Encoding modality can affect memory accuracy via retrieval orientation.

Research indicates that false memory is lower following visual than auditory study, potentially because visual information is more distinctive. In the present study we tested the extent to which retrieval orientation can cause a modality effect on memory accuracy. Participants studied unrelated words in different modalities, followed by criterial recollection tests that selectively oriented retrieval toward one study modality at a time. Memory errors were lower when oriented toward visual than toward auditory information, thereby generalizing the modality effect to an explicit source memory task. Moreover, these effects persisted independent of the test presentation modality, indicating that retrieval orientation overrode the potential cuing properties of the test stimulus. An independent manipulation check confirmed that visual recollections were subjectively experienced as more distinctive than auditory recollections. These results suggest that retrieval orientation is sufficient to cause a modality effect on memory accuracy by focusing monitoring processes on the recollection of studied features that are diagnostic of prior presentation. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Reducing gist-based false recognition in older adults: Encoding and retrieval manipulations.

Using a categorized pictures paradigm, Koutstaal and Schacter (1997) reported high levels of false recognition of lures that were categorically related to presented items. Although also shown by younger adults, false recognition was markedly higher for older adults. To probe the factors underlying this age difference, these experiments required participants to engage in more careful scrutiny of the items at retrieval or to notice specific differentiating perceptual features of the objects during encoding. False recognition was reduced with each of these manipulations, but neither manipulation, either separately or together, eliminated the age difference in false recognition. Older adults can considerably reduce false recognition if encouraged to use more stringent decision criteria. Persistent difficulty in opposing familiarity-based responding and comparatively more generic encoding may contribute to residual deficits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Encoding and retrieval processes in velo-cardio-facial syndrome (VCFS).

Velo-cardio-facial syndrome (VCFS) is a neurogenetic disorder associated with very high risk for developing schizophrenia. More than half of affected individuals experience transient psychotic symptoms during childhood and a third may develop schizophrenia. Memory regulation deficits disturbing both the encoding and retrieval stages of memory represent core deficits in the cognitive profile associated with schizophrenia. In this study, the authors investigate memory regulation processes in 33 individuals with VCFS along with 33 age- and sex-matched control participants. By using a directed forgetting paradigm and a continuous recognition paradigm, the authors examined selective encoding and suppression of irrelevant contents during retrieval in VCFS. Group comparison analyses revealed comparable performances on selective encoding and recognition accuracy between the VCFS group and control group. However, individuals with VCFS were more likely to make false recognitions and showed deficits in the suppression of irrelevant contents. Results suggest that trait-like deficits of memory regulation in VCFS can be observed during the retrieval stage, while selective encoding remains efficient. Memory regulation processes during retrieval may constitute a trait deficit in the memory profile of individuals with VCFS and may contribute to the cognitive deficits underlying an increased risk for developing schizophrenia in this population. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Menopausal age in relation to smoking

A population study of women revealed more smokers among 50-year-old postmenopausal women than among women of the same age who still menstruated. The difference was statistically significant. The postmenopausal smokers had on average smoked as long as or longer than the smokers who still menstruated. The higher number of smokers among postmenopausal women could thus not be explained by these women starting to smoke in connection with the menopause. Non-smoking women were on average heavier than smoking women. Previous studies indicate that an increased amount of adipose tissue might delay the menopausal age. It is therefore possible that the difference in menopausal age between smoking and non-smoking women might be explained either by a delayed menopause in non-smoking women due to an increased amount of adipose tissue in these women, or by a precocious menopause in smokers due to toxic effects from smoking. Probably both factors are of importance, but our results indicate that smoking per se is the main factor. The increased number of smokers among women with precocious menopause can probably explain part of the overrepresentation of women with precocious menopause among those who have myocardial infarction.     

Speed and coding effects in relation to age and ability level.

Studied 2 dimensions measured by the Digit Symbol subtest of the WAIS—speed and cognition—in relation to age. Data from 20–30 and 65–75 yr olds of average and high verbal ability are congruent with previous findings that both the speed and coding components are important factors contributing to a substantial age decline in Digit Symbol performance, but raise questions about the effects of Ss' educational experience. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Countercontrol treatment of sleep-maintenance insomnia in relation to age.

Administered countercontrol behavioral therapy for sleep-maintenance insomnia to 34 insomniacs (aged 35–78 yrs) in small groups. 22 Ss received immediate and 12 received delayed treatment. Three self-report measures of sleep disruption were collected on daily sleep diaries at baseline, termination of treatment, 1-mo follow-up, and 12-mo follow-up. Although amount of time awake at night was correlated with age, response to treatment was not. Even though older Ss experienced more time awake after sleep onset prior to treatment, they were able to profit from therapy as well as the younger insomniacs. Countercontrol therapy reduced the sleep complaint for the total group by about 30% at the end of treatment, with gradual improvement continuing through a 4-wk follow-up. It is suggested, however, that sleep-maintenance insomnia may be more difficult to treat than sleep-onset problems. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Memory for spatial layouts in relation to age and schema typicality.

The hypothesis that prior experience, specifically a knowledge-based schema for typical house layouts, can compensate for age declines in spatial memory was evaluated in 4 experiments. Old and young adults explored and subsequently recalled house layouts presented 1 room at a time on a computer screen. The findings failed to support the compensation hypothesis in that schema-relevant layouts facilitated recall equivalently for the 2 age groups. Violation of a typical house schema had a more negative effect on recall of the older group. Individual differences in spatial visualization ability explained much of the age difference in performance but not the effects of schema manipulations. It was concluded that there is age invariance in the facilitatory effects of relevant prior knowledge on spatial memory but an age-related decrease in the ability to inhibit irrelevant prior knowledge. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adult age differences in retrieval: Trace-dependent and cue-dependent forgetting.

A multitrial free recall task was presented to 3 age groups of men and women (18-34, 50-64, and 65-83 yrs) under cued and noncued recall conditions to determine whether age-related differences in retrieval were attributable to the availability of elementary units (trace-dependent forgetting), the accessibility of higher order units (cue-dependent forgetting), or both. Results show significant age differences in words recalled, categories recalled (accessibility), and words recalled per category (availability). It is concluded that adult age differences in retrieval are a function of both cue-dependent and trace-dependent forgetting. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The next-in-line effect: Encoding or retrieval deficit?

The phenomenon that people cannot remember what happens when they are next-in-line to perform was investigated in 2 experiments with 144 undergraduates to determine whether this memory deficit reflects a failure to encode or an inability to retrieve preperformance events. In Exp I, 96 Ss participated in 4 memory trials; in each trial, half the Ss were called on to read words, and the other half merely listened. Before each trial, Ss were told whether they would be readers or listeners and the order in which numbers would be called. Thus, readers could anticipate precisely when they would be called on to perform. After hearing the 28 words in random order, all Ss wrote down the recalled words on cued or noncued sheets. Although the semantic cues strongly facilitated access to memories, they did not moderate the next-in-line effect. In Exp II, Ss were told—either before or after performing—to make a special effort to remember preperformance events. If instructed afterward, Ss displayed the usual memory deficit. If instructed beforehand, they reversed the deficit and showed a superior preperformance recall. It is concluded that the next-in-line effect is a failure at encoding, not at retrieval. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Encoding context and retrieval conditions as determinants of the effects of natural category size.

Studying a familiar word activates its associates in long-term memory. In the present experiments we manipulated the number of associates activated by words studied in the presence of unrelated context words, meaningfully related context words, or in the absence of modifying context words. Memory was tested by either cued or free recall. The results showed that the number of directly activated associates can facilitate, have no effect, or disrupt recall for studied words. The direction and magnitude of the effects of number of activated associates is shown to be determined by the encoding/retrieval context. Implications for the distinction between episodic and semantic memory are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Person-specific paths of cognitive decline in Alzheimer's disease and their relation to age.

Change in global and specific measures of cognitive function was studied in a cohort of 410 persons with Alzheimer's disease. Persons completed up to 5 annual evaluations; follow-up participation among survivors exceeded 90%. Average annual decline was 0.57 standard score units (95% confidence interval [CI]: -0.51 to -0.62) on a composite measure based on 17 individual tests and 3.26 points (95% CI: -3.06 to -3.46) on the Mini-Mental State Examination, but substantial heterogeneity was apparent. On both global and specific measures, rate of cognitive decline was reduced in older persons compared with younger persons. A similar effect was observed for estimated age of disease onset. The effect of age was approximately linear and was not attributable to education, sex, race, other conditions that impair cognition, or mortality. The results indicate that person-specific paths of cognitive decline in Alzheimers disease vary substantially and suggest that in clinical settings some of this variability is related to age. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Development of tactile patterns in relation to age, sex, and race.

Two observers recorded the frequency of touch between male and female and Black and White kindergartners and 1st-6th graders in school cafeteria lines. In same-sex pairs, boys and girls in White and in integrated schools showed a reduction in frequency of touch from kindergarten to 6th grade, but in the Black school, no reduction was observed. Only 1 cross-racial hand-to-hand touch was observed. Data show that social norms related to sexual and racial interaction are the most important factors in the development of touch and interaction distance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Encoding and retrieval differences between young and old: The impact of attentional capacity usage.

An experiment was conducted to investigate (a) whether the semantic processing deficit in the aged can be attributed to age differences in capacity usage during encoding and (b) age differences in terms of the interaction between encoding and retrieval operations. Young and older adults engaged in both a primary (semantic, rhyme, and arithmetic questions) and secondary task (probe monitoring) at encoding and retrieval. The study provided no evidence for the hypothesis that the age-related semantic processing deficit is the result of age differences in capacity usage during semantic and nonsemantic encoding. However, there was evidence that reinstating the encoded semantic context with the same semantic cue at retrieval did not help older subjects as much as younger subjects at recall. These results were interpreted as suggesting that there may be an age deficit in the effective use of semantic contextual information at encoding and retrieval rather than a simple age deficit in semantic processing at encoding. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adult age differences in memory in relation to availability and accessibility of knowledge-based schemas.

Three experiments investigated whether, over adulthood, the use of schemas to process and remember new information increases (developmental shift hypothesis), decreases (production deficiency hypothesis) or remains constant (age-invariance hypothesis). Effects of schema access were studied by having young, middle-aged, and old music experts and nonexperts recall information that was relevant or irrelevant to music (Experiment 1) and by comparing young and old participants' memory for prose passages when they knew or did not know the subject of the passage (Experiments 2 and 3). In each case, schema access facilitated memory equally across age levels, supporting the age-invariance hypothesis and implying that the basic structures and operations of memory do not necessarily change with age. Possible limits on the independence of age and schema utilization were considered in relation to the conditions under which each of the two alternative hypotheses might hold. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Estrogen-receptor expression and function in thymocytes in relation to gender and age

INTRODUCTION: The mechanism of action of N-acetylcysteine in early acetaminophen poisoning is well understood, but much remains to be learned of the mechanism of its possible benefit in acetaminophen poisoning presenting beyond 15 hours. METHODS: Selective review of medical literature. N-acetylcysteine should be used in all cases of early acetaminophen poisoning where the plasma acetaminophen concentration lies "above the line;" which line is chosen depends on individual preference and whether enzyme induction is suspected. Particular care should be taken with the use of the nomogram for patients with chronic excess ingestion of acetaminophen or for those who have taken slow-release formulations. CONCLUSIONS: While there is a trend suggesting a beneficial effect of N-acetylcysteine in some patients presenting beyond 15 hours, further research is necessary to establish just how effective N-acetylcysteine is, particularly in patients presenting with fulminant hepatic failure. Candidate mechanisms for a beneficial effect in-clude improvement of liver blood flow, glutathione replenishment, modification of cytokine production, and free radical or oxygen scavenging. Hemody-namic and oxygen delivery and utilization parameters must be monitored carefully during delayed N-acetylcysteine treatment of patients with fulminant hepatic failure, as unwanted vasodilation may be deleterious to the maintenance of mean arterial blood pressure.     

Repetition deficit in rapid-serial-visual-presentation displays: Encoding failure or retrieval failure?

The repetition deficit associated with rapid serial visual presentation (RSVP) has been explained as a repetition-induced blindness, that is, as a perceptual or encoding failure. The repetition deficit was replicated in a standard free-recall RSVP task, and it was shown that participants were able to report the lost item when they were prompted with a retrieval probe. The authors argue that both copies of the repeated items were available in memory but that they were not accessible for report. Hence, they conclude that the repetition deficit in the RSVP task reflects a retrieval failure, not a perceptual failure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

IQ at age 4 in relation to maternal alcohol use and smoking during pregnancy.

Examined the relationship of prenatal alcohol exposure to the IQ of children at age 4 in a longitudinal prospective, population-based study. Multiple-regression analyses on data from 421 children indicated that use of more than 1.5 oz (44 ml, or approximately 3 drinks) of alcohol per day during pregnancy was significantly related to an average IQ decrement of almost 5 IQ points (? of a standard deviation; p?=?.008), even after adjustment for maternal and paternal education, race, prenatal nutrition, aspirin and antibiotics, child's sex and birth order, mother–child interaction, and preschool attendance. We caution against using these data to describe "safe" drinking levels, because other outcomes, more sensitive than IQ tests, show significant alcohol effects at lower drinking levels. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Examining age differences in performance of a complex information search and retrieval task.

This study examined age differences in performance of a complex information search and retrieval task by using a simulated real-world task typical of those performed by customer service representatives. The study also investigated the influence of task experience and the relationships between cognitive abilities and task performance. One hundred seventeen participants from 3 age groups, younger (20–39 years), middle-aged (40–59 years), and older (60–75 years), performed the task for 3 days. Significant age differences were found for all measures of task performance with the exception of navigational efficiency and number of problems correctly navigated per attempt. There were also effects of task experience. The findings also indicated significant direct and indirect relations between component cognitive abilities and task performance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Incremental lines in human dental cementum in relation to age

We have studied day-time vigilance in 31 patients (median age 49 years) with suspected sleep disorders using a new visual reaction time and performance test. The findings in the day-time vigilance test were compared with the number of desaturation events and movement arousals measured with a sensitive movement detector in the night-time. In our statistical model the high number of desaturations correlated with a high dispersion in reaction-times. The squared multiple r was 0.465 in a model where the dispersion of reaction times was the dependent variable and the number of desaturations, duration of quiet sleep and the mode of oxygen saturation were independent variables. A high amount of body movements (movement arousals, duration less than 5 seconds) correlated with gradual deterioration in the performance test. The squared multiple r was 0.447 in a model where the regression coefficient of reaction times was the dependent variable and active sleep and number of body movements less than 5 seconds in duration were the independent variables. Frequent arousals in apnoeic patients are observed in hyper-excitable responders and are known to cause sleep deprivation and hypersomnia. Our findings in desaturating patients indicate that in those with a low chemoreceptor response to hypoxia the failure in day-time regulation of vigilance may differ from the failure associated with sleep-deprivation.