A comparison of "dreamers" and "nondreamers": Eye movements, electroencephalograms, and the recall of dreams.

Research had established that rapid eye movement during sleep was correlated with dreaming, and both to light sleep as defined by EEG reactivity. In an attempt to cross validate these findings, Ss were selected as to whether they generally recalled dreaming. Ss slept in a laboratory setting wherein electro-oculograms and EEG's were taken during the period of sleep. Ss were awakened when the characteristic eye movement suggesting dreaming was observed, and during periods of quiescence. Recall of dream activity during both was solicited. Results suggest that "dreamers" manifest more ocular movement and reports of dreaming during periods of eye movement than "nondreamers." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Daily stress interacts with trait dissociation to predict sleep-related experiences in young adults.

Building on the previously documented effects of stress and dissociation on sleep and dreaming, we examined their interactive role in general sleep-related experiences (GSEs; e.g., nightmares, falling dreams, hypnagogic hallucinations; see Watson, 2001). Stress, sleep quality, and GSEs were assessed daily for 14 days among young adults. Baseline assessment included life stress, sleep quality, psychopathology, dissociation, and related dimensions. Multilevel analyses indicated that daily stress brings about GSEs among highly dissociative young adults. Additionally, baseline trait dissociation predicted within-subject elevation in GSEs when daily stress was high. Flawed sleep–wake transitions, previously linked to dissociation and sleep-related experiences, might account for this effect. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Finger electromyographic activity during sleep: Its relation to dreaming in deaf and normal subjects.

Observations carried out during the sleep of 13 deaf Ss showed that: (a) the rates of dream recall from rapid eye movement (REM) periods were similar to those for normal hearing Ss; (b) finger electromyographic (EMG) bursts outside of REM periods were not related to the recall of mental activity; (c) in both deaf and hearing Ss, REM periods showed a consistently accelerated rate of finger EMG activity in comparison with other stages of sleep; (d) contrary to expectations, rates of finger EMG activity for 10 normal hearing Ss were just as high as those of the deaf group. The implications of this finding for the motor theory of thinking were discussed. (18 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Patterns of dreaming recall: An EEG study.

11 recallers and 11 nonrecallers of dreams were compared with respect to several characteristics of their rapid eye movement (REM) periods during sleep. Continuous recordings of REMs and EEGs were obtained for 2 consecutive nights of uninterrupted sleep for each S. The records were scored to yield measures of total dream time (TDT) and rate of eye movements during REM periods. Recallers had significantly higher TDT than nonrecallers. However, contrary to prediction, nonrecallers had a significantly higher rate of REMs during dreaming than recallers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Development of beliefs about the origins and controllability of dreams.

In three studies the authors investigated the development of beliefs about dreaming. Study 1 assessed 3 to 5-year-old children's beliefs about the origins and controllability of dreams. Results revealed significant changes in children's beliefs about the roles of behavioral experiences and mental processes in the generation of dream content. Results also revealed that young children consider both dreams and imagination to be highly controllable. In Study 2, preschool-age children, elementary school-age children, and adults received either imagination or dream stories and were questioned about controllability. In Study 3, emotional valence of the dream content was varied. Results of Studies 2 and 3 revealed significant development in beliefs that dreams are not subject to conscious control. Beliefs in controllability were higher among females. Study 3 showed that the emotional content of a dream affects these claims. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An electrophysiological study of the postnatal development of the corticospinal system in the macaque monkey

We characterized toxin-insensitive calcium currents expressed by acutely dissociated embryonic dorsal root ganglion neurons. In the presence of 3 microM omega-conotoxin-GVIA, 3 microM nitrendipine and either 500 nM omega-agatoxin-IVA or 500 nM omega-conotoxin-MVIIC to inhibit N-, L- and P/Q-type currents, respectively, all neurons expressed two residual currents: a T-type and another which we referred to as toxin-resistant current. The toxin-resistant current (i) consisted of an inactivating and a sustained components, (ii) had a threshold of activation and a steady-state inactivation comprised between that of the T-type current and that of the other high-voltage-activated currents, (iii) had the same permeability for barium and calcium used as charge carriers, (iv) was highly sensitive to both cadmium and nickel; and (v) was insensitive to 500 microM amiloride which abolished the T-type at this concentration. The properties of the toxin-resistant current are very similar to those of the currents expressed in oocytes following injection of alpha(1E) subunits which we demonstrated to be present in these neurons. Therefore a component of the toxin-resistant current calcium channels in sensory neurons may be closely related to those calcium channels formed by alpha(1E) subunits.     

Pharmacology of the GABA receptor functions in the central nervous systems

gamma-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system. GABA receptors have been classified into at least two categories, GABA(A) receptors, which are heterogeneous multimeric ligand-gated Cl channels, and GABA(B) receptors, which are coupled to G-proteins. GABA(B) receptors have not only a physiological role in synaptic transmission, but also are important in pathological conditions associated with absence epilepsy, cognitive disorders and nociception. This review describes our current knowledge of the neuropharmacology and neurochemistry of GABA(B) receptors, including their heterogeneity as well as the therapeutic potential of the drugs which interact with these sites.     

Nervous regulation of the tone of the retractor penis muscle in the goat

The nervous control of the retractor penis muscle (rp) was investigated in the anaesthetized goat. Also, isolated field stimulated strips of the muscle were studied. The noradrenaline (NA) and acetylcholine (ACh) content of the rp was determined, and histochemistry for adrenergic and acetylcholinesterase (AChE) positive nerves was performed. The muscle exhibited spontaneous activity that persisted after section of all nerves. There was, however, also a tendency of the activity to follow the general vasomotor tone, which disappeared after section of the sympathetic chains. The excitatory adrenergic nerves which innervate the muscle come from the sympathetic chains and run along the pudendal, the hypogastric and the pelvic nerves. The rp has a dense network of adrenergic fibres and is very sensitive to excitatory adrenergic stimulation. It has a fairly large NA content, which is higher in old goats (5.95 +/- 0.42 micrograms g-1) than in young goats (2.87 +/- 0.78 micrograms g-1). Inhibitory non-adrenergic non-cholinergic (NANC) innervation reaches it via the pelvic and the hypogastric nerves. The maximum inhibitory response is reached at low frequencies (2-4 Hz). Cholinergic prejunctional inhibition of the excitatory response to sympathetic chain stimulation was effected by simultaneous stimulation of the hypogastric nerves. In vitro experiments confirmed the presence of endogenous cholinergic muscarinic suppression of the excitatory adrenergic neurotransmission. Significant amounts of ACh (0.81 +/- 0.18 micrograms g-1) are present in the muscle, and it contains strongly AChE positive nerve fibres and nerve cell bodies. It is concluded that the goat rp is innervated by sympathetic adrenergic excitatory nerves and parasympathetic NANC inhibitory nerves. It further has a direct sympathetic inhibitory NANC innervation, and an indirect inhibitory cholinergic innervation which at least in part is sympathetic.     

Readers' acquisition of the components of the text-lookback strategy.

Investigated the order in which the components of the text-lookback strategy are acquired in an experiment in which 100 5th-grade students at 2 reading proficiency levels (50 proficient and 50 less proficient readers) were asked to tutor 20 3rd-grade readers who acted as confederates in the study. As the younger students read a short expository text and answered 5 questions, tutor encouragement of text-lookback behaviors was observed; tutees had been trained not to initiate any lookbacks. For both proficient and less proficient readers, the order of acquisition posited and confirmed statistically was as follows: undifferentiated rereading (general reaccessing of text to locate unrecalled information), text sampling (scanning the text, rereading only the relevant segments), question differentiation (deciding which questions cue reaccessing), and text manipulation (integrating information across sentences to answer questions). Reader proficiency groups differed in the proportion of members having acquired particular strategic components. This finding confirms that use of the components of the lookback strategy is positively related to global reading performance level. (37 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Morphology and laminar distribution of nonpyramidal neurons in the auditory cortex of the rabbit

A study of the morphology and laminar distribution of nonpyramidal neurons in Golgi-Nissl preparations of electrophysiologically verified auditory cortex was carried out in the adult rabbit. Nonpyramidal neurons were located primarily within laminae I-IV and were only infrequently seen in lamina V and VI. In lamina I, four nonpyramidal cell types were observed: (1) small, spine-free horizontal neurons, (2) small, sparsely spined multipolar neurons with radiate dendrites, (3) large, multipolar neurons with fusiform somata and vertically aligned, sparsely spined dendrites, and (4) small, spine-free neurogliform neurons. The horizontal and small multipolar neurons had tangentially running axons confined to lamina I. The large, fusiform cells had descending axons which arborized in lamina II and occasionally reached lamina III. In lamina II and the upper part of lamina III, seven nonpyramidal cell types were observed: (1) spine-free bipolar neurons with vertically aligned dendrites and axonal arbors; (2) large, (3) medium, and (4) small, spine-free and sparsely spined multipolar neurons, all with locally ramifying axons; (5) pear-shaped cells with highly oriented dendrites which branched toward the pial surface and vertically arborizing axons; (6) multipolar cells with tangentially and vertically oriented dendrites and ascending axons which entered lamina I, and (7) tufted cells with local axons. Three types of nonpyramidal cells were observed in lamina IV and the lower part of lamina III: (1) large, multipolar cells with radiate, spine-free dendrites and stout axons which arborized locally, (2) spiny multipolar cells with vertically aligned dendrites and ascending axons which arborized in lamina II and III via long horizontal collaterals, and (3) spine-free bipolar cells with vertical dendrites and axons which arborized in a narrow vertical column adjacent to the dendrites. Nonpyramidal neurons in lamina V and VI were primarily multipolar cells with sparsely spined and spine-free dendrites. A comparison of these data with those of other species indicates that the neuronal organization of the rabbit auditory cortex is similar to that of the sensory cortex of the rodent but is strikingly different from that of carnivores and primates.     

World psychology and the role of the Office of Naval Research.

Supports M. R. Rosenzweig's (1984) argument for increased communication between US psychologists and psychologists in other parts of the world and notes that Rosenzweig failed to mention the Liaison Science Program of the US Office of Naval Research (ONR), which promotes the exact type of international communication espoused by Rosenzweig. Liaison activities of the ONR are detailed, and problems faced by the ONR behavioral scientist (a post held by the present author) are identified. Three ways in which individuals and organizations (i.e., the American Psychological Association) can participate in and promote international psychology are suggested. (4 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Aromatic stacking and bending of the DNA helix by the individual repeat units of the carboxy-terminal domain of RNA polymerase II

The carboxy-terminal domain (CTD) of RNA polymerase II consists of multiple repeats of the unique heptad sequence -(Ser-Pro-Thr-Ser-Pro-Ser-Tyr)- which may interact with DNA through the intercalation of adjacent tyrosine aromatic rings. We have examined details of the interaction of this motif with calf thymus DNA through analysis of peptide analogues that contain (1) an amino-terminal tyrosine which mimics the presence of an adjacent heptad repeat and (2) positively-charged lysine residues which facilitate the initial contact between peptide and DNA. Results of fluorescence experiments, NMR titrations, and viscometric analyses indicate that these peptides bind to the DNA helix through a non-classical intercalation mode involving partial aromatic stacking of the tyrosine rings with the Watson-Crick base pairs.     

Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin

The synthesis and evaluation of two key analogs 3 and 4 of the potent antitumor antibiotics deoxybouvardin (1) and RA-VII (2) which contain fundamental modifications in the tetrapeptide subunit are described. Unlike the natural products, these agents 3 and 4, which substitute (Gly)4 and (Gly)3 for the D-Ala-Ala-NMe-Tyr(OMe)-Ala tetrapeptide subunit, adopt conformations in which the central amide in the cycloisodityrosine subunit adopts its inherently preferred trans stereochemistry and both were found to be biologically inactive.     

Use of the omentum in the treatment of chronic thoracic empyema

Thoracic empyema (development of suppuration in the thoracic cavity, usually after pneumonectomy) remains a serious complication which is difficult to treat. Failure of classical procedures (lavage-drainage) in the treatment of certain forms of pleural empyema (post-pulmonary resections), with or without associated fistula, led the authors to use the pedicled omental flaps filling material for the chronic empyema cavity. They report their experience (6 cases over a period of 4 years) and define the indications. Omentoplasty has a real place, next to myoplasty, in the therapeutic arsenal for chronic empyema due to its detersion capacity, particularly useful in a "septic" context and because of its volume which is usually sufficient in retracted cavities. The existence of an associated bronchial fistula, history of radiotherapy, posterolateral thoracostomy (sectioned latissimus dorsi) are additional reasons to prefer omentoplasty over myoplasty.     

Evaluation of a new chromogenic substrate assay for the measurement of the prothrombin time

Since the ingestion studies by Marshall and Morris, Helicobacter pylori has been known to cause both acute and chronic infection in the human stomach activating both the cellular and the humoral immune system. It is of little or no value to evaluate the causative relationship of an infectious agent using Koch's criteria. The more recent criteria for causative relationships used in the science of epidemiology are more useful. These criteria include: (i) the characteristic of the association which is fulfilled for most cases of both duodenal and gastric ulcer; (ii) the temporal relationship which is fulfilled for duodenal ulcer and has not been investigated for gastric ulcer; (iii) the biological gradient which has been fulfilled for duodenal ulcer in a few studies but not investigated for gastric ulcer; (iv) the biological plausibility which is easily fulfilled for both duodenal and gastric ulcer; (v) the effect of an intervention which has been fulfilled for duodenal ulcer and in a few studies for gastric ulcer; and (vi) the coherence of these data with what is known about the disease which is fulfilled for both duodenal and gastric ulcer. Even though there is no need for all criteria to be fulfilled, further studies are necessary to confirm the temporal relationship between H. pylori and peptic ulcer, and the biological gradient of H. pylori in relation to the gastric ulcer. Even so, there is a strong indication that most of the peptic ulcers, apart from those caused by non-steroid anti-inflammatory drugs and Zollinger-Ellison-like syndromes, are caused by H. pylori infection.     

Key analogues of the tetrapeptide subunit of RA-VII and deoxybouvardin

The synthesis and evaluation of the analogues 3 and 4 of deoxybouvardin (1) and RA-VII (2), which contain modifications in the tetrapeptide subunit, are described. Unlike the natural products and similar to our prior disclosure, the agents 3 and 4, which substitute (Gly)4 and (Gly)3 for the D-Ala-Ala-NMe-Tyr(OMe)-Ala tetrapeptide subunit, exist in single rigid conformations in which the central cycloisodityrosine amide adopts its preferred trans stereochemistry and both were found to be biologically inactive.     

Continuity and the persistence of objects: when the whole is greater than the sum of the parts

In three experiments, a total of 480 participants heard a version of the story of the ship of Theseus (Hobbes, 1672/1913), in which a novel object, labeled with a possessive noun phrase, underwent a transformation in which its parts were replaced one at a time. Participants then had to decide which of two objects carried the same possessive noun phrase as the original: the one made entirely of new parts (that could be inferred to be continuous with the original) or one reassembled from the original parts (that could not be inferred to be continuous with the original). Participants often selected the object made of new parts, despite the radical transformation. However, the tendency to do so was significantly stronger (1) if the object was described as an animal than if it was described as an artifact, (2) if the animal's transformation lacked a human cause than if it possessed one, and (3) if the selection was made by adults or 7-year-olds than if it was made by 5-year-olds. The findings suggest that knowledge about specific kinds of objects and their canonical transformations exerts an increasingly powerful effect, over the course of development, upon people's tendency to rely on continuity as a criterion for attributing persistence to objects that undergo change.     

Postoperative allergic complications: the role of the anesthetist in conducting the immuno-allergic investigation

When peri-anaesthesia anaphylactic and/or anaphylactoid reactions occur, anaesthetist is the first investigator: the quality of immuno-allergological investigations depends on these initial investigational procedures. We have used sample kits for several years in order to make easier the immediate investigation. From retrospective analysis of the allergic complications which happened in 1997, the importance of these sample kits as well as the anaesthetist's part in the immuno-allergological management are examined. Nine observations were itemized (0.047%): 3 generalized erythema observations (grade I), in which atracurium was incriminated twice, and propacetamol once; 2 observations of grade II, in which vecuronium (elevated tryptase) and atracurium were incriminated; 4 anaphylactic shocks, in which three neuromuscular blocking drugs (suxamethonium, vecuronium and pancuronium), and one antibiotic (cloxacilline) were incriminated. The use of sample kits allowed an early diagnosis approach, confirmed by skin tests. Diagnosis should be thought closely between anaesthetists and immunologists for investigations.     

A decisional analysis of the effects of inferotemporal lesions in the rhesus monkey.

Modified signal detection procedures were used to analyze the effects of inferotemporal cortical resections in 2 experiments with a total of 14 adolescent rhesus monkeys. Results demonstrate (a) a severe difficulty in responding to differences in luminance; (b) a small but consistent change in sensitivity, which is attributed to an increased sensitivity to noise or a deficiency in the suppression of irrelevant aspects of the environment; and (c) an enhanced bias to respond to a nonrewarded stimulus (a lowering of criterion). This altered bias contrasts with the results obtained from limbic resections in a previous experiment, which produced a marked increase in bias to a rewarded contingency without influencing discrimination or detection. (43 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Testing models of the experience of self-determination in intrinsic motivation and the conundrum of choice.

The authors investigated 3 commonly cited experiential qualities to propose a model of the essential nature of perceived self-determination in intrinsic motivation--internal locus, volition, and perceived choice. In 3 studies, they used structural equation modeling to compare a series of nested models in which 1, 2, or all 3 of these qualities were used to identify the best fitting conceptual model. Results consistently supported the model in which internal locus and volition, but not perceived choice, constitute valid indicators of self-determination. In light of the findings, the authors proposed a modified definition for perceived self-determination and discussed the conundrum of choice by proposing the conditions under which teachers can (and cannot) expect choice to increase students' intrinsic motivation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)