Hierarchical fuzzy segmentation of brain MR images

In brain magnetic resonance (MR) images, image segmentation and 3D visualization are very useful tools for the diagnosis of abnormalities. Segmentation of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is the basic process for 3D visualization of brain MR images. Of the many algorithms, the fuzzy c‐means (FCM) technique has been widely used for segmentation of brain MR images. However, the FCM technique does not yield sufficient results under radio frequency (RF) nonuniformity. We propose a hierarchical FCM (HFCM), which provides good segmentation results under RF nonuniformity and does not require any parameter setting. We also generate Talairach templates of the brain that are deformed to 3D brain MR images. Using the deformed templates, only the cerebrum region is extracted from the 3D brain MR images. Then, the proposed HFCM partitions the cerebrum region into WM, GM, and CSF. © 2003 Wiley Periodicals, Inc. Int J Imaging Syst Technol 13, 115–125, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ima.10035     

Automated brain tumour segmentation techniques— A review

Automatic segmentation of brain tumour is the process of separating abnormal tissues from normal tissues, such as white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). The process of segmentation is still challenging due to the diversity of shape, location, and size of the tumour segmentation. The metabolic process, psychological process, and detailed information of the images, are obtained using positron emission tomography (PET) image, Computer Tomography (CT) image and Magnetic Resonance Image (MRI). Multimodal imaging techniques (such as PET/CT and PET/MRI) that combine the information from many imaging techniques contribute more for accurate brain tumour segmentation. In this article, a comprehensive overview of recent automatic brain tumour segmentation techniques of MRI, PET, CT, and multimodal imaging techniques has been provided. The methods, techniques, their working principle, advantages, their limitations, and their future challenges are discussed in this article. © 2017 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 27, 66–77, 2017     

A rapid automatic brain tumor detection method for MRI images using modified minimum error thresholding technique

This proposed work is aimed to develop a rapid automatic method to detect the brain tumor from T2‐weighted MRI brain images using the principle of modified minimum error thresholding (MET) method. Initially, modified MET method is applied to produce well segmented and sub‐structural clarity for MRI brain images. Further, using FCM clustering the appearance of tumor area is refined. The obtained results are compared with corresponding ground truth images. The quantitative measures of results were compared with the results of those conventional methods using the metrics predictive accuracy (PA), dice coefficient (DC), and processing time. The PA and DC values of the proposed method attained maximum value and processing time is minimum while compared to conventional FCM and k‐means clustering techniques. This proposed method is more efficient and faster than the existing segmentation methods in detecting the tumor region from T2‐weighted MRI brain images. © 2015 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 25, 77–85, 2015     

Segmentation of tumor using PCA based modified fuzzy C means algorithms on MR brain images

In the field of medical sciences, automatic detection of tumor using magnetic resonance (MR) brain images is a major research area. The goal of the proposed work is to identify the tumors in MR images using segmentation methods and to locate the affected regions of the brain more accurately. Medical images have vast information but they are difficult to examine with lesser computational time. An innovative process is proposed to extract tumor cells using the discrete wavelet transform (DWT). After extracting features with DWT feature reduction is carried out with the principal component analysis (PCA). Modified fuzzy C means (MFCM) technique is used for segmenting the tumor cells. The efficiency of the proposed method to identify different abnormalities in real MR images for intracranial neoplasm detection, tuberculoma, and bilateral thalamic fungal granulomas identification is tested. The results obtained are shown in-terms of Accuracy, Dice Similarity Index (DSI), and Jaccard Index (JI) measures. The performance of the proposed method is tested in terms of performance measures like Accuracy, DSI, and JI. These results are compared with the conventional fuzzy C means (FCM) method.     

Brain tumor detection and diagnosis using ANFIS classifier

In this article, the segmented brain tumor region is diagnosed into mild, moderate, and severe case based on the presence of tumor cells in the brain components such as Gray Matter (GM), White Matter (WM), and cerebrospinal fluid (CSF). The modified spatial fuzzy c mean algorithm is used to segment brain tissues. The feature Local binary pattern is extracted from segmented tissues, which is trained and classified by ANFIS Classifier. The performance of the proposed brain tissues segmentation system is analyzed in terms of sensitivity, specificity, and accuracy with respect to manually segmented ground truth images. The severity of brain tumor is diagnosed into mild case if the segmented brain tumor is present in the grey matter. The severity of brain tumor is diagnosed into moderate case if the segmented brain tumor is present in the WM. The severity of brain tumor is diagnosed into severe case if the segmented brain tumor is present in the CSF region. The immediate surgery is required for severe case and medical treatment is preferred for mild and moderate case.     

A comprehensive review: Segmentation of MRI images—brain tumor

Segmentation of tumors in human brain aims to classify different abnormal tissues (necrotic core, edema, active cells) from normal tissues (cerebrospinal fluid, gray matter, white matter) of the brain. In existence, detection of abnormal tissues is easy for studying brain tumor, but reproducibility, characterization of abnormalities and accuracy are complicated in the process of segmentation. The magnetic resonance imaging (MRI)‐based segmentation of tumors in brain images is more enhancing and attracting in current years of research studies. It is due to non‐invasive examination and good contrast prone to soft tissues of images obtained from MRI modality. Medical approval of different segmentation techniques depends on the benchmark and simplicity of the method. This article incorporates both fully‐automatic and semi‐automatic methods for segmentation. The outlook study of this article is to provide the summary of most significant segmentation methods of tumors in brain using MRI. © 2016 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 26, 295–304, 2016     

Performance analysis of brain tissues and tumor detection and grading system using ANFIS classifier

Abnormal growth of cells in brain leads to the formation of tumors, which are categorized into benign and malignant. In this article, Co‐Active Adaptive Neuro Fuzzy Inference System (CANFIS) classification based brain tumor detection and its grading system is proposed. It has two phases as brain tumor segmentation and brain tissue segmentation. In brain tumor segmentation, CANFIS classifier is used to classify the test brain image into benign or malignant. Then, morphological operations are applied over the malignant image in order to segment the tumor regions in brain image. The K‐means classifier is used to classify the brain tissues into Grey Matter (GM), White Matter (WM) and Cerebro Spinal Fluid (CSF) regions as three different classes. Next, the segmented tumor is graded as mild, moderate or severe based on the presence of segmented tumor region in brain tissues.     

An efficient approach for brain image (tissue) compression based on the position of the brain tumor

Medical image processing plays an important role in brain tissue detection and segmentation. In this paper, a computer aided detection of brain tissue compression based on the estimation of the location of the brain tumor. The proposed system detects and segments the brain tissues and brain tumor using mathematical morphological operations. Further, the brain tissue with tumor is compressed using lossless compression technique and the brain tissue without tumor is compressed using lossy compression technique. The proposed method achieves 96.46% sensitivity, 99.20% specificity and 98.73% accuracy for the segmentation of white matter regions from the brain. The proposed method achieves 98.16% sensitivity, 99.36% specificity and 98.78% accuracy for the segmentation of cerebrospinal fluid (CSF) regions from the brain and also achieves 93.07% sensitivity, 98.79% specificity and 97.63% accuracy for the segmentation of grey matter regions from the brain. This paper focus the brain tissue compression based on the location of brain tumor. The grey matter of the brain is applied to lossless compression due to the presence of the tumor in grey matter of the brain. The proposed system achieves 29.23% of compression ratio for compressing the grey matter of the brain region. The white matter and CSF regions of the brain are applied to lossy compression due to the non‐presence of the tumor. The proposed system achieves 39.13% of compression ratio for compressing the white matter and also achieves 37.5% of compression ratio for compressing the CSF tissue. © 2016 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 26, 237–242, 2016     

Hybrid GrabCut Hidden Markov Model for Segmentation

Diagnosing data or object detection in medical images is one of the important parts of image segmentation especially those data which is less effective to identify in MRI such as low-grade tumors or cerebral spinal fluid (CSF) leaks in the brain. The aim of the study is to address the problems associated with detecting the low-grade tumor and CSF in brain is difficult in magnetic resonance imaging (MRI) images and another problem also relates to efficiency and less execution time for segmentation of medical images. For tumor and CSF segmentation using trained light field database (LFD) datasets of MRI images. This research proposed the new framework of the hybrid k-Nearest Neighbors (k-NN) model that is a combination of hybridization of Graph Cut and Support Vector Machine (GCSVM) and Hidden Markov Model of k-Mean Clustering Algorithm (HMMkC). There are four different methods are used in this research namely (1) SVM, (2) GrabCut segmentation, (3) HMM, and (4) k-mean clustering algorithm. In this framework, on the one hand, phase one is to perform the classification of SVM and Graph Cut algorithm to create the maximum margin distance. This research use GrabCut segmentation method which is the application of the graph cut algorithm and extract the data with the help of scale-invariant features transform. On the other hand, in phase two, segment the low-grade tumors and CSF using a method adapted for HMkC and extract the information of tumor or CSF fluid by GCHMkC including iterative conditional maximizing mode (ICMM) with identifying the range of distant. Comparative evaluation is also performing by the comparison of existing techniques in this research. In conclusion, our proposed model gives better results than existing. This proposed model helps to common man and doctor that can identify their condition of brain easily. In future, this will model will use for other brain related diseases.     

Rapid brain tissue segmentation process by modified FCM algorithm with CUDA enabled GPU machine

The proposed work introduces a modified method of fuzzy c means (FCM) algorithm using bias field correction and partial supervision techniques. The proposed method is named as bias corrected partial supervision FCM (BCPSFCM). The modified membership function takes the advantage of available knowledge from labeled patterns with the bias field correction. The experiment is tested on internet brain segmentation repository with their gold standard. The performance of the method is compared with three existing methods and 12 state of the art methods using dice coefficient, sensitivity, specificity, and accuracy. Accuracy of the proposed method reached upto 98%, 98%, and 99% of GM, WM, and CSF segmentation but required additional computation power from graphics processing unit (GPU). Further parallel BCPSFCM is proposed with the help of compute unified device architecture enabled GPU machine and the processing time is reduced up to 49 times than the serial implementation.     

An efficient and automatic glioblastoma brain tumor detection using shift‐invariant shearlet transform and neural networks

The detection and segmentation of tumor region in brain image is a critical task due to the similarity between abnormal and normal region. In this article, a computer‐aided automatic detection and segmentation of brain tumor is proposed. The proposed system consists of enhancement, transformation, feature extraction, and classification. The shift‐invariant shearlet transform (SIST) is used to enhance the brain image. Further, nonsubsampled contourlet transform (NSCT) is used as multiresolution transform which transforms the spatial domain enhanced image into multiresolution image. The texture features from grey level co‐occurrence matrix (GLCM), Gabor, and discrete wavelet transform (DWT) are extracted with the approximate subband of the NSCT transformed image. These extracted features are trained and classified into either normal or glioblastoma brain image using feed forward back propagation neural networks. Further, K‐means clustering algorithm is used to segment the tumor region in classified glioblastoma brain image. The proposed method achieves 89.7% of sensitivity, 99.9% of specificity, and 99.8% of accuracy.     

Brain segmentation in magnetic resonance human head scans using multi-seeded region growing

This paper presents a skull stripping method to segment the brain from MRI human head scans using multi-seeded region growing technique. The proposed method has two stages. In Stage-1, the brain in the middle slice is segmented, the brains in the remaining slices are segmented in Stage-2. In each stage, the proposed method is required to identify the rough brain mask. The fine brain region in the rough brain mask is segmented using multi-seeded region growing approach. The proposed method uses multiple seed points which are selected automatically based on the intensity profile of grey matter (GM), white matter (WM) and cerebrospinal fluid (CSF) of the brain image. The proposed brain segmentation method using multi-seeded region growing (BSMRG) was validated using 100 volumes of T1, T2 and PD-weighted MR brain images obtained from Internet Brain Segmentation Repository (IBSR), LONI and Whole Brain Atlas (WBA). The best Dice (D) value of 0·971 and Jaccard (J) value of 0·944 were recorded by the proposed BSMRG method on IBSR dataset. For LONI dataset, the best values of D?=?0·979 and J?=?0·960 were obtained for the sagittal oriented images by the proposed method. The performance consistency of the proposed method was tested on the brain images of all types and orientation and have and produced better and stable results than the existing methods Brain Extraction Tool (BET), Brain Surface Extraction (BSE), Watershed Algorithm (WAT), Hybrid Watershed Algorithm (HWA) and Skull Stripping using Graph Cuts (GCUT).     

Residual UNet with Dual Attention—An ensemble residual UNet with dual attention for multi-modal and multi-class brain MRI segmentation

In this paper, we have proposed a variant of UNet for brain magnetic resonance imaging (MRI) segmentation. The proposed model, termed as Residual UNet with Dual Attention (RUDA), addresses the two significant challenges of UNet: extraction of the complex features with unclear boundaries and the problem of over-segmentation due to the redundancy caused by the skip connection usage. RUDA is constituted upon the residual blocks for extracting the complex structures. It Introduces attention into the skip connections to avoid redundancy and thereby the chance of over-segmentation. Our model segments brain MRI into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) regions, which are considered crucial informative substructures for diagnosing neurological disorders such as Alzheimer's. It has been implemented in an ensemble manner to accommodate the multi-sequence (T1-weighted, IR, and T2-FLAIR) scans. The empirical analysis shows that with an accuracy of 93.80%, RUDA outperforms the two baseline models: UNet (91.37%), ResUNet (91.44%).     

Denoising and segmentation of MR images using fourth order non-linear adaptive PDE and new convergent clustering

At present, digital image processing plays a vital role in medical imaging areas and specifically in magnetic resonance imaging (MRI) of brain images such as axial and coronal sections. This article mainly focused on the MRI brain images. The existing methods such as total variation (MC), parallel MRI, modified pyramidal dual-tree direction filter, adaptive dictionary selection algorithm, classifier methods, and fuzzy clustering techniques are poor in image eminence and precision. Thus, this article presents a novel approach consisting of denoising followed by segmentation. The objective of these proposed methods was visual eminence improvement of medical images to examine tumor extent using an adaptive partial differential equation (APDE)-based analysis with soft threshold function in denoising. The fourth order, nonlinear APDE was used to denoise the image depending on gradient and Laplacian operators associated with the new adaptive Haar-type wavelet transform. A second approach was the new convergent K-means clustering for segmentation. The convergent K-means procedure diminishes the summation of the squared deviations of structures in a cluster from the center. The significance of these proposed methods was to compute their performances in terms of mean squared error, peak signal-to-noise ratio, structure similarity, segmentation accuracy, false hit, missed-term, and elapsed time. The results were analyzed with the MATLAB software.     

MRI brain segmentation in combination of clustering methods with Markov random field

Medical image segmentation is a preliminary stage of inclusion in identification tools. The correct segmentation of brain Magnetic Resonance Imaging (MRI) images is crucial for an accurate detection of the disease diagnosis. Due to in‐homogeneity, low distinction and noise the segmentation of the brain MRI images is treated as the most challenging task. In this article, we proposed hybrid segmentation, by combining the clustering methods with Hidden Markov Random Field (HMRF) technique. This aims to decrease the computational load and improves the runtime of segmentation method, as MRF methodology is used in post‐processing the images. Its evaluation has performed on real imaging data, resulting in the classification of brain tissues with dice similarity metric. These results indicate the improvement in performance of the proposed method with various noise levels, compared with existing algorithms. In implementation, selection of clustering method provides better results in the segmentation of MRI brain images.     

Segmentation of glioma tumors using convolutional neural networks

The abnormal development of cells in brain leads to the formation of tumors in brain. In this article, image fusion based brain tumor detection and segmentation methodology is proposed using convolutional neural networks (CNN). This proposed methodology consists of image fusion, feature extraction, classification, and segmentation. Discrete wavelet transform (DWT) is used for image fusion and enhanced brain image is obtained by fusing the coefficients of the DWT transform. Further, Grey Level Co‐occurrence Matrix features are extracted and fed to the CNN classifier for glioma image classifications. Then, morphological operations with closing and opening functions are used to segment the tumor region in classified glioma brain image.     

An Efficient Image Analysis Framework for the Classification of Glioma Brain Images Using CNN Approach

The identification of brain tumors is multifarious work for the separation of the similar intensity pixels from their surrounding neighbours. The detection of tumors is performed with the help of automatic computing technique as presented in the proposed work. The non-active cells in brain region are known to be benign and they will never cause the death of the patient. These non-active cells follow a uniform pattern in brain and have lower density than the surrounding pixels. The Magnetic Resonance (MR) image contrast is improved by the cost map construction technique. The deep learning algorithm for differentiating the normal brain MRI images from glioma cases is implemented in the proposed method. This technique permits to extract the linear features from the brain MR image and glioma tumors are detected based on these extracted features. Using k-mean clustering algorithm the tumor regions in glioma are classified. The proposed algorithm provides high sensitivity, specificity and tumor segmentation accuracy.     

Brain tumor segmentation using a deep Shuffled-YOLO network

Brain tumor is an anomalous proliferation of cells in the brain that can evolve to malignant and benign tumors. Currently, segmentation of brain tumor is the most important surgical and pharmaceutical procedures. However, manually segmenting brain tumors is hard because it is hard to find erratically shaped tumors with only one modality; the MRI modalities are integrated to provide multi-modal images with data that can be utilized to segment tumors. The recent developments in machine learning and the accessibility of medical diagnostic imaging have made it possible to tackle the challenges of segmenting brain tumors with deep neural networks. In this work, a novel Shuffled-YOLO network has been proposed for segmenting brain tumors from multimodal MRI images. Initially, the scalable range-based adaptive bilateral filer (SCRAB) pre-processing technique was used to eliminate the noise artifacts from MRI while preserving the edges. In the segmentation phase, we propose a novel deep Shuffled-YOLO architecture for segmenting the internal tumor structures that include non-enhancing, edema, necrosis, and enhancing tumors from the multi-modality MRI sequences. The experimental fallouts reveal that the proposed Shuffled-YOLO network achieves a better accuracy range of 98.07% for BraTS 2020 and 97.04% for BraTS 2019 with very minimal computational complexity compared to the state-of-the-art models.     

Computer aided automated detection and classification of brain tumors using CANFIS classification method

The development of abnormal cells in human brain leads to the formation of tumors. This article proposes an efficient approach for brain tumor detection and segmentation using image fusion and co-active adaptive neuro fuzzy inference system (CANFIS) classification method. The brain MRI images are fused and the dual tree complex wavelet transform is applied on the fused image. Then, the statistical features, local ternary pattern features and gray level co-occurrence matrix features. These extracted features are classified using CANFIS classification approach for the classification of source brain MRI image into either normal or abnormal. Further, morphological operations are applied on the abnormal brain MRI image for segmenting the tumor regions. The proposed methodology is evaluated with respect to the performance metrics sensitivity, specificity, positive predictive value, negative predictive value, tumor segmentation accuracy with detection rate. The proposed image fusion based brain tumor detection and classification methodology stated in this article achieves 96.5% of average sensitivity, 97.7% of average specificity, 87.6% of positive predictive value, 96.6% of negative predictive value, and 98.8% of average accuracy.