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近日 ,马鞍山钢铁集团 2 0 0 2年 11月开工兴建的钢水炉后真空处理 VD炉 ,在其三钢厂已系统全自动抽真空运行处理钢水一次热试成功。经过程测定 ,钢中氧含量由进 VD站前的 98.5× 10 - 6 已降至出 VD炉后的 37× 10 - 6 ,所有的真空处理指标都达到设计的理想值。马钢钢水真空净化处理VD炉热试成功@陈钢 相似文献
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为给SW718H钢真空脱氢处理提供一定依据,对在干式机械泵真空脱气炉(VD炉)中生产SW718H钢的真空脱氢工艺技术进行了研究.叙述了真空脱氢的动力学控制因素,对VD炉的SW718H钢真空脱氢生产实践进行分析,发现干式机械泵VD炉真空脱氢主要集中在钢液近表面反应区域(渣眼).总结了在干式机械泵VD炉处理中真空度66.7 Pa以下和近表面反应面积控制在0.277 m2以上时,某一终点氢含量的氩气量和脱氢时间的理论计算公式,可为生产提供指导依据.结果表明,采用干式机械泵VD炉精确控制脱氢时间、真空度可以使SW718H钢真空脱气后的氢含量达到1.0×10-4%以下. 相似文献
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为了充分发挥VD炉的脱氢作用,提高生产效率,以VD炉脱氢热力学和动力学为基础,对影响脱氢率的因素进行对比分析。结果表明:钢水原始氢含量、真空度、高真空保持时间、氩气流量等是影响VD炉脱氢效果的主要因素。通过现场真空脱气工艺参数优化,VD炉的脱氢率得到提高,为生产低氢高质量品种钢创造了条件。 相似文献
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Retinoids and 1alpha,25-dihydroxyvitamin D3 (VD3) cooperatively induce the differentiation of myeloid leukemia cells. We investigated the role of retinoid receptors (RARs and RXRs) in the combined effects of retinoids and VD3 on growth inhibition and differentiation induction in human monoblastic leukemia U937 cells by using RAR- or RXR-selective retinoids. An isobologram analysis showed that both combinations were synergistic with regard to inhibiting the proliferation, and RAR agonists exhibited greater synergism with VD3 than did RXR agonists. RXR agonists alone induced nitroblue tetrazolium (NBT) reduction and expression of CD11b in U937 cells, whereas RAR agonists alone did not. On the other hand, RAR agonists and RXR agonists enhanced the differentiation induced by VD3, but RXR agonists required higher concentrations. An RAR antagonist inhibited the differentiation induced by RAR agonists plus VD3, but not that induced by RXR agonists plus VD3. Thus, RARs and RXRs act differently in their synergism with VD3. RAR agonists are more potent than RXR agonists with regard to synergism with VD3, and their combination may be useful in differentiation therapy against myeloid leukemia. 相似文献
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The classical action of the hormone 1,25-dihydroxyvitamin D3 (VD) is the regulation of calcium metabolism. In contrast, the peptide hormone atrial natriuretic factor (ANF) is one of the few known nonclassical VD responding genes. We screened the promoter of the rat ANF gene and identified a typical VD receptor (VDR) binding site formed by a direct repeat of two hexameric core binding motifs spaced by three nucleotides, between positions -907 and -891. Like most of the DR3-type VD response elements this sequence is bound with high affinity (Kd = 0.53 nM) by a heterodimer formed by VDR and retinoid X receptor. In a heterologous promoter context one copy of this sequence mediated an about fourfold gene activation by VD and a half-maximal activation (EC50) value of 0.48 nM VD. This characterizes the identified sequence as one of the most potent VD response elements. 相似文献
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D Lester 《Canadian Metallurgical Quarterly》1998,138(4):535-536
1,25-dihydroxyvitamin D3 (VD) is a modulator of growth and differentiation of many cell types, including keratinocytes. We have recently shown in cultured keratinocytes that VD induces tyrosine phosphorylation of proteins involved in signal transduction, such as Shc. In an attempt to identify VD-responsive tyrosine kinases, we studied the effects of VD on the activity of the nonreceptor tyrosine kinase Src. Although VD did not stimulate Src activity in keratinocytes cultured in standard media containing 0.15 mM calcium, preincubation of the cells with 1.8 mM Ca2+ caused a rapid activation of Src in response to VD (10(-8)-10(-7) M). Elevation of calcium concentration alone caused an increase in Src activity as well, but the peak of Src activity was delayed (60 min vs. 15 min) and approximately 2-fold lower in comparison with VD-treated cells. VD treatment also induced tyrosine dephosphorylation of Src and a formation of an Src-Shc-Grb2 complex. Taken together, these findings imply that Src is involved in VD signaling in keratinocytes. 相似文献
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Investigated the effects of transfer from a modified free-recall task to verbal-discrimination (VD) learning. The free-recall procedure was designed to impact increments in experimental frequency to specific words that appeared in VD. 4 experimental groups, with 30 undergraduates in each, were given prior free-recall exposure to either all right VD items (A-R), all wrong (A-W), both the right and wrong items from same VD pairs (B-S), or both the right and wrong items from different VD pairs (B-D). A 5th group of 30 Ss served as a control and learned a free-recall list which did not contain any VD items (C). In terms of number of correct responses during VD learning, the groups were ordered as follows: A-R, C, A-W, B-S, and B-D. Results are interpreted as being consistent with derivations from the frequency theory of VD learning. (French summary) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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T Fujioka M Hasegawa K Ishikura Y Matsushita M Sato S Tanji 《Canadian Metallurgical Quarterly》1998,160(1):247-251
PURPOSE: To investigate the effect of active vitamin D3(VD) agents on tumor growth and metastasis. MATERIALS AND METHODS: BALB/c mice were inoculated with murine renal cancer Renca and graded doses of 1,25-dehydrovitamin D3 or 1- hydrovitamin D3 were given intraperitoneally every other day beginning on day 1, 3, or 7 and ending on day 9, 11, or 15. Direct cytocidal activity and angiogenic activity were evaluated by 48-hour MTT assay and by the colorimetric method, respectively. RESULTS: Both VD agents inhibited tumor growth and prolonged the life span of Renca-bearing mice in a dose-dependent manner and both suppressed tumor growth in athymic mice and euthymic mice with eliminated NK activity. Marginal body-weight loss without appreciable hypercalcemia was observed in mice given VD agents. When treatment was delayed on day 7, the VD agents failed to inhibit tumor growth. The MTT assay showed no direct cytotoxicity of VD agents on Renca. Tumor angiogenesis was inhibited to 46 to 30% of the control level by VD agents. Furthermore, VD agents reduced pulmonary and hepatic foci in the metastatic models. CONCLUSIONS: These results suggest that VD agents may be effective as a treatment for renal cell carcinoma, especially when micrometastases are involved. 相似文献
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转炉生产过程中产生大量的饱和蒸汽,但没有得到有效的利用;而VD精炼需要一定的微过热蒸汽。转炉蒸汽供应VD精炼的结果表明,2座100 t转炉的饱和蒸汽得到有效利用,转炉蓄热器饱和蒸汽完全满足VD使用要求,供给VD的蒸汽压力0.8~1.0 MPa,过热度10~15℃。钢水经VD 15 min精炼后,[H]≤1.5×10-6,总[O]≤15×10-6,脱氮率≥25%。文中介绍了转炉余热蒸汽在100 t VD精炼设备上的应用难点及解决方案。 相似文献