共查询到20条相似文献,搜索用时 15 毫秒
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Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery 下载免费PDF全文
Sanyang Han Animesh Samanta Xiaoji Xie Ling Huang Juanjuan Peng Sung Jin Park Daniel Boon Loong Teh Yongdoo Choi Young‐Tae Chang Angelo Homayoun All Yanmei Yang Bengang Xing Xiaogang Liu 《Advanced materials (Deerfield Beach, Fla.)》2017,29(40)
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Chunxia Li Dongmei Yang Ping'an Ma Yinyin Chen Yuan Wu Zhiyou Hou Yunlu Dai Jihong Zhao Changping Sui Jun Lin 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(24):4150-4159
Incorporating the agents for magnetic resonance imaging (MRI), optical imaging, and therapy in one nanostructured matrix to construct multifunctional nanomedical platform has attracted great attention for simultaneous diagnostic and therapeutic applications. In this work, a facile methodology is developed to construct a multifunctional anticancer drug nanocarrier by combining the special advantages of upconversion nanoparticles and mesoporous silica. β‐NaYF4:Yb3+, Er3+@β‐NaGdF4:Yb3+ is chosen as it can provide the dual modality of upconversion luminescence and MRI. Then mesoporous silica is directly coated onto the upconversion nanoparticles to form discrete, monodisperse, highly uniform, and core–shell structured nanospheres (labeled as UCNPs@mSiO2), which are subsequently functionalized with hydrophilic polymer poly(ethylene glycol) (PEG) to improve the colloidal stability and biocompatibility. The obtained multifunctional nanocomposites can be used as an anticancer drug delivery carrier and applied for imaging. The anticancer drug doxorubicin (DOX) is absorbed into UCNPs@mSiO2‐PEG nanospheres and released in a pH‐sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verify that the DOX‐loaded UCNPs@mSiO2‐PEG has comparable cytotoxicity with free DOX at the same concentration of DOX. In addition, the T1‐weighted MRI that measures in aqueous solutions reveals that the contrast brightening increases with the concentration of Gd3+ component. Upconversion luminescence images of UCNPs@mSiO2‐PEG uptaken by cells show green emission under 980 nm infrared laser excitation. Finally, the nanocomposites show low systematic toxicity and high in vivo antitumor therapy efficacy. These findings highlight the fascinating features of upconversion‐mesoporous nanocomposites as multimodality imaging contrast agents and nanocarrier for drug molecules. 相似文献
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Li Zhou Zhenhua Li Enguo Ju Zhen Liu Jinsong Ren Xiaogang Qu 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(24):4262-4268
Multifunctional lanthanide‐doped porous nanoparticles are prepared via a facile one‐step solvothermal route by employing aptamers as the biotemplate. The nanoparticles feature excellent aqueous dispersibility and biospecific properties and could work as effective nanoprobes for targeted imaging and drug delivery. With aptamer being in principle available for any kind of target, this synthetic strategy may open the door to a new generation of nanoprobes for bioapplications such as time‐resolved biodetection, multimode bioimaging/biolabeling, and targeted cancer therapy. 相似文献
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Theranostic Upconversion Nanobeacons for Tumor mRNA Ratiometric Fluorescence Detection and Imaging‐Monitored Drug Delivery 下载免费PDF全文
Qianwen Ding Qiuqiang Zhan Xiaoming Zhou Tao Zhang Da Xing 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(43):5944-5953
Remote optical detection and imaging of specific tumor‐related biomarkers and simultaneous activation of therapy according to the expression level of the biomarkers in tumor site with theranostic probes should be an effective modality for treatment of cancers. Herein, an upconversion nanobeacon (UCNPs‐MB/Dox) is proposed as a new theranostic nanoprobe to ratiometrically detect and visualize the thymidine kinase 1 (TK1) mRNA that can simultaneously trigger the Dox release to activate the chemotherapy accordingly. UCNPs‐MB/Dox is constructed with the conjugation of a TK1 mRNA‐specific molecular beacon (MB) bearing a quencher (BHQ‐1) and an alkene handle modified upconversion nanoparticle (UCNP) through click reaction and subsequently loading with a chemotherapy drug (Dox). With this nanobeacon, quantitative ratiometric upconversion detection of the target with high sensitivity and selectivity as well as the target triggered Dox release in vitro is demonstrated. The sensitive and selective ratiometric detection and imaging of TK1 mRNA under the irradiation of near infrared light (980 nm) and the mRNA‐dependent release of Dox for chemotherapy in the tumor MCF‐7 cells and A549 cells are also shown. This work provides a smart and robust platform for gene‐related tumor theranostics. 相似文献
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Qiao Jiang Shaoli Liu Jianbing Liu Zhen‐Gang Wang Baoquan Ding 《Advanced materials (Deerfield Beach, Fla.)》2019,31(45)
The recent decades have seen a surge of new nanomaterials designed for efficient drug delivery. DNA nanotechnology has been developed to construct sophisticated 3D nanostructures and artificial molecular devices that can be operated at the nanoscale, giving rise to a variety of programmable functions and fascinating applications. In particular, DNA‐origami nanostructures feature rationally designed geometries and precise spatial addressability, as well as marked biocompatibility, thus providing a promising candidate for drug delivery. Here, the recent successful efforts to employ self‐assembled DNA‐origami nanostructures as drug‐delivery vehicles are summarized. The remaining challenges and open opportunities are also discussed. 相似文献
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Hongyu Chen Bin Qi Thomas Moore Daniel C. Colvin Thomas Crawford John C. Gore Frank Alexis O. Thompson Mefford Jeffrey N. Anker 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(1):160-168
A method is developed to fabricate monodispersed biocompatible Yb/Er or Yb/Tm doped β‐NaGdF4 upconversion phosphors using polyelectrolytes to prevent irreversible particle aggregation during conversion of the precursor, Gd2O(CO3)2?H2O:Yb/Er or Yb/Tm, to β‐NaGdF4:Yb/Er or Yb/Tm. The polyelectrolyte on the outer surface of nanophosphors also provided an amine tag for PEGylation. This method is also employed to fabricate PEGylated magnetic upconversion phosphors with Fe3O4 as the core and β‐NaGdF4 as a shell. These magnetic upconversion nanophosphors have relatively high saturation magnetization (7.0 emu g?1) and magnetic susceptibility (1.7 × 10?2 emu g?1 Oe?1), providing them with large magnetophoretic mobilities. The magnetic properties for separation and controlled release in flow, their optical properties for cell labeling, deep tissue imaging, and their T1‐ and T2‐weighted magnetic resonance imaging (MRI) relaxivities are studied. The magnetic upconversion phosphors display both strong magnetophoresis, dual MRI imaging (r1 = 2.9 mM?1 s?1, r2 = 204 mM?1 s?1), and bright luminescence under 1 cm chicken breast tissue. 相似文献
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Chung Yen Ang Si Yu Tan Cathleen Teh Jia Min Lee Mun Fei Eddy Wong Qiuyu Qu Li Qing Poh Menghuan Li Yuanyuan Zhang Vladimir Korzh Yanli Zhao 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(7)
Responsive nanomaterials have emerged as promising candidates as drug delivery vehicles in order to address biomedical diseases such as cancer. In this work, polymer‐based responsive nanoparticles prepared by a supramolecular approach are loaded with doxorubicin (DOX) for the cancer therapy. The nanoparticles contain disulfide bonds within the polymer network, allowing the release of the DOX payload in a reducing environment within the endoplasm of cancer cells. In addition, the loaded drug can also be released under acidic environment. In vitro anticancer studies using redox and pH dual responsive nanoparticles show excellent performance in inducing cell death and apoptosis. Zebrafish larvae treated with DOX‐loaded nanoparticles exhibit an improved viability as compared with the cases treated with free DOX by the end of a 3 d treatment. Confocal imaging is utilized to provide the daily assessment of tumor size on zebrafish larva models treated with DOX‐loaded nanoparticles, presenting sustainable reduction of tumor. This work demonstrates the development of functional nanoparticles with dual responsive properties for both in vitro and in vivo drug delivery in the cancer therapy. 相似文献
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Megan E. Kizer Robert J. Linhardt Arun Richard Chandrasekaran Xing Wang 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(26)
Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA‐based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification to enrich or achieve the needed “properties” and make it whole. These modifications total what are categorized as the molecular hero suit of DNA nanotechnology. Like a hero, DNA nanostructures have the ability to put on a suit equipped with honing mechanisms, molecular flares, encapsulated cargoes, a protective body armor, and an evasive stealth mode. 相似文献
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Rui Guo Rutian Li Xiaolin Li Leyang Zhang Xiqun Jiang Baorui Liu 《Small (Weinheim an der Bergstrasse, Germany)》2009,5(6):709-717
An effective and facile approach to prepare gold‐nanoparticle‐encapsulated alginic acid‐poly[2‐(diethylamino)ethyl methacrylate] monodisperse hybrid nanospheres (ALG–PDEA–Au) is developed by using monodisperse ALG–PDEA nanospheres as a precursor nanoparticulate reaction system. This approach utilizes particle‐interior chemistry, which avoids additional reductant or laborious separation process and, moreover, elegantly ensures that all the gold nanoparticles are located inside the hybrid nanospheres and every nanosphere is loaded with gold nanoparticles. These obtained ALG–PDEA–Au hybrid nanospheres have not only uniform size, similar surface properties, and good biocompatibility but also unique optical properties provided by the embedded gold nanoparticles. It is demonstrated that negatively charged ALG–PDEA–Au hybrid nanospheres can be internalized by human colorectal LoVo cancer cells and hence act as novel optical‐contrast reagents in tumor‐cell imaging by optical microscopy. Moreover, these hybrid nanospheres can also serve as biocompatible carriers for the loading and delivery of an anti‐cancer drug doxorubicin. In vitro cell viability tests reveal that drug‐loaded ALG–PDEA–Au hybrid nanospheres exhibit similar tumor cell inhibition to the free drug doxorubicin. Therefore, the obtained hybrid nanospheres successfully combine two functions, that is, cell imaging and drug delivery, into one single system, and may be of great application potential in other biomedical‐related areas. 相似文献
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Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH‐/H2O2‐Responsive UCL Imaging and Oxygen‐Elevated Synergetic Therapy 下载免费PDF全文
Wenpei Fan Wenbo Bu Bo Shen Qianjun He Zhaowen Cui Yanyan Liu Xiangpeng Zheng Kuaile Zhao Jianlin Shi 《Advanced materials (Deerfield Beach, Fla.)》2015,27(28):4155-4161
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Near‐Infrared‐Triggered Azobenzene‐Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance 下载免费PDF全文
Chi Yao Peiyuan Wang Xiaomin Li Xiaoyu Hu Junli Hou Leyong Wang Fan Zhang 《Advanced materials (Deerfield Beach, Fla.)》2016,28(42):9341-9348
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Drug Delivery: Long‐Term Real‐Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer (Small 7/2017) 下载免费PDF全文
Sing Shy Liow Qingqing Dou Dan Kai Zibiao Li Sigit Sugiarto Chris Yee Yung Yu Ryan Tsz Kin Kwok Xiaohong Chen Yun‐Long Wu Seow Theng Ong Atish Kizhakeyil Navin K. Verma Ben Zhong Tang Xian Jun Loh 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(7)