共查询到20条相似文献，搜索用时 15 毫秒
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Fangyuan Zhou Bing Feng Tingting Wang Dangge Wang Zhirui Cui Siling Wang Chunyong Ding Zhiwen Zhang Jian Liu Haijun Yu Yaping Li 《Advanced functional materials》2017,27(46)
A reactive oxygen species (ROS)‐activatable doxorubicin (Dox) prodrug vesicle (RADV) is presented for image‐guided ultrafast drug release and local‐regional therapy of the metastatic triple‐negative breast cancer (TNBC). RADV is prepared by integrating a ROS‐activatable Dox prodrug, a poly(ethylene glycol) (PEG)‐modified photosensitizer pyropheophorbide‐a, an unsaturated phospholipid 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine, and cholesterol into one single nanoplatform. RADV is of extremely high drug loading ratio (27.5 wt%) by self‐assembly of the phospholipid‐mimic Dox prodrug into the liposomal bilayer membrane. RADV displays good colloidal stability to prevent premature drug leakage during the blood circulation and inert photochemotoxicity to avoid nonspecific side effect. RADV passively accumulates at tumor site through the enhanced permeability and retention effect when administrated systemically. Once deposited at the tumor site, RADV generates fluorescent and photoacoustic signals to guide near‐infrared (NIR) laser irradiation, which can induce localized ROS generation, not only to trigger prodrug activation and ultrafast drug release but also conduct photodynamic therapy in a spatiotemporally controlled manner. In combination with NIR laser irradiation, RADV efficiently inhibits the tumor growth and distant metastasis of TNBC. Local‐regional tumor therapy using intelligent theranostic nanomedicine might provide an alternative option for highly efficient treatment of the metastatic TNBC. 相似文献
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Kochurani K. Johnson Pramod Koshy Jia-Lin Yang Charles C. Sorrell 《Advanced functional materials》2021,31(43):2104199
Nanomaterials with cancer-imaging and therapeutic properties have emerged as the principal focus of nanotheranostics. The past decade has experienced a significant increase in research in the design, formulation, and preclinical and clinical trials of theranostic nanosystems. However, current theranostic nanoformulations have yet to be approved by the FDA for clinical use. Consequently, the present review focuses on the importance of the careful examination of the in vivo preclinical status of specific nanotheranostic materials as a prerequisite for their clinical translation. The scope of coverage is structured according to all of the major organic, inorganic, 2D, and hybrid nanotheranostic materials and their in vivo preclinical status. The therapeutic advantages and limitations of these materials in animal models are considered and the various strategies to enhance the biocompatibility of theranostic nanoparticles are summarized. 相似文献
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Zachary T. Rosenkrans Jessica C. Hsu Eduardo Aluicio-Sarduy Todd E. Barnhart Jonathan W. Engle Weibo Cai 《Advanced functional materials》2023,33(33):2302777
The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy referred to as Cerenkov radiation-induced therapy (CRIT). Semiconducting polymer nanoparticles (SPNs) have ideal optical properties, such as large absorption cross-sections and broad absorbance, which can be utilized to harness the relatively weak CL produced by radionuclides. SPNs can be doped with photosensitizers and have ≈100% energy transfer efficiency by multiple energy transfer mechanisms. Herein, an optimized photosensitizer-doped SPN is investigated as a nanosystem to harness and amplify CL for cancer theranostics. It is found that semiconducting polymers significantly amplify CL energy transfer efficiency. Bimodal positron emission tomography (PET) and optical imaging studies show high tumor uptake and retention of the optimized SPNs when administered intravenously or intratumorally. Lastly, it is found that photosensitizer-doped SPNs have excellent potential as a cancer theranostics nanosystem in an in vivo tumor therapy study. This study shows that SPNs are ideally suited to harness and amplify CL for cancer theranostics, which may provide a significant advancement for CRIT that are unabated by tissue penetration limits. 相似文献
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Gallium-based liquid metal (LM) nanoparticles are among the most promising nanoscale materials for biomedicinal applications because of their outstanding physicochemical properties, including unique flexibility, easy surface modification, excellent photothermal conversion efficiency, and high biocompatibility. Further exploration of the modification and remote-controlling performances of LM nanoparticles with functional bioactive molecules for the development of an innovative treatment modality for diseases is challenging. Herein, it is reported that near-infrared (NIR) light-activatable LM nanoparticle, which functionalized with immunological activators of T and dendritic cells, can work as highly immunogenic and photo-exothermic nanoscale stimulants for cancer treatment. The synthesized LM nanostimulant, which has low toxicity, powerful photothermal conversion property, and high immunogenic features, can effectively eliminate cancer cells, cancer spheroids, and colorectal tumors in living mice under NIR laser illumination. Moreover, the fluorescent LM nanostimulant can express strong fluorescence as a reporter agent to identify the targeted tumors in living mice for optical cancer diagnosis. Therefore, such a smart nanostimulant represents a way toward combination photothermal immunotheranostics. 相似文献
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Recently, lanthanide nanoparticles have aroused widespread interest in cancer theranostics by virtue of their excellent photoresponsive performance in deep-seated tumors. The abundant ladder-like energy levels, controllable emission profiles, and unique photoluminescence properties make lanthanide nanoparticles highly efficient for deep skin-penetration of near-infrared (NIR) light, concentrating light energy in tumors with negligible scattering and minimal autofluorescence from biological tissues. High-Z radio-sensitization of lanthanide elements endows lanthanide nanoparticles with a high X-ray attenuation coefficient, making them effective nanoprobes for X-ray-excited bioimaging and synchronous radiotherapy-related treatments. In this review, comprehensive progressions including the synthesis, structural characteristics of lanthanide nanoparticles, and distinct optical excitation mechanisms with NIR and X-ray triggers, are summarized. Advances in NIR-excited and X-ray-triggered cancer imaging methods and therapies are described in detail, wherein NIR-induced luminescence from upconversion nanoparticles and downconversion nanoparticles are introduced separately based on some typical sensitization. Finally, the challenges and opportunities of lanthanide nanoparticles as light-triggered cancer theranostic candidates are discussed, whose translation from bench to bedside still has a long journey to go. 相似文献
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Cancer Therapy: Multifunctional Carbon–Silica Nanocapsules with Gold Core for Synergistic Photothermal and Chemo‐Cancer Therapy under the Guidance of Bimodal Imaging (Adv. Funct. Mater. 24/2016) 
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下载免费PDF全文 Linlin Li Chuanfang Chen Huiyu Liu Changhui Fu Longfei Tan Shunhao Wang Shiyan Fu Xi Liu Xianwei Meng Hong Liu 《Advanced functional materials》2016,26(24):4424-4424
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Linlin Li Chuanfang Chen Huiyu Liu Changhui Fu Longfei Tan Shunhao Wang Shiyan Fu Xi Liu Xianwei Meng Hong Liu 《Advanced functional materials》2016,26(24):4252-4261
Carbon‐based nanomaterials have been developed for photothermal cancer therapy, but it is still a great challenge to fabricate their multifunctional counterparts with facile methods, good biocompatibility and dispersity, and high efficiency for cancer theranostics. In this work, an alternative multifunctional nanoplatform is developed based on carbon–silica nanocapsules with gold nanoparticle in the cavity (Au@CSN) for cancer theranostics. The encapsulated chemodrug doxorubicin can be released from the Au@CSN with mesoporous and hollow structure in a near‐infrared light and pH stimuli‐responsive manner, facilitating spatiotemporal therapy to decrease off‐target toxicity. The nanocapsules with efficient photothermal conversion and excellent biocompatibility achieve a synergistic effect of photothermal and chemotherapy. Furthermore, the nanocapsules can act as a multimodal imaging agent of computed tomography and photoacoustic tomography imaging for guiding the therapy. This new design platform can provide a promising strategy for precise cancer theranostics. 相似文献
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Lei Duan Fang Yang Wen He Lina Song Fan Qiu Ning Xu Lu Xu Yu Zhang Zichun Hua Ning Gu 《Advanced functional materials》2016,26(45):8313-8324
The accurately and efficiently targeted delivery of therapeutic/diagnostic agents into tumor areas in a controllable fashion remains a big challenge. Here, a novel cancer targeting magnetic microbubble is elaborately fabricated. First, the γ‐Fe2O3 magnetic iron oxide nanoparticles are optimized to chemically conjugate on the surface of polymer microbubbles. Then, arginine‐glycine‐aspartic acid‐l ‐tumor necrosis factor‐related apoptosis‐inducing ligand (RGD‐l ‐TRAIL), antitumor targeting fusion protein, is precisely conjugated with magnetic nanoparticles of microbubbles to construct RGD molecularly targeted magnetic microbubble, which is defined as RGD‐l ‐TRAIL@MMBs. Such RGD‐l ‐TRAIL@MMBs is endowed with the multigradient cascade targeting ability following by magnetic targeting, RGD, as well as enhanced permeability and retention effect regulated targeting to result in high cancerous tissue targeting efficiency. Due to the highly specific accumulation of RGD‐l ‐TRAIL@MMBs in the tumor, the accurate diagnostic information of tumor can be obtained by dual ultrasound and magnetic resonance imaging. After imaging, the TRAIL molecules as anticancer agent also get right into the cancer cells by nanoparticle‐ and RGD‐mediated endocytosis to effectively induce the tumor cell apoptosis. Therefore, RGD‐l ‐TRAIL conjugated magnetic microbubbles could be developed as a molecularly targeted multimodality imaging delivery system with the addition of chemotherapeutic cargoes to improve cancer diagnosis and therapy. 相似文献
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Shichao Zhang Qinzhe Li Nan Yang Yunhao Shi Wei Ge Wenjun Wang Wei Huang Xuejiao Song Xiaochen Dong 《Advanced functional materials》2019,29(49)
Tumor hypoxia strengthens tumor resistance to different therapies especially oxygen involved strategies, such as photodynamic therapy (PDT). Herein, the thermal responsive phase change materials (PCM) are utilized to coencapsulate ultrasmall manganese dioxide (sMnO2) and organic photosensitizer IR780 to obtain IR780‐sMnO2‐PCM nanoparticles for controlled tumor hypoxia modulation and enhanced phototherapy. The thermal responsive protective PCM layer can not only prevent IR780 from photodegradation, but also immediately release sMnO2 to decompose endogenous H2O2 and generate enough oxygen for PDT under laser irradiation. Owing to the efficient accumulation of IR780‐sMnO2‐PCM nanoparticles in tumor under intravenous injection as revealed by both florescence imaging and photoacoustic imaging, the tumor hypoxia is greatly relieved. Furthermore, in vivo combined photothermal therapy (PTT) and PDT, IR780‐sMnO2‐PCM nanoparticles, compared to IR780‐PCM nanoparticles, exhibit better performance in inhibiting tumor growth. The results highlight the promise of IR780‐sMnO2‐PCM in controlled modulation of tumor hypoxia to overcome current limitations of cancer therapies. 相似文献
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Venkata M. Suresh Subi J. George Tapas Kumar Maji 《Advanced functional materials》2013,23(45):5684-5684
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Venkata M. Suresh Subi J. George Tapas Kumar Maji 《Advanced functional materials》2013,23(45):5585-5590
Metal‐organic vesicular and toroid nanostructures of Zn(OPE)·2H2O are achieved by coordination‐directed self‐assembly of oligo‐phenyleneethynylenedicarboxylic acid (OPEA) as a linker with Zn(OAc)2 by controlling the reaction parameters. Self‐assembled nanostructures are characterized by powder X‐ray diffraction, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and adsorption study. The amphiphilic nature of the coordination‐polymer with long alkyl chains renders different soft vesicular and toroidal nanostructures. The permanent porosity of the framework is established by gas adsorption study. Highly luminescent 3D porous framework is exploited for Froster's resonance energy transfer (FRET) by encapsulation of a suitable cationic dye ( DSMP ) which shows efficient funneling of excitation energy. These results demonstrate the dynamic and soft nature of the MOF, resulting in unprecedented vesicular and toroidal nanostructures with efficient light harvesting applications. 相似文献
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Cancer Phototherapy: Mitochondria‐Targeted Small‐Molecule Fluorophores for Dual Modal Cancer Phototherapy (Adv. Funct. Mater. 17/2016) 下载免费PDF全文
下载免费PDF全文 Shenglin Luo Xu Tan Shengtao Fang Yu Wang Tao Liu Xin Wang Yi Yuan Huiqin Sun Qingrong Qi Chunmeng Shi 《Advanced functional materials》2016,26(17):2975-2975
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Shenglin Luo Xu Tan Shengtao Fang Yu Wang Tao Liu Xin Wang Yi Yuan Huiqin Sun Qingrong Qi Chunmeng Shi 《Advanced functional materials》2016,26(17):2826-2835
Mitochondria are recognized as the ideal target for cancer treatment because they play a central role in oxidative metabolism and apoptosis. In this work, a mitochondria‐targeted near‐infrared (NIR) photosensitizer (PS) for synchronous cancer photodynamic therapy (PDT) and photothermal therapy (PTT) is synthesized. This multifunctional small‐molecule PS is developed from a variety of synthesized heptamethine cyanine dyes, which are modified with various N‐alkyl side chains on the lipophilic cationic heptamethine core. It is demonstrated to preferentially accumulate in cancer cells by organic‐anion transporting polypeptide mediated active transport and retain in mitochondria by its lipophilic cationic property. As mitochondria are susceptible to hyperthermia and excessive reactive oxygen species, this new PS integrating PTT and PDT treatment exhibits highly efficient phototherapy in multiple cancer cells and animal xenograft models. Furthermore, this targeted PS with NIR imaging property also enables tumors and their margins clearly visualized, providing the potential for precisely imaging‐guided phototherapy and treatment monitoring. This is the first report that a small‐molecule PS integrates both cancer PTT and PDT treatment by targeting mitochondria, significantly increasing the photosensitization. This work may also present a practicable strategy to develop small‐molecule‐based cancer theranostic agents for simultaneous cancer targeting, imaging, and therapy. 相似文献
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Photoresponsive actuators are built by introducing oligo(ethylene glycol) (OEG)‐modified W18O49 nanowires into cross‐linked polyethylene glycol diacrylate (cPEGDA) polymer matrices. Due to the good compatibility, OEG‐W18O49 NWs disperse well and increase the crystallinity of cPEGDA matrices even in high loading concentrations (4.0 wt%). The cPEGDA/W18O49 nanocomposites show efficient photothermal transition and rapid shape memory behaviors. They can raise the local temperature to 160 °C in only 8.5 s and recover the initial shape within 10 s. Making use of the broad and strong absorption property of W18O49, the cPEGDA/W18O49 NW actuators respond to both ultraviolet and near‐infrared light and make contraction and bending motions. Furthermore, by utilizing oriented chain segments of the crystalline polymer and vector sum of shape recovery forces, the cPEGDA/W18O49 NW hybrid actuators exhibit stable helical deformation (right‐handed and left‐handed). 相似文献
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Lang Rao Lin‐Lin Bu Qian‐Fang Meng Bo Cai Wei‐Wei Deng Andrew Li Kaiyang Li Shi‐Shang Guo Wen‐Feng Zhang Wei Liu Zhi‐Jun Sun Xing‐Zhong Zhao 《Advanced functional materials》2017,27(9)
Nanoparticles possess the potential to revolutionize cancer diagnosis and therapy. The ideal theranostic nanoplatform should own long system circulation and active cancer targeting. Additionally, it should be nontoxic and invisible to the immune system. Here, the authors fabricate an all‐in‐one nanoplatform possessed with these properties for personalized cancer theranostics. Platelet‐derived vesicles (PLT‐vesicles) along with their membrane proteins are collected from mice blood and then coated onto Fe3O4 magnetic nanoparticles (MNs). The resulting core–shell PLT‐MNs, which inherit the long circulation and cancer targeting capabilities from the PLT membrane shell and the magnetic and optical absorption properties from the MN core, are finally injected back into the donor mice for enhanced tumor magnetic resonance imaging (MRI) and photothermal therapy (PTT). Meanwhile, it is found that the PTT treatment impels PLT‐MNs targeting to the PTT sites (i.e., tumor sites), and exactly, in turn, the enhanced targeting of PLT‐MNs to tumor sites can improve the PTT effects. In addition, since the PLT membrane coating is obtained from the mice and finally injected into the same mice, PLT‐MNs exhibit stellar immune compatibility. The work presented here provides a new angle on the design of biomimetic nanoparticles for personalized diagnosis and therapy of various diseases. 相似文献
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Bowen Li Jianwu Tian Xin Xie Fu Zhang Chongzhi Wu Yi Shan Guobin Qi Wentao Song Yuan Ping Bin Liu 《Advanced functional materials》2024,34(4):2309524
Triple-negative breast cancer (TNBC) is endowed with a highly aggressive nature that results in distant metastases and high recurrence rates, yet limited success is realized in traditional chemotherapy. Activatable photosensitizers (PSs) may provide an effective and non-invasive strategy to induce TNBC cell death in a precise way by offering stimuli-responsive reactive oxygen species (ROS). However, the toxicity of ROS is often mitigated and even devitalized by the instinctive behavior of ROS resistance in TNBC cells. To address this issue, herein a small molecular self-assembly nano-prodrug is presented to co-deliver an activatable PS and ROS resistance inhibitor. In TNBC cells, the overexpressed glutathione can disassemble the nano-prodrug, thereby releasing ROS resistance inhibitor and activating the PS for photodynamic therapy and fluorescence imaging. A hybrid membrane coating-assisted nanoparticle formation strategy is further demonstrated for efficient inhibition of tumor growth and distant metastases on both subcutaneous and orthotopic TNBC mice models. 相似文献
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Ke Ma Wei Xie Wei Liu Lei Wang Dong Wang Ben Zhong Tang 《Advanced functional materials》2021,31(36):2102645
Graphene oxide (GO)-based fluorescent DNA aptasensors are promising nanomaterials in bioassays owing to the fluorescent ultrasensitivity and target identification ability. However, their in vivo application remains an appealing yet significantly challenging task. In this contribution, for the first time, a nanomaterial for in vivo diagnosis and therapy of liver tumors is demonstrated. A DNA nanomaterial consisting of DNA tetrahedron and aptamers, aggregation-induced emission luminogens, and antitumor drug doxorubicin, is fabricated and attached on the GO surface. This developed hybrid with good biocompatibility exhibits high selectivity to target liver cancer cells, and performs well in in vitro and in vivo liver tumor fluorescence imaging diagnosis and chemotherapy. Additionally, a GO-based fluorescent DNA nanodevice is also constructed by using microfluidic chips for liver tumor cell screening. 相似文献
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Sumit Kumar Jae‐A Han Issac J. Michael Dongyeob Ki Vijaya Sunkara Juhee Park Shreedhar Gautam Hong Koo Ha Liangfang Zhang Yoon‐Kyoung Cho 《Advanced functional materials》2019,29(30)
The possibility of functional roles played by platelets in close alliance with cancer cells has inspired the design of new biomimetic systems that exploit platelet–cancer cell interactions. Here, the role of platelets in cancer diagnostics is leveraged to design a microfluidic platform capable of detecting cancer‐derived extracellular vesicles (EVs) from ultrasmall volumes (1 µL) of human plasma samples. Further, the captured EVs are counted by direct optical coding of plasmonic nanoprobes modified with EV‐specific antibodies. Owing to the inherent properties of platelets for multifaceted interaction with cancer cells, the microfluidic chip equipped with a biologically interfaced platelet membrane‐cloaked surface (denoted “PLT‐Chip”) can capture a significantly higher number of EVs from multiple types of cancer cell lines (prostate, lung, bladder, and breast) than the normal cell‐derived EVs. Furthermore, this chip allows the monitoring of the growth of tumor spheroids (100 µm–2.5 mm) and clearly distinguishes the plasma of cancer patients from that of normal healthy controls. This robust, multifaceted, and cancer‐specific binding affinity, coupled with excellent biocompatibility, is a unique feature of platelet membrane‐cloaked surfaces, which therefore represent promising alternatives to antibodies for application in EVs‐based cancer theranostics. 相似文献