Female idiopathic urethra tumor: clinical features diagnosis and treatment]

Female idiopathic urethra tumors are reported rarely. We treated fourteen patients patients, and described the clinical manifestations and local features of the tumors, urethra liomyoma, and fibropolypus. We found that there are close relations among tumor stage, prognosis and pathological classification. The main diagnostic methods include vaginal touch, urethroscopy, B-ultrasound exam and biopsy. The diagnostic procedure recommended is tumor location-quality-stage or a three-step method. The main treatment is operation, however, the operative mode should depend on tumor stage and patient's life quality after operation.     

Aphasia outcome in stroke: a clinical neuroradiological correlation

Fourteen aphasic patients with acute onset of thromboembolic cerebrovascular insults demonstrable by angiography or radioscintigrams who were available for long-term follow-up have been studied. Their aphasia evolution was compared with acute angiographical and radioisotopic findings, and the lesions shown by follow-up computerized axial tomography (CT). Angiographical site of occlusion, evidence of early reopening of occluded vessels, and radioisotopic flow asymmetries including the "hot-stroke" luxury perfusion failed to correlate with aphasia outcome. Radioisotopic static images were more helpful by depicting lesion location and number but lacked the definition seen on the CT scan. The long-term CT scan by showing the size, location and number of lesions had a good correlation with aphasia outcome. Those patients with large dominant hemisphere involvements, either one large or many smaller lesions, fared poorly while those with lesser lesions did better. Bilateral lesions, at times evasive clinically, helped to account for significant aphasia residuals.     

Comparison of clinical features and prognosis of cardiac sarcoidosis and idiopathic dilated cardiomyopathy

In the present study, clinical findings of 15 patients with cardiac sarcoidosis presenting as dilated cardiomyopathy were compared with those of 30 consecutive patients with idiopathic dilated cardiomyopathy. The sarcoidosis patients had different clinical features, including female predominance, a high incidence of grave conduction disturbance and abnormal wall thickness, uneven wall motion abnormalities, and perfusion defects preferentially affecting the anteroseptal and apical regions, and poor prognosis compared with those with idiopathic dilated cardiomyopathy.     

Progressive degenerative aphasia: clinical and neuroradiological observations in 18 cases

INTRODUCTION: In some types of degenerative dementia aphasia is the main disorder. In primary progressive aphasia. (PPA) atrophy is limited to the dominant peri-sylvan region. We present 18 cases of progressive aphasia of degenerative origin, with or without dementia. MATERIAL AND METHODS: We describe the clinical and neuro-radiological findings in 3 patients with 'aphasic dementia and motor neuron disease (ADMND)', 7 with 'semantic dementia' (DS), and 4 with 'fronto-temporal dementia' with 'marked non-fluent aphasia' (AFTD). Criteria published in recent years were used. RESULTS: In patients with ADMND non-fluent aphasia progressed to global aphasia, with dementia occurring after 2-9 months, and death after an average of 17 months. In cases with SD, initial anomic aphasia progressed to transcortical sensory or global aphasia, and in patients with AFTD, Broca's aphasia or motor transcortical aphasia progressed to global aphasia. Seven of these patients had been initially diagnosed as having PPA and became demented after two years or more. In most of the cases the cognitive disorder had the characteristics of fronto-temporal dementia. All cases had cortical atrophy or asymmetrical cortical or cortico-subcortical atrophy. The 4 cases of non-fluent PPA were not demented after 21 months-6 years of illness, and showed perisylvan and left fronto-temporopolar atrophy. CONCLUSIONS: The PPA may correspond to the initial form of at least three varieties of dementia, usually the fronto-temporal type. Dementia occurs after two years or more, except in patients with motor neurone disease, when there is a latent period of less than one year.     

Neuropsychological and neuroradiological distinctions between Alzheimer's and Huntington's diseases.

Examined neuropsychological and magnetic resonance imaging (MRI) differences among 23 Ss (mean age 70 yrs) with Alzheimer's disease (AD), 9 Ss (mean age 49.2 yrs) with Huntington's disease (HD), and 13 normal controls (mean age 71.7 yrs). Neuropsychological results show that HD Ss' episodic and semantic memory deficits were attributable to retrieval deficiencies, whereas AD Ss' impairments reflected a lack of storage and a breakdown in the structure of semantic knowledge. MRI results show that these cognitive changes were mirrored by significant group differences in striatal and cortical degeneration. AD Ss evidenced more widespread cortical damage, and HD Ss showed more striatal destruction. Both groups evidenced significant deterioration in medial temporal lobe and diencephalic structures. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationships between depressive rumination, anger rumination, and borderline personality features.

We examined relationships between depressive rumination, anger rumination, and features of borderline personality disorder in a sample of 93 students with a wide range of borderline symptoms. All completed self-report measures of borderline features; trait-level negative affect; depressive and anger rumination; and current symptoms of depression, anxiety, and stress. Depressive and anger rumination were strongly associated with borderline features after controlling for comorbid symptoms of depression, anxiety, and stress. Both types of rumination showed significant incremental validity over trait-level sadness, anger, and general negative affect in predicting borderline features. Relationships with borderline features were stronger for anger rumination than for depressive rumination. Relationships between trait-level negative affect and borderline features were substantially reduced when anger rumination was included in regression models, suggesting the need for longitudinal analyses of mediation. Findings suggest that severity of borderline symptoms is influenced by ruminative thinking in response to negative affect, especially anger. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Iniencephaly: neuroradiological and surgical features. Case report and review of the literature

We present a gridded genomic library of the honey-bee (Apis mellifera) for comparative and basic genetic study of the honeybee genome. The library will be established as a "Reference Library" system, and clones as well as data will be shared with the entire scientific community. This will accelerate the molecular level of honeybee genetics, combining the efforts of different laboratories. Because of male haploidy and the high rate of recombination, the honeybee is becoming a model organism for genomic studies of naturally occurring traits and behavioral genetics. The library consists of about 110,000 clones spotted at high density onto four filter membranes, representing 22 genome equivalents. Preliminary analysis using single-copy sequences revealed a positive clone number of the same order. The techniques for library generation and preliminary analysis as well as library access are described.     

Relationships between counseling centers and academic programs of counseling and clinical psychology.

Outlines 12 characteristics of a strong and positive relationship between the academic departments of clinical and counseling psychology and the university counseling center. It is concluded that (1) for a reciprocally beneficial relationship to exist, each organization must commit itself to the importance of such a relationship; and (2) this commitment entails both the offering and soliciting of assistance in a variety of areas as well as willingness to search actively for ways to strengthen the relationship. (1 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationships between lymphography and the histologic nodal and splenic types in Hodgkin''s disease. Considerations on clinical evolution

Trying to establish the eventual interrelations of the initial histologic nodal type and the splenic one, the general lymphographic picture, the histologic nodal type and spleen involvement, lymphographic and histologic examinations were carried out in 151 patients with Hodgkin's disease. Lympographies were performed in 139 cases, and splenectomy (followed by splenic, hepatic and abdominal lymph node biopsies) in 32. Lymphocyte depletion was found in 72.7% of the patients with lymph node obstruction diagnosed lymphographically. Splenic involvement was more frequent in cases with pathologic lymphographic picture and histologic aspects of lymphocyte predominance or nodular sclerosis. In patients with initial nodal histologic types of nodular sclerosis or lymphocyte depletion, the splenic histopathologic types were the same, but they got more severe in cases with lymphocyte predominance or mixed cellularity. Splenic biopsy might be unconclusive after protracted cytostatic treatment or splenic X-ray therapy. In the authors' opinion, early routine splenectomy is rather more advisable than differentiated splenectomy.     

Intracellular levels of the LIS1 protein correlate with clinical and neuroradiological findings in patients with classical lissencephaly

We report on the genotype-phenotype correlation in 7 patients with classical lissencephaly carrying a heterozygous subtle mutation in the LIS1 gene. Six patients, showed a mutation predicted to encode for a truncated protein, and one mutation altered a splicing site, resulting in skipping of exon 4. Western blot analysis performed on the lymphoblastoid cell line of 2 patients bearing truncating mutations indicated that the mutated allele did not produce a detectable amount of the LIS1 protein; whereas the analysis performed on the fibroblasts from the patient with a splice-site mutation was suggestive of partial protein synthesis from the mutated allele. Although clinical and magnetic resonance imaging findings of patients with truncating mutations did not differ from those observed in patients with a heterozygous deletion, the patient bearing the exon-skipping mutation had less severe clinical and brain involvement. Our data suggest that truncating mutations in the LIS1 gene are relatively common among patients with classical lissencephaly not bearing a heterozygous deletion at 17p13.3, and strengthen the relevance of correct intracellular dosage of the LIS1 protein in the neuronal migration process.     

The clinical spectrum of narcolepsy and idiopathic hypersomnia

To better define the clinical spectra of narcolepsy and idiopathic hypersomnia, we retrospectively compared clinical and polygraphic findings and questionnaire results in groups of subjects with narcolepsy with or without cataplexy, idiopathic hypersomnia, insufficient sleep syndrome, mild sleep apnea, and excessive daytime sleepiness not otherwise specified. Sleep paralysis and sleep-related hallucinations were most frequent in narcolepsy-cataplexy, but their frequency did not differ between narcolepsy without cataplexy and idiopathic hypersomnia. Mean durations of nocturnal sleep, daytime naps, and morning grogginess were not increased in idiopathic hypersomnia compared with other groups. Among subjects without cataplexy, symptoms of sleep paralysis and sleep-related hallucinations were equally common in subjects with and without frequent sleep-onset REM periods. These findings suggest that the occurrence of these symptoms in subjects without classical narcolepsy-cataplexy is a function of factors other than a propensity for early onset of REM sleep and indicate a need to reevaluate diagnostic criteria for narcolepsy and idiopathic hypersomnia.     

Relationship between imaging and pathological features and clinical factors in surgical cases of temporal lobe epilepsy]

The advantages of the free TRAM flap over the conventional Tram flap are known. The use of its main pedicle--the deep inferior epigastric system--improves the blood supply, decreasing the risk of skin and fat necrosis. The harvesting of 5-7 cm of muscle, and the preservation of its lateral border decreases the risk of abdominal wall bulge or hernias. Delayed breast reconstructions in patients submitted to radiotherapy were performed by end to side anastomosis between flap vessels and axillary vessels, avoiding the thoracodorsal irradiated vessels, and improving the blood flow. Ten patients were submitted to breast reconstruction by free TRAM flaps. There was one total flap necrosis, and one delayed healing around the periumbilical suture. Neither skin nor fat necrosis were seen. One patient developed an abdominal wall bulge. Two patients presenting tumor metastasis abandoned the plastic surgery outpatient clinic. Two patients refused the nipple-areolar complex (NAC) reconstruction. The outcome of five NAC reconstructions was very good, breasts being symmetrical without an opposite breast operation.     

Relationships between suicidal behavior and personality types

This study examined the hypotheses that introversion in general and the introverted-intuitive-feeling-perceiving (INFP) type as measured by the Meyers-Briggs Type Indicator are related to suicidal ideation and behaviors. Analyses of data from 330 university students found four interactive suicidal behavior risk models: introverted-perceiving (IP) (females); introverted-sensing-feeling (ISF) (males); introverted-intuitive-perceiving (INP) (males); extraverted-intuitive-judging (ENJ) (males). Study findings were interpreted in terms of implications for risk assessment and intervention.     

Relationships between otitis media sequelae and age

OBJECTIVES: To explore relationships between age and sequelae in two groups of children treated with tympanostomy tubes for chronic otitis media with effusion (OME). STUDY DESIGN: Cross-sectional study of sequelae among children, adolescents, and adults at 4 years and 9 to 23 years after tympanostomy tube treatment. METHODS: Group I was examined with otomicroscopy, tympanometry, and audiometry two to four times a year as part of a prospective study, and they were evaluated 4 years after initial tube treatment for this study. Group II received tubes while participating in a chronic OME study, but participants were not followed prospectively after treatment. Nine to 23 years after tube treatment, they were examined with otomicroscopy, tympanometry, and hearing screening. RESULTS: Among the 5- to 28- year-old subjects, cholesteatoma (< or = 1%) and perforation (< or = 2%) were rare. In Group I, tympanosclerosis increased with age (P < .01), and OME (flat tympanograms) decreased with age in Group II (P < .01). The older cohort was more likely to have severe retractions (18% vs. 4%, P = .02), hearing loss (21% vs. 10%, P < .01), and severe atrophy (24% vs. 0%, P < .01) than the younger cohort, but they were less likely to have flat tympanograms (2% vs. 12%, P < .01). CONCLUSIONS: Although OME became less prevalent with age, important sequelae (severe atrophy, severe tympanic membrane retraction, hearing loss, cholesteatoma, and chronic perforation) may develop in children with chronic OME as they become adolescents and young adults. Long-term prospective studies are important in defining the progression of sequelae in these children.     

Relationships between grain boundary structure and energy

The Read-Shockley equation describing the dependence of the grain boundary energy on misorientation of the grains, has been reformulated using the recently developed structural unit model of the atomic structure of grain boundaries, so that it is applicable to general high angle boundaries. The boundary energy then consists of the energy of a reference structure, and of the core and elastic energies of the corresponding DSC dislocations. While the latter part of the boundary energy is determined using the elastic theory of dislocations the former two parts are determined on the basis of atomistics of grain boundaries employing the structural unit model. In the framework of this analysis the minimum number of reference structures in a given misorientation range as well as the extent of misorientations related to a given reference structure are determined unambiguously. Hence, the positions of cusps in the energy vs misorientation dependence and their relative depths and extents are also determined uniquely. The validity of this model is demonstrated for the [001] and [111&#x0304;] symmetrical tilt boundaries which have been studied by atomistic computer simulations.     

Relationships between self-acceptance and sociometric choice.

"Lipsitt's… [see 34: 4134] Self-Concept and Ideal-Self scales and two Sociometric scales were given to fourth, sixth, and eighth grade subjects… Acceptance of others, acceptance by others, and acceptance by best friends were curvilinearly related to self-concept scores… . trends were not significantly different in different grades or sexes… . Acceptance by others was more strongly related to self-concept than was acceptance by best friends… . The sociometric measures were not significantly related to the discrepancy between ideal-self and self-concept scores suggesting that the discrepancy score obtained by subtraction may not be a valid measure of self-acceptance." From Psyc Abstracts 36:04:4FF72R. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

MRI and clinical features in amyotrophic lateral sclerosis

MRI of the brain and spinal cord was performed in 21 patients with amyotrophic lateral sclerosis (ALS), 8 normal volunteers and 16 neurological disease controls. High signal was seen in the intracranial corticospinal tract in 16 of the 21 patients on T2-weighted and in 10 on proton density (PD)-weighted images. In one patient, the high signal on T2-weighted images became less marked with progression of the disease. Low signal intensity was seen in the motor cortex in 12 of the 21 patients. High signal in the anterolateral column of the spinal cord on T1 weighted images was seen in 14, and high signal in the lateral corticospinal tract on T2 weighted images was seen in 7 of the 21 patients. The relationship between the abnormal images and upper motor neurone signs remained unclear. High signal intensity was seen in the corticospinal tract in the brain on T2-weighted images in two normal volunteers and four disease controls, and on PD weighted images in three disease controls. Low signal intensity in the motor cortex on T2 weighted images was seen in three normal volunteers and four disease controls. However, high signal intensity was seen in the intracranial corticospinal tract on T1 weighted images in five patients with ALS who showed pronounced upper motor neurone signs including spastic paraparesis, but not in controls. Thus, abnormalities on MRI in the brain and spinal cord should be considered in the diagnosis of ALS, and high signal intensity of the intracranial corticospinal tract on T1-weighted images may reflect the severe pathological changes of the upper motor neurones in ALS.     

Relationships between expectancies and adolescent dieting behaviors

Dieting expectancies are cognitive variables pertaining to anticipated outcomes individuals expect to obtain from dieting to lose weight. This investigation examined the factor structure of dieting expectancies in an adolescent population, age 10-18, and tested the ability of factors to distinguish among types of dieter, diet pill user, and vomiter groups. Emerging from a principal components analysis were five reliable expectancy factors: Social Confidence, Social Approval, Self-Worth, Positive Performance, and Negative Consequences. Results indicate dieting expectancies and gender are important in distinguishing among adolescents who engage in different dieting practices. Gender and Self-Worth were particularly important in distinguishing frequent dieters from nondieters. Social Approval was best at separating frequent dieters from occasional dieters, diet pills users from nonusers, and vomiters from nonvomiters.     

Relationships between basic sciences and medicine revisited

1. The role of basic research in medical institutions and in particular in Medical Schools is discussed. 2. Clinical practice is characterized, in its technical aspects, as a branch of biological technology. 3. It is suggested that the main functions of basic research practiced in medical institutions is to promote the interaction between physicians and scientists in other fields and to train physicians in the practices of other scientists. 4. It is suggested that the introduction of basic research in medical institutions implies: the recruitment of scientists from non-medical disciplines; a policy of funding that does not favour exclusively the clinical sector; the setting up of a regular graduate program, based on the scientifically active groups and adequately regulated.