离心萃取器提取氢化可的松的工业试验研究

开发了用环隙式离心萃取器连续逆流提取氢化可的松的工艺流程,用D20和D230环隙式离心萃取器分别进行了台架试验和工业规模试验。台架试验结果表明,当转速为3400－4200r/min,醋酸丁酯与发酵液的流量分别为20mL／min和45mL/min时,氢化可的松粗品收率比工厂现行生产岗位的收率提高1．78％－12．1％,质量达到生产要求。工业试验结果表明,当转速为2000r/min,醋酸丁酯与发酵液的流量分别为1m^3/h和2m^3/h时,氢化可的松粗品收率比工厂现行生产岗位的收率提高2％,且减少了萃取剂耗量,降低了能耗。另外,用环隙式离心萃取器还可从染菌的发酵液中提取到氢化可的松。     

连续逆流提取氢化可的松的实验研究

首先对以乙酸丁酯为萃取剂从发酵液中萃取氢化可的松的液液平衡数据进行了测定,并在此基础上进行了多级逆流模拟试验和单级试验,最后以五级混合澄清槽为萃取设备,进行了连续逆流萃取试验。在选定的实验条件下,氢化可的松的萃取率可以达到98.7%,乙酸丁酯的消耗量相比现行的错流萃取工艺下降了50%。     

氢化可的松母液错流萃取行为研究

将氢化可的松母液解析为氢化可的松、表氢化可的松和６α－羟基ＲＳ三种组分，模拟了母液的表观分配系数。拟合结果与实验值符合较好，平均相对误差＜５．５％。     

溶剂萃取法分离氢化可的松和表氢化可的松

针对工业上现有结晶分离工艺的缺点,提出了分离氢化可的松及其光学异构体表氢化可的松的新方法——溶剂萃取法。实验发现,在常规醇类、酮类、酯类、醚类、氯代烃类和芳香烃等溶剂中,乙酸丁酯具有较好的萃取分离性能,以乙酸丁酯为萃取剂用溶剂萃取法分离氢化可的松粗品可获得纯度为９８％以上的氢化可的松,已达到工业生产水平。文中还研究了乙醇含量、温度、盐析效应和ｐＨ对分配的影响。     

圆筒式离心萃取器的探讨

圆简式离心萃取器具有容积效率高、处理能力大、两相停留时间短,并能分离两相密度小至0.01g/cm~2的液系,因此目前在化工、医疗、食品等行业越来越受到重视。本文介绍了该设备的基本原理、水力学特性、操作特性、结构设计等方面问题。     

玻璃钢离心萃取器及其应用

介绍玻璃钢离心萃取器的结构设计和性能实验，包括材料的选定，对样机进行连续运转７００ｈ的力学性能实验，以及流体力学性能和传质性能实验。结果表明玻璃钢离心萃取器具有良好的性能，可应用于工业生产有萃取、净化流程中。     

圆筒式离心萃取器性能研究

以煤油—水—丁酸为体系,通过实验,研究了HL—20型离心萃取器的水力学及传质性能。一、概述圆筒式离心萃取器是60年代后期发展起来的一种离心萃取设备,与其它离心萃取器相比,圆筒式离心萃取器有其自己的特点,即结构简单,适应性强。在离心萃取器的加工中,技术要求最严格的是转鼓。不同规格的转鼓,生产能力可以从每小时几升到100m3/h,且其转鼓是上悬的,浸在液体部分的转动件没有密封的问题,消除了液体的漏液。在圆筒式离心萃取器中由于     

微型离心萃取器在萃取工艺实验研究中的应用

微型离心萃取器是一种新型高效液-液萃取实验设备,具有许多显著优点。介绍了微型离心萃取器的基本结构、工作过程及其在一些萃取新工艺实验研究中的应用。     

离心萃取器在咖啡因工业生产中的应用

在咖啡因工业生产中,一般是采用静态混合器为萃取设备、氯仿为萃取剂来回收母液中的咖啡因,主要缺点是萃取率只在90％左右以及氯仿损失大。离心萃取器是一种高效的液一液萃取设备,具有许多显著优点,为此,采用了4台Ф230离心萃取器代替静态混合器组成串联逆流萃取流程,对该生产环节进行了技术改造,结果表明,萃取率提高到了99％,氯仿用量降低到了25％。     

离心萃取器提取对甲酚的实验和模拟研究

In this study, extraction of p-cresol from the simulated wastewater has been studied using centrifugal extractors and QH-1 extractant. The distribution ratio of p-cresol was approximately 308.5 in the QH-1-p-cresol （pH =2.0） system. The extraction stage efficiency of the single-stage centrifugal extractor was higher than 92%, and the extraction rate of the three-stage cascade was higher than 99%. When 15% NaOH was used for the stripping of p-cresol in QH-1 solution, the stripping rate of the three-stage cascade reached 100%. A mathematical model of multistage countercurrent extraction process that considers the phase volume change, extraction stage efficiency, and phase entrainment was used to simulate the extraction of p-cresol using centrifugal extractors. The calculated results using this model were in good agreement with the experimental results.     

Synergistic Extraction of Lanthanides in a Liquid-Liquid Countercurrent Centrifugal Extractor

We have developed a liquid-liquid countercurrent centrifugal extractor that induces Taylor vortices in the annular fluid region. To demonstrate extraction of multiple species (Nd/Sm/Eu/Gd/Dy) with N,N,N′,N′-tetraoctyl diglycolamide (TODGA), additional chemical agents, such as a surfactant (sodium bis(2-ethylhexyl) sulfosuccinate (AOT)), a synergist (nonanoic acid) and a masking agent (N,N,N′,N′-tetraethyl-3,6-dioxaoctane-1,8-diamide (DOODA(C2))) were employed. When only TODGA was utilized, extraction performance was not effective due to the insufficient dispersion even under a high rotating speed. By combining TODGA and other chemical agents, the separation performance was improved considerably in the countercurrent flow of aqueous and organic phases due to the synergistic effect and improved dispersion.     

Extraction of Hydrocortisone from the Fermentation Liquor with Annular Centrifugal Contactors

Abstract

A continuous countercurrent extraction process for the recovery of hydrocortisone from the fermentation liquor has been developed with annular centrifugal contactors. When the hydrocortisone was extracted from the fermentation liquor with the butyl acetate, the distribution ratio increased with increase of the hydrocortisone concentration in the equilibrium aqueous phase. Both the laboratory tests and the plant tests have been finished with Φ20 mm and Φ230 mm annular centrifugal contactors respectively. In the laboratory tests, when the rotor speed was 3400～4200 r/min, the fermentation liquor flow was 30～50 mL/min and the phase ratio (V_O/V_A) was 0.36～0.50, the percent recovery of hydrocortisone was higher than 92%. In the plant tests, when the rotor speed was 2000 r/min, the fermentation liquor flow was 2000 L/h and the butyl acetate flow was 1000 L/h, the percent recovery of hydrocortisone was about 96.5～98%.     

新型离心萃取机的开发及其应用前景

介绍了离心萃取机的结构和工作原理,国内外发展历程,对比了国内外机型的技术参数。着重分析了自行开发的新型离心萃取机的技术创新点和优点,探讨了新型离心萃取机在核能、环保、湿法冶金、生物制药、精细化工等行业的市场应用前景。     

Extraction of Caffeine with Annular Centrifugal Contactors

Abstract

An extraction process for caffeine has been developed with annular centrifugal contactors. The caffeine distribution ratio in the mother solution effluent‐chloroform system was measured to be about 18.6. Both the pilot tests and the plant tests have been completed with Φ20 mm and Φ230 mm annular centrifugal contactors, respectively. The extraction rate higher than 99% was achieved in the pilot tests, when the rotor speed was 3000‐4500 r/min, the total flow was 20‐80 mL/min, and the flow ratio (A/O) was 2/1. When the rotor speed was 1800 r/min, the mother solution flow was 2000 L/h, and the chloroform flow was 1000 L/h; the extraction rate was also more than 99% in the plant tests.     

离心萃取器用于反胶束溶液萃取牛血清白蛋白

离心萃取器用于反胶束溶液萃取牛血清白蛋白陆强，李宽宏，施亚钧（华东理工大学化学工程研究所，上海２００２３７）关键词离心萃取器，反胶束溶液，牛血清白蛋白１前言以表面活性剂溶于非极性有机溶剂所形成的反胶束溶液为萃取剂，提取与分离水溶液中的蛋白质，是一种有...     

CTXL325-N离心萃取器处理对硝基酚钠废水试验

介绍了用ＣＴＸＬ３２５－Ｎ离心萃取器、ＡＢＫ萃取剂络合萃取处理对硝基酚钠废水的方法,提出了合理的工艺条件,确认ＣＴＸＬ３２５－Ｎ离心萃取器、ＡＢＫ萃取剂络合萃取处理含酚废水工艺是经济有效的