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A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics 
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下载免费PDF全文 Amir Nasajpour Sahar Ansari Chiara Rinoldi Afsaneh Shahrokhi Rad Tara Aghaloo Su Ryon Shin Yogendra Kumar Mishra Rainer Adelung Wojciech Swieszkowski Nasim Annabi Ali Khademhosseini Alireza Moshaverinia Ali Tamayol 《Advanced functional materials》2018,28(3)
Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth‐supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering. 相似文献
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Qian Wang Yunbo Feng Min He Weifeng Zhao Li Qiu Changsheng Zhao 《Advanced functional materials》2021,31(8):2008906
An ideal guided bone regeneration membrane (GBRM) is expected not only to perform barrier function, but also to enhance osteogenesis and resist bacteria infection. However, currently available membranes have limited bioactivities. To address this challenge, a Janus GBRM (JGM) is designed and fabricated by sequential fractional electrospinning here. The random gelatin fibers loaded with hydroxyapatite (HAP) are designed as the inner face to promote the osteoblasts’ adhesion, proliferation, and osteogenic differentiation, meanwhile the aligned poly(caprolactone) (PCL) nanofibers loaded with poly(methacryloxyethyltrimethyl ammonium chloride-co-2-Aminoethyl 2-methylacrylate hydrochloride) (P(DMC-AMA)) are designed as the outer layer to resist epithelia invasion and bacterial infection. In vitro assays reveal that the inner face displays enhanced osteogenic effects, meanwhile the outer surface can regulate the epithelia to spread along the aligned direction and kill the contacted bacteria. Interestingly, the outer face can induce macrophages to polarize toward the M2 phenotype, thus manipulating a favorable osteoimmune environment. These results suggest that the JGM simultaneously meets the critical requirements of barrier, osteogenic, antibacterial, and osteoimmunomodulatory functions. Consequently, the JGM shows better in vivo bone tissue regeneration performance than the commercial Bio-Gide membrane. This work provides a novel platform to design multi-functional membranes/scaffolds, displaying great potential applications in tissue engineering. 相似文献
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Xian Tong Yue Han Li Zhu Runqi Zhou Zhiqiang Lin Hongning Wang Shengbin Huang Yuncang Li Jianfeng Ma Cuie Wen Jixing Lin 《Advanced functional materials》2023,33(31):2214657
Zinc (Zn) and its alloys have recently gained research interest due to their good biosafety, biological function, biodegradability, and formability. Zinc-phosphate (ZnP) coating has been shown to improve the corrosion resistance and biocompatibility of Zn alloys. Here, a biodegradable ZnP-coating on Zn 1Cu 0.1Ti (ZCT) membrane with high strength-ductility and mechanical stability, suitable degradation rate, effective antibacterial ability, excellent in vitro and in vivo cytocompatibility, and osteogenesis is reported. The ZnP-coated ZCT exhibits high strength-ductility with a yield strength of 264 MPa, ultimate tensile strength of 312 MPa, elongation of 36.0%, and high mechanical stability before and after 30 d immersion in Hanks’ and AS solutions, all of which are higher than those of ZCT. The ZnP coating shows good deformation resistance, healing effect, and bond strength with the substrate, meeting the clinical contour shaping requirements. The ZnP-coated ZCT membrane sample shows higher cell viability toward MC3T3-E1 and MG-63 cells, osteogenic and mitochondrial quality-control properties in vitro than those of the ZCT sample. Using a rat calvarial defect model, the ZnP-coated ZCT membrane shows complete biosafety and considerable osteogenesis performance. Overall, the ZnP-coated ZCT membrane is recommended as a promising biodegradable implant material for oral guided bone regeneration application. 相似文献
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Lukuan Cheng Wenzheng Li Mengrui Li Shiqiang Zhou Jingyi Yang Wen Ren Lina Chen Yan Huang Suzhu Yu Jun Wei 《Advanced functional materials》2024,34(48):2408863
The major challenges of aqueous zinc-ion batteries (ZIBs) are the dendrite formation and the passivation of zinc metal anode, which restrict their practical applications. Herein, polyacrylonitrile (PAN) and zwitterionic surfactant (Sulfobetaine methacrylate, SBMA) are combined as a precursor to design a modified PAN nanofiber separator by electrospinning. SBMA with sulfonate group [SO3−] can alter the physical property of the precursor solution and electrostatic field during the electrospinning process. Besides, it can regulate the zinc ions crossing and homogenize the electric field by minimizing the zinc ion concentration polarization on the zinc foil surface due to the polar group. As a result, Zn symmetric cells with PAN@SBMA separators show long-term stability (up to 1700 h), which outdistances the cell with GF-D (only up to 50 h) under current density at 1 mA cm−2. Meanwhile, the Zn//PAN@SBMA//NH4V4O10 full cells have high specific capacity (236 mAh g−1) and excellent long-term durability with 84.2% capacity retention after 2000 cycles at 5 A g−1. This work illustrates an easy and effective way to design a high ion transference number and functional PAN-based separator for regulating Zn2+ deposition for the development of high-performance ZIBs. 相似文献
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Indium zinc oxide (IZO) films with surface roughness Ra<0.3 nm have been prepared by radio frequency sputtering. The IZO film is the possible candidate for replacing the indium tin oxide (ITO) film in pattern precision or low processing temperature concern. Instead of commonly used In2O3:ZnO=90:10 in weight percentage (wt%) target, a target doped with 5 wt% impurities was used in this study. It was found that the electrical resistivity of the IZO film increases rapidly if oxygen gas was introduced during the sputtering process. This increase tendency in electrical resistivity is much more significant than the IZO film prepared with a 10 wt% doped ZnO target. The electrical resistivity increased rapidly as soon as the IZO film became crystallized in heat treatment. Optical properties of the IZO film do not change significantly with varying process parameters. The appropriate processing condition for the prepared IZO film is no oxygen feeding and no heat treatment. 相似文献
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采用聚乙烯醇(PVA,Mw=80000g/mol)和五水合四氯化锡(SnCl4.5H2O)作为静电纺丝前驱液,着重研究了纺丝电压、前驱液中PVA浓度及煅烧温度等因素对纺丝过程及纤维特性的影响,并用扫描电镜(SEM)和X射线衍射(XRD)等分析手段对纤维的微观结构、表面形貌和结晶状态进行了表征。结果表明,当纺丝电压为4kV、纺丝液中PVA质量分数为7%、退火温度为700℃时,可以得到平均直径为300nm的连续SnO2纳米纤维。该纤维对乙醇的响应恢复时间小于15s,检测极限低于10×10-9。 相似文献
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采用聚乙烯醇（PVA，Mw=80000g/mol）和五水合四氯化锡（SnCl4.5H2O）作为静电纺丝前驱液，着重研究了纺丝电压、前驱液中PVA浓度及煅烧温度等因素对纺丝过程及纤维特性的影响，并用扫描电镜（SEM）和X射线衍射（XRD）等分析手段对纤维的微观结构、表面形貌和结晶状态进行了表征。结果表明，当纺丝电压为4kV、纺丝液中PVA质量分数为7%、退火温度为700℃时，可以得到平均直径为300nm的连续SnO2纳米纤维。该纤维对乙醇的响应恢复时间小于15s，检测极限低于10×10^-9。 相似文献
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Yaping Ding Wei Li Feng Zhang Zehua Liu Nazanin Zanjanizadeh Ezazi Dongfei Liu Hlder A. Santos 《Advanced functional materials》2019,29(2)
The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug‐inclusion processes via electrospinning could be employed to achieve programmed, multi‐staged, or stimuli‐triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drug‐eluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges. 相似文献
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Marco Angarano Simon Schulz Martin Fabritius Robert Vogt Thorsten Steinberg Pascal Tomakidi Christian Friedrich Rolf Mülhaupt 《Advanced functional materials》2013,23(26):3277-3285
In a versatile modular scaffold system, gradient nonwovens of in situ crosslinked gelatin nanofibers (CGN), fabricated by reactive electrospinning, are laminated with perforated layers and nonwovens of thermoplastic non‐crosslinked biodegradable polyesters. The addition of glyoxal to a gelatin solution in a non‐toxic solvent mixture consisting of acetic acid, ethyl acetate, and water (5:3:2 w/w/w) enables the in situ crosslinking of gelatin nanofibers during electrospinning. The use of this fluorine‐free crosslinking system eliminates the need of post‐treatment crosslinking and purification steps typical for conventional CGN scaffolds. The slowly progressing crosslinking of the dissolved gelatin in the presence of glyoxal increases the viscosity of the gelatin solution during electrospinning so that the average diameter of the crosslinked gelatin nanofibers gradually increases from 90 to 680 nm. During the subsequent lamination process, alternating layers of CGN and polycaprolactone (PCL) nonwovens, produced by 3D microextrusion of micrometer‐sized PCL fibers, are bonded together upon heating above the PCL melting temperature. In contrast to the water‐soluble gelatin nanofibers and the comparatively weak CGN, the CGN/PCL/CGN layered biocomposites are water‐resistant and very robust. In such modular scaffold systems, strength, biodegradation rate, and biological functions can be controlled by varying the type, composition, fiber diameter, porosity, number, and sequence of the individual layers. The CGN/PCL multilayer biocomposites can be cut into any desired scaffold shape and attached to tissue by surgical sutures in order to suit the needs of individual patients. 相似文献
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Chaobo Huang Stefaan J. Soenen Joanna Rejman Jesse Trekker Liu Chengxun Liesbet Lagae Wim Ceelen Claire Wilhelm Jo Demeester Stefaan C. De Smedt 《Advanced functional materials》2012,22(12):2479-2486
Iron oxide nanoparticles (IONPs) for magnetic hyperthermia in cancer treatment have recently gained substantial interest. Unfortunately, the use of free IONPs still faces major challenges such as poor tumor targetability, high variability in the amount of IONPs taken up by the tumor and the IONP leakage from dead cancer cells into the surrounding healthy tissues. The present work reports on electrospun fiber webs, heavily loaded with 50 nm sized IONPs. The high loading capacity of the fibers enables significant heating of the environment upon applying an alternating magnetic field. Furthermore, magnetic fibers can be repeatedly heated without loss of heating capacity or release of IONPs. Upon functionalization of the fiber surface with collagen, human SKOV‐3 ovarian cancer cells attached well to the fibers. Applying an alternating magnetic field during 10 minutes to the fiber webs killed all fiber‐associated cancer cells. Killing the cells using this method seemed more efficient compared to the use of a warm water bath. As the fiber webs can be i) loaded with a well‐controlled amount of IONPs and ii) localized in the body by Magnetic Resonance Imaging, magnetic electrospun fibers may become promising materials for a highly reproducible (repeated) heating of cancer tissues in vivo. 相似文献
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Dimitry Papkov Alexander Goponenko Owen C. Compton Zhi An Alexander Moravsky Xing‐Zhong Li SonBinh T. Nguyen Yuris A. Dzenis 《Advanced functional materials》2013,23(46):5763-5770
Continuous carbon nanofibers (CNF) present an attractive building block for a variety of multifunctional materials and devices. However, the carbonization of poly(acrylonitrile) (PAN) precursors usually results in CNFs with poor graphitic structure and, consequently, modest/non‐optimized properties. This paper reports that the graphitic structure of CNFs can be improved with an addition of a small amount of graphene oxide into PAN prior to processing. Continuous CNFs with 1.4 wt% of graphene oxide nanoparticles are prepared from PAN solutions by electrospinning, stabilized, and carbonized at 800 °C, 1200 °C, and 1850 °C. While the as‐prepared graphene oxide‐filled PAN nanofibers exhibit a considerable reduction in polymer crystallinity, Raman analysis of the carbonized nanofibers shows that both templating with graphene oxide and increasing the carbonization temperature significantly improve the graphitic order in CNFs. The effect of graphene oxide is more significant at higher carbonization temperatures. Selected area electron diffraction analysis of individual nanofibers reveals increased graphitic order and preferred orientation both in the vicinity of visible graphene oxide nanoparticles and in the regions where nanoparticles were not visible. These results indicate a possibility of global templating in CNFs, where the addition of a small amount of graphene oxide nanoparticles can template the formation of good, preferentially oriented graphitic crystallites in CNFs, leading to improved structure and mechanical and transport properties. 相似文献
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Leipeng Li Chongyang Cai Xiaohuan Lv Xingqiang Shi Dengfeng Peng Jianrong Qiu Yanmin Yang 《Advanced functional materials》2023,33(32):2301372
Owing to the forthcoming global energy crisis, the search for energy-saving materials has intensified. Over the past two decades, mechanically induced luminescent materials have received considerable attention as they can convert waste into useful components, for instance, the conversion from stress into light. However, this material features many constraints that limit its widespread application. Herein, a strategy to improve the mechanoluminescence (ML) of ZnO by embedding it in a ZnF2:Mn2+ matrix is introduced. Upon dynamic excitation via an external stress, the reddish-yellow ML is confirmed to originate from the 4T1 (4G) → 6A1 (6S) transition of the optically active Mn2+ center. Moreover, the sample with the strongest ML contains the appropriate amount of ZnF2 (ZnF2:ZnO = 7:3). By performing density functional theory calculations, a possible ML-enhancement mechanism is elucidated, which indicates the formation of a ZnF2/ZnO:Mn2+ heterojunction. Considering the unique characteristics of ML, its promising applications are demonstrated in various mechano-optics scenarios, including flexible and stretchable optoelectronics, advanced self-powered displays, e-skins/e-signatures, and anti-counterfeiting, without the use of external light/electric-incentive sources. The study significantly increases the variety of ML materials and is expected to strengthen the foundation for the future development of smart mechanically controlled devices and energy-saving systems. 相似文献
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Runheng Liu Shoucheng Chen Peina Huang Guanqi Liu Pu Luo Zhipeng Li Yin Xiao Zhuofan Chen Zetao Chen 《Advanced functional materials》2020,30(21)
The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of metal implants in soft‐tissue‐related areas. Prompted by the close association between soft tissue integration and the immune response, an immunomodulation‐based strategy is proposed to manipulate the immune microenvironment and improve metal implant–soft tissue integration. Considering their vital roles in soft tissue responses to metal implants, macrophages are used and the cytokines fingerprints of M1 and M2 macrophage immune microenvironments are evaluated for their potential modulatory effects on metal implant–soft tissue integration. The modulatory effects of different immune microenvironments on model soft tissue cells (human gingival epithelium cells) cultured on model metal implants (titanium alloy disks) are then described, with the underlying possible mechanism FAK‐AKT‐mTOR signaling unveiled. As further proof of concept, IL‐4/PDA (polydopamine)‐coated titanium alloy implants, aiming at modulating M2 macrophage polarization, are prepared and found to improve the in vivo metal implant‐soft tissue integration. It is the authors' ambition that this immunomodulation‐based strategy will change the negative perception and encourage the active development of metal materials with favorable soft tissue integration properties, thus improving the success rates of perforating metal implants and broadening their application in soft‐tissue‐related areas. 相似文献
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In the pursuit of sustainable energy solutions, zinc-based flow batteries stand out for their potential in large-scale energy storage, offering a blend of cost efficiency and safety. Although the porous electrode provides an increased specific surface area for reaction, the non-uniform deposition of zinc, attributed to uneven concentration distribution within the porous electrode, has been a pivotal issue in accelerating the formation of zinc dendrites, which hinders the enhancement of energy density. A composite electrode with a strategic hierarchical pore structure has been developed with aligned nitrogen-doped carbon fibers and traditional carbon felt. This structure takes advantage of the large pores of the carbon felt for efficient through-flow paths, ensuring higher flow rates, while the dual-scale pores within the electrospun film enhance mass transfer and increase the specific surface area. At 320 mA cm−2, it achieved an ≈11.4% improvement in the battery's energy efficiency. Moreover, the nitrogen doping and the optimized reaction uniformity within the composite electrode have been instrumental in reducing the generation of zinc dendrites. The battery, integrated with the innovative composite electrode, maintained an energy efficiency of 59.2% at 320 mA cm−2 after 300 cycles, which is a substantial improvement in operational longevity. 相似文献
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