共查询到20条相似文献,搜索用时 15 毫秒
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Soo Yun Hwang Kyoung Sun Jhang Hyeong Jun Park Young Hwan Bae Han Jin Cho 《ETRI Journal》2006,28(3):397-400
The multi‐layer advanced high‐performance bus (ML‐AHB) BusMatrix proposed by ARM is an excellent architecture for applying embedded systems with low power. However, there is one clock cycle delay for each master in the ML‐AHB BusMatrix of the advanced microcontroller bus architecture (AMBA) design kit (ADK) whenever a master starts new transactions or changes the slave layers. In this letter, we propose an improved design method to remove the one clock cycle delay in the ML‐AHB BusMatrix of an ADK. We also remarkably reduce the total area and power consumption of the ML‐AHB BusMatrix of an ADK with the elimination of the heavy input stages. 相似文献
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Siew‐Kit Hoi Xiao Chen Vanga Sudheer Kumar Sureerat Homhuan Chorng‐Haur Sow Andrew A. Bettiol 《Advanced functional materials》2011,21(15):2847-2853
A microfluidic chip that incorporates colloidal crystals inside a microchannel system for on‐chip integration of optical components is presented. It is demonstrated that the use of fluorescent spheres offers added advantages and functionality to the colloidal crystal array. Multifunctional optical components are demonstrated that are able to serve as a reference wavelength calibration line in measured reflectance spectra. Integrating colloidal crystals with varying filtering effects into a microfluidic chip enables selective transmission or blocking of a particular range of wavelengths locally. In addition, combinations of double‐band colloidal crystal filters provide further tunability of the working wavelength for on‐chip detection applications. 相似文献
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Richie J. Shilton Virgilio Mattoli Marco Travagliati Matteo Agostini Andrea Desii Fabio Beltram Marco Cecchini 《Advanced functional materials》2015,25(37):5895-5901
Fast and controllable surface acoustic wave (SAW) driven digital microfluidic temperature changes are demonstrated. Within typical operating conditions, the direct acoustic heating effect is shown to lead to a maximum temperature increase of about 10 °C in microliter water droplets. The importance of decoupling droplets from other on‐chip heating sources is demonstrated. Acoustic‐heating‐driven temperature changes reach a highly stable steady‐state value in ≈3 s, which is an order of magnitude faster than previously published. This rise time can even be reduced to ≈150 ms by suitably tailoring the applied SAW‐power excitation profile. Moreover, this fast heating mechanism can lead to significantly higher temperature changes (over 40 °C) with higher viscosity fluids and can be of much interest for on‐chip control of biological and/or chemical reactions. 相似文献
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In the current very deep submicron technology era, fault tolerant mechanisms perform an essential function to cope with the effects of soft errors. To evaluate the effectiveness of the fault tolerant mechanism, reliability engineers use simulated fault injections using either saboteur modules or mutants in the simulation model. However, the two methods suffer from both inefficiency in the simulation mechanism and difficulties with the experimental setups. To overcome these inefficiencies, we propose the Verilog‐based simulated fault injection (VFI) technique. VFI has the following advantages. First, modification of the design model is unnecessary. Second, the fault injection simulation procedure is simple and efficient. Third, various types of fault injection experiments can be performed. To evaluate the effectiveness of the proposed methodology, we developed a VFI environment using the ICARUS Verilog Simulator. From the experimental results, we were able to qualitatively evaluate the reliability of the target simulation models and to assess the effectiveness of the employed fault‐tolerance mechanisms. 相似文献
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Multicellular spheroids and organoids are promising in vitro 3D models in personalized medicine and drug screening. They replicate the structural and functional characteristics of human organs in vivo. Microfluidic technology and micro-nano fabrication can fulfill the high requirement of the engineering approach in the growing research interest in spheroids and organoids. In this review, spheroids and organoids are comparatively introduced. Then it is illustrated how spheroids- and organoids-on-a-chip technology facilitates their establishment, expansion, and application through spatial-temporal control, mechanical cues modeling, high-throughput analysis, co-culture, multi-tissue interactions, biosensing, and bioimaging integration. The potential opportunities and challenges in developing spheroids- and organoids-on-a-chip technology are finally outlooked. 相似文献
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Shi‐Yang Tang Xuchun Zhang Shuaishuai Sun Dan Yuan Qianbin Zhao Sheng Yan Lei Deng Guolin Yun Jun Zhang Shiwu Zhang Weihua Li 《Advanced functional materials》2018,28(8)
Microfluidic systems enable rapid diagnosis of diseases, biological analysis, drug screening, and high‐precision materials synthesis. In spite of these remarkable abilities, conventional microfluidic systems are microfabricated monolithically on a single platform and their operations rely on bulky expensive external equipment. This restricts their applications outside of research laboratories and prevents development and assembly of truly versatile and complex systems. Here, novel magnetorheological elastomer (MRE) microactuators are presented including pumps and mixers using an innovative actuation mechanism without the need of delicate elements such as thin membranes. Modularized elements are realized using such actuators, which can be easily integrated and actuated using a single self‐contained driving unit to create a modular, miniaturized, and robust platform. The performance of the microactuators is investigated via a series of experiments and a proof‐of‐concept modular system is developed to demonstrate the viability of the platform for self‐contained applications. The presented MRE microactuators are small size, simple, and efficient, offering a great potential to significantly advance the current research on complex microfluidic systems. 相似文献
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Xia Cao Ramla Ashfaq Feng Cheng Sushila Maharjan Jun Li Guoliang Ying Shabir Hassan Haiyan Xiao Kan Yue Yu Shrike Zhang 《Advanced functional materials》2019,29(31)
Current in vitro antitumor drug screening strategies insufficiently mimic biological systems. They tend to lack true perfusion and draining microcirculation systems, which may post significant limitations in explicitly reproducing the transport kinetics of cancer therapeutics. Herein, the fabrication of an improved tumor model consisting of a bioprinted hollow blood vessel and a lymphatic vessel pair, hosted in a 3D tumor microenvironment‐mimetic hydrogel matrix is reported, termed as the tumor‐on‐a‐chip with a bioprinted blood and a lymphatic vessel pair (TOC‐BBL). The bioprinted blood vessel is a perfusable channel with an opening on both ends, while the bioprinted lymphatic vessel is blinded on one end, both of which are embedded in a hydrogel tumor mass, with vessel permeability individually tunable through optimization of the compositions of the bioinks. It is demonstrated that systems with different combinations of these bioprinted blood/lymphatic vessels exhibit varying levels of diffusion profiles for biomolecules and anticancer drugs. The results suggest that this unique in vitro tumor model containing the bioprinted blood/lymphatic vessel pair may have the capacity of simulating the complex transport mechanisms of certain pharmaceutical compounds inside the tumor microenvironment, potentially providing improved accuracy in future cancer drug screening. 相似文献
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Linjie Li Zhuoyue Chen Changmin Shao Lingyu Sun Lingyun Sun Yuanjin Zhao 《Advanced functional materials》2020,30(3)
Heart‐on‐a‐chip based on microfluidic platform can simulate the structure and reveal the function of heart at the micrometer level, compensating the gap between organism and experiments in vitro. In this paper, a novel heart‐on‐a‐chip system integrated with reduced graphene oxide (rGO) hybrid anisotropic structural color film is designed for cardiac sensing and evaluation. This hybrid anisotropic film is based on the opposite adhesion properties of the polyethylene glycol diacrylate (PEGDA) and gelatin methacryloyl (GelMA). The PEGDA area with low adhesion rate has inverse opal structure and specific reflection peak, while microgroove‐patterned rGO‐doped GelMA area with high adhesion rate provides the cardiomyocytes with excellent growing environment and induced orientation property. Benefiting from the design, the cultured cardiomyocytes only adhere in specific area without affecting the surface microstructure of the structural color. When cardiomyocytes recover beating, its elongation and contraction will stretch the structure of PEGDA and result in a color shift, which realizes the transformation from micromechanics to macroscopic optics. In addition, the heart‐on‐a‐chip system based on the anisotropic structural color hydrogels and microfluidics provides an outstanding visible method for cardiac sensing, which is of great significance in cardiac pathophysiological studies and drug detection in vitro. 相似文献
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Fatemeh Sadat Majedi Mohammad Mahdi Hasani‐Sadrabadi Jules John VanDersarl Nassir Mokarram Shahirar Hojjati‐Emami Erfan Dashtimoghadam Shahin Bonakdar Mohammad Ali Shokrgozar Arnaud Bertsch Philippe Renaud 《Advanced functional materials》2014,24(4):432-441
The use of solvent‐free microfluidics to fine‐tune the physical and chemical properties of chitosan nanoparticles for drug delivery is demonstrated. Nanoparticle self‐assembly is driven by pH changes in a water environment, which increases biocompatibility by avoiding organic solvent contamination common with traditional techniques. Controlling the time of mixing (2.5–75 ms) during nanoparticle self‐assembly enables us to adjust nanoparticle size and surface potential in order to maximize cellular uptake, which in turn dramatically increases drug effectiveness. The compact nanostructure of these nanoparticles preserves drug potency better than previous nanoparticles, and is more stable during long‐term circulation at physiological pH. However, when the nanoparticles encounter a tumor cell and the associated drop in pH, the drug contents are released. Moreover, the loading efficiency of hydrophobic drugs into the nanoparticles increases significantly from previous work to over 95%. The microfluidic techniques used here have applications not just for drug‐carrying nanoparticle fabrication, but also for the better control of virtually any self‐assembly process. 相似文献
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Drug Delivery: On‐Chip Fabrication of Paclitaxel‐Loaded Chitosan Nanoparticles for Cancer Therapeutics (Adv. Funct. Mater. 4/2014)
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Fatemeh Sadat Majedi Mohammad Mahdi Hasani‐Sadrabadi Jules John VanDersarl Nassir Mokarram Shahirar Hojjati‐Emami Erfan Dashtimoghadam Shahin Bonakdar Mohammad Ali Shokrgozar Arnaud Bertsch Philippe Renaud 《Advanced functional materials》2014,24(4):418-418
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Shreya Mehrotra Bruna A. G. de Melo Minoru Hirano Wendy Keung Ronald A. Li Biman B. Mandal Su Ryon Shin 《Advanced functional materials》2020,30(12)
Bioprinting holds great promise toward engineering functional cardiac tissue constructs for regenerative medicine and as drug test models. However, it is highly limited by the choice of inks that require maintaining a balance between the structure and functional properties associated with the cardiac tissue. In this regard, a novel and mechanically robust biomaterial‐ink based on nonmulberry silk fibroin protein is developed. The silk‐based ink demonstrates suitable mechanical properties required in terms of elasticity and stiffness (≈40 kPa) for developing clinically relevant cardiac tissue constructs. The ink allows the fabrication of stable anisotropic scaffolds using a dual crosslinking method, which are able to support formation of aligned sarcomeres, high expression of gap junction proteins as connexin‐43, and maintain synchronously beating of cardiomyocytes. The printed constructs are found to be nonimmunogenic in vitro and in vivo. Furthermore, delving into an innovative method for fabricating a vascularized myocardial tissue‐on‐a‐chip, the silk‐based ink is used as supporting hydrogel for encapsulating human induced pluripotent stem cell derived cardiac spheroids (hiPSC‐CSs) and creating perfusable vascularized channels via an embedded bioprinting technique. The ability is confirmed of silk‐based supporting hydrogel toward maturation and viability of hiPSC‐CSs and endothelial cells, and for applications in evaluating drug toxicity. 相似文献
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This paper describes the implementation of a digital audio effect system‐on‐a‐chip (SoC), which integrates an embedded digital signal processor (DSP) core, audio codec intellectual property, a number of peripheral blocks, and various audio effect algorithms. The audio effect SoC is developed using a software and hardware co‐design method. In the design of the SoC, the embedded DSP and some dedicated hardware blocks are developed as a hardware design, while the audio effect algorithms are realized using a software centric method. Most of the audio effect algorithms are implemented using a C code with primitive functions that run on the embedded DSP, while the equalization effect, which requires a large amount of computation, is implemented using a dedicated hardware block with high flexibility. For the optimized implementation of audio effects, we exploit the primitive functions of the embedded DSP compiler, which is a very efficient way to reduce the code size and computation. The audio effect SoC was fabricated using a 0.18 μm CMOS process and evaluated successfully on a real‐time test board. 相似文献
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Jaesung Lee 《ETRI Journal》2010,32(4):540-547
One of the critical issues in on‐chip serial communications is increased power consumption. In general, serial communications tend to dissipate more energy than parallel communications due to bit multiplexing. This paper proposes a low‐power bus serialization method. This encodes bus signals prior to serialization so that they are converted into signals that do not greatly increase in transition frequency when serialized. It significantly reduces the frequency by making the best use of word‐to‐word and bit‐by‐bit correlations presented in original parallel signals. The method is applied to the revision of an MPEG‐4 processor, and the simulation results show that the proposed method surpasses the existing one. In addition, it is cost‐effective when implemented as a hardware circuit since its algorithm is very simple. 相似文献
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Shuaizhong Zhang Ye Wang Patrick R. Onck Jaap M. J. den Toonder 《Advanced functional materials》2019,29(6)
Biological cilia are versatile hair‐like organelles that are very efficient in manipulating particles for, e.g., feeding, antifouling, and cell transport. Inspired by the versatility of cilia, this paper experimentally demonstrates active particle‐removal by self‐cleaning surfaces that are fully or partially covered with micromolded magnetic artificial cilia (MAC). Actuated by a rotating magnet, the MAC can perform a tilted conical motion, which leads to the removal of spherical particles of different sizes in water, as well as irregular‐shaped sand grains both in water and in air. These findings can contribute to the development of novel particulate manipulation and self‐cleaning/antifouling surfaces, which can be applied, e.g., to prevent fouling of (bio)sensors in lab‐on‐a‐chip devices, and to prevent biofouling of submerged surfaces such as marine sensors and water quality analyzers. 相似文献
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June‐Young Chang Won‐Jong Kim Young‐Hwan Bae Jin Ho Han Han‐Jin Cho Hee‐Bum Jung 《ETRI Journal》2005,27(5):497-503
In this paper, we present a performance analysis for an MPEG‐4 video codec based on the on‐chip network communication architecture. The existing on‐chip buses of system‐on‐a‐chip (SoC) have some limitation on data traffic bandwidth since a large number of silicon IPs share the bus. An on‐chip network is introduced to solve the problem of on‐chip buses, in which the concept of a computer network is applied to the communication architecture of SoC. We compared the performance of the MPEG‐4 video codec based on the on‐chip network and Advanced Micro‐controller Bus Architecture (AMBA) on‐chip bus. Experimental results show that the performance of the MPEG‐4 video codec based on the on‐chip network is improved over 50% compared to the design based on a multi‐layer AMBA bus. 相似文献
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为了能够实现通过集成所获得的优点,像高性能、低价格、较小的接触面、电源管理和缩短产品进入市场的时间,出现了针对晶圆级的系统级芯片(system on a chip简称SOC)和针对组件级的系统级组件(system on a pakage简称SOP)。本文介绍了SOC和SOP的益处、功能和优点。 相似文献