Spatially localized 31P NMR measurements of longitudinal relaxation rates in the canine myocardium

FLAX-ISIS spatial localization was combined with inversion recovery to enable the measurement of spatially localized T1 values. This approach was applied to the transmural determination of creatine phosphate longitudinal relaxation times in the canine myocardium. By examining five voxels spanning the left myocardial wall, we observed that transmural T1 values for creatine phosphate ranged from 3.61 +/- 0.20 in the endocardium to 4.00 +/- 0.20 in the epicardium at 4.7 Tesla. As such, the canine myocardium exhibits no transmural variation in the T1 values of creatine phosphate. This simple approach can be extended to enable the in vivo measurement of transmural enzymatic rates.