Time–frequency localized three-band biorthogonal wavelet filter bank using semidefinite relaxation and nonlinear least squares with epileptic seizure EEG signal classification

In this paper, we design time–frequency localized three-band biorthogonal linear phase wavelet filter bank for epileptic seizure electroencephalograph (EEG) signal classification. Time–frequency localized analysis and synthesis low-pass filters (LPF) are designed using convex semidefinite programming (SDP) by transforming a nonconvex problem into a convex SDP using semidefinite relaxation technique. Three-band parameterized lattice biorthogonal linear phase perfect reconstruction filter bank (BOLPPRFB) is chosen and nonlinear least squares algorithm is used to determine its parameters values that generate the designed analysis and synthesis LPF such that the band-pass and high-pass filters are also well localized in time and frequency domain. The designed analysis and synthesis three-band wavelet filter banks are compared with the standard two-band filter banks like Daubechies maximally regular filter banks, Cohen–Daubechies–Feauveau (CDF) biorthogonal filter banks and orthogonal time–frequency localized filter banks. Kruskal–Wallis statistical test is employed to measure the statistical significance of the subband features obtained from the various two and three-band filter banks for epileptic seizure EEG signal classification. The results show that the designed three-band analysis and synthesis filter banks both outperform two-band filter banks in the classification of seizure and seizure-free EEG signals. The designed three-band filter banks and multi-layer perceptron neural network (MLPNN) are further used together to implement a signal classifier that provides classification accuracy better than the recently reported results for epileptic seizure EEG signal classification.     

Automatic recognition of alertness level from EEG by using neural network and wavelet coefficients

Electrophysiological recordings are considered a reliable method of assessing a person's alertness. Sleep medicine is asked to offer objective methods to measure daytime alertness, tiredness and sleepiness. As EEG signals are non-stationary, the conventional method of frequency analysis is not highly successful in recognition of alertness level. This paper deals with a novel method of analysis of EEG signals using wavelet transform, and classification using ANN. EEG signals were decomposed into the frequency sub-bands using wavelet transform and a set of statistical features was extracted from the sub-bands to represent the distribution of wavelet coefficients. Then these statistical features were used as an input to an ANN with three discrete outputs: alert, drowsy and sleep. The error back-propagation neural network is selected as a classifier to discriminate the alertness level of a subject. EEG signals were obtained from 30 healthy subjects. The group consisted of 14 females and 16 males with ages ranging from 18 to 65 years and a mean age of 33.5 years, and a Body Mass Index (BMI) of 32.4±7.3 kg/m². Alertness level and classification properties of ANN were tested using the data recorded in 12 healthy subjects, whereby the EEG recordings were not used to train the ANN. The statistics were used as a measure of potential applicability of the ANN. The accuracy of the ANN was 95±3% alert, 93±4% drowsy and 92±5% sleep.     

基于深度神经网络的个性化睡眠癫痫发作预测

现有癫痫发作预测方法存在精度较低、错误报警率较高、癫痫患者睡眠脑电特异性、致痫灶位置和类型不同导致脑电信号存在差异的问题.文中提出基于深度神经网络的个性化睡眠癫痫发作预测方法,帮助医生和患者采取及时有效的治疗措施,降低患者患并发症和猝死的概率.对原始脑电信号滤波和分段以去除噪声,保证短时间内触发警报,利用离散小波变换分解信号并提取统计特征表征脑电信号时频特征.再应用双向长短期记忆网络挖掘最具鉴别能力的特征并结合留一法分类,经过决策过程优化得到预测结果.在不同频带限制条件下的实验表明,与睡眠癫痫相关的δ频带信号是影响发作预测性能的重要因素.相比现有睡眠癫痫预测方法,文中方法性能较优.     

基于SVM和小波分析的脑电信号分类方法

根据癫痫脑电信号与正常脑电信号波形和能量特征的不同,研究了两种的脑电信号分类方法,一种采用支持向量机SVM(Support Vector Machines)分类器对正常脑电和癫痫脑电进行分类;另一种使用小波分析和支持向量机相结合的方法对脑电进行分类,并比较了这两种方法对正常脑电和癫痫脑电分类的正确率。实验结果表明,小波分析和SVM结合的方法对脑电信号分类可以取得更好的效果,能有效区分癫痫脑电和正常脑电。     

Examination of the wavelet-based approach for measuring self-similarity of epileptic electroencephalogram data

Self-similarity or scale-invariance is a fascinating characteristic found in various signals including electroencephalogram （EEG） signals. A common measure used for characterizing self-similarity or scale-invariance is the spectral exponent. In this study, a computational method for estimating the spectral exponent based on wavelet transform was examined. A series of Daubeehies wavelet bases with various numbers of vanishing moments were applied to analyze tile self-similar characteristics of intracranial EEG data corresponding to different pathological states of the brain, i.e., ictal and interictal states, in patients with epilepsy. The computational results show that the spectral exponents of intracranial EEG signals obtained during epileptic seizure activity tend to be higher than those obtained during non-seizure periods. This suggests that the intracranial EEG signals obtained during epileptic seizure activity tend to be more self-similar than those obtained during non-seizure periods. The computational results obtained using the wavelet-based approach were validated by comparison with results obtained using the power spectrum method.     

Epileptic EEG detection using neural networks and post-classification

Electroencephalogram (EEG) has established itself as an important means of identifying and analyzing epileptic seizure activity in humans. In most cases, identification of the epileptic EEG signal is done manually by skilled professionals, who are small in number. In this paper, we try to automate the detection process. We use wavelet transform for feature extraction and obtain statistical parameters from the decomposed wavelet coefficients. A feed-forward backpropagating artificial neural network (ANN) is used for the classification. We use genetic algorithm for choosing the training set and also implement a post-classification stage using harmonic weights to increase the accuracy. Average specificity of 99.19%, sensitivity of 91.29% and selectivity of 91.14% are obtained.     

基于可调Q因子小波变换和迁移学习的癫痫脑电信号检测

针对癫痫脑电信号的检测问题,提出一种基于可调Q因子小波变换和迁移学习的癫痫脑电信号检测方法。首先,对EEG信号进行可调Q因子小波变换,并选择能量差异较大的子带进行部分重构,重排重构信号,将其表示为二维彩色图像数据;其次,通过对现有的癫痫发作自动检测算法和深度可分离卷积网络Xception模型的分析,使用ImageNet数据集分类的预训练模型参数进行网络参数初始化,得到深度可分离卷积网络Xception的预训练模型;最后,利用迁移学习方法将Xception模型的预训练结果迁移至癫痫发作自动检测任务。所提方法在BONN癫痫数据集上的准确度达到99.37%,敏感度达到100%,特异度达到98.48%,证明了该模型在癫痫发作自动检测任务上具有良好的泛化能力。与传统检测方法和其他深度学习方法相比,所提自动检测方法达到了较高的准确率,避免了人工设计和提取特征的过程,具有较好的应用价值。     

脑磁图脑功能连接网络癫痫棘波识别方法研究

脑磁图（MEG）现在被广泛用于临床检查及很多领域的医学研究中,基于静息态的脑磁图脑网络分析能用于研究大脑生理或病理机制。脑磁图分析对癫痫疾病的诊断具有重要的参考价值。对癫痫脑磁信号的自动分类可以及时对患者的情况作出判断,在临床上有很重要的意义。现有文献中对癫痫脑电信号的自动分类方法的研究已比较充分,但对癫痫脑磁信号的研究比较薄弱。提出了一种基于脑功能连接网络的全频段机器学习癫痫脑磁棘波信号自动判别方法,对四种分类器进行了综合判别对比,选择了效果最优的分类器,判别准确率可达到93.8%。因此,该方法在脑磁图癫痫棘波的自动识别与标记方面有较好的应用前景。     

Epileptic seizure classification in EEG signals using second-order difference plot of intrinsic mode functions

Epilepsy is a neurological disorder which is characterized by transient and unexpected electrical disturbance of the brain. The electroencephalogram (EEG) is a commonly used signal for detection of epileptic seizures. This paper presents a new method for classification of ictal and seizure-free EEG signals. The proposed method is based on the empirical mode decomposition (EMD) and the second-order difference plot (SODP). The EMD method decomposes an EEG signal into a set of symmetric and band-limited signals termed as intrinsic mode functions (IMFs). The SODP of IMFs provides elliptical structure. The 95% confidence ellipse area measured from the SODP of IMFs has been used as a feature in order to discriminate seizure-free EEG signals from the epileptic seizure EEG signals. The feature space obtained from the ellipse area parameters of two IMFs has been used for classification of ictal and seizure-free EEG signals using the artificial neural network (ANN) classifier. It has been shown that the feature space formed using ellipse area parameters of first and second IMFs has given good classification performance. Experimental results on EEG database available by the University of Bonn, Germany, are included to illustrate the effectiveness of the proposed method.     

A comparative study of wavelet families for EEG signal classification

Over the past two decades, wavelet theory has been used for the processing of biomedical signals for feature extraction, compression and de-noising applications. However the question as to which wavelet family is the most suitable for analysis of non-stationary bio-signals is still prevalent among researchers. This paper attempts to find the most useful wavelet function among the existing members of the wavelet families for electroencephalogram signal (EEG) analysis. The EEGs considered for this study belong to both normal as well as abnormal signals like epileptic EEG. Important features such as energy, entropy and standard deviation at different sub-bands were computed using the wavelet functions—Haar, Daubechies (orders 2-10), Coiflets (orders 1-10), and Biorthogonal (orders 1.1, 2.4, 3.5, and 4.4). Feature vectors were used to model and train the Probabilistic Neural Network (PNN) and the classification accuracies were evaluated for each case. The results obtained from PNN classifier were compared with Support Vector Machine (SVM) classifier. From the statistical analysis, it was found that Coiflets 1 is the most suitable candidate among the wavelet families considered in this study for accurate classification of the EEG signals. In this work, we have attempted to improve the computing efficiency as it selects the most suitable wavelet function that can be used for EEG signal processing efficiently and accurately with lesser computational time.     

Best basis-based wavelet packet entropy feature extraction and hierarchical EEG classification for epileptic detection

In this study, a hierarchical electroencephalogram (EEG) classification system for epileptic seizure detection is proposed. The system includes the following three stages: (i) original EEG signals representation by wavelet packet coefficients and feature extraction using the best basis-based wavelet packet entropy method, (ii) cross-validation (CV) method together with k-Nearest Neighbor (k-NN) classifier used in the training stage to hierarchical knowledge base (HKB) construction, and (iii) in the testing stage, computing classification accuracy and rejection rate using the top-ranked discriminative rules from the HKB. The data set is taken from a publicly available EEG database which aims to differentiate healthy subjects and subjects suffering from epilepsy diseases. Experimental results show the efficiency of our proposed system. The best classification accuracy is about 100% via 2-, 5-, and 10-fold cross-validation, which indicates the proposed method has potential in designing a new intelligent EEG-based assistance diagnosis system for early detection of the electroencephalographic changes.     

基于小波系数特征融合的小鼠癫痫脑电分类

采集癫痫小鼠模型在常态与致癫状态下的脑电信号以研究其癫痫脑电的自动分类。对经过噪声和伪迹消除预处理的脑电信号进行小波变换,获得不同频率子带的小波系数,对脑电信号及与癫痫特征波相关的小波系数提取相应的线性特征（标准差）和非线性特征（样本熵）;基于这些特征及其组合使用支持向量机分类器实现分类。实验发现基于小鼠脑电本身的标准差和样本熵的分类正确率分别为59.10%和58.00%;而融合各相关小波系数的标准差或样本熵,分类正确率分别达到86.60%和88.60%;融合全部相关小波系数的线性和非线性特征后分类正确率为99.80%。这些结果说明基于小波系数特征融合的分类算法性能有显著提升,能有效实现小鼠癫痫脑电的自动分类。     

Combined neural network model employing wavelet coefficients for EEG signals classification

This paper illustrates the use of combined neural network model to guide model selection for classification of electroencephalogram (EEG) signals. The EEG signals were decomposed into time–frequency representations using discrete wavelet transform and statistical features were calculated to depict their distribution. The first-level networks were implemented for the EEG signals classification using the statistical features as inputs. To improve diagnostic accuracy, the second-level networks were trained using the outputs of the first-level networks as input data. Three types of EEG signals (EEG signals recorded from healthy volunteers with eyes open, epilepsy patients in the epileptogenic zone during a seizure-free interval, and epilepsy patients during epileptic seizures) were classified with the accuracy of 94.83% by the combined neural network. The combined neural network model achieved accuracy rates which were higher than that of the stand-alone neural network model.     

基于同步压缩和DCGAN的癫痫脑电信号检测方法

脑电信号智能识别是癫痫病检测的重要手段,为更加准确地预测癫痫发作,针对目前的深度学习方法特别是卷积神经网络在脑电信号分类方面存在的一些问题,如算法复杂度过高、样本量太少导致分类效果差等,提出基于傅里叶同步压缩变换和深度卷积生成对抗网络的癫痫脑电信号检测方法。首先同步压缩方法将短时傅里叶变换处理后的信号时频能量进行压缩,使得频谱图像精度更高;其次构建深度卷积生成对抗网络来提取特征;最后实现癫痫发作预测。实验在CHB-MIT脑电数据集上进行,结果表明该方法具有97.9%的检测准确率。使用生成对抗网络有效解决了样本量不足的问题,结合同步压缩处理方法后,具有良好的识别准确性。     

Automatic recognition of vigilance state by using a wavelet-based artificial neural network

In this study, 5-s long sequences of full-spectrum electroencephalogram (EEG) recordings were used for classifying alert versus drowsy states in an arbitrary subject. EEG signals were obtained from 30 healthy subjects and the results were classified using a wavelet-based neural network. The wavelet-based neural network model, employing the multilayer perceptron (MLP), was used for the classification of EEG signals. A multilayer perceptron neural network (MLPNN) trained with the Levenberg–Marquardt algorithm was used to discriminate the alertness level of the subject. In order to determine the MLPNN inputs, spectral analysis of EEG signals was performed using the discrete wavelet transform (DWT) technique. The MLPNN was trained, cross-validated, and tested with training, cross-validation, and testing sets, respectively. The correct classification rate was 93.3% alert, 96.6% drowsy, and 90% sleep. The classification results showed that the MLPNN trained with the Levenberg–Marquardt algorithm was effective for discriminating the vigilance state of the subject.     

Adaptive multi-parent crossover GA for feature optimization in epileptic seizure identification

EEG signal analysis involves multi-frequency non-stationary brain waves from multiple channels. Segmenting these signals, extracting features to obtain the important properties of the signal and classification are key aspects of detecting epileptic seizures. Despite the introduction of several techniques, it is very challenging when multiple EEG channels are involved. When many channels exist, a spatial filter is required to eliminate noise and extract relevant information. This adds a new dimension of complexity to the frequency feature space. In order to stabilize the classifier of the channels, feature selection is very important. Furthermore, and to improve the performance of a classifier, more data is required from EEG channels for complex problems. The increase of such data poses some challenges as it becomes difficult to identify the subject dependent bands when the channels increase. Hence, an automated process is required for such identification.The proposed approach in this work tends to tackle the multiple EEG channels problem by segmenting the EEG signals in the frequency domain based on changing spikes rather than the traditional time based windowing approach. While to reduce the overall dimensionality and preserve the class-dependent features an optimization approach is used. This process of selecting an optimal feature subset is an optimization problem. Thus, we propose an adaptive multi-parent crossover Genetic Algorithm (GA) for optimizing the features used in classifying epileptic seizures. The GA-based approach is used to optimize the various features obtained. It encodes the temporal and spatial filter estimates and optimize the feature selection with respect to the classification error. The classification was done using a Support Vector Machine (SVM).The proposed technique was evaluated using the publicly available epileptic seizure data from the machine learning repository of the UCI center for machine learning and intelligent systems. The proposed approach outperforms other ones and achieved a high level of accuracy. These results, indicate the ability of a multi-parent crossover GA in optimizing the feature selection process in EEG classification.     

Multiple classifier system for EEG signal classification with application to brain–computer interfaces

In this paper, we demonstrate the use of a multiple classifier system for classification of electroencephalogram (EEG) signals. The main purpose of this paper is to apply several approaches to classify motor imageries originating from the brain in a more robust manner. For this study, dataset II from BCI competition III was used. To extract features from the brain signal, discrete wavelet transform decomposition was used. Then, several classic classifiers were implemented to be utilized in the multiple classifier system, which outperforms the reported results of other proposed methods on the dataset. Also, a variety of classifier combination methods along with genetic algorithm feature selection were evaluated and compared in order to diminish classification error. Our results suggest that an ensemble system can be employed to boost EEG classification accuracy.     

A real time experimental setup for classification of epilepsy risk levels

The objective of this paper is to analyze the performance of singular value decomposition, expectation maximization, and Elman Neural Networks in optimization of code converter outputs in the classification of epilepsy risk levels from EEG (electroencephalogram) signals. The signal parameters such as the total number of positive and negative peaks, spikes and sharp waves, their duration etc., were extracted using morphological operators and wavelet transforms. Code converters were considered as a level one classifier. Code converters were found to have a performance index and quality value of 33.26 and 12.74, respectively, which is low. Consequently, for the EEG signals of 20 patients, the post classifiers were applied across 3 epochs of 16 channels. After having made a comparative study of different architectures, SVD was found to be the best post classifier as it marked a performance index of 89.48 and a quality value of 20.62. Elman neural network also exhibits good performance metrics than SVD in the morphological operator based feature extraction method.     

A novel selection of optimal statistical features in the DWPT domain for discrimination of ictal and seizure-free electroencephalography signals

Properly determining the discriminative features which characterize the inherent behaviors of electroencephalography (EEG) signals remains a great challenge for epileptic seizure detection. In this present study, a novel feature selection scheme based on the discrete wavelet packet decomposition and cuckoo search algorithm (CSA) was proposed. The normal as well as epileptic EEG recordings were first decomposed into various frequency bands by means of wavelet packet decomposition, and subsequently, statistical features at all developed nodes in the wavelet packet decomposition tree were derived. Instead of using the complete set of the extracted features to construct a wavelet neural networks-based classifier, an optimal feature subset that maximizes the predictive competence of the classifier was selected by using the CSA. Experimental results on the publicly available benchmarks demonstrated that the proposed feature subset selection scheme achieved promising recognition accuracies of 98.43–100%, and the results were statistically significant using z-test with p value <0.0001.     

EEG signal classification using wavelet feature extraction and a mixture of expert model

Mixture of experts (ME) is modular neural network architecture for supervised learning. A double-loop Expectation-Maximization (EM) algorithm has been introduced to the ME network structure for detection of epileptic seizure. The detection of epileptiform discharges in the EEG is an important component in the diagnosis of epilepsy. EEG signals were decomposed into the frequency sub-bands using discrete wavelet transform (DWT). Then these sub-band frequencies were used as an input to a ME network with two discrete outputs: normal and epileptic. In order to improve accuracy, the outputs of expert networks were combined according to a set of local weights called the “gating function”. The invariant transformations of the ME probability density functions include the permutations of the expert labels and the translations of the parameters in the gating functions. The performance of the proposed model was evaluated in terms of classification accuracies and the results confirmed that the proposed ME network structure has some potential in detecting epileptic seizures. The ME network structure achieved accuracy rates which were higher than that of the stand-alone neural network model.