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甲醛与4-氨基-3-联氨-5-巯基-1,2,4-三氮杂茂(简称AHMT)溶液在碱性条件下缩合,然后经高碘酸钾氧化成6-巯基-5-三氮杂茂(4,3-b)-S-四氮杂苯紫红色化合物,其颜色的深浅与甲醛含量成正比。方法的最大吸收波长为554nm,甲醛含量在0~12μg·10mL-1范围内具有良好的线性关系,相关系数为0.9959,用于测定有机实验废水中微量甲醛的含量,相对标准偏差为3.45%,加标回收率在95.4%~110.5%之间。 相似文献
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采用KromasilC18柱为分离柱 ,甲醇 -水 (体积比 6 0∶4 0 )为流动相 ,检测波长为 2 5 4nm ,苯乙酮做内标 ,对二氮杂芴 9 酮的含量进行了液相色谱定量检测。在 8~ 180 μg/mL峰面积 (y ,Ai/As)对标准溶液的质量浓度 (x ,μg/mL)线性关系良好 (r =0 99996 ) ,该法快速、准确 相似文献
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<正> 2,5-二巯基-1,3,4-硫二氮茂(DMTD)的烷基或二烷基衍生物是优良的霉菌抑制剂,避免显影液变暗和产生沉淀的添加剂;润滑油抗腐蚀添加剂;以及输油管路中防腐蚀的保护剂。文献[1]报道过DMTD的合成法。为了促进该产品的工业化和降低成本,我们用水代替乙醇精制。 DMTD的卤代烷衍生物种类繁多,其基本方法是DMTD的碱金属盐与Rx(R=烷基,x=Cl,Br等)在回流温度下反应生成烷基或二烷基衍生物。我们合成的硫代十二烷基-二巯基1,3,4-硫二氮茂(Ⅰ)。 相似文献
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为掌握乌洛托品的硝解机理,研究了直接法硝解乌洛托品制备黑索今(RDX)的废水。实验通过乙酸乙酯萃取富集废水中的副产物,水洗至中性,浓缩,用薄层色谱法分析,展开系统为:丙酮/二氯甲烷/冰乙酸=1/6/0.1。采用硅胶柱柱层析法分离,丙酮/二氯甲烷梯度洗脱,分离得到两种物质,一种物质通过熔点、红外、核磁比对确认为1,3,5-三硝基-1,3,5-三氮杂环己烷(RDX);另一种物质采用红外光谱、核磁、质谱、元素分析及单晶衍射等分析方法进行结构表征,认定其为3,5-二硝基-1-氧杂-3,5-二氮杂环己烷。用DSC-TG技术研究了3,5-二硝基-1-氧杂-3,5-二氮杂环己烷热行为,结果表明该化合物是一种熔点低、热稳定性好的化合物,对主要副产物的分离和结构鉴定为直接法硝解反应机理提供了可靠的实验依据。 相似文献
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Phenanthro[3,4-b]thiophene (P[3,4-b]T) and phenanthro[4,3-b]thiophene (P[4,3-b]T) are thiasters of weakly mutagenic benzo[c]phenanthrene (B[c]P). These polycyclic sulfur heterocycles (thia-PAHs) represent a group of chemicals which have been identified in cigarette smoke. P[3,4-b]T is a potent mutagen in Salmonella typhimurium strain TA100 in the presence of rat liver S9, whereas its isosteric isomer P[4,3-b]T is a nonmutagenic compound. In order to understand the mechanism underlying the differences in the mutagenic activity of P[3,4-b]T and P[4,3-b]T, we have investigated the metabolism of P[3,4-b]T, P[4,3-b]T, and their carbon analogue B[c]P by rat liver microsomes. The liver microsomes from rats treated with Aroclor 1254 metabolized P[3,4-b]T, P[3,4-b]T, and B[c]P at a rate nearly 7- to 9-fold greater than of the control liver microsomes. High-performance liquid chromatography (HPLC) analysis of the metabolites formed showed that B[c]P was metabolized almost exclusively to its dihydrodiols which comprised predominantly K-region diol as noted in the previous studies. Our preliminary studies on the metabolism of P[3,4-b]T, P[4,3-b]T and B[c]P by liver microsomes from control and Aroclor 1254-treated rats have shown a significant reduction in the formation of 6,7-diol (K-region diol) and 8,9-diol (diol with a bay-region double bond) of the two thia-PAHs compared to the formation of analogous 5,6-diol (K-region diol) and 3,4-diol (diol with a bay-region double bond) from B[c]P. Both P[3,4-b]T and P[4,3b]T produced a major, relatively nonpolar metabolite(s) (80–96% of total metabolites). These studies indicate that the highly mutagenic P[3,4-b]T is not metabolized to dihydrodiol with a bay-region double bond to any greater extent than the weakly or nonmutagenic B[c]P or P[4,3-b]T, suggesting that the metabolite(s) other than P[3,4-b]T8,9-diol is likely to be involved in the mutagenicity of P[3,4-b]T. 相似文献
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A. D. Dunn 《Advanced Synthesis \u0026amp; Catalysis》1987,329(4):557-562
The synthesis of 5H-thiopyrano[4,3-b]pyridines, 8H-thiopyrano[3,4-b]pyridines, 1H-thiopyrano[3,4-c]pyridines and 1H-thiopyrano[4,3-c]pyridines from methyl pyridine esters 5–8 and nitriles 17–20 by simple photobromination, followed by reaction of the intermediate bromomethyl derivative with methyl thioglycolate and subsequent base induced cyclisation of the latter are reported. 相似文献
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为了筛选出新的高活性化合物,以二氨基硫脲与有机羧酸为原料,回流反应生成中间体4-氨基-5-取代-1,2,4-三唑硫酮,再与羧酸在POCl3的催化下合成了3,6-双取代1,2,4-三唑并[3,4-b]-1,3,4-噻二唑新化合物。目标化合物通过IR、元素分析和1H NMR对其结构进行了表征。并初步测定了该化合物对5种植物病原菌(烟草赤星病、马铃薯干腐病、小麦赤霉病、番茄早疫病、西瓜枯萎病)的杀菌活性,结果表明此类化合物对所测菌种具有良好的杀菌、抑菌作用。 相似文献
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Three fatty acid triazoles, namely, 3-undecane-4-aryl-5-mercapto-1,2,4-triazole (triazole 1), 3(heptadeca-8-ene)-4-aryl-5-mercapto-1,2,4-triazole
(triazole 2), and 3(deca-9-ene)-4-aryl-5-mercapto-1,2-4-triazole (triazole 3) were synthesized and their corrosion-inhibiting
action in 15% hydrochloric acid was evaluated by weight-loss method and electrochemical techniques. Electrochemical polarization
studies at room temperature indicated that all the triazoles are mixed-type inhibitors, i.e., they inhibit both anodic and
cathodic reactions. The adsorption of these compounds onto mild steel from 15% HCl followed Temkin's adsorption isotherm. 相似文献
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Majid Ghashang Syed Sheik Mansoor Mohammad Reza Mohammad Shafiee Mahboubeh Kargar Mohammad Najafi Biregan Fateme Azimi 《Journal of Sulfur Chemistry》2016,37(4):377-390
A mild and efficient method for the synthesis of thiochro meno[4,3-b]pyran and thiopyrano[4,3-b]pyran derivatives using MgO nanopowders as a catalyst is described. The MgO nanopowders were prepared via a green biosynthesis method using an extract of Rosmarinus officinalis leaves and were characterized by Field Emission Scanning Electron Microscopy and X-ray diffraction analyses. 相似文献
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建立了紫外分光光度法测定阔草清合成原料5-氨基-3-巯基-1,2,4-三唑的含量.方法为:用0.01M NaOH溶液溶解样品,在240nm处测定样品的吸光度,确定组分含量:该方法设备简单、操作迅速、方法准确。适于推广。 相似文献
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2,3-Heterocondensed Thiophenes from Substituted 2-Aminothiophen-3-thiole Ethyl 5-amino-4-mercapto-3-methyl-thiophen-2-carboxylate ( 2 ), obtainable from the appropriate thienylthiocyanate 1 by reduction, undergoes reactions in analogy to the 2-aminobenzenthiole. Thus, with formic acid or trimethylorthoacetat the thieno [2,3-d]thiazoles 4 and 5 are formed. Aromatic aldehydes yield the thieno[2,3-d]thiazolines ( 6 ) which can be dehydrogenated by sulphur to form 9 . From carbon disulfide and 2 the thieno[2,3-d]thiazol-2-thione ( 7 ) is formed. With phenacylbromide or ethyl bromoacetate 2 can be converted into the thieno[3,2-b] thiazine derivatives 11 or 12 . Diazotation of 2 yields the thieno[2,3-d]1,2,3-thiadiazole derivative ( 14 ). 相似文献
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芳香羧酸酯化、肼解、成盐、环化成3-芳基-4-氨基-5-巯基-1,2,4-三唑与2,6-吡啶二甲酸在相转移催化剂四丁基碘化铵和POCl3作用下,高产率制得8种标题化合物,并利用IR、1HNMR、MS和元素分析对目标化合物的结构进行了表征.初步的抗菌实验表明,部分目标化合物表现出较好的抑菌活性. 相似文献