The impact of personality disorders on behavioral treatment outcome for social phobia

The impact of personality disorders (PDs) on exposure in vivo treatment for social phobia was investigated in three groups of social phobics: social phobia without any PD (n = 30), social phobia with a single diagnosis of avoidant PD (n = 18) and social phobia with multiple PDs (n = 13). We hypothesized parallel change for social phobia with and without an avoidant PD with the latter group being more impaired before and after treatment. In order to test this hypothesis, confidence intervals for change were computed. In line with our hypothesis, social phobics in all three groups improved significantly during treatment and no interaction effects were found on the repeated MANOVAs. By using a confidence interval, parallel change was found on most measures. The impact of additional anxiety and mood disorders on treatment outcome was investigated separately. The analyses showed that an additional anxiety or mood disorder also did not predict outcome of exposure treatment.     

The impact of postnatal depression and associated adversity on early mother-infant interactions and later infant outcome

The impact of maternal depression and adversity on mother-infant face-to-face interactions at 2 months, and on subsequent infant cognitive development and attachment, was examined in a low-risk sample of primiparous women and their infants. The severe disturbances in mother-infant engagement characteristic of depressed groups in disadvantaged populations were not evident in the context of postpartum mood disorder in the present study. However, compared to well women, depressed mothers were less sensitively attuned to their infants, and were less affirming and more negating of infant experience. Similar difficulties in maternal interactions were also evident in the context of social and personal adversity. Disturbances in early mother-infant interactions were found to be predictive of poorer infant cognitive outcome at 18 months. Infant attachment, by contrast, was not related to the quality of 2-month interactions, but was significantly associated with the occurrence of adversity, as well as postpartum depression.     

A meta-analysis of fluoxetine outcome in the treatment of depression

A meta-analysis was conducted on all the double-blind, placebo-controlled efficacy trials of the antidepressant fluoxetine (Prozac). This drug has become the antidepressant most frequently prescribed by psychiatrists and has been hailed by the media as a "wonder drug." Results produced a relatively modest overall effect size that was no greater than effect sizes obtained by previous meta-analyses of tricyclic antidepressants. This study also examined the possibility that bias may have contaminated study outcome ratings. Because past studies suggest that the greater frequency of side effects in active drug groups unblinds study participants, we examined the relationship between study effect sizes and the percentage of patients reporting side effects. As predicted, both clinician and patient outcome ratings correlated significantly with the percentage of patients experiencing side effects. Questions are raised about the role of side effects in mediating drug outcome results.     

Key ingredients to effective addictions treatment

Based on previous reviews and recent empirical findings a number of assertions can be made as to what constitutes the active ingredients for the effective treatment of addictive disorders. These key ingredients include the following: easy accessibility of care, treatment flexibility, the involvement of collaterals, good therapists, motivated clients, matching treatment to salient client variables, client accountability for their sobriety, focused treatment approaches, and the follow-up of drop-outs and program graduates. A program developed based on these key ingredients showed a 64% abstinence rate among clients in the Action stage of recovery and a 56% abstinence rate for clients in the Contemplation stage. It is proposed that these key ingredients are generic to all effective substance abuse treatment programs and apply at both a programmatic level and an individual practitioner level.     

Group treatment of depression: Individual predictors of outcome.

The present study attempted to identify patient characteristics predictive of individual outcome in a psychoeducational group treatment for unipolar depression. Forty participants meeting Research Diagnostic Criteria for depressive disorders were assessed on demographic and psychological variables at both pre- and posttreatment and on participation variables during treatment. The treatment modality was the Coping With Depression Course. At the end of treatment, 85% of the subjects no longer met diagnostic criteria for depressive disorders. A stepwise multiple regression analysis attained a multiple correlation of .92, accounting for 85% of the variance in posttreatment depression level. Ten variables accounted for significant portions of the outcome variance beyond that explained by pretreatment Beck Depression Inventory scores. The results of previous studies were partially replicated; predictive ability was improved markedly over prior reports. The results suggest that the most robust predictors of outcome are pretreatment levels of depression, social functioning, perceived mastery over events, and early positive perceptions of group cohesiveness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The impact of major depression on chronic medical illness

Femoral head necrosis is thought to be the consequence of decreased venous drainage. To confirm this pathogenetic model in lunatomalacia, the intraosseous pressure in 16 necrotic, 16 normal lunates and 16 normal capitates was measured. Intraosseous pressure was recorded in different functional positions: neutral position, extension, flexion, venous stasis, and exsanguinated conditions. Both in extension and in flexion, the intraosseous pressures of all bones exceeded those in neutral position; this corresponded to the increase in pressure during venous stasis. The increase in pressure in normal lunates and capitates could not be explained by mechanical deformation. Lunates showed a much higher increase in pressure than did capitates. Some necrotic lunates showed an intraosseous pressure during extension which exceeded the systolic blood pressure. This implies that mechanical deformation contributed to increased intraosseous pressure in necrotic lunates. The variation of intraosseous pressure suggests a physiological but unstable balance. An increase in pressure reduces the bloodflow and in addition to other promoting influences can lead to pathological conditions. The daily load of the wrist in extension is in accordance with the model of the origin of osteonecrosis on the venous side. The model that lunate necrosis is the consequence of impaired venous outflow can be accepted.     

The impact of depression on social economic decision making.

[Correction Notice: An erratum for this article was reported in Vol 119(3) of Journal of Abnormal Psychology (see record 2010-15289-020). In the article, the last revision received date printed on the final page of the article was incorrect due to an error in the production process. The correct publication dates are as follows: Received April 14, 2009; Revision received November 6, 2009; Accepted November 9, 2009.] Although the role of emotion in social economic decision making has been increasingly recognized, the impact of mood disorders, such as depression, on such decisions has been surprisingly neglected. To address this gap, 15 depressed and 23 nondepressed individuals completed a well-known economic task, in which they had to accept or reject monetary offers from other players. Although depressed individuals reported a more negative emotional reaction to unfair offers, they accepted significantly more of these offers than did controls. A positive relationship was observed in the depressed group, but not in controls, between acceptance rates of unfair offers and resting cardiac vagal control, a physiological index of emotion regulation capacity. The discrepancy between depressed individuals' increased emotional reactions to unfair offers and their decisions to accept more of these offers contrasts with recent findings that negative mood in nondepressed individuals can lead to lower acceptance rates. This suggests distinct biasing processes in depression, which may be related to higher reliance on regulating negative emotion. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychosocial treatment of the addictions: Problems in specific populations.

Psychosocial treatment programs have made recent advances in understanding and intervening with the problems of addiction. This article reviews the contributions included in this special series, which encompasses several specific issues facing psychologists who conduct treatment, research, and teaching in the field of addictive behaviors. These topics include a mood management intervention for Spanish-speaking substance abusers, factors influencing crack cocaine use by African-American teens, development of culturally sensitive treatment models, patients with the dual diagnoses of mental illness and substance abuse, and recent developments regarding substance abusers and human immunodeficiency virus and acquired immunodeficiency syndrome. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychosocial treatment of the addictions: General issues facing psychologists.

Treatment of the addictions is changing. Psychosocial treatment programs and research projects have changed the way helping professionals view, treat, and prevent drug abuse. This article reviews the contributions included in this special series; they encompass several general issues facing psychologists who conduct treatment, research, and teaching in the field of addictive behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multidrug resistance-associated protein in acute myeloid leukemia: No impact on treatment outcome

Drug resistance remains a major problem in the treatment of patients with acute myeloid leukemia (AML). Expression of the MDR1 gene in leukemic cells was shown previously to be associated with worse clinical outcome of the patients. The multidrug resistance-associated protein (MRP) has been shown recently to be another protein causing the multidrug resistance phenotype in cell lines, but its impact on clinical outcome in patients with AML remains to be proven. To determine the clinical significance of MRP in patients with de novo AML, we have studied the MRP expression in leukemic cells and its association with both response to induction chemotherapy and survival of the patients. MRP gene expression was determined by immuno-cytochemistry (n = 80) by means of the monoclonal antibodies QCRL-1 and QCRL-3. MRP expression was low, intermediate, and high in 19, 55, and 26% of the patients, respectively. High MRP expression was independent of age and sex of the patients, WBC count, and percentage of blasts. However, high MRP expression was more frequent in the FAB M5 subtype as compared to the other subtypes. MRP expression had no impact on clinical outcome. The complete remission rates were 65, 68, and 63% for patients with low, intermediate, and high expression, respectively. Overall survival was also independent of MRP expression. In contrast, patients with P-glycoprotein-positive AML had lower complete remission rates and shorter durations of survival. These data indicate that MRP is expressed in patients with de novo AML but, in contrast to P-glycoprotein, does not predict for outcome of induction chemotherapy or survival.     

The impact of perceived interpersonal functioning on treatment for adolescent depression: IPT-A versus treatment as usual in school-based health clinics.

Objective: Aspects of depressed adolescents’ perceived interpersonal functioning were examined as moderators of response to treatment among adolescents treated with interpersonal psychotherapy for depressed adolescents (IPT-A; Mufson, Dorta, Moreau, & Weissman, 2004) or treatment as usual (TAU) in school-based health clinics. Method: Sixty-three adolescents (12–18 years of age) participated in a clinical trial examining the effectiveness of IPT-A (Mufson, Dorta, Wickramaratne, et al., 2004). The sample was 84.1% female and 15.9% male (mean age = 14.67 years). Adolescents were 74.6% Latino, 14.3% African American, 1.6% Asian American, and 9.5% other. They came primarily from low-income families. Adolescents were randomly assigned to receive IPT-A or TAU delivered by school-based mental health clinicians. Assessments, completed at baseline and at Weeks 4, 8, and 12 (or at early termination), included the Hamilton Rating Scale for Depression (Hamilton, 1967), the Conflict Behavior Questionnaire (Robin & Foster, 1989), and the Social Adjustment Scale–Self-Report (Weissman & Bothwell, 1976). Results: Multilevel modeling indicated that treatment condition interacted with adolescents’ baseline reports of conflict with their mothers and social dysfunction with friends to predict the trajectory of adolescents’ depressive symptoms over the course of treatment, controlling for baseline levels of depression. The benefits of IPT-A over TAU were particularly strong for the adolescents who reported high levels of conflict with their mothers and social dysfunction with friends. Conclusions: Replication with larger samples would suggest that IPT-A may be particularly helpful for depressed adolescents who are reporting high levels of conflict with their mothers or interpersonal difficulties with friends. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychotherapy for the treatment of depression: A comprehensive review of controlled outcome research.

Previous quantitative reviews of research on the efficacy of psychotherapy for depression have included only a subset of the available research or limited their focus to a single outcome measure. The present review offers a more comprehensive quantitative integration of this literature. Using studies that compared psychotherapy with either no treatment or another form of treatment, this article assesses (1) the overall effectiveness of psychotherapy for depressed clients, (2) its effectiveness relative to pharmacotherapy, and (3) the clinical significance of treatment outcomes. Findings from the review confirm that depressed clients benefit substantially from psychotherapy, and these gains appear comparable to those observed with pharmacotherapy. Initial analysis suggested some differences in the efficacy of various types of treatment; however, once the influence of investigator allegiance was removed, there remained no evidence for the relative superiority of any 1 approach. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The cumulative impact of nonsevere life events predicts depression recurrence during maintenance treatment with interpersonal psychotherapy.

Although much research has focused on the role of severe life events as risk factors for depression onset, less is known about the relationship between nonsevere life events and depression recurrence. The current study examined the cumulative effects of nonsevere and positive life events on depression recurrence in an outpatient sample of recurrently depressed women treated to remission with interpersonal psychotherapy (IPT). A Cox proportional hazards model was used to test this relationship in 124 adult women who entered into the maintenance phase of IPT treatment and completed at least 1 Life Events and Difficulties Schedule interview. The cumulative experience of nonsevere life events that were subject- or joint-focused and nonindependent was significantly related to depression recurrence during the maintenance treatment phase. None of the other event categories were significantly related to depression recurrence. These findings may help to clarify the mechanisms by which life events contribute to depression recurrence and to guide the development of more efficacious maintenance treatments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The impact of advanced age on the results of carotid endarterectomy: an outcome analysis

BACKGROUND: This study examined whether advanced age adversely influences the outcome of carotid endarterectomy. STUDY DESIGN: The records of 173 patients who underwent 187 carotid endarterectomies performed by the author from January 1990 through December 1995 were retrospectively reviewed. Group 1 included 58 patients, ranging in age from 75 to 92 years (mean, 79.4 years), who underwent 63 procedures, and group 2 included 115 patients, ranging in age from 41 to 74 years (mean, 66.3 years), who underwent 124 procedures. The operation was performed for symptomatic disease in 67 percent of the cases in each group. The operated lesion was more than 80 percent stenotic in 85 percent of the group 1 and 79 percent of the group 2 cases. RESULTS: No significant differences were found in the operative mortality (1.6 percent compared with 1.6 percent), incidence of perioperative stroke (4.8 percent compared with 1.6 percent), or rate of major cardiac complications (7.9 percent compared with 7.3 percent) between groups 1 and 2. No significant difference was found in the mean postoperative length of hospital stay between the group 1 and group 2 patients (4.13 +/- 2.58 days compared with 3.68 +/- 1.40 days). However, during the last 2 years of the study, the mean postoperative length of stay among the group 2 patients (3.06 +/- 1.44 days) was significantly shorter than among the group 1 patients (4.15 +/- 1.45 days) (p < .05). CONCLUSIONS: Advanced age does not adversely affect the results of carotid endarterectomy. However, the very elderly may be expected to experience a longer postoperative length of stay because of associated comorbid conditions.     

The impact of maternal depression on adolescent adjustment: The role of expressed emotion.

The present study evaluated the role of expressed emotion (EE) as a predictor of child symptomatology and functional impairment in a sample of nearly 800 adolescent children of mothers with varying histories of depression or who were nondepressed. Structural equation modeling was used to test the hypothesized associations in half of the sample, and all models were cross-validated on the other half of the study sample. Results indicated that EE criticism and degree of maternal depression both had independent predictive associations with youths' externalizing symptoms and functional impairment. In addition, high EE criticism served as an intervening variable between maternal depression and child functioning (externalizing symptoms and functional impairment). Results are discussed in terms of the mutual effects of depressed mothers and dysfunctional youths on each other. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Individual differences in latent neuropsychological abilities at addictions treatment entry.

The latent structure of neuropsychological abilities and risk factors for impairment were examined in 197 persons entering addictions treatment. Confirmatory factor analysis yielded 4 factors: Executive, Memory, Verbal, and Processing Speed. The measurement model was consistent with evidence that neuropsychological test performance is factorially complex and supported by multiple brain regions. Path analyses showed that risk factors explained 34-57% of the true variance in abilities. Age, education, and medical status had the most generalized and robust associations with abilities. Drug use disorder diagnoses, childhood behavior problems, familial alcoholism, and psychopathology were also significantly related to specific latent abilities. Knowledge of neuropsychological impairment may be clinically useful, and selected risk factors may help treatment providers decide which clients should receive formal neuropsychological assessment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)