Interphex 2004: Exhibitor focus

The exhibition component of Interphex 2004 has attracted more than 950 exhibitors from around the globe. There are representatives from every conceivable pharmaceutical sector, including ethical/proprietary drugs, cosmetics, R&D, the biotech field, and full-scale manufacturing support. The various companies have been attracted to New York by the thousands and thousands of visitors and industry decision-makers who are expected to attend this year's event. A number of companies will be showcasing their latest filtration and separation equipment systems, accessories and process solutions for application in the pharmaceutical market. Below Filtration+Separation presents a selection of new products and systems that will be on display in New York, covering everything from vertical centrifuges, membrane filters and sanitary sieves, to disposable filtration solutions, filter housings, depth filtration systems, and metal detection devices for process flows. We hope our “Exhibitor Focus” section helps you to select the companies that will be of most interest to you.     

离心机在制药工业应用中的技术要求

从离心机在制药工业中应用的基本要求和针对GMP要求出发,为确保离心机在生产过程中(处理特定产品时)的可靠性、可重复性、一致性、安全性,提出设计要求。对过滤型离心机的材料选用、结构设计与表面处理、在线清洗、密闭性、防爆要求的实现、气源、残余滤饼清理、滤布再生等设计细节提出了一些改进措施。     

GMP in pharmaceutical processing and its implications for centrifuges

Good Manufacturing Practice (GMP) regulations were introduced as a means to ensure that a given product is processed reliably, repeatedly, consistently, safely and to a high quality. In the pharmaceutical processing industry GMP is an essential part of the production process. Centrifuges are a major processing tool used in this industry. In the following article, Nigel Day discusses the implications that GMP has had on the design, manufacture and operation of industrial centrifuges, with a particular focus on horizontal peeler type machines.     

Benefication of coking-coal slimes by means of screen centrifuges

A new slime-benefication technology has been developed at Coal Preparation Plant Neryungrinskaya. In this technology, the product is separated in screen centrifuges. As a result, small particles with relatively high ash content are extracted in the centrifugate. Correspondingly, the cake has the required ash content of ≤10%. Industrial tests indicate that this technology is feasible at the facility. The parameters that ensure most effective slime separation are determined. The new slime-benefication system is simple and characterized by relatively low operating costs: the expected reduction in production costs relative to the existing technology is ∼126 million rub/yr.     

TRH系列离心机在PVC树脂生产中的应用

介绍了离心机的工作原理及特点,并基于生产经验,阐述了TRH系列离心机的正常操作、维护与保养及故障处理方法。     

Innovating the Pusher Centrifuge for Bulk Chemical Separation

The continuous output capability of the pusher centrifuge makes it ideal for modern bulk chemical production. However, a drawback of this machine is that it can require an additional pre_thickening step to ensure good separation. Now through an initiative called ‘Centrifuge Technology Solutions’ Ferrum Ltd, Switzerland, has integrated a thickening function into its latest range of pusher centrifuges. Furthermore, the same initiative has resulted in a reduction in the total cost of ownership of its centrifuges. Sandro Schneider explains.     

Evaluation of specific cost of obtainment of lead-208 isotope by gas centrifuges using various raw materials

Evaluations of the specific cost of producing by gas centrifuges highly enriched ²⁰⁸Pb isotope, which may be used as a coolant and a neutron reflector in promising fast neutron reactors, have been carried out. The methodology originally developed for column type separation elements was applied in the calculations. As raw materials, a mixture of natural lead isotopes and radiogenic lead were considered. In the latter case which the content of the target isotope is nearly 1.5 times greater than in a former one. The price limit for the cost of radiogenic lead was established, up to which lower specific cost of producing highly enriched ²⁰⁸Pb isotope were achieved compared to the natural isotopic mixture.     

双级推料离心机在氯酸钠生产中的应用及改进

双级活塞推料离心机以其独有的自动连续操作、生产能力高、功率消耗低等优势,已被越来越多的氯酸盐生产企业认识和使用。针对双级推料离心机结构特点、氯酸钠物料特性及在氯酸钠脱水中存在的问题,提出了对双级推料离心机在结构及操作维护上的改进。     

离心机转鼓整体三维有限元分析与强度计算

转鼓是离心机的关键部件,其设计正朝着转速更高,直径更大的方向发展,因此鼓壁鼓底等零部件间的相互影响和作用越来越大。这类结构的强度问题更为突出,对强度分析的要求也越来越高。为此,本文提出用三维立体单元对过滤式离心机整个转鼓进行分析。由于此方法对转鼓全部采用三维立体单元进行网格划分,因而可以模拟复杂的局部结构和边界条件。本文对某国产卧式刮刀卸料离心机大直径转鼓的有限元计算结果表明,在转鼓底和拦液板中的应力水平较低;在转筒体中应力水平较高,在开孔周围存在着应力集中现象,最大虚拟弹性应力值远大于材料的屈服限。最后,对该离心机转进行了强度评定     

Liquid‐to‐solid ratio control as an advanced process control solution for continuous twin‐screw wet granulation

Assuring compliance of intermediate and final quality attributes in a continuous pharmaceutical manufacturing campaign is of utmost importance. Application of corrective actions might be required in real‐time. This work exemplifies the steps needed to identify a linear pulse transfer function for the dynamic behavior of the granule liquid‐to‐solid ratio (%w/w) at the end of the granulation unit of a commercial ConsiGma^TM‐25 production line. Near‐infrared spectroscopy was used to monitor the granule composition in‐line. The outcome for both the tracking and regulator problem using either conventional or model predictive control was implemented and evaluated. Dynamic setpoints were correctly followed and an RMSE of 0.25%w/w with respect to the setpoint was obtained when inducing artificial disturbances. Important practical challenges were also tackled. Examples are fouling, computational limitations, and the limited flexibility of the automation software. Applying the proposed advanced process control solution offers an answer to upstream material flow rate deviations. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2500–2514, 2018     

Filtration 2003: Exhibitor Focus

The Filtration 2003 exhibition is an ideal opportunity for indsutry professionals to see the latest products and developments in the field of filtration. Below Filtration+Separation presents a selection of new products and systems that will be showcased in Chicago on 18-20 November, covering everything from new netting, production machines, cartridge bags, and HEPA/ULPA filters for application in pharmaceutical procedures and other hygienic environments. There will also be a number of new membranes, electronic aids and measuring/efficiency devcies on display at the Navy Pier venue in Chicago. We present these together with an overview of the aims and ambitions of the exhibiting companies, including those looking for distribution partners or focusing on particular filtration fields. We hope our ‘Exhibitor Focus’ section helps you to select the companies and organisations that will be of most interest to you.     

A New Annular Centrifugal Contactor for Pharmaceutical Processes

A new annular centrifugal contactor capable of rapid disassembly for inspection and cleaning is presented. The unique design enhances the utility of this liquid-liquid centrifuge in processes requiring cleaning and inspection of all wetted parts. This new model differs from previous designs in that it can be manufactured to meet the requirements of the pharmaceutical industry. Annular centrifugal contactors are vertical, direct-drive centrifuges providing an efficient mixing and separation device in a single unit. They can be directly coupled for multiple-stage processes. Other features include small hold up volume, rapid start-up and shutdown, variable speed control, interchangeable heavy phase weirs, and very compact size. Mixing and disengaging residence times of 3 and 20 s, respectively, are typical. Single stage efficiencies for processes with rapid kinetics are greater than 90%. Annular centrifugal contactors can be used to convert processes from batch to continuous due to their ability to handle intermittent feed flows and 100% phase ratio changes.     

Reaction Engineering for the Industrial Implementation of Biocatalysis

Biocatalytic processes (using one or more enzymes) for the production of chemicals is an important potential route to more sustainable manufacturing and today have found application in several industries, but most notably in the pharmaceutical sector. For high-priced pharmaceuticals, the development of new processes is primarily dependent upon enzyme development. However, the wider application of biocatalytic processes towards lower-priced chemicals will demand reaction engineering to be considered, alongside biocatalyst development. Bioreaction engineering should include an evaluation of the thermodynamics and reaction kinetics, as well as the stability of the biocatalyst. In this brief article, tools to assist in the collection and evaluation of reaction engineering data will be discussed, and illustrated using biological oxidation as an example.

     

A New Annular Centrifugal Contactor for Pharmaceutical Processes

A new annular centrifugal contactor capable of rapid disassembly for inspection and cleaning is presented. The unique design enhances the utility of this liquid-liquid centrifuge in processes requiring cleaning and inspection of all wetted parts. This new model differs from previous designs in that it can be manufactured to meet the requirements of the pharmaceutical industry. Annular centrifugal contactors are vertical, direct-drive centrifuges providing an efficient mixing and separation device in a single unit. They can be directly coupled for multiple-stage processes. Other features include small hold up volume, rapid start-up and shutdown, variable speed control, interchangeable heavy phase weirs, and very compact size. Mixing and disengaging residence times of 3 and 20 s, respectively, are typical. Single stage efficiencies for processes with rapid kinetics are greater than 90%. Annular centrifugal contactors can be used to convert processes from batch to continuous due to their ability to handle intermittent feed flows and 100% phase ratio changes.     

浅谈OEM与药企发展之路

研究了OEM的发展和现状,结合国内制药企业生存现状,权衡了OEM生产方利弊,进而探讨工业化大生产中的国内制药企业面对复杂的国内外市场环境以及产能过剩的现实条件,能否将OEM作为企业生存发展的途径。     

ADC发泡剂生产的清洁技术改进

介绍了ADC发泡剂生产工艺以及污染的主要来源,提出了从源头削减污染物排放的技术改进措施,主要有提高水合肼合成自动控制水平,氯化钙法除粗肼中的碳酸钠,采用新型离心机洗涤联二脲和ADC,实现母液和洗涤液分开处理和综合利用,采用自动反冲洗过滤器回收废水中的联二脲和ADC.技术改进后水合肼的质量浓度提高5g/L；缩合母液硫酸钠...     

Centrifuge treatment of coal tar

New technology is required for the removal of water and heavy fractions from regular coal tar. Centrifuges offer the best option. Purification of coal tar by means of centrifuges at OAO NLMK permits the production of pitch coke or electrode pitch that complies with current standards.     

Filter media investment in Italy continues

Ahlstrom Corp, a leader in high-performance fibre based materials, has announced its decision to invest €5.5 million (US$6.2 million) in a fine fibres production line at its plant in Turin, Italy. The new line will produce advanced filter media and composites.This is a short news story only. Visit www.filtsep.com for the latest filtration industry news.     

生产大颗粒药用磷酸氢钙的探索研究

针对生产药用磷酸氢钙的工艺过程中得率低只有32％,制造成本高、产能低,导致药用大颗粒磷酸氢钙在国内市场供不应求。通过添加颗粒促进剂氢氧化钾将得率提高至66．2％,产能提高一倍,同时生产成本降低1276．4元／吨,大大缓解国内市场供给紧张现状。     

Cleaning process waste water with pressure centrifuges

Conclusions Pressure centrifuges of diameter 25–50 mm can be used to clean process waste water contaminated with fine fireclay, magnesite, chrome-magnesite, or fireclay-clay mixtures; the centrifuges may be combined into blocks.Pressure centrifuges may be used to clean the process water used in wet air-cleaning systems to free the air from fireclay, magnesite, and clay dusts.Translated from Ogneupory, No. 7, pp. 19–24, July, 1968.