A historical perspective on recent studies of social learning about foods by Norway rats.

Reviews historical developments in the study of animal learning in social environments from the 19th century to the present. The need to combine the advantages of studying adaptive behavior in natural settings with carefully controlled laboratory experiments is stressed. Research on acquiring safe food preferences in wild rats is summarized. Data from both laboratory studies and naturalistic observation indicate that rats can be influenced in their choice of feeding sites and of food by the behavior of other rats. Broader applications of the ethopsychological approach to the study of animal learning are described. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Towards a cross-species pharmacology of sensorimotor gating: effects of amantadine, bromocriptine, pergolide and ropinirole on prepulse inhibition of acoustic startle in rats

Animal models in behavioral pharmacology can be evaluated based on their face, predictive and construct validity. A further level of validity may be achieved if a model is reproduced precisely across species--from laboratory animal to human--using identical conditions and manipulations to elicit identical behavioral changes. Under circumstances in which a model achieves 'homologous' validity, it should be possible to demonstrate that the same pharmacological agents produce parallel changes in the same behavior (as distinct from the clinical condition that the animal behaviors are hypothesized to model), when studied in laboratory animals and in humans. Studies have demonstrated that the disruption of sensorimotor gating of the startle reflex, measured by prepulse inhibition (PPI), in rats by dopamine agonists exhibits face, predictive and construct validity for the relative loss of PPI in schizophrenia patients. To assess the homologous validity of this model, and to expand its utility in understanding the pathophysiology of sensorimotor gating deficits and in developing novel antipsychotic agents to reverse these deficits, it will be important to study PPI across species, comparing response profiles to identical pharmacological manipulations. In the present studies, we report that PPI in rats is reduced in a dose-dependent manner by four dopamine agonists that can be administered with relative ease to humans. We also report that the PPI-disruptive effects of the clinically useful dopamine agonist pergolide are reversed by both typical and atypical antipsychotics. These studies establish a foundation for pursuing human pharmacological studies of PPI, and for extrapolating the substantial neurochemical and neurophysiological information from animal studies of PPI, towards understanding the neural basis for deficient sensorimotor gating in specific neuropsychiatric disorders.     

Genetic mechanisms controlling the domestication of a wild house mouse population (Mus musculus L.).

A controlled reenactment of the domestication process provided information on the relative effects of natural selection, inbreeding, and habitat upon an originally wild house-mouse population. Effects were assessed in 2 experiments by testing offspring that were bred under either laboratory or simulated natural conditions, systematically inbred or outbred, and postnatally fostered in laboratory or simulated natural habitats. Ss were a total of 100 male laboratory C57BL/6J, DBA/2J, and A/J mice, and 372 mice descended from wild mice. 10 generations of domestication failed to reveal any behavioral differences due to either natural selection or habitat on 9 different behavioral tests. Inbreeding strongly reduced intermale aggression, partially reduced resistance to recapture by humans, and failed to affect any of the 7 other behaviors. (40 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comparative view of face perception.

Face perception serves as the basis for much of human social exchange. Diverse information can be extracted about an individual from a single glance at their face, including their identity, emotional state, and direction of attention. Neuropsychological and functional magnetic resonance imaging (fMRI) experiments reveal a complex network of specialized areas in the human brain supporting these face-reading skills. Here we consider the evolutionary roots of human face perception by exploring the manner in which different animal species view and respond to faces. We focus on behavioral experiments collected from both primates and nonprimates, assessing the types of information that animals are able to extract from the faces of their conspecifics, human experimenters, and natural predators. These experiments reveal that faces are an important category of visual stimuli for animals in all major vertebrate taxa, possibly reflecting the early emergence of neural specialization for faces in vertebrate evolution. At the same time, some aspects of facial perception are only evident in primates and a few other social mammals, and may therefore have evolved to suit the needs of complex social communication. Because the human brain likely utilizes both primitive and recently evolved neural specializations for the processing of faces, comparative studies may hold the key to understanding how these parallel circuits emerged during human evolution. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Spatial orientation on a vertical maze in free-ranging fox squirrels (Sciurus niger).

To determine how squirrels return to remembered locations in an arboreal environment, wild fox squirrels (Sciurus niger) were trained on an outdoor vertical maze. Squirrels were trained on 1 route and tested with all routes accessible. Possible mechanisms of spatial orientation were distinguished with manipulations such as rotations, shifts, and blocked routes. Squirrels consistently used an extra-maze, allothetic frame of reference to orient and appeared to organize their memory of the route hierarchically. This study demonstrates that a laboratory technique, the maze, can be successfully brought into the field to measure mechanisms of spatial orientation under natural conditions in free-ranging wild rodents. Such studies will allow researchers to determine what kind of spatial information is acquired by wild animals under natural conditions and how this information is used. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Animal hypnosis: Factual status of a fictional concept.

Notes that animal hypnosis, or tonic immobility, is an easily induced and readily quantifiable phenomenon found in many different species. Recent findings on the behavioral, ecological, chemical, neurological, genetic, and ontogenetic aspects of animal hypnosis are reviewd in light of current and historical interpretations. The response seems to be quite sensitive to manipulations designed to affect fear. In terms of adaptive significance, the reaction can be modified through selective breeding, and both naturalistic as well as laboratory investigations bolster the thesis that tonic immobility may participate in the ecology of predator-prey relationships. (93 ref) (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The effects of choice on intrinsic motivation and related outcomes: A meta-analysis of research findings.

A meta-analysis of 41 studies examined the effect of choice on intrinsic motivation and related outcomes in a variety of settings with both child and adult samples. Results indicated that providing choice enhanced intrinsic motivation, effort, task performance, and perceived competence, among other outcomes. Moderator tests revealed the effect of choice on intrinsic motivation was stronger (a) for instructionally irrelevant choices compared to choices made between activities, versions of a task, rewards, and instructionally relevant options, (b) when 2 to 4 successive choices were given, (c) when rewards were not given after the choice manipulation, (d) when participants given choice were compared to the most controlling forms of control groups, (e) for children compared to adults, (f) for designs that yoked choice and control conditions compared to matched designs in which choice was reduced or designs in which nonyoked, nonmatched controls were used, and (g) when the experiment was conducted in a laboratory embedded in a natural setting. Implications for future research and applications to real-world settings are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of domestication on production and perception of mallard maternal alarm calls: Developmental lag in behavioral arousal.

Conducted field and laboratory studies to assess the effects of intense genetic selection on the production and perception of the maternal alarm calls of 150 domestic (Peking) and 120 wild mallard ducks (Anas platyrhynchos). With respect to production, the calls of wild and domestic Ss were comparable on 4 acoustic features and differed only slightly on 2 features. With respect to perception, the calls of wild and domestic hens were equally effective in promoting behavioral inhibition in wild and domestic ducklings. Although data reveal little or no effect of domestication on maternal alarm call, an unexpected effect was found regarding the domestic ducklings' behavior. Peking Ss showed a greater level of behavioral inhibition than mallards at 24 hrs of age. Further experiments indicated that the differential level of inhibition in the wild and domestic birds reflects a developmental lag in arousal consequent to domestication: 72-hr-old Peking ducklings were behaviorally more aroused than 24-hr-old Peking ducklings and were similar to 24-hr-old mallard ducklings in that respect. This appears to be the first demonstration of behavioral heterochrony, which is believed to be an important mechanism of behavioral evolution. (24 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-controlled visual discrimination learning of group-housed dwarf goats (Capra hircus): Behavioral strategies and effects of relocation on learning and memory.

In most studies on animal learning, individual animals are tested separately in a specific learning environment and with a limited number of trials per day. An alternative approach is to test animals in a familiar environment in their social group. In this study, the authors--applying a fully automated learning device--investigated voluntary, self-controlled visual shape discrimination learning of group-housed dwarf goats (Capra hircus). The majority of the tested goats showed successful shape discrimination, which indicates the adaptive value of an effective learning strategy. However, in each group, a few individual goats developed behavioral strategies different from shape discrimination to get reward. Relocation impairs memory retrieval (probably by attention shifting) only temporarily for previously learnt shapes. The results demonstrate the usefulness of a self-controlled learning paradigm to assess learning abilities of social species in their normal social settings. This may be especially relevant for captive animals to improve their welfare. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Role of melatonin in mediating seasonal energetic and immunologic adaptations

Winter is energetically demanding and stressful; thermoregulatory demands increase when food availability usually decreases. Physiological and behavioral adaptations, including termination of breeding, have evolved among nontropical animals to cope with the energy shortages during winter. Presumably, selection for the mechanisms that permit physiological and behavioral anticipation of seasonal ambient changes have led to current seasonal breeding patterns for many populations. In addition to the well-studied seasonal cycles of mating and birth, there are also significant seasonal cycles of illness and death among field populations of mammals and birds. Energetically challenging winter conditions can directly induce death via hypothermia, starvation, or shock; surviving these demanding conditions likely puts individuals under great physiological stress. The stress of coping with energetically demanding conditions may increase adrenocortical steroid levels that could indirectly cause illness and death by compromising immune function. Individuals would enjoy a survival advantage if seasonally recurring stressors could be anticipated and countered by bolstering immune function. The primary environmental cue that permits physiological anticipation of season is daily photoperiod, a cue that is mediated by melatonin. However, other environmental factors may interact with photoperiod to affect immune function and disease processes. Immune function is compromised during the winter in field studies of birds and mammals. However, laboratory studies of seasonal changes in mammalian immunity consistently report that immune function is enhanced in short day lengths. To resolve this apparent discrepancy, we hypothesize that winter stressors present in field studies counteract short-day enhancement of immune function. Prolonged melatonin treatment mimics short days, and also enhances rodent immune function. Reproductive responsiveness to melatonin appears to affect immune function. In sum, melatonin may be part of an integrative system to coordinate reproductive, immunologic, and other physiological processes to cope successfully with energetic stressors during winter.     

New cytotoxics in the treatment of bronchial cancers

The mammalian defense repertory comprises an array of individual behaviors that are extraordinarily sensitive to relevant features of the threat stimulus and the situation in which it occurs. In parallel with increasing awareness of the specificity and complexity of defensive behaviors and of their potential relevance to psychopathologies (e.g. anxiety, panic, and depression) is an escalating use of natural threat stimuli such as attacking conspecifics or predators in paradigms aimed at evaluating drug effects on defense. A review of the literature on benzodiazepine (BZ) and serotonin (5-HT) effects on conspecific and antipredator defense, including defensive analgesia, indicates that both types of stimuli elicit a wide array of relevant defensive behaviors. These studies suggest specificity of drug effects on particular behaviors, rather than a general alteration of all aspects of defense. However, stimulus variability and possible confounding of effects are a considerable problem with conspecific defense paradigms, while antipredator paradigms utilizing human experimenters as the predator may be difficult to use with the domesticated laboratory animal subjects. In addition, sensitivity to the organization of defensive behaviors and to differences between species in defense patterns is necessary to adequate interpretation of results. Nonetheless, these paradigms have permitted major advancements in analysis of the behavioral defense systems and their sensitive use in drug studies will greatly facilitate an understanding of the physiology of defense.     

Captivity and feralization.

Suggests that captivity is a neglected variable in behavioral research and that its effects are too often simplified as either distorting or facilitating. The present critical review begins with a working definition of captivity (constraint, segregation, protection, taming, and dependency) and moves to problems in measuring its behavioral effects. Many problems are based on indifference and misunderstanding. Ethologists have traditionally supposed the effects of captivity to be distorting, psychologists have supposed them innocuous or helpful, and zoo keepers and others have dramatized them as aberrant. Although uncommon, actual research on captivity suggests that many behaviors generalize well across laboratory and wild situations. Methods of systematic analysis of captivity are suggested. Feralization, the study of captive and domestic animals returned to wild conditions, is demonstrated in 2 experiments that assessed cage vs burrow raising and litter size as an agent of feralization in rats; such studies are seen as a convenient and productive means of studying the behavioral effects of captivity. (104 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Species differences in N-glucuronidation

Glucuronidation of amines has been shown to exhibit species differences in vitro and in vivo. Substrates for N-glucuronidation can be classified according to the chemical structures of the resulting glucuronides into two groups: compounds that form non-quaternary N-conjugates, and those that form the quaternary counterparts. For compounds of the former class-such as sulfonamides, arylamines, and alicyclic, cyclic, and heterocyclic amines-species differences appear to be less striking and are of a quantitative nature. No one common laboratory animal species used routinely in metabolism research (e.g. rat, mouse, dog, non-human primate, rabbit, and guinea pig) has been shown to be deficient in N-glucuronidation when all of the substrates studied and reported are taken into consideration. The ability of a species to form N-glucuronides is compound-dependent, although rabbit and guinea pig appear to exhibit the highest capacity for this bioconjugation among preclinical species. For tertiary amines, most notably the tricyclic antidepressant and antihistamine drugs, N-glucuronidation is commonly observed in non-human primates and man. There are examples, however, of quaternary glucuronidation occurring in lower animal species. In exploring species differences in amine conjugation in vivo, it is noted that the apparent absence of N-glucuronides in animal urine may not reflect the inability of that species to form such conjugates, since the N-glucuronides may be excreted in bile. Problems such as degradation or low recoveries commonly encountered in isolation and identification of in vivo metabolites further complicate the interpretation of data. Because of the wide range of pKa values exhibited by various classes of amines, caution also should be exercised for in vitro studies since incubation conditions for N-glucuronidation often are substrate- and species-dependent. Explanations for the species differences observed in N-glucuronidation appear to be emerging as rapid advances are made in the understanding of the glucuronosyltransferases at the molecular level. More information, however, remains to be gathered from the glucuronosyltransferase genes of animal species other than humans before a better understanding of species differences in N-glucuronidation can be achieved.     

Endocrine disruption in wildlife: a critical review of the evidence

In recent years, a number of man-made chemicals have been shown to be able to mimic endogenous hormones, and it has been hypothesized that alterations in the normal pattern of reproductive development seen in some populations of wildlife are linked with exposure to these chemicals. Of particular importance are those compounds that mimic estrogens and androgens (and their antagonists), because of their central role in reproductive function. In fact, the evidence showing that such chemicals actually do mimic (or antagonize) the action of hormones in the intact animal is limited. In only a few cases have laboratory studies shown that chemicals that mimic hormones at the molecular level (in vitro) also cause reproductive dysfunction in vivo at environmentally relevant concentrations. In addition, the reported studies on wild populations of animals are limited to a very few animal species and they have often centered on localized 'hot-spots' of chemical discharges. Nevertheless, many of these xenobiotics are persistent and accumulate in the environment, and therefore a more widespread phenomenon of endocrine disruption in wildlife is possible. This article reviews the evidence, from both laboratory and field studies, that exposure to steroid hormone mimics may impair reproductive function and critically assesses the weight of evidence for endocrine disruption in wildlife.     

Selective serotonin reuptake inhibitors dissociate fenfluramine's anorectic and neurotoxic effects: importance of dose, species and drug

Fenfluramine, a clinically prescribed appetite suppressant, has been found to damage brain serotonin (5-HT) neurons in every animal species tested to date. Recent findings indicate that fluoxetine, a selective 5-HT reuptake inhibitor (SSRI), can prevent fenfluramine-induced 5-HT neurotoxicity without blocking fenfluramine-induced appetite suppression. The purpose of our studies was several-fold: 1) To determine whether the ability for fluoxetine to dissociate fenfluramine-induced anorexia and neurotoxicity is dose-related; 2) to ascertain whether other SSRIs also prevent fenfluramine-induced neurotoxicity without altering its anorectic effect; 3) to determine whether similar fluoxetine/fenfluramine interactions are seen in another animal species (i.e., mice) and 4) to determine whether decreases in food intake seen after the fluoxetine/fenfluramine combination can be attributed to nonspecific behavioral suppression. Results from our studies indicate that fluoxetine's effects are, indeed, dose-related, because higher doses of fluoxetine are required to protect against the 5-HT neurotoxic effects of higher doses of fenfluramine. Further, our results indicate that fluoxetine's effects generalize to all other SSRIs tested (citalopram, paroxetine and sertraline), as well as to other species (mice). Finally, our results demonstrate that anorexia in animals receiving the fenfluramine/fluoxetine combination is not secondary to nonspecific behavioral suppression, because water intake is increased although food intake is decreased in the same animals. Together, these data suggest that the anorectic and 5-HT neurotoxic effects of fenfluramine may involve different mechanisms, and that by combining fenfluramine with SSRIs, it may be possible to exploit fenfluramine's clinically useful properties (e.g., anorexia) without risking brain 5-HT neural injury.     

An overview of wildlife husbandry and diseases in captivity

Wild animals have been maintained in close association with humans since the dawn of human creation. Tremendous advances have been made in the care and management of wild animals, but some areas still need improvement. It is therefore important to identify the husbandry factors which minimize or maximize the occurrence of infectious or parasitic diseases. A universal influence on all animals is stress, and it is critical that managers, administrators, veterinarians and regulatory officials understand the basic concepts and take steps to minimize stress in captive wild animal husbandry. To study the epizootiology of infectious and parasitic diseases, one must also understand the nidus concept of disease, which essentially holds that all animals evolved with a group of infectious and parasitic agents that have generally lived in harmony with their host. Now, with the movement of animals and agents throughout the world, explosive outbreaks of disease may occur, unless the responsible persons know which species may be closely associated, and follow appropriate husbandry practices and appropriate quarantine procedures.     

Strategies for change in substance abuse: Bridging community and clinical approaches.

Suggests that interventions for substance abuse problems in both community and clinical settings require considerations for epidemiology, natural course, and the personal processes necessary for behavior changes. In the community, public health approaches to effect positive health behavior changes are designed to use research and education, adoption of behavioral norms, and enactment of supportive legislation. Similar strategies can be used effectively in clinical settings; specifically, these may be empirically based assessments and feedback, treatment measures and environments that support sober functioning, and appropriate ground rules governing the conditions and expectations of treatment. The unique role of psychologists in the planning, implementation, and evaluation of both community and clinical interventions is described. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Entomological and rodent surveillance of suspected plague foci in agro-environmental and feral biotopes of a few districts in Maharashtra and Gujarat states of India

Studies carried out on entomological and rodent surveillance in agroclimatic and feral biotopes of five districts of Maharashtra and two districts of Gujarat revealed that the terrain features of the seven districts surveyed were conducive to wild rodent species, Tatera indica, a natural reservoir of plague and vector flea species, Xenopsylla cheopis. A total of 214 Tatera indica and three Bandicoota bengalensis were collected from burrows by the digging method and 89 rat fleas were retrieved. The flea index calculated ranged from 0.26 to 1.0 in different districts. The examination of blood serum samples, contact tissue impression smears and tissue organs (heart, lung, liver and spleen) of these wild rodents did not reveal any evidence of plague activity. The natural harbourages of Tatera indica were found to be elevated land or raised margins of agricultural fields or barren land with thorny bushes/xerophytic plants and parthenium grass. Agricultural fields having wet soil were found to be the preferred harbourages of Bandicoota bengalensis. Movement of wild rodents toward human settlement was observed to be the common phenomenon during the harvesting season which may lead to the creation of favorable conditions for plague outbreaks.     

Divergent expression of alpha1-protease inhibitor genes in mouse and human

The alpha1-protease inhibitor proteins of laboratory mice are homologous in sequence and function to human alpha1-antitrypsin and are encoded by a highly conserved multigene family comprised of five members. In humans, the inhibitor is expressed in liver and in macrophages and decreased expression or inhibitory activity is associated with a deficiency syndrome which can result in emphysema and liver disease in affected individuals. It has been proposed that macrophage expression may be an important component of the function of human alpha1-antitrypsin. Clearly, it is desirable to develop a mouse model of this deficiency syndrome, however, efforts to do this have been largely unsuccessful. In this paper, we report that aside from the issues of potentially redundant gene function, the mouse may not be a suitable animal for such studies, because there is no significant expression of murine alpha1-protease inhibitor in the macrophages of mice. This difference between the species appears to result from an absence of a functional macrophage-specific promoter in mice.     

Three dimensions of naturalness: An expanded definition of field research.

Reviews several definitions of field research, and presents an expanded framework for conceptualizing field research. Three theoretically independent dimensions commonly used in field designs—natural behavior, natural setting, and natural treatment—are defined and exemplified. Advantages of combining all 3 dimensions in research include the discovery of new empirical laws and increased internal and external validity. Empirical examples are given that illustrate how naturalistic dimensions can be implemented in many settings, both laboratory and field, often without loss of experimental control. (52 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)