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A coupled population balance model and CFD approach for the simulation of mixing issues in lab‐scale and industrial bioreactors
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Jérôme Morchain Jean‐Christophe Gabelle Arnaud Cockx 《American Institute of Chemical Engineers》2014,60(1):27-40
Lab‐scale (70 L) and industrial scale (70 m3) aerated fermenters are simulated using a commercial computational fluid dynamics code. The model combines an Euler‐Euler approach for the two‐phase flow, a population balance model for biological adaptation to concentration gradients, and a kinetic model for biological reactions. Scale‐up at constant volumetric mass transfer coefficient is performed, leading to concentration gradients at the large scale. The results show that for a given concentration field and a given circulation time tc, the population (physiological) state depends on the characteristic time of biological adaptation Ta. The population specific growth rate (Ta?tc) is found independent of the spatial location and closely related to the volume average concentration. Oppositely, the population specific uptake rate (Ta~tc) is spatially heterogeneous. The resulting local disequilibria between the uptake rate and the growth rate provide an explanation for the decreased performances of poorly macromixed industrial bioreactors. © 2013 American Institute of Chemical Engineers AIChE J, 60: 27–40, 2014 相似文献
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Arturo Macchi Patrick Plouffe Gregory S. Patience Dominique M. Roberge 《加拿大化工杂志》2019,97(10):2578-2587
Whereas the bulk chemical industry has historically sought economic advantage through economies of scale, a paradigm shift has researchers developing systems on smaller scales. Nano‐cages and nano‐actuators increase selectivity and robustness at the molecular scale. In parallel, micro‐contactors with sub‐millimetre lateral dimensions are decreasing boundary layers that restrict heat and mass transfer and thus meet the objectives of process intensification with great increases in productivity with a smaller footprint. These contactors continue to serve chemical engineers and chemists to synthesize fine chemicals and characterize catalysts; however, they have now been adopted for sensors in biological and biochemical systems. A bibliometric analysis of articles indexed in the Web of Science in 2016 and 2017 identified five major clusters of research: catalysis and bulk chemicals; nanoparticles; organic synthesis and flow chemistry; systems and micro‐fluidics applied to biochemistry; and micro‐channel reactors and mass transfer. In the early 1990s, less than 100 articles a year mentioned micro‐reactors, while over 943 articles mentioned it in 2017. Here, we introduce micro‐reactors and their role in the continuous synthesis of fine chemicals across the various scales to commercialization. 相似文献
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Some empirical mixing models were used to describe the imperfect mixing in precipitation process.However, the models can not, in general, reflect the details of interactions between mixing and crystallization in a vessel. In this study, CFD (computational fluid dynamics) technique were developed by simulating the precipitation of barium sulphate in stirred tanks by integration of population balance equations with a CFD solver. Two typical impellers, Rushton and pitched blade turbines, were employed for agitation. The influence of feed concentration and position on crystal product properties was investigated by CFD simulation. The scale-up of these precipitators was systematically studied. Significant effect on the crystal properties was found for the scale-up under some conditions.Keywords simulation, scale up, precipitation, CFD(computational fluid dynamics) 相似文献
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Ruina Qu De Lu Lei Su Min Niu Kang Peng Hongfei Gao Pengfei Guo Liang Xu Lei Zhuang Hongjie Wang 《Journal of the American Ceramic Society》2023,106(1):681-688
SiC nanowires (SiC NWs) possess both high thermal stability of SiC ceramic and one-dimensional nanoscale features, which makes them highly attractive as reinforcements in ceramics or building units in resilient ceramic nanowires aerogels (NWAs) as well as blocks for electronic nanodevices. Understanding the oxidation behavior of SiC NWs at high temperatures is essential for their practical applications. Herein, we investigated the oxidation behavior of SiC NWs at 900–1200°C in air. Two oxidation stages were found, including an initial stage controlled by the reaction between oxygen and SiC at the SiO2/SiC interface and a subsequent oxygen diffusion–dependent stage. The oxide scale thickness was strongly influenced by the radius of the SiC NWs. With the increase of the NW radius from 40 to 120 nm, the oxidation activation energy of the oxidation process increases from 84.05 to 98.32 kJ/mol. The thermal insulation performances of SiC NWA, which is composed of SiC NWs, have been improved after oxidation. The evolution of the thermal insulation performance of SiC NWA during oxidation is consistent with the trends of the growth of the amorphous oxide layer, which indicates that exploring the oxidation kinetics is of great significance in understanding the high-temperature behavior of SiC NW-based materials. The present work provides insight into exploring the size effects on oxidation of SiC NWs, which may be helpful to further understanding the high-temperature applications of SiC NWA. 相似文献
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ABSTRACT: A novel and convenient one-pot electrodeposition approach has been developed for precisely controlled fabrication of large-scale Bi-Ni nanowire and nanocable arrays. Using porous anodic aluminum oxide as a shape-directing template, by simply changing the electrochemical deposition mode, desired Bi-Ni hybrid nanowires and Bi-Ni core-shell nanocables have been obtained in the CV and CC modes, respectively. The structure, morphology, and composition of the as-prepared samples were characterized using X-ray powder diffraction, transmission electron microscopy, elemental mapping, and energy-dispersive X-ray spectrometry. 相似文献
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Bing Wang Kaisong Zhang Robert W. Field 《American Institute of Chemical Engineers》2018,64(7):2721-2736
Having previously established that the hydrodynamic effect introduced by slug bubbles is more effective and economic in fouling amelioration in flat sheet MBRs (FSMBR) than conventional bubbling, this work is focused on its implementation in a commercial FSMBR. The overall objective is to enhance the hydrodynamic effect on fouling control through the use of two‐stage large‐sized bubble development (coalescence and split). Computational Fluid Dynamics (CFD) was used to predict hydrodynamic features and substantial agreement was observed with experimental measurements. The critical height for bubble development space was determined to be circa 250 mm. Slug bubbles could be introduced into 14 channels, resulting in six‐fold stronger shear stress than that from single bubbles. Energy demand could be reduced by circa 50% compared with industry average usage and the shear stresses developed would, for most applications, be sufficient to ameliorate fouling. Furthermore, the specific air demand per permeate would be halved. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2721–2736, 2018 相似文献
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Zhenping Liu Alberto Passalacqua Michael G. Olsen Rodney O. Fox James C. Hill 《American Institute of Chemical Engineers》2016,62(7):2570-2578
The multi‐inlet vortex reactor (MIVR) is used for flash nanoprecipitation to manufacture functional nanoparticles. A validated computational fluid dynamics model is needed for the design, scale‐up, and optimization of the MIVR. Unfortunately, available Reynolds‐averaged Navier‐Stokes methods are unable to accurately model the highly swirling flow in the MIVR. Large‐eddy simulations (LES) are also problematic, as excessively fine grids are required to accurately model this flow. These dilemmas led to the application of the dynamic delayed detached eddy simulation (DDES) method to the MIVR. In the dynamic DDES model, the eddy viscosity has a form similar to the Smagorinsky sub‐grid viscosity in LES, which allows the implementation of a dynamic procedure to determine its model coefficient. Simulation results using the dynamic DDES model are found to match well with experimental data in terms of mean velocity and turbulence intensity, suggesting that the dynamic DDES model is a good option for modeling the turbulent swirling flow in the MIVR. © 2016 American Institute of Chemical Engineers AIChE J, 62: 2570–2578, 2016 相似文献
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Sepideh Afshar Lloyd Metzger Hasmukh Patel Cordelia Selomulya Meng Wai Woo 《Drying Technology》2019,37(7):824-838
Industrial multistage spray drying systems often have limited in situ process measurements to provide sufficient information for computational fluid dynamics (CFD) simulations of the primary drying chamber. In this case study on the spray dryer at Davis Dairy Plant (South Dakota State University), uncertainties were encountered in specifying the outlet boundary conditions of the spray drying chamber with two outlets: the side outlet and the bottom outlet leading to the second stage external vibrating bed. Using the available data on the vacuum pressure of the chamber, a numerical framework was introduced to approximate suitable outlet boundary conditions for the drying chamber. The procedure involved analyzing the ratio of the airflow rate between the two outlets and using a pseudo-tracer inert particle injection analysis. The goal of this approach was to determine a suitable range of outlet vacuum pressure that will lead to realistic particle movement behaviors during the actual plant operation. The protocol developed here will be a useful tool for CFD modeling of large scale multistage spray drying systems.
Abbreviations: ARC: Australian Research Council; CFD: Computational Fluid Dynamics; FFT: Fast Fourier Transform; MCC: Micellar Casein Concentrate; PRESTO: Pressure Staggering Option; SDSU: South Dakota State University; SIMPLE: Semi???Impilicit Method for Pressure Linked Equations; WPC: Whey Protein Concentrate 相似文献
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A hybrid approach to computing electrostatic forces in fluidized beds of charged particles
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Jari Kolehmainen Ali Ozel Christopher M. Boyce Sankaran Sundaresan 《American Institute of Chemical Engineers》2016,62(7):2282-2295
In particulate flow devices particles acquire electric charge through triboelectric charging, and resulting electrostatic forces can alter hydrodynamics. To capture this effect, the electrostatic force acting on individual particles in the device should be computed accurately. Electrostatic force is calculated using a hybrid approach consisting of: (1) long‐range contributions from an Eulerian electric field solved using the Poisson equation (2) short‐range contributions calculated using a truncated pairwise sum and (3) a correction to avoid double counting. Euler‐Lagrange simulation of flows incorporating this hybrid approach reveals that bed height oscillations in small fluidized beds of particles with monopolar charge decreases with increasing charge level, which is related to lateral segregation of particles. A ring‐like layer of particles, reported in experimental studies, forms at modestly high charge levels. Beds with equal amounts of positively and negatively charged particles are fluidized in a manner similar to uncharged particles. © 2016 American Institute of Chemical Engineers AIChE J, 62: 2282–2295, 2016 相似文献
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Xiao Xu Xiao‐Ling Ge Yun‐Dong Qian Hua‐Lin Wang Qiang Yang 《American Institute of Chemical Engineers》2018,64(7):2689-2701
A planar cyclone is designed for visualizing bubbles in the cross‐section of a degassing hydrocyclone. The pressure distribution is studied through a series of experiments and Reynolds stress model simulations. The velocity distribution of the planar cyclone mostly exhibits the quasi‐forced vortex zone and boundary layer zone. The bubble dynamics are simulated using both Euler‐Euler and Euler‐Lagrange approaches, and the output is compared with the imaging results. The Euler‐Euler simulation provides more accurate predictions of the bubble trajectory. The histograms of residence time and traveling distance given by the Euler‐Lagrange approach exhibit a reasonably regular pattern. With higher values of the inlet Reynolds number, stronger forces acting on the bubbles lead to a decreased but more uniform residence time. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2689–2701, 2018 相似文献
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在外加竖直方向梯度磁场的气固鼓泡流化床中,考虑铁磁颗粒受到的梯度磁场力和颗粒间磁感应力,对气相采用流体力学方法(CFD),颗粒相采用离散元法(DEM),建立二维磁鼓泡流化床数学模型,模拟不同磁场强度下全磁颗粒圆形床料的气固流动过程,分析了不同磁场强度对磁流化床中气泡生长、颗粒运动、床层压降和磁颗粒受力的影响。研究结果表明在沿高度磁感应强度递减的梯度磁场中,磁颗粒在颗粒间磁感应力的作用下凝聚成链,破坏了大气泡的形成。随着磁场强度增加,颗粒扩散系数减小,颗粒间磁感应力和梯度磁场力增大;气体与颗粒相间作用力先减小、后增加;而颗粒接触力先增加、后减小。 相似文献
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Rahmani Mohamed Ali Chahed Jamel Bellakhal Ghazi Alain Line 《American Institute of Chemical Engineers》2011,57(12):3315-3330
Gas dispersion in an airlift reactor focusing on the closure law on turbulent contribution of added mass is presented. A data bank for bubbly flow in an airlift reactor is presented. The liquid velocity is measured by hot film anemometry and gas fraction and velocity are measured with an optical probe. The sensitivity of numerical simulations of gas dispersion to the modeling of turbulent contribution of added mass is shown. Without the turbulent contribution, the bubbles move toward the region where the turbulence is high and the pressure is low. When the turbulent contribution is introduced, the bubble migration towards the low pressure region is counter‐balanced and the void fraction profile is significantly modified. The modeling of the turbulent contribution of added mass is expressed in terms of the turbulent correlations in the gas phase, uGi′uGj′ , that can be related to the Reynolds stress in the liquid phase, ui′uj′ . © 2011 American Institute of Chemical Engineers AIChE J, 2011 相似文献
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Shantanu Roy 《American Institute of Chemical Engineers》2017,63(1):314-326
Radiotracer techniques are widely used for troubleshooting and detection of pathological flows in industrial reactors. In recent decades, there has been a trend towards using radiotracer techniques for assessing flow field in industrial vessels, likening them to residence time distribution (RTD) measurements. On the other hand, radiation‐based particle tracking techniques such as Radioactive Particle Tracking (RPT) methods have become popular for laboratory investigations flow fields in multiphase reactors. Both the methods have been used to validate respective‐scale phenomenological and CFD models to some success, but in a rather independent and ad hoc fashion and not attempting to link the two techniques as flow interrogators in their respective domains. This communication tries to bridge these two techniques and proposes a way to link the two, and makes a case for using them as complementary techniques for measurements at the two scales, and for validating models at the two scales. © 2016 American Institute of Chemical Engineers AIChE J, 63: 314–326, 2017 相似文献
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A multicontinuum approach for the problem of filtration of oily water systems across thin flat membranes: I. The framework
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Amgad Salama Mohamed Zoubeik Amr Henni 《American Institute of Chemical Engineers》2017,63(10):4604-4615
A multicontinuum model is built to estimate the permeate flux of an oily water system across a thin flat membrane in cross filtration methodology is demonstrated. Several continua are constructed to represent droplet and pore‐size distribution of both the dispersed oil phase and the porous membrane, respectively. The possible permeation of the oil phase has been divided into three criteria. In the first criterion, oil droplets of a given size range may permeate through a given size range of the porous membrane, in the second criterion, oil droplets of another size range may be rejected through another pore size range, and in the third criterion, oil droplets may break apart leaving a tail inside the pore space, which will eventually permeate, and the rest will sweep off due to shear stress. These protocols identify the methodology of the proposed multicontinuum approach, which is introduced in this first part. © 2017 American Institute of Chemical Engineers AIChE J, 63: 4604–4615, 2017 相似文献