The social and health characteristics of California cities

The ethmoid sinuses play a key role in the health or disease of the entire paranasal sinus complex. Multiple underlying inflammatory processes may easily obstruct the narrow ostia of each ethmoid air cell, leading to infection. By virtue of its unique anatomic position and relationship to the ostiomeatal complex, the ethmoid labyrinth becomes the key to treatment of acute and chronic sinusitis. Surgical intervention for sinus disorders in children has grown in popularity. This article reviews the anatomy and pathophysiology of ethmoid sinusitis and discusses the role of surgery for these disorders.     

The validity of the California Q-set Alexithymia Prototype

Classic antihistamines, namely diphenhydramine, chlorpheniramine, clemastine, perphenazine, hydroxyzine, and tripelennamine, share structural features with substrates and inhibitors of the polymorphic cytochrome P450 (CYP) isozyme CYP2D6. Therefore, the current study was undertaken to characterize the in vitro inhibition of CYP2D6 by these commonly used, histamine H1 receptor antagonists. Microsomal incubations were performed using bufuralol as a specific CYP2D6 substrate and microsomes derived from human cells transfected with CYP2D6 cDNA. Reaction velocities were assessed in the absence and presence of antihistamines (20 microM) at 11 substrate concentrations (1, 2.5, 5, 7.5, 10, 15, 20, 25, 50, 75, and 100 microM), as well as at three nonsaturating substrate concentrations (2.5, 5, and 20 microM) and three inhibitor concentrations (5, 20, and 50 microM). In the presence of all antihistamines, the Vmax and KM of bufuralol 1'-hydroxylation were significantly altered, compared with the uninhibited reaction (p < 0.05). Lineweaver-Burke plots suggested competitive inhibition of the reaction by diphenhydramine and mixed inhibition by all other antihistamines tested. Diphenhydramine and chlorpheniramine, with estimated Ki values of approximately 11 microM, were the weakest inhibitors of CYP2D6 in vitro. Whereas tripelennamine, promethazine, and hydroxyzine were similar in their inhibitory capacities (Ki approximately 4-6 microM), clemastine appeared to be significantly more potent, with a Ki of approximately 2 microM. These data demonstrate that classic histamine H1 receptor antagonists, available in over-the-counter preparations, inhibit CYP2D6 in vitro. Furthermore, the CYP2D6-inhibitory concentrations of these antihistamines are in the range of their expected hepatic blood concentrations, suggesting that, under specific circumstances, clinically relevant interactions between classic antihistamines and CYP2D6 substrates might occur.     

The Psychoanalytic Institute of Northern California: A graduation.

This article presents Peskin's speech at the second graduation of the Psychoanalytic Institute of Northern California. In it, he discusses psychoanalytic politics and the continuing development of psychoanalysis. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The managed care backlash and the task force in California

Signs of a managed care backlash in California are increasing. This paper reports and interprets the recently completed work of the California Managed Health Care Improvement Task Force, focusing on the managed care backlash and the state's regulatory response. Although cost containment was a contributing factor, the causes of and solutions to the backlash differ among consumers, physicians, health care workers, politicians, and health plans. The recommendations of the task force could improve the market for health insurance. However, lasting solutions to the profound problems causing the backlash will require fundamental cultural and systemic change.     

The prediction of academic achievement with the California Psychological Inventory.

An attempt to use the California Psychological Inventory to predict the academic grades of students in 3 military courses: Neuropsychiatric, Clinical Psychology, and Social Work Procedures. The data indicated that a combination of the Achievement via Independence scale of the California Psychological Inventory and the General Technical score from the Army Classification Battery, makes an effective instrument for screening students for admittance to these courses. The predicted criterion scores, obtaned from 2 multiple prediction equations, were correlated with the academic grades achieved by students in 2 samples (N = 98; N = 64). The obtained r's were .610 and .600 (p     

Coccidioidomycosis in free-living California sea lions (Zalophus californianus) in central California

Coccidioidomycosis is described in seven California sea lions (Zalophus californianus) admitted to The Marine Mammal Center, Sausalito, California (USA), between January 1986 and December 1994. Diagnoses were confirmed by histology in all seven cases, culture in three cases, and serology in one case. These are believed to be the first published cases of coccidioidomycosis in free-ranging California sea lions.     

The impact of the Postponing Sexual Involvement curriculum among youths in California

Postponing Sexual Involvement (PSI) is a widely implemented middle school curriculum designed to delay the onset of sexual intercourse. In an evaluation of its effectiveness among seventh and eighth graders in California, 10,600 youths from schools and community-based organizations statewide were recruited and participated in randomly assigned intervention or control groups; the curriculum was implemented by either adult or youth leaders. Survey data were collected before the program was implemented, and at three months and 17 months afterward. At three months, small but statistically significant changes were found in fewer than half of the measured attitudes, behaviors and intentions related to sexual activity; at 17 months, none of these significant positive effects of the PSI program had been sustained. At neither follow-up were there significant positive changes in sexual behavior; Youths in treatment and control groups were equally likely to have become sexually active, and youths in treatment groups were not less likely than youths in control groups to report a pregnancy or a sexually transmitted infection. The evaluation suggests that PSI may be too modest in length and scope to have an impact on youths' sexual behavior.     

The use of cervical caps at the university of California/Berkeley

A pilot project was conducted at the University of California Student Health Services on student women fitted with a cervical cap. Follow-up was obtained in 34 of 36 women who purchased caps between spring 1978 and summer 1979. On the initial visit, the woman was presented with information on the cervical cap and its use and was loaned a cap after proper fitting. After the trial period, the woman returned for follow-up where she could elect to purchase a cap and if so, was then given a questionnaire to be returned later. The group of 34 women were divided into regular and irregular users: of the 24 regular users, 7 became pregnant using the cap and 2 of the irregular users became pregnant. 9 of the 24 users had 1 or more unwanted pregnancies aborted prior to the use of the cap, and 4 of the 7 regular users who became pregnant while using the cap had a previous pregnancy. While users were initially motivated, some did not actually use the method properly and even with proper fit, some found the cap became dislodged. This study did not bear out the high hopes many had for the cap's convenience and effectiveness although 16 or 17 regular users who did not become pregnant did continue use. Cap use should probably be discouraged as a primary contraceptive but it is a useful contraceptive to have available as an alternative. The cap's use will be regulated under "Medical Devices; Procedures for Investigational Device Exemption."     

The California F scale in psychological research: 1950-1955.

The purpose of this paper is to present a review of those studies using the F scale in substantially its original form which appeared in the literature between 1950 and 1955. The studies were grouped into five major categories: (a) ideology; (b) personality correlates; (c) interpersonal behavior; (d) cultural and sub-cultural variations; and (e) studies of the instrument. It was concluded that "many questions still remain to be answered before its (the F scale) use would have much meaning in terms of predicting human behavior." 64-item bibliography. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Recent mortality patterns in California

Mortality among people with developmental disabilities was reviewed using recent data obtained from the California Department of Developmental Services. The time interval for this report was 1991-1995. We defined two study cohorts: one beginning in January 1991 and a second in April 1993. The latter period represented the years of implementation of the Coffelt settlement. Our primary interest was in the Coffelt period cohort. Statistically significant association with increased rates of mortality was found for community residence. A trend of declining mortality was noted for the community facilities from 1991-1995, but not for the developmental centers.     

The association between Harris lines and enamel hypoplasia in prehistoric California Indians

Hypoplastic defects of tooth enamel and Harris lines in the long bones have been heralded as potentially useful indicators of health conditions in prehistoric populations. Both result from temporary cessation of growth processes due to similar types of disease, malnutrition, or other metabolic insult. An association test for the first six years of life was conducted on a large series of prehistoric California Indians, using femora and canines from young adults. No significant association was found. This is ascribable to differences in etiology and stability.     

Spirochetosis in California game chickens

An outbreak of spirochetosis occurred in a flock of 75 game chickens in California during fall 1991. Affected birds were weak and anemic. Many had greenish diarrhea. Spirochetes were seen on Giemsa-stained blood smears and in silver-stained tissue sections of kidney, liver, and spleen. Splenomegaly, which is reported to be characteristic of fowl spirochetosis, was not observed in two acutely infected chickens.     

The PACT model

Topical application of the vitamin D analogue calcipotriol has been found to be of clinical value in the treatment of dermatological disorders. This is considered to be safe with respect to alterations in calcium homeostasis. We report a 17-year-old female patient who developed hypercalcaemic crisis after excessive use of calcipotriol for ichthyosis. The clinical condition and serum calcium improved after cessation of calciprotiol treatment and rehydration with intravenous fluids and electrolytes. The case emphasizes the importance of limiting the topical use of calcipotriol as recommended by the manufacturer.     

Observations on the California mortality studies

Since the discovery of aquaporin water channels, insight into the molecular mechanism by which rapid osmotic water occurs across cell membranes has greatly improved. Aquaporin-2 is the vasopressin-responsive water channel in the collecting duct, and vasopressin control of water permeability in the collecting duct occurs in two ways: a short-term regulation and a long-term adaptation. In congenital nephrogenic diabetes insipidus, the kidney does not respond to vasopressin. Ninety percent of these patients carry a mutation in the gene coding for the vasopressin V2 receptor located on the X chromosome. Autosomal recessive and dominant forms of nephrogenic diabetes insipidus that are caused by mutations in the aquaporin-2 gene have now been described. This review focuses on recent insight in the molecular and cellular defect in autosomal nephrogenic diabetes insipidus.     

Mental health expenditures in California counties

In 1957 California began placing responsibility for public mental health services on county programs still vary widely in emphasis and size. The authors explored determinants of counties' unequal program developments using per capita expenditures as the measure of county services. Sociodemographic variables that help explain states' social program expenditures correlate weakly or not at all with county mental health expenditures. The most powerful predictor of these expenditures is number of psychiatrists per 10,000 population. Equal per capita expenditures, however, are not a reasonable goal; these can mask wide variations in program content, efficiency, and quality of care.