy-9, 12-dihydroxy-10-octadecyne. The lithium aluminum hydride
reduction of the conjugated hydroxy acetylenic bond, protection of hydroxyl groups as benzoates and oxidation of the primary
ether group, followed by removal of benzoate groups, gave DOD.
IICT Communication No. 2995. 相似文献