共查询到20条相似文献,搜索用时 328 毫秒
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Dietary apigenin reduces LPS‐induced expression of miR‐155 restoring immune balance during inflammation
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Daniel Arango Mayra Diosa‐Toro Laura S. Rojas‐Hernandez Jessica L. Cooperstone Steven J. Schwartz Xiaokui Mo Jinmai Jiang Thomas D. Schmittgen Andrea I. Doseff 《Molecular nutrition & food research》2015,59(4):763-772
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Dietary lipids modulate the expression of miR‐107, a miRNA that regulates the circadian system
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Lidia Daimiel‐Ruiz Valentini Konstantinidou Victor Micó Juan Francisco Aranda Belén García Javier Martínez‐Botas Alberto Dávalos Carlos Fernández‐Hernando José Maria Ordovás 《Molecular nutrition & food research》2015,59(9):1865-1878
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Dietary lipids modulate the expression of miR‐107, an miRNA that regulates the circadian system
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Lidia Daimiel‐Ruiz Valentini Konstantinidou Victor Micó Juan F. Aranda Belén García Javier Martínez‐Botas Alberto Dávalos Carlos Fernández‐Hernando Jose M. Ordovás 《Molecular nutrition & food research》2015,59(3):552-565
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Theobromine Does Not Affect Fasting and Postprandial HDL Cholesterol Efflux Capacity,While It Decreases Fasting miR‐92a Levels in Humans
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Charlotte P.J. Talbot Ronald P. Mensink Lotte Smolders Virginie Bakeroot Jogchum Plat 《Molecular nutrition & food research》2018,62(13)
Scope
Chocolate consumption lowers cardiovascular disease risk, which might be attributed to the methylxanthine theobromine. These effects may be mediated through effects on HDL‐mediated cholesterol efflux, which may be affected by microRNA (miRNA) levels in the HDL particles. Therefore, the aim of this study is to investigate effects of theobromine consumption on fasting and postprandial cholesterol efflux and miRNAs levels.Methods and results
Thirty overweight and 14 obese healthy men and women participated in this randomized, double‐blind crossover study. Participants consumed 500 mg d?1 of theobromine or placebo for 4 weeks. ABCA1‐mediated cholesterol efflux was measured using J774 macrophages. MiRNAs levels (miR‐92a, miR‐223, miR‐135a*) were quantified in apolipoprotein B‐depleted serum. Theobromine consumption did not affect fasting and postprandial cholesterol efflux. Fasting miR‐223 and miR‐135a levels were unchanged, while miR‐92a levels were decreased (?0.21; p < 0.05). The high‐fat meal increased postprandial cholesterol efflux capacity (+4.3 percentage points; p ≤ 0.001), miR‐92a (+1.21; p < 0.001), and miR‐223 (+1.79; p < 0.001) levels, while a trend was found for miR‐135a (+1.08; p = 0.06).Conclusion
Theobromine did not improve fasting and postprandial ABCA1‐mediated cholesterol efflux capacity, but decreased fasting miR‐92a levels. High‐fat meal intake increased postprandial cholesterol efflux and the three selected miRNAs levels.18.
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Ping‐Jun Zhang Zhen‐Gang Zhao Shu‐Juan Yu Shu‐Zhen He 《International Journal of Food Science & Technology》2012,47(3):475-481
The formation and degradation of N‐(1‐Deoxy‐d ‐xylulos‐1‐yl)glycine and N‐(1‐Deoxy‐d ‐xylulos‐1‐yl)proline, derived from the secondary amine Maillard reaction in xylose‐amino acid model solutions, were detailed in this study. The identification and quantitative analysis of N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)glycine and N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)proline were carried out using high‐performance anion‐exchange chromatography and high‐performance liquid chromatography. The formation of intermediate and advanced products derived from N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)glycine and N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)proline was also tested using an UV‐Vis spectrophotometer to gain a better comparing of the degradation process of the two important Maillard reaction products using thermal treatment. Results showed that the degradation of N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)glycine was more significant than N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)proline. Moreover, xylose was tested in the degradation products of both N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)glycine and N‐(1‐Deoxy‐d‐ xylulos‐1‐yl)proline, which indicated that the degradation of N‐substituted 1‐amino‐1‐deoxyketoses was a reversible reaction to form reducing sugar. 相似文献