共查询到20条相似文献,搜索用时 46 毫秒
1.
Shailendra Shakya Yaping He Xiaohong Ren Tao Guo Abi Maharjan Ting Luo Tingting Wang Ramesh Dhakhwa Balmukunda Regmi Haiyan Li Ruxandra Gref Jiwen Zhang 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(27)
The challenge of bacterial infection increases the risk of mortality and morbidity in acute and chronic wound healing. Silver nanoparticles (Ag NPs) are a promising new version of conventional antibacterial nanosystem to fight against the bacterial resistance in concern of the drug discovery void. However, there are several challenges in controlling the size and colloidal stability of Ag NPs, which readily aggregate or coalesce in both solid and aqueous state. In this study, a template‐guided synthesis of ultrafine Ag NPs of around 2 nm using water‐soluble and biocompatible γ‐cyclodextrin metal‐organic frameworks (CD‐MOFs) is reported. The CD‐MOF based synthetic strategy integrates AgNO3 reduction and Ag NPs immobilization in one pot achieving dual functions of reduced particle size and enhanced stability. Meanwhile, the synthesized Ag NPs are easily dispersible in aqueous media and exhibit effective bacterial inhibition. The surface modification of cross‐linked CD‐MOF particles with GRGDS peptide boosts the hemostatic effect that further enhances wound healing in synergy with the antibacterial effect. Hence, the strategy of ultrafine Ag NPs synthesis and immobilization in CD‐MOFs together with GRGDS modification holds promising potential for the rational design of effective wound healing devices. 相似文献
2.
Composites of Bacterial Cellulose and Small Molecule‐Decorated Gold Nanoparticles for Treating Gram‐Negative Bacteria‐Infected Wounds
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Ying Li Yue Tian Wenshu Zheng Yan Feng Rong Huang Jingxin Shao Rongbing Tang Peng Wang Yuexiao Jia Jiangjiang Zhang Wenfu Zheng Guang Yang Xingyu Jiang 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(27)
Bacterial infections, especially multidrug‐resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6‐diamino‐2‐pyrimidinethiol (DAPT)‐modified gold nanoparticles (Au‐DAPT NPs) is presented as a dressing (BC‐Au‐DAPT nanocomposites) for treating bacterially infected wounds. BC‐Au‐DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram‐negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility. On Escherichia coli‐ or Pseudomonas aeruginosa‐infected full‐thickness skin wounds on rats, the BC‐Au‐DAPT nanocomposites inhibit bacterial growth and promote wound repair. Thus, the BC‐Au‐DAPT nanocomposite system is a promising platform for treating superbug‐infected wounds. 相似文献
3.
DNA‐Assembled Core‐Satellite Upconverting‐Metal–Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy
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Liangcan He Michael Brasino Chenchen Mao Suehyun Cho Wounjhang Park Andrew P. Goodwin Jennifer N. Cha 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(24)
DNA‐mediated assembly of core–satellite structures composed of Zr(IV)‐based porphyrinic metal‐organic framework (MOF) and NaYF4,Yb,Er upconverting nanoparticles (UCNPs) for photodynamic therapy (PDT) is reported. MOF NPs generate singlet oxygen (1O2) upon photoirradiation with visible light without the need for additional small molecule, diffusional photosensitizers such as porphyrins. Using DNA as a templating agent, well‐defined MOF–UCNP clusters are produced where UCNPs are spatially organized around a centrally located MOF NP. Under NIR irradiation, visible light emitted from the UCNPs is absorbed by the core MOF NP to produce 1O2 at significantly greater amounts than what can be produced from simply mixing UCNPs and MOF NPs. The MOF–UCNP core–satellite superstructures also induce strong cell cytotoxicity against cancer cells, which are further enhanced by attaching epidermal growth factor receptor targeting affibodies to the PDT clusters, highlighting their promise as theranostic photodynamic agents. 相似文献
4.
Eyal Malka Ilana Perelshtein Anat Lipovsky Yakov Shalom Livnat Naparstek Nina Perkas Tal Patick Rachel Lubart Yeshayahu Nitzan Ehud Banin Aharon Gedanken 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(23):4069-4076
Zinc‐doped copper oxide nanoparticles are synthesized and simultaneously deposited on cotton fabric using ultrasound irradiation. The optimization of the processing conditions, the specific reagent ratio, and the precursor concentration results in the formation of uniform nanoparticles with an average size of ≈30 nm. The antibacterial activity of the Zn‐doped CuO Cu0.88Zn0.12O in a colloidal suspension or deposited on the fabric is tested against Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) bacteria. A substantial enhancement of 10 000 times in the antimicrobial activity of the Zn–CuO nanocomposite compared to the pure CuO and ZnO nanoparticles (NPs) is observed after 10 min exposure to the bacteria. Similar activities are observed against multidrug‐resistant bacteria (MDR), (i.e., Methicillin‐resistant S. aureus and MDR E. coli) further emphasizing the efficacy of this composite. Finally, the mechanism for this enhanced antibacterial activity is presented. 相似文献
5.
Xin Pang Xue Liu Yi Cheng Chang Zhang En Ren Chao Liu Yang Zhang Jing Zhu Xiaoyuan Chen Gang Liu 《Advanced materials (Deerfield Beach, Fla.)》2019,31(35)
Antibiotic‐free methods hold particular promise for preventing and controlling multidrug‐resistant (MDR) bacterial infection via eradiation of bacteria and their pathogenic virulence. A facile and bioinspired strategy is presented for bridging antibacterial sonodynamic therapy and antivirulence immunotherapy. As a proof‐of‐concept, an antibody which neutralizes alpha‐toxin of methicillin‐resistant Staphylococcus aureus (MRSA) is genetically engineered on to the surface of cell membrane nanovesicles, which then undergo sonosensitizer encapsulation. Compared with conventional passive virulence absorption using natural red blood membrane, the highly active antibody–toxin interaction enables the nanovesicles to capture virulence more potently in vitro. Upon ultrasound activation, the sonosensitizers efficiently generate reactive oxygen species to kill bacteria and accelerate the virulence clearance. In vivo optical imaging shows that the antibody‐piloted nanocapturer can successfully locate MRSA infection and accurately distinguish the foci from sterile inflammation. In situ magnetic resonance imaging and oxyhemoglobin saturation detection visualize the treatment progression, revealing a complete sono‐immunotherapeutic eradication of MRSA myositis in mice. The first combination of antibacterial sonodynamic therapy and antivirulence immunotherapy, which promises a new way for antibiotic‐free nanotheranostics to robustly combat MDR bacterial infections, is presented. 相似文献
6.
Ya‐Fang Xiao Chenyang Xiang Shengliang Li Cong Mao Haoting Chen Jia‐Xiong Chen Shuang Tian Xiao Cui Yingpeng Wan Zhongming Huang Xiaozhen Li Xiao‐Hong Zhang Weisheng Guo Chun‐Sing Lee 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(34)
Multi‐modality imaging‐guided cancer therapy is considered as a powerful theranostic platform enabling simultaneous precise diagnosis and treatment of cancer. However, recently reported multifunctional systems with multiple components and sophisticate structures remain major obstacles for further clinical translation. In this work, a single‐photomolecular theranostic nanoplatform is fabricated via a facile nanoprecipitation strategy. By encapsulating a semiconductor oligomer (IT‐S) into an amphiphilic lipid, water‐dispersible IT‐S nanoparticles (IT‐S NPs) are prepared. The obtained IT‐S NPs have a very simple construction and possess ultra‐stable near‐infrared (NIR) fluorescence (FL)/photoacoustic (PA) dual‐modal imaging and high photothermal conversion efficiency of 72.3%. Accurate spatiotemporal distribution profiles of IT‐S NPs are successfully visualized by NIR FL/PA dual‐modal imaging. With the comprehensive in vivo imaging information provided by IT‐S NPs, tumor photothermal ablation is readily realized under precise manipulation of laser irradiation, which greatly improves the therapeutic efficacy without any obvious side effects. Therefore, the IT‐S NPs allow high tumor therapeutic efficacy under the precise guidance of FL/PA imaging techniques and thus hold great potential as an effective theranostic platform for future clinical applications. 相似文献
7.
One‐Pot Synthesis of Multifunctional Au@Graphene Oxide Nanocolloid Core@Shell Nanoparticles for Raman Bioimaging,Photothermal, and Photodynamic Therapy
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Young‐Kwan Kim Hee‐Kyung Na Seongchan Kim Hongje Jang Sung‐Jin Chang Dal‐Hee Min 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(21):2527-2535
The paper reports a facile one‐pot synthesis of core@shell nanoparticles (NPs) composed of Au core and graphene oxide nanocolloid (GON) shell. Unique properties of Au NPs and GON can be incorporated into a single nanohybrid structure to provide desirable functions for theranosis such as localized surface plasmon resonance, Raman scattering, amphiphilic surface, and photothermal conversion. Synthesis of Au@GON NPs is achieved by simple one‐pot reaction in aqueous phase utilizing GON as a reducing and stabilizing agent without any additional reducing agent. The zinc phthalocyanine, a photosensitizer, loaded Au@GON NPs show excellent multifunctional properties for combinational treatment of photothermal and photodynamic therapy in addition to Raman bioimaging with low cytotoxicity. 相似文献
8.
Dongdong Wang Huihui Wu Wei Qi Lim Soo Zeng Fiona Phua Pengping Xu Qianwang Chen Zhen Guo Yanli Zhao 《Advanced materials (Deerfield Beach, Fla.)》2019,31(27)
Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen (1O2). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal–organic frameworks (MOFs) is presented for in situ generation of endogenous O2 to enhance the PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese‐based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post‐modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O2 generation through the catalytic reaction between the catalytic amount NE and the endogenous H2O2, the hypoxic tumor microenvironment is relieved. Thus, Ce6‐loaded NE serves as a H2O2‐activated oxygen supplier to increase the local O2 concentration for significantly enhanced antitumor PDT efficacy in vitro and in vivo. In addition, the NE also shows T2‐weighted magnetic resonance imaging ability for its in vivo tracking. This work presents an interesting biomedical use of MOF‐derived mesoporous NE as a multifunctional theranostic agent in cancer therapy. 相似文献
9.
Changyu Cao Wei Ge Jiajia Yin Dongliang Yang Wenjun Wang Xuejiao Song Yanling Hu Jie Yin Xiaochen Dong 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(24)
The emergence of multidrug resistant bacteria has resulted in plenty of stubborn nosocomial infections and severely threatens human health. Developing novel bactericide and therapeutic strategy is urgently needed. Herein, mesoporous silica supported silver–bismuth nanoparticles (Ag‐Bi@SiO2 NPs) are constructed for synergistic antibacterial therapy. In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin‐resistant Staphylococcus aureus (MRSA). Besides, under laser irradiation, Ag‐Bi@SiO2 NPs at 100 µg mL?1 can effectively obliterate mature MRSA biofilm and cause a 69.5% decrease in the biomass, showing a better therapeutic effect than Bi@SiO2 NPs with laser (26.8%) or Ag‐Bi@SiO2 NPs without laser treatment (30.8%) groups. More importantly, in vivo results confirm that ≈95.4% of bacteria in abscess are killed and the abscess ablation is accelerated using the Ag‐Bi@SiO2 NPs antibacterial platform. Therefore, Ag‐Bi@SiO2 NPs with photothermal‐enhanced antibacterial activity are a potential nano‐antibacterial agent for the treatment of skin infections. 相似文献
10.
Dapeng Chen Qing Yu Xuan Huang Hanming Dai Tao Luo Jinjun Shao Peng Chen Jie Chen Wei Huang Xiaochen Dong 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(23)
Hypoxia severely impedes photodynamic therapy (PDT) efficiency. Worse still, considerable tumor metastasis will occur after PDT. Herein, an organic superoxide radical (O2??) nano‐photogenerator as a highly effcient type I photosensitizer with robust vascular‐disrupting efficiency to combat these thorny issues is designed. Boron difluoride dipyrromethene (BODIPY)‐vadimezan conjugate (BDPVDA) is synthesized and enwrapped in electron‐rich polymer‐brushes methoxy‐poly(ethylene glycol)‐b‐poly(2‐(diisopropylamino) ethyl methacrylate) (mPEG‐ PPDA) to afford nanosized hydrophilic type I photosensitizer (PBV NPs). Owing to outstanding core–shell intermolecular electron transfer between BDPVDA and mPEG‐PPDA, remarkable O2?? can be produced by PBV NPs under near‐infrared irradiation even in severe hypoxic environment (2% O2), thus to accomplish effective hypoxic‐tumor elimination. Simultaneously, the efficient ester‐bond hydrolysis of BDPVDA in the acidic tumor microenvironment allows vadimezan release from PBV NPs to disrupt vasculature, facilitating the shut‐down of metastatic pathways. As a result, PBV NPs will not only be powerful in resolving the paradox between traditional type II PDT and hypoxia, but also successfully prevent tumor metastasis after type I PDT treatment (no secondary‐tumors found in 70 days and 100% survival rate), enabling enhancement of existing hypoxic‐and‐metastatic tumor treatment. 相似文献
11.
Reassembly of 89Zr‐Labeled Cancer Cell Membranes into Multicompartment Membrane‐Derived Liposomes for PET‐Trackable Tumor‐Targeted Theranostics
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Bo Yu Shreya Goel Dalong Ni Paul A. Ellison Cerise M. Siamof Dawei Jiang Liang Cheng Lei Kang Faquan Yu Zhuang Liu Todd E. Barnhart Qianjun He Han Zhang Weibo Cai 《Advanced materials (Deerfield Beach, Fla.)》2018,30(13)
Nanoengineering of cell membranes holds great potential to revolutionize tumor‐targeted theranostics, owing to their innate biocompatibility and ability to escape from the immune and reticuloendothelial systems. However, tailoring and integrating cell membranes with drug and imaging agents into one versatile nanoparticle are still challenging. Here, multicompartment membrane‐derived liposomes (MCLs) are developed by reassembling cancer cell membranes with Tween‐80, and are used to conjugate 89Zr via deferoxamine chelator and load tetrakis(4‐carboxyphenyl) porphyrin for in vivo noninvasive quantitative tracing by positron emission tomography imaging and photodynamic therapy (PDT), respectively. Radiolabeled constructs, 89Zr‐Df‐MCLs, demonstrate excellent radiochemical stability in vivo, target 4T1 tumors by the enhanced permeability and retention effect, and are retained long‐term for efficient and effective PDT while clearing gradually from the reticuloendothelial system via hepatobiliary excretion. Toxicity evaluation confirms that the MCLs do not impose acute or chronic toxicity in intravenously injected mice. Additionally, 89Zr‐labeled MCLs can execute rapid and highly sensitive lymph node mapping, even for deep‐seated sentinel lymph nodes. The as‐developed cell membrane reassembling route to MCLs could be extended to other cell types, providing a versatile platform for disease theranostics by facilely and efficiently integrating various multifunctional agents. 相似文献
12.
In Situ Disinfection through Photoinspired Radical Oxygen Species Storage and Thermal‐Triggered Release from Black Phosphorous with Strengthened Chemical Stability
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Lei Tan Jun Li Xiangmei Liu Zhenduo Cui Xianjin Yang Kelvin Wai Kwok Yeung Haobo Pan Yufeng Zheng Xianbao Wang Shuilin Wu 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(9)
Photodynamic therapy (PDT) utilizing light‐induced reactive oxygen species (ROS) is a promising alternative to combat antibiotic‐resistant bacteria and biofilm. However, the photosensitizer (PS)‐modified surface only exhibits antibacterial properties in the presence of light. It is known that extended photoirradiation may lead to phototoxicity and tissue hypoxia, which greatly limits PDT efficiency, while ambient pathogens also have the opportunity to attach to biorelevant surfaces in medical facilities without light. Here, an antimicrobial film composed of black phosphorus nanosheets (BPSs) and poly (4‐pyridonemethylstyrene) endoperoxide (PPMS‐EPO) to control the storage and release of ROS reversibly is introduced. BPS, as a biocompatible PS, can produce high singlet oxygen under the irradiation of visible light of 660 nm, which can be stably stored in PPMS‐EPO. The ROS can be gradually thermally released in the dark. In vitro antibacterial studies demonstrate that the PPMS‐EPO/BPS film exhibits a rapid disinfection ability with antibacterial rate of 99.3% against Escherichia coli and 99.2% against Staphylococcus aureus after 10 min of irradiation. Even without light, the corresponding antibacterial rate reaches 76.5% and 69.7%, respectively. In addition, incorporating PPMS significantly improves the chemical stability of the BPS. 相似文献
13.
Ultrastable Near‐Infrared Conjugated‐Polymer Nanoparticles for Dually Photoactive Tumor Inhibition
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Tao Yang Ling Liu Yibin Deng Zhengqing Guo Guobing Zhang Zhishen Ge Hengte Ke Huabing Chen 《Advanced materials (Deerfield Beach, Fla.)》2017,29(31)
It is highly desired that satisfactory photoactive agents with ideal photophysical characteristics are explored for potent cancer phototherapeutics. Herein, bifunctional nanoparticles of low‐bandgap donor–acceptor (D–A)‐type conjugated‐polymer nanoparticles (CP‐NPs) are developed to afford a highly efficient singlet‐to‐triplet transition and photothermal conversion for near‐infrared (NIR) light‐induced photodynamic (PDT)/photothermal (PTT) treatment. CP‐NPs display remarkable NIR absorption with the peak at 782 nm, and perfect resistance to photobleaching. Photoexcited CP‐NPs undergo singlet‐to‐triplet intersystem crossing through charge transfer in the excited D–A system and simultaneous nonradiative decay from the electron‐deficient electron acceptor isoindigo derivative under single‐wavelength NIR light irradiation, leading to distinct singlet oxygen quantum yield and high photothermal conversion efficiency. Moreover, the CP‐NPs display effective cellular uptake and cytoplasmic translocation from lysosomes, as well as effective tumor accumulation, thus promoting severe light‐triggered damage caused by favorable reactive oxygen species (ROS) generation and potent hyperthermia. Thus, CP‐NPs achieve photoactive cell damage through their photoconversion ability for synergistic PDT/PTT treatment with tumor ablation. The proof‐of‐concept design of D–A‐type conjugated‐polymer nanoparticles with ideal photophysical characteristics provides a general approach to afford potent photoactive cancer therapy. 相似文献
14.
Metal–Organic‐Framework‐Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy
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Duo Mao Fang Hu Kenry Shenglu Ji Wenbo Wu Dan Ding Deling Kong Bin Liu 《Advanced materials (Deerfield Beach, Fla.)》2018,30(18)
Bacterial infection is one of the most serious physiological conditions threatening human health. There is an increasing demand for more effective bacterial diagnosis and treatment through noninvasive theranostic approaches. Herein, a new strategy is reported to achieve in vivo metabolic labeling of bacteria through the use of MIL‐100 (Fe) nanoparticles (NPs) as the nanocarrier for precise delivery of 3‐azido‐d ‐alanine (d ‐AzAla). After intravenous injection, MIL‐100 (Fe) NPs can accumulate preferentially and degrade rapidly within the high H2O2 inflammatory environment, releasing d ‐AzAla in the process. d ‐AzAla is selectively integrated into the cell walls of bacteria, which is confirmed by fluorescence signals from clickable DBCO‐Cy5. Ultrasmall photosensitizer NPs with aggregation‐induced emission characteristics are subsequently designed to react with the modified bacteria through in vivo click chemistry. Through photodynamic therapy, the amount of bacteria on the infected tissue can be significantly reduced. Overall, this study demonstrates the advantages of metal–organic‐framework‐assisted bacteria metabolic labeling strategy for precise bacterial detection and therapy guided by fluorescence imaging. 相似文献
15.
Metal–organic frameworks (MOFs)—an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers—have attracted increasing attention in recent years. The superior properties of MOFs, such as well‐defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here. 相似文献
16.
Photoreduction of CO2 into reusable carbon forms is considered as a promising approach to address the crisis of energy from fossil fuels and reduce excessive CO2 emission. Recently, metal–organic frameworks (MOFs) have attracted much attention as CO2 photoreduction‐related catalysts, owing to their unique electronic band structures, excellent CO2 adsorption capacities, and tailorable light‐absorption abilities. Recent advances on the design, synthesis, and CO2 reduction applications of MOF‐based photocatalysts are discussed here, beginning with the introduction of the characteristics of high‐efficiency photocatalysts and structural advantages of MOFs. The roles of MOFs in CO2 photoreduction systems as photocatalysts, photocatalytic hosts, and cocatalysts are analyzed. Detailed discussions focus on two constituents of pure MOFs (metal clusters such as Ti–O, Zr–O, and Fe–O clusters and functional organic linkers such as amino‐modified, photosensitizer‐functionalized, and electron‐rich conjugated linkers) and three types of MOF‐based composites (metal–MOF, semiconductor–MOF, and photosensitizer–MOF composites). The constituents, CO2 adsorption capacities, absorption edges, and photocatalytic activities of these photocatalysts are highlighted to provide fundamental guidance to rational design of efficient MOF‐based photocatalyst materials for CO2 reduction. A perspective of future research directions, critical challenges to be met, and potential solutions in this research field concludes the discussion. 相似文献
17.
Wenjia Xie Junyu Chen Xinting Cheng Hao Feng Xin Zhang Zhou Zhu Shanshan Dong Qianbing Wan Xibo Pei Jian Wang 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(14):2205941
Drug-resistant bacterial infection impairs tissue regeneration and is a challenging clinical problem. Metal–organic frameworks (MOFs)-based photodynamic therapy (PDT) opens up a new era for antibiotic-free infection treatment. However, the MOF-based PDT normally encounters limited photon absorbance under visible light and notorious recombination of photogenerated holes and electrons, which significantly impede their applications. Herein, a MOFs-based nanosystem (AgNPs@MOFs) with enhanced visible light response and charge carrier separation is developed by modifying MOFs with silver nanoparticles (AgNPs) to improve PDT efficiency. The AgNPs@MOFs with enhanced photodynamic performance under visible light irradiation mainly disrupt bacteria translation process and the metabolism of purine and pyrimidine. In addition, the introduction of AgNPs endows nanosystems with chemotherapy ability, which causes destructive effect on bacterial cell membrane, including membrane ATPase protein and fatty acids. AgNPs@MOFs show excellent synergistic drug-resistant bacterial killing efficiency through multiple mechanisms, which further restrain bacterial resistance. In addition, biocompatible AgNPs@MOFs pose potential tissue regeneration ability in both Methicillin–resistant Staphylococcus aureus (MRSA)-related soft and hard tissue infection. Overall, this study provides a promising perspective in the exploration of AgNPs@MOFs as nano antibacterial medicine against drug-resistant bacteria for infected tissue regeneration in the future. 相似文献
18.
Hao Chen Jie Yang Lin Sun Hengrui Zhang Yishun Guo Jia Qu Wenya Jiang Wei Chen Jian Ji Ying‐Wei Yang Bailiang Wang 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(47)
Endophthalmitis, derived from the infections of pathogens, is a common complication during the use of ophthalmology‐related biomaterials and after ophthalmic surgery. Herein, aiming at efficient photodynamic therapy (PDT) of bacterial infections and biofilm eradication of endophthalmitis, a pH‐responsive zeolitic imidazolate framework‐8‐polyacrylic acid (ZIF‐8‐PAA) material is constructed for bacterial infection–targeted delivery of ammonium methylbenzene blue (MB), a broad‐spectrum photosensitizer antibacterial agent. Polyacrylic acid (PAA) is incorporated into the system to achieve higher pH responsiveness and better drug loading capacity. MB‐loaded ZIF‐8‐PAA nanoparticles are modified with AgNO3/dopamine for in situ reduction of AgNO3 to silver nanoparticles (AgNPs), followed by a secondary modification with vancomycin/NH2‐polyethylene glycol (Van/NH2‐PEG), leading to the formation of a composite nanomaterial, ZIF‐8‐PAA‐MB@AgNPs@Van‐PEG. Dynamic light scattering, transmission electron microscopy, and UV–vis spectral analysis are used to explore the nanoparticles synthesis, drug loading and release, and related material properties. In terms of biological performance, in vitro antibacterial studies against three kinds of bacteria, i.e., Escherichia coli, Staphylococcus aureus, and methicillin‐resistant S. aureus, suggest an obvious superiority of PDT/AgNPs to any single strategy. Both in vitro retinal pigment epithelium cellular biocompatibility experiments and in vivo mice endophthalmitis models verify the biocompatibility and antibacterial function of the composite nanomaterials. 相似文献
19.
Site‐Selective Catalysis of a Multifunctional Linear Molecule: The Steric Hindrance of Metal–Organic Framework Channels
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Weina Zhang Bing Zheng Wenxiong Shi Xinyi Chen Zhiling Xu Shuzhou Li Yonggui Robin Chi Yanhui Yang Jun Lu Wei Huang Fengwei Huo 《Advanced materials (Deerfield Beach, Fla.)》2018,30(23)
The site‐selective reaction of a multifunctional linear molecule requires a suitable catalyst possessing both uniform narrow channel to limit the molecule rotation and a designed active site in the channel. Recently, nanoparticles (NPs) were incorporated in metal–organic frameworks (MOFs) with the tailorable porosity and ordered nanochannel, which makes these materials (NPs/MOFs) highly promising candidates as catalytic nanoreactors in the field of heterogeneous catalysis. Inspired by a “Gondola” sailing in narrow “Venetian Canal” without sufficient space for a U‐turn, a simple heterogeneous catalyst based on NPs/MOFs is developed that exhibits site‐selectivity for the oxidation of diols by restricting the random rotation of the molecule (the “Gondola”) in the limited space of the MOF channel (the narrow “Venetian Canal”), thereby protecting the middle functional group via steric hindrance. This strategy is not limited to the oxidation of diols, but can be extended to the site‐selective reaction of many similar multifunctional linear molecules, such as the reduction of alkadienes. 相似文献
20.
Carl D. Saquing Joshua L. Manasco Saad A. Khan 《Small (Weinheim an der Bergstrasse, Germany)》2009,5(8):944-951
A facile approach to synthesize and incorporate metal nanoparticles (NPs) into electrospun polymer nanofibers (NFs) wherein the electrospinning polymer acts as both a reducing agent for the metal salt precursor, as well as a protecting and templating agent for the ensuing NPs, is reported. Such a true one‐step process at ambient conditions and free of organic solvents is demonstrated using a system comprising AgNO3 and poly(ethylene oxide) (PEO) at electrospinnable molecular weights of 600, 1000, or 2000 kDa. The PEO transforms Ag+ into AgNPs, a phenomenon that has not been previously possible at PEO molecular weights less than 20 kDa without the addition of a separate reducing agent and stabilizer or the application of heat. Results from X‐ray photoelectron spectroscopy and UV–Vis absorption spectrophotometry analyses support the formation of pseudo‐crown ethers in high molecular weight PEO as the mechanism in the development of NPs. The AgNPs reduce fiber diameter and enhance fiber quality (reduced beading) due to increased electrical conductivity. Interestingly, several of the NFs exhibit AgNP‐localized nanochain formation and protrusion from the NF surface that can be attributed to the combined effect of applied electrical field on the polymer and the differences between the electrical conductivity and polarizability of the polymer and metal NPs. 相似文献