Low blood alcohol discrimination and self-titration skills of social drinkers with widely varied drinking habits.

Six alcohol drinking sessions were administered to 20 males ranging widely in age (18-55 yrs) and classified as "light" or "heavy" social drinkers on the basis of their frequency of drinking and customary dose (ml absolute alcohol/kg). Pretraining measures of accuracy in discriminating low blood alcohol concentrations (BAC) were obtained on Session 1. Training in BAC discrimination (immediate feedback about actual BAC) occurred during Session 2, and Session 3 assessed posttraining effects. Sessions 4-6 tested "self-titration" skill (i.e., self-administration of alcohol to achieve a specific pre-assigned peak BAC). Discrimination of BAC on all posttraining sessions (3-6) was significantly more accurate than pretraining performance. The accuracy with which Ss self-titrated their alcohol to hit a particular peak BAC was consistent over Sessions 4-6 and was comparable to their accuracy in BAC discrimination. The development of these skills had no significant relation to age or drinking habits, suggesting that the training technique may be applicable to a broad spectrum of social drinkers. The importance of feedback in establishing BAC discrimination is discussed, and the consequences of this training, as well as the definition of "light" and "heavy" social drinkers, are identified as important areas for further research. (French summary) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of extinction context and retrieval cues on alcohol cue reactivity among nonalcoholic drinkers.

Pavlovian conditioning models have influenced the development of cue exposure treatments for drug abuse. However, poor maintenance of extinction performance (renewal) after treatment is a common problem. A treatment-analogue experiment tested the role of context in renewal, as well as a potential strategy for reducing renewal. Seventy-eight social drinkers completed extinction trials to reduce saliva and urge reactivity to alcohol cues and were randomly assigned to a renewal test in either the same context as extinction, a different context, or the different context containing a cue from the extinction context (E-cue). As predicted, the different context produced greater renewal than the same context and renewal was attenuated when the E-cue was present. These results offer preliminary evidence for the context dependence of extinction to alcohol cues and for the use of an extinction cue to improve the generalizability of exposure therapies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Brief alcohol intervention with college student drinkers: Face-to-face versus computerized feedback.

Research has demonstrated that brief interventions featuring personalized feedback can be used to decrease alcohol use among heavy-drinking college students. The current study investigated the efficacy of face-to-face and computer delivered interventions relative to an assessment-only control condition. The content of the personalized feedback was identical across the face-to-face and computerized conditions. There were 84 at-risk students assessed before, and 4 weeks after, the delivery of the interventions. The results suggest that both face-to-face and computerized interventions were equally successful in reducing the quantity and frequency of alcohol consumption, and that both interventions were more effective than the control condition. Participants also rated both interventions as acceptable, although the face-to-face intervention was given a more favorable rating. These initial results suggest that computerized interventions can be used to efficiently reduce alcohol use among college students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Secondary prevention with college drinkers: Evaluation of an alcohol skills training program.

This study evaluated secondary prevention approaches for young adults (N?=?36, mean age 23 yrs) at risk for alcohol problems. Ss were randomly assigned to cognitive-behavioral alcohol skills training, a didactic alcohol information program, or assessment only. The skills program included training in blood alcohol level estimation, limit setting, and relapse prevention skills. All Ss maintained daily drinking records during the 8-wk intervention and for 1 wk at each follow-up. Repeated measures multivariate analysis of variance (MANOVA) found a significant reduction over 1-yr follow-up in self-reported alcohol consumption for the total sample. For all drinking measures, the directional findings consistently favored skills training. Despite overall reductions, most Ss continued to report occasional heavy drinking. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of alcohol on aggression in male social drinkers.

Assigned 96 male undergraduates to 1 of 8 groups in a 2 * 2 * 2 factorial design. To control fully for expectation effects, 48 Ss were led to believe that they would be drinking alcohol (vodka and tonic), and 48 believed they would be drinking only tonic water. Within each of these 2 groups, 24 Ss actually received alcohol, but 24 were given only tonic. Following the beverage administration, 48 Ss were provoked to aggress by exposing them to an insulting confederate, whereas control Ss experienced a neutral interaction. Aggression was assessed by the intensity and duration of shocks administered to the confederate on a modified version of A. H. Buss's aggression apparatus. The only significant determinant of aggression was the expectation factor: Ss who believed they had consumed alcohol were more aggressive than Ss who believed they had consumed a nonalcoholic beverage, regardless of the actual alcohol content of the drinks. Ss receiving alcohol, however, showed a significant increase in a reaction time measure, regardless of the expectation condition. Provocation to aggress was also a significant determinant of aggression, but it did not interact with the beverage conditions. (31 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modeling and instructions in training for counselor empathy.

Assessed the relative contributions of modeling and instructions to training of counselor empathy in a factorial design incorporating 2 instruction conditions (instructions or no instructions) and 3 modeling conditions (high-empathy model, low-empathy model, or no model). Ss were 68 clergymen from various religious denominations. Ss wrote responses to a taped client in Phase 1, a training phase, and conducted an interview with a client (actor) in Phase 2, a generalization phase. Instructions had no effect on empathy offered by Ss, but Ss hearing a high-empathy model showed significantly higher empathy in Phase 1 responses than all other Ss. Findings were not significant in Phase 2. Reasons for lack of generalization and implications for further research and training are noted. (23 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential discriminative stimulus control of nonalcoholic beverage consumption in alcoholics and in normal drinkers.

Investigated the validity of applying the internality–externality model of obesity to conceptualize the determinants of drinking behavior. 30 alcoholics and 30 normal drinkers (male prison inmates) consumed either a liquid, a food, or nothing (no preload) and then received free access to preferred and nonpreferred nonalcoholic beverages under the guise of a taste-rating task. Alcoholics were predicted to consume proportionally more of their preferred beverage (external cue hypothesis) and to be less affected by the liquid preload manipulation (internal cue hypothesis) than normal drinkers. Both alcoholics and normal drinkers also were expected to consume less beverage after a food preload than after no preload. Results support the external and internal cue hypotheses but not the food preload prediction. Although differences apparently exist between the way internal and external discriminative stimuli govern eating behavior and drinking behavior, these results generally attest to the viability of applying such a model to conceptualize the determinants of nonalcoholic beverage consumption. This conceptualization has implications for the development of treatments that address the alcoholic's demonstrated vulnerability to external drink-related stimuli and lack of responsivity to internal stimuli. (13 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Blood alcohol level discrimination by alcoholics: The role of internal and external cues.

Two groups of 4 chronic alcoholics lived in Rutgers' Alcohol Behavior Research Laboratory for separate 2-wk periods. During that time, Ss were taught to attend either to internal or to external cues to blood alcohol level (BAL). Mean age of the internal group was 36.2 yrs, and that of the external was 35.7 yrs. Internal Ss completed the Body Sensation Checklist and the Mood Adjective Check List. During a single training session, Ss received feedback on actual BAL following each of their BAL estimates. During pretraining and posttraining sessions, assessments of BAL estimation accuracy were obtained in the absence of feedback. Prior to training, both groups were equally inaccurate in estimating BAL. During training, when accurate BAL feedback was provided, estimation accuracy increased significantly for both groups. Once feedback of actual BAL was removed during the posttraining test session, however, only externally trained Ss maintained the ability to estimate BAL accurately. It is concluded that unlike the nonalcoholic Ss studied by H. Huber, R. Karlin, and A. E. Nathan (1976), the alcoholic Ss of the present study did not learn to discriminate BAL on the basis of internal feelings and sensations nearly as adequately as they did when they referred to external cues. It is suggested that these findings may have important implications for the clinical application of BAL discrimination training. (23 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of instructions and modeling on self-disclosure.

Examined the relative effectiveness of modeling and instructional procedures in training college students to self-disclose. 48 male undergraduates were randomly assigned to 1 of the following instructional conditions: specific instructions to discuss personal feelings within specified topic areas, general instructions to discuss personal feelings within the same topics, or no instructions. Half of the Ss also listened to a model discussing his feelings within identical topic areas, and half did not receive a model. All Ss then participated in a brief monologue, which was scored for self-disclosure. Instructions and modeling, alone and in combination, increased the occurrence of self-disclosure, but the performance of the combination condition was not significantly greater than the performance of modeling or instructions alone. A post hoc analysis showed the instructional effect was due to the difference between specific instructions and no instructions. (30 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The impact of familial alcoholism on alcohol reactivity in female social drinkers.

Some individuals may have an inherent reactivity to alcohol that facilitates early development of characteristics associated with alcoholism. Although response to alcohol cues has been used to assess this reactivity, few studies have included women or investigated familial alcoholism as a variable. In this study, 23 female college students were divided into groups according to family history of alcoholism (positive or negative). Alcohol reactivity was measured by salivation, skin temperature, heart rate, mood state, and craving for alcohol following presentation of alcohol-related and neutral cues. Results indicate no correlation between salivary reactivity and alcohol craving, which suggests that these variables tap into different domains of cue reactivity. Findings demonstrate that alcohol cue reactivity can be assessed in female social drinkers and that familial alcoholism may influence salivary reactivity to alcohol-related cues. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of contingent and noncontingent feedback and subject expectancies on electoencephalogram biofeedback training.

80 undergraduates either received auditory feedback contingent on their production of alpha or they received noncontingent feedback. In addition, Ss were led to expect either a positive or a negative experience. Ss who received contingent feedback produced significantly more alpha than Ss who received noncontingent feedback, but the type of feedback did not seem related to mood. Instead, Ss led to expect a positive experience reported significant reductions in anxiety. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Acute alcohol tolerance on subjective intoxication and simulated driving performance in binge drinkers.

High rates of binge drinking and alcohol-related problems, including drinking and driving, occur among college students. Underlying reasons for the heightened impaired driving rates in this demographic group are not known. The authors hypothesized that acute tolerance to the interoceptive cues of intoxication may contribute to these maladaptive decisions to drive in binge drinkers. Groups of binge-drinking and non-binge-drinking college students (N = 28) attended sessions during which they received a moderate dose of alcohol (0.65 g/kg) or a placebo. The development of acute tolerance to subjective ratings of intoxication and simulated driving performance was assessed by comparing measures taken during the ascending phase and descending phases of the blood alcohol curve. Compared with placebo, alcohol increased ratings of intoxication and impaired multiple aspects of simulated driving performance in both binge and non-binge drinkers. During the descending phase of the blood alcohol curve, binge drinkers showed acute tolerance to alcohol’s effect on subjective intoxication, and this effect was accompanied by an increased rating of willingness to drive. By contrast, non-binge drinkers showed no acute tolerance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expectancies, alcohol, and sexual arousal in male social drinkers.

Randomly assigned 40 undergraduate males, all social drinkers, to 1 of 2 expectation conditions in which they were led to believe that the beverage they were administered contained either vodka and tonic or tonic only. For half of the Ss in each expectation condition, the beverage contained vodka; the others drank only tonic. After their drinks, measures of penile tumescence were taken from Ss using a penile strain gauge during 2 erotic films, 1 depicting a heterosexual interaction, the other a male homosexual interaction. Although analyses of variance failed to reveal any effect of alcohol per se, there were significant effects of expectation on penile tumescence during both the heterosexual and homosexual films. Ss who believed that they had consumed an alcoholic beverage manifested significantly greater sexual arousal than those believing they had consumed a nonalcoholic beverage, regardless of the contents of their drinks. Although no consistent effects were observed on additional measures of sexual arousal, including the TAT, the Word Association Test, and forehead skin temperature, there was a significant positive correlation between self-report measures of sexual arousal and penile tumescence. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relative reinforcing efficacy of alcohol among college student drinkers.

The construct of relative reinforcing efficacy (RRE) is central to many laboratory and theoretical models of drug abuse, but it has not been widely measured in applied clinical research contexts. The authors used a simulated alcohol purchase task to measure RRE in a sample of 267 college student drinkers. Participants reported their alcohol consumption across a range of prices, and their responses were well-described by a regression equation that has been used to construct demand curves in drug self-administration studies. Several measures of relative reinforcing efficacy were generated, including breakpoint, intensity of demand, elasticity, Pmax (price at which response output is maximized), and Omax (maximum alcohol expenditures). Demand for alcohol was inelastic across the initial range of prices but became elastic as price increased. Students who reported recent heavy drinking reported significantly greater intensity of demand, Omax, and breakpoint. These results provide initial support for the validity of the RRE indices generated with the alcohol purchase task. These results also provide empirical support for programs that attempt to reduce alcohol abuse by eliminating low-cost access to alcohol. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral effects of alcohol in novice and experienced drinkers: alcohol expectancies and impairment

The possibility was examined that mutational events at the glucose 6-phosphate dehydrogenase locus can be delayed for significantly more than one or two cell divisions following treatment of Chinese hamster cells with UV light. To detect these later mutant events, the proportion of G6PD-mutant cells in a colony was obtained by replating cells from a single colony 5-7 days after UV irradiation and staining the resulting colonies for G6PD activity. Eight colonies out of a total of 1657 colonies from the treated population yielded G6PD-negative colonies upon replating, while no mutant clones were obtained from 947 colonies grown from untreated cells. One clone contained only mutant cells suggesting that the mutation occurred before the first cell division after irradiation. A second clone contained a 1:1 ratio of mutant to wild-type cells suggesting that the mutation occurred at the first cell division. The remaining six clones contained low numbers of mutant cells and the ratio of mutant to wild-type cells in these clones was in agreement with the theoretical ratios expected for mutations occurring at the fourth (1:13), sixth (1:63), seventh (1:127), eighth (1:255), ninth (1:511), and eleventh (1:2047) cell division after UV light exposure. G6PD-mutant cells deficient in staining activity were isolated from five clones and all have significant reductions in G6PD activity confirming the genetically stable character of these mutants. These results support the conclusion that UV light induces mutants for up to 11 cell generations after treatment of mammalian cells and suggest that mutagens can induce in mammalian DNA long-term alterations which act to increase the apparently spontaneous mutation frequency.     

Risk-taking and alcohol use disorders symptomatology in a sample of problem drinkers.

The relationship between risk-taking behavior and alcohol use disorder (AUD) symptoms is poorly understood. This study employed a modified version of a behavioral measure of risk-taking, the Balloon Analogue Risk Task (BART), to examine its relationship to alcohol use and related symptoms in a community sample of individuals with or at risk for AUD. A total of 158 (71.9% male) participants completed a testing battery that included the BART, a structured diagnostic interview for AUD, and measures of alcohol use and related problems. Estimates of IQ and working memory were assessed as covariates. Results indicated that the relationship between risk-taking propensity, as assessed by the BART, and alcohol problems was significant and negative. Individuals with higher symptom count made fewer pumps per trial on the BART, indicating less risk-taking. It is important to note that this relationship was attenuated when controlling for estimated IQ and working memory span. Further examination demonstrated that IQ and age mediated the relationship between risk-taking propensity and symptom count. The main negative relationship observed between risk-taking on the BART and alcohol use and AUD symptomatology in this sample stands in contrast to the positive relationships observed in adolescent and nonclinical samples. Together, these findings highlight the need to consider development and the course of addiction to fully elucidate the effects of risky-decision making on AUD liability. Furthermore, our results demonstrate the importance of inclusion of neurocognitive covariates (IQ), as well as demographic variables (age) when using this task. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Effect of consistency of reward during runway training on subsequent discrimination performance in rats.

Describes 2 experiments with male albino Holtzman rats (N = 64). In Exp. I, Ss were trained under partial (PR) or continuous (CR) reward in a gray or striped runway and were then trained on a simultaneous stripe-orientation discrimination. PR caused a decrement in discrimination performance after training in the striped runway but had no effect after training in the gray runway. In Exp. II, Ss received PR, CR, or no training in a runway with stripe cues on the floor of the runway varying randomly in orientation. All Ss were then trained on a simultaneous compound-cues discrimination with orientation and width of stripes relevant. After reaching criterion each S was given single-dimension tests on each dimension. PR Ss performed worse on orientation tests but not on width tests. Results are interpreted as supporting stimulus-analyzer theory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of training on general practitioners'' use of a brief intervention for excessive drinkers

During recent years the outcome of acute hepatitis A in chronic liver disease has been discussed controversially. Data from large hepatitis A epidemics and surveillance data from the United States suggest a significantly higher risk of fatal outcome in patients with chronic hepatitis B. Patients with chronic active hepatitis or liver cirrhosis seem to be at highest risk, while HBsAg carriers may exhibit a benign course of the disease. Patients with chronic hepatitis C also seem to have a significantly higher risk of fulminant hepatic failure when superinfected with hepatitis A. The recently reported unsuspected coincidence of autoimmune markers with a fulminant course of hepatitis A in those patients needs to be confirmed. Vaccination against hepatitis A in patients with chronic liver disease has been shown to be safe and effective.     

Increased sensitivity to the disinhibiting effects of alcohol in binge drinkers.

Heavy episodic alcohol use, or binge drinking, is a serious public health problem. Binge drinking is endemic in college students and has resulted in numerous alcohol-related tragedies, including acute alcohol poisonings, falls, and automobile collisions. Such negative outcomes might occur because binge drinkers are generally more impulsive, and this impulsivity might be exacerbated under alcohol. The purpose of this study was to examine this hypothesis by comparing the acute effects of alcohol on a cognitive measure of behavioral control in binge and nonbinge drinkers. The results indicated that binge drinkers act more impulsively and report feeling more stimulated under an acute 0.65 g/kg dose of alcohol compared to nonbinge drinkers. The present finding of a heightened disinhibitory reaction to alcohol in binge drinkers may help explain the link between impulsivity and problem drinking at a more fundamental level of behavioral control. (PsycINFO Database Record (c) 2010 APA, all rights reserved)