Edward N. Brandt, Jr., M.D

We present the profile of risk factors, etiologic and clinical data of 2,000 consecutive patients with first-ever-in-a-lifetime stroke (cerebral infarction, cerebral hemorrhage and subarachnoid hemorrhage), admitted to the Ege University Hospital between January 1, 1991, and September 31, 1995. This hospital-based registry is the first systematic epidemiologic report on the stroke profile of Turkish people The Ege University Stroke Unit is the only tertiary medical care facility which is organized for patients with different stroke subtypes in Izmir, Turkey. A prospective hospital-based registry using systematic computer coding of data of all stroke patients has been used since January 1991. All patients were evaluated by clinical examination, CT and/or MRI, color duplex and specific cardiac investigations. They were followed up for at least 6 months. The mean age was 62.3 +/- 12 years, and 44.4% were females. Ischemic stroke was found in 77%, primary intracerebral hemorrhage in 19% and subarachnoid hemorrhage in 4%. The major risk factor of ischemic stroke was hypertension (63%), followed by hypercholesterolemia (37%), diabetes mellitus (35%), ischemic heart disease (23%), atrial fibrillation (20%) and smoking (17%). The main cause of primary intracerebral hemorrhage was hypertension (88%), and the principal localization was the thalamus (38%), followed by putamen (28%), lobar(16%), pons(6%), cerebellar(4%), primary intraventricular hemorrhage (4%) and multiple hemorrhages (2%). The over- all 30-day case-fatality rate was 19.7% and the higher mortality rate was found in patients with primary intracerebral hemorrhage (29%) than in those with ischemic stroke (17%). The Ege Stroke Registry allows to estimate the stroke-related problems in patients admitted to a stroke unit and to evaluate the risk factors, etiology and clinical manifestations of stroke in Turkey.     

Phase Equilibrium of Ternary Systems LaX 3 C 18 H 16 N 3O 2Cl H 2O

Ａｎｔｉｐｙｒｉｎｅａｎｄｓｏｍｅｏｆｉｔｓｄｅｒｉｖａｔｉｖｅｓｃａｎｂｅｕｓｅｄｉｎｓｙｎｅｒｇｉｓｔｉｃｅｘｔｒａｃｔｉｏｎｏｆｔｈｅｒａｒｅｅａｒｔｈｉｏｎｓ．Ｓｏｍｅｏｆｔｈｅｉｒｒａｒｅｅａｒｔｈｃｏｍｐｌｅｘｅｓｓｈｏｗｔｈｅｌｕｍｉｎ...     

I/O Psychology and the bridging of A. N. Leont'ev's activity theory.

Soviet activity theory, largely developed by A. N. Leont'ev, can be seen as a European complement of American I/O psychology and an important current of action theories in general. This paper identifies the major strength of Leont'ev's theory as the bridging potential it achieves by situating activity between each of several major pairs of opposite poles: mind and matter or body (exemplified by thinking workers and their work tasks), subject and object, understanding and explanation, theory and practice, humanist psychology and behaviourism. Some implications of activity theory and its bridging potential are pursued in the contexts of I/O theory-construction and research methods, and in the substantive problem areas of job design,job analysis, organization development, and personnel training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

中厚板探伤不合的原因分析及控制措施

济钢针对钢板探伤综合合格率偏低的问题,对探伤不合的原因进行了分析。统计表明,缺陷部位主要集中在钢板的头部和边部,占统计量的73.74%,主要是长条状和点状密集型缺陷;缺陷类型包括分层、偏析、疏松、白点及夹杂物,并分析了其探伤波形。通过严格控制钢中S和夹杂物含量、改善连铸坯内部质量、保证加热时间、增加单道次压下量、强化热处理的挽救措施,使探伤合格率稳定在99.0%以上。     

The crystal and molecular structure of a valinomycin analogue cyclo[(D-Val-L-Lac-L-Ala-D-Hyi)2(D-Val-L-Lac-L-Val-D-Hyi)]. H2O(C50H82N6 O18.H2O)

The crystal and molecular structure of the valinomycin analogue, cyclo[(D-Val-L-Lac-L-Ala-D-Hyi)2(D-Val-L-Lac-L-Val-D-Hyi)] has been solved by x-ray direct methods using the "Shake and Bake" procedure. The crystals, grown from a mixture of octane/CH2Cl2, belong to space group P2(1) (Z = 4) with cell parameters a = 10.29, b = 32.08, c = 18.73 A, beta = 97.05 degrees, and contain two molecules per asymmetric unit. After anisotropic refinement the standard reliability factor was Rl = 0.058. The conformations of both independent molecules is similar to that observed for isoleucinomycin, cyclo[-(D-Ile-L-Lac-L-Ile-D-Hyi)3] [V. Z. Pletnev et al. (1980) Biopolymers, Vol. 19, pp. 1517-1534]. The structure has an asymmetric conformation stabilized by six intramolecular H bonds, five bonds being of the 4-->1 type and one bond being of the 5-->1 type. One water molecule is caged in the internal cavity of each cyclodepsipeptide. This conformation could represent an intermediate state between free and complexed forms of valinomycin.     

光度法联合测定锰矿中的铬和钒

采用过氧化钠-碳酸钠熔融锰矿,热水浸取,经过滤后,于同一种母液中分别移取适当滤液,在酸性介质中,用光度法连续测定铬和钒的含量。试验选定硫酸（1＋1）用量为2 mL,磷酸（1＋1）3 mL,稳定时间分别是10 min及30 min,该方法操作过程简单,测定值与标准值相符,RSD（n=8）Cr≤4.98%,V≤4.87%,而且不易受锰矿中其他成分对测定结果的影响。     

粉末冶金气门导管内孔及其直线度的控制

介绍了通过正确选用铁粉，使用下模冲移动式带摩擦芯棒（型芯）的阴模模腔装料，合理分配烧结坯的整形余量和自动整形等措施，可以将粉末冶金气门导管的内径及其直线度控制在设计图纸范围内。     

M.D.M.A. ("Ecstasy"); a case of possible drug-induced psychosis

3, 4, Methylenedioxymetamphetamine (M.D.M.A., Ecstasy) is a modified amphetamine with stimulant and hallucinogenic properties. Ecstasy has been increasingly abused in Dublin in recent years. It is commonly perceived by users as a safe drug. We report a case of prolonged psychosis following brief recreational use of Ecstasy.     

新型间硝基苯甲酸稀土配位聚合物[Nd2(C7H4O4N)7(H2O)4]n的水热合成和晶体结构

采用水热方法合成出一种新型的间硝基苯甲酸稀土配位聚合物[Nd2(C7H4O4N)7H2O]n,并通过元素分析、红外光谱、X射线单晶结构分析对该配位聚合物进行了表征.标题配位聚合物的晶体属于三斜晶系,P1空间群,晶胞参数a=0.9848(2)nn,b=1.131 4(2)nm,c=1.366 3(3)nm,α=69.22(3).,β=82.48(3).,γ=82.21(3).,V=1.4045(5)nm3,Dc=1.806g/cm3,Z=1.结构分析表明:标题化合物是由稀土金属Nd(Ⅲ)和间硝基苯甲酸组成的配位聚合物,此聚合物通过Ln-O-C-O-Ln形成无限一维链状结构,进一步又通过分子间氢键连接形成复杂的三维氢键网络结构.     

Characterization of a soluble IL-6 receptor alpha mutant C277D/H280I expressed in E.coli

BACKGROUND: Cyclo-oxygenase-1 (COX-1) is believed to produce prostaglandins vital to mucosal defence, whereas cyclo-oxygenase-2 (COX-2) is induced at sites of inflammation. Little is known about the regulation of COX-2 in the stomach, particularly during the period following mucosal injury. In this study, we examined COX-1 and COX-2 expression shortly after administration of NSAIDs or ethanol. METHODS: Fasted rats were given aspirin, salicylate, indomethacin or ethanol (20% or 40%) orally. Three hours later the stomach was excised, the severity of damage scored and samples taken for RT-PCR of COX-1 and COX-2 mRNA and immunohistochemistry. Nitric oxide synthase mRNA (iNOS and eNOS) and activity were also measured. RESULTS: Aspirin, indomethacin and the higher concentration of ethanol produced widespread mucosal damage, whereas salicylate and 20% ethanol caused only superficial epithelial damage. Aspirin caused a significant increase in COX-2 mRNA expression and a marked increase in COX-2 immunoreactivity, particularly in the superficial mucosa. Expression of COX-1 (mRNA and protein) was unaffected by aspirin, as were NOS mRNA expression and enzyme activity. Pre-treatment with prostaglandin E2 prevented the induction of COX-2 by aspirin. Salicylate and indomethacin caused modest increases in COX-2 immunoreactivity but no change in COX-2 mRNA. Neither concentration of ethanol affected COX-2 mRNA or protein expression, suggesting that this was a specific response to the aspirin, rather than to injury. CONCLUSIONS: These results demonstrate a rapid up-regulation of COX-2 expression in response to aspirin, possibly representing a compensatory response to inhibition of gastric prostaglandin synthesis.