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Thiolation and Cell‐Penetrating Peptide Surface Functionalization of Porous Silicon Nanoparticles for Oral Delivery of Insulin 下载免费PDF全文
Neha Shrestha Francisca Araújo Mohammad‐Ali Shahbazi Ermei Mäkilä Maria João Gomes Bárbara Herranz‐Blanco Rici Lindgren Sari Granroth Edwin Kukk Jarno Salonen Jouni Hirvonen Bruno Sarmento Hélder A. Santos 《Advanced functional materials》2016,26(20):3405-3416
During the last decades, advanced oral delivery systems to enhance the intestinal absorption of widely applicable proteins and peptides, particularly insulin, have been developed. Here, chitosan‐conjugated undecylenic acid‐modified thermally hydrocarbonized porous silicon nanoparticles (CSUn NPs) are used, which promote the mucoadhesion and cellular interactions, thus boosting the intestinal permeability of insulin. Then, to further potentiate the mucoadhesion and permeability enhancement of chitosan‐modified NPs, the surface of the NPs is further modified with either l ‐cysteine (CYS‐CSUn NPs) or a cell‐penetrating peptide (CPP‐CSUn NPs). CYS‐CSUn and CPP‐CSUn NPs show 17‐ and 12‐fold increase in the apparent permeability of insulin across cellular intestinal cells, respectively, with significant enhancement in the cellular interactions. The insulin uptake mechanism pathways in intestinal cells from the developed NPs are also unraveled, which demonstrates major involvement of active transport process and electrostatic interactions, along with adsorptive and clathrin‐mediated endocytic pathways. Moreover, after oral administration in diabetic rats, CYS‐CSUn NPs show 1.86‐ and 2.03‐fold increase in the relative bioavailability of insulin, as compared to empty NPs and oral insulin solution, respectively. In conclusion, this study presents l ‐cysteine modified CSUn NPs as a promising strategy with the ability to overcome the multiple barriers for oral delivery of insulin. 相似文献
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Antibiotic Nanoparticles: Quaternized Silicon Nanoparticles with Polarity‐Sensitive Fluorescence for Selectively Imaging and Killing Gram‐Positive Bacteria (Adv. Funct. Mater. 33/2016) 下载免费PDF全文
Xiaodong Zhang Xiaokai Chen Jingjing Yang Hao‐Ran Jia Yan‐Hong Li Zhan Chen Fu‐Gen Wu 《Advanced functional materials》2016,26(33):5949-5949
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Nanoparticles: Germanium Nanograin Decoration on Carbon Shell: Boosting Lithium‐Storage Properties of Silicon Nanoparticles (Adv. Funct. Mater. 43/2016) 下载免费PDF全文
Wei Luo Dengke Shen Renyuan Zhang Binwei Zhang Yunxiao Wang Shi Xue Dou Hua Kun Liu Jianping Yang 《Advanced functional materials》2016,26(43):7799-7799
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Drug Delivery: On‐Chip Self‐Assembly of a Smart Hybrid Nanocomposite for Antitumoral Applications (Adv. Funct. Mater. 10/2015) 下载免费PDF全文
Bárbara Herranz‐Blanco Dongfei Liu Ermei Mäkilä Mohammad‐Ali Shahbazi Eloy Ginestar Hongbo Zhang Vladimir Aseyev Vimalkumar Balasubramanian Jarno Salonen Jouni Hirvonen Hélder A. Santos 《Advanced functional materials》2015,25(10):1612-1612
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Microcarriers: Luminescent Silicon Diatom Replicas: Self‐Reporting and Degradable Drug Carriers with Biologically Derived Shape for Sustained Delivery of Therapeutics (Adv. Funct. Mater. 32/2015) 下载免费PDF全文
Shaheer Maher Mohammed Alsawat Tushar Kumeria Dina Fathalla Gihan Fetih Abel Santos Fawzia Habib Dusan Losic 《Advanced functional materials》2015,25(32):5240-5240
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Drug Delivery: On‐Chip Fabrication of Paclitaxel‐Loaded Chitosan Nanoparticles for Cancer Therapeutics (Adv. Funct. Mater. 4/2014) 下载免费PDF全文
Fatemeh Sadat Majedi Mohammad Mahdi Hasani‐Sadrabadi Jules John VanDersarl Nassir Mokarram Shahirar Hojjati‐Emami Erfan Dashtimoghadam Shahin Bonakdar Mohammad Ali Shokrgozar Arnaud Bertsch Philippe Renaud 《Advanced functional materials》2014,24(4):418-418
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Drug Delivery: Polylactide‐block‐Polypeptide‐block‐Polylactide Copolymer Nanoparticles with Tunable Cleavage and Controlled Drug Release (Adv. Funct. Mater. 26/2014) 下载免费PDF全文
Robert Dorresteijn Nils Billecke Mischa Schwendy Sabine Pütz Mischa Bonn Sapun H. Parekh Markus Klapper Klaus Müllen 《Advanced functional materials》2014,24(26):4025-4025
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Photodynamic Therapy: Porous Porphyrin‐Based Organosilica Nanoparticles for NIR Two‐Photon Photodynamic Therapy and Gene Delivery in Zebrafish (Adv. Funct. Mater. 21/2018) 下载免费PDF全文
Chiara Mauriello Jimenez Dina Aggad Jonas G. Croissant Karen Tresfield Danielle Laurencin Dorothée Berthomieu Nicolas Cubedo Mireille Rossel Shahad Alsaiari Dalaver H. Anjum Rachid Sougrat Manuel A. Roldan‐Gutierrez Sébastien Richeter Erwan Oliviero Laurence Raehm Clarence Charnay Xavier Cattoën Sébastien Clément Michel Wong Chi Man Marie Maynadier Vincent Chaleix Vincent Sol Marcel Garcia Magali Gary‐Bobo Niveen M. Khashab Nadir Bettache Jean‐Olivier Durand 《Advanced functional materials》2018,28(21)
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