Left ventricular diastolic function in young men with high normal blood pressure

OBJECTIVE: Abnormalities in left ventricular (LV) diastolic filling have been reported in hypertensive patients. This study was designed to compare LV diastolic filling between individuals with high normal blood pressure (HNBP) and optimal blood pressure (OBP). SUBJECTS AND DESIGN: From a survey of 219 young male individuals (age 21 +/- 0.1 years), two groups were selected according to their BP (group A: systolic BP [SBP] 120 mmHg and diastolic BP [DBP] 80 mmHg, n = 23 and group B: SBP 130 to 139 mmHg and/or DBP 85 to 89 mmHg, n = 21). Subjects habits, anthropometric characteristics, LV structure and systolic and diastolic function were compared. RESULTS: No differences were detected between the two groups in habits, systolic function or early diastole. LV mass index (LVMI) was higher in group B (103.6 +/- 4.58 g/m2 versus 90.49 +/- 3.27 g/m2 in group A, P < 0.05), though the values were not high enough to indicate LV hypertrophy. The pattern of LV late filling was different between the two groups. The peak late diastolic flow velocity (A) was 0.45 +/- 0.02 m/s in group B and 0.52 +/- 0.03 m/s in group A (P < 0.05). The early peak velocity (E):A ratio was 1.82 +/- 0.08 in group A and 1.59 +/- 0.08 in group B (P < 0.05). The early filling fraction also demonstrated a significant shift to more prominent late diastolic filling in group B (0.68 +/- 0.01% versus 0.73 +/- 0.01% in group A, P < 0.05). This pattern in LV filling did not correlate to inheritance, age, sex, heart rate, habits or body mass index. CONCLUSIONS: This shift in filling pattern to a late flow in young men with HNBP seemed to be an early indicator of an increased dependence of LV filling on atrial contraction and may reflect an impairment in LV relaxation.     

Endothelium and high blood pressure

Due to its strategic anatomical position, the endothelium is constantly exposed to the different risk factors for atherosclerosis. During the last decade it has become clear that hypertension profoundly affects endothelial function. Depending on the form of hypertension, endothelium-dependent relaxation is impaired in most vascular beds. In spontaneous hypertension, the production of nitric oxide, which in endothelial cells is formed from L-arginine via the constitutively expressed enzyme endothelial nitric oxide synthase, represents the main mediator of endothelium-dependent vasodilation and seems to be enhanced. On the other hand, the release of endothelium-dependent contracting factors such as prostaglandin H2 and thromboxane A2 have been demonstrated in this model of hypertension. Similar results have been obtained in the forearm circulation of patients with essential hypertension. In contrast, in models of salt-sensitive hypertension no release of vasoconstrictor prostanoids can be found indicating a decreased production of nitric oxide. Thus, in spontaneous hypertension an increased production of nitric oxide seems to occur, which is ineffective due to either the simultaneous release of endothelium-dependent vasoconstrictors and/or inactivation of nitric oxide, or due to anatomical changes such as hypertension-induced intimal thickness which inhibits its action on vascular smooth muscle cells. In summary, in hypertension, endothelium-dependent vasodilation is blunted and the endothelial L-arginine nitric oxide pathway is altered. These changes seem to represent a consequence rather than a cause of hypertension.     

Caffeine and behavioral stress effects on blood pressure in borderline hypertensive Caucasian men.

Caffeine in dietary amounts raises blood pressure (BP), and its use increases during work stress; however, caffeine combined with behavioral stress has not been tested in borderline hypertensive (BH) men. Accordingly, this study tested a psychomotor stressor plus caffeine (3.3 mg/kg, equivalent to 2–3 cups of coffee) using a double-blind, crossover design in 24 BH men (140/90 mmHg?≤?BP?160/95 mmHg) and 24 controls (BP?≤?135/85 mmHg). BH men had modestly larger BP increases to the task and showed a greater combined effect of caffeine plus the task (+15/+11 mmHg) than controls (+10/+6 mmHg). BH men maintained response to the stressor in the face of an exaggerated BP response to caffeine, suggesting that use of caffeine during behavioral stress may elevate BP in BH individuals to a clinically meaningful degree. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Impact of caffeine and psychological stress on blood pressure in Black and White men.

Examined the effects of caffeine and psychological stress on systolic blood pressure (SBP) and heart rate (HR) in 40 healthy Black and White male college students (aged 18–35 yrs) who were regular coffee drinkers. Half the Ss had a positive family history of hypertension, and half did not. The effects of 250 mg of caffeine vs placebo (3 mg) in decaffeinated coffee were compared in a within-subject, double-blind, cross-over design. Results confirm previous findings (J. D. Lane and R. B. Williams; see record 1988-19531-001) with White men that a moderate dose of caffeine produced significant increases in SBP and little effect on HR and that the pressor effects of caffeine and stress combined additively (W. Greenberg and D. Shapiro; see record 1988-20603-001). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive coping strategies and blood pressure responses to real-life stress in healthy young men.

10 high- and 10 low-self-focused-coping (SFC) male college students (aged 18–22 yrs) were tested with ambulatory blood pressure (BP) monitoring on 2 typical schooldays, one of which included an examination. The high-SFC Ss (those who tend to keep to themselves and/or blame themselves in stressful situations) showed higher BP responses on the exam day, not only during the exam, but also during other activities throughout the same day, including evening rest. Results are discussed in terms of the relation between psychological and physiological responding. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reconsideration of a measure of power motivation.

A review of research using a thematic apperceptive measure suggests that power motivation largely reflects a person's fear of weakness. Evidence for this assertion comes from demographic distributions of the measure, and from its associations with feelings of adjustment in specific and general life-roles. In different instances, fear of weakness seems to lead to avoidant power behaviors, some cost in adjustment, or a positive adjustment. A context for thinking about power motivation as an orientation to a negative goal is provided. (38 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cardiac adaptation to increased systemic blood pressure in borderline hypertensive men

Two women, aged 28 and 32, presented with primary infertility and severe dysmenorrhea. The younger woman developed recalcitrant and recurrent firm vaginal, cervical and possibly endometrial lesions over a period of six years; the older patient had similar material in the cervix, endometrium and a fallopian tube. The lesions were composed of amorphous eosinophilic hyaline or necrotic material, shown by histochemical and immunoperoxidase stains to be partly fibrin. Pathologic examination showed that the lesions were similar to those of ligneous (pseudomembranous) conjunctivitis, a rare disease that may occasionally affect the lower female genital tract. However, neither patient had eye disease, and ligneous conjunctivitis has not previously been reported to involve the upper genital tract. Endometrial and tubal involvement could readily explain primary infertility and dysmenorrhea in these patients.     

The power motive in women—and men.

Previous studies and original research on the power motive (n Power) in women show no sex differences in the ways in which the power motive is aroused, in average levels of n Power, or in relationships between n Power and getting formal social power, power-related careers, and prestige. While in women n Power does not predict the "profligate impulsive" behaviors that it often does in men (drinking, aggression, sexual exploitation), a closer analysis shows that for both sexes having younger siblings and/or having children—interpreted as proxy variables for responsibility training—moderate the relationship between n Power and profligate (versus leadership) behaviors. Thus to some extent socialization experience rather than gender determines the channels of expression of power motivation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Childhood predictors for high adult blood pressure. The Muscatine Study

In adult populations, elevated blood pressure is related to the development of stroke, renal disease, and occlusive atherosclerosis. The significance of blood pressure levels in childhood, unless extremely elevated, has not been related to disease outcomes. In a study carried out in Muscatine, Iowa, the risk of high blood pressure in young adult life was evaluated based on the observations of blood pressure and other factors made during the school-aged years. Subjects, 2445 in number, were first observed at ages 7 through 18 years and again between 20 and 30 years. During childhood, measurements of blood pressure, height, and weight were made on alternate years. At adult ages, the same measurements were again made and a health questionnaire was administered. Adult blood pressure was correlated with childhood blood pressure, body size, and change in ponderosity from childhood to adult life. Adult ponderosity was related to childhood ponderosity, and those who were most obese as adults showed the greatest increase in weight from their childhood years. These observations suggest that strategies to prevent the acquisition of excess ponderosity during childhood may be useful in preventing adult hypertension.     

Academic intrinsic motivation in elementary and junior high school students.

Investigated in 3 studies the significance of academic intrinsic motivation (AIM) for children's education. Ss for Studies 1–3 were 77 4th graders and 64 7th graders; 260 Ss in Grades 4–7; and 166 White middle-class Ss in Grades 5–8, respectively. Ss were administered an AIM inventory and an inventory of academic anxiety (AA). As predicted, AIM was found to be significantly and positively correlated with Ss' school achievement and perceptions of academic competence and negatively correlated with AA. Findings support the view that AIM is differentiated into school subject areas and is also a general orientation toward school learning. Relations between motivation and perception of competence and anxiety were differentiated by subject area, whereas achievement was more pervasively related to general motivation. Mathematics motivation, however, emerged as a unique predictor of mathematics achievement. The significance of AIM as differentiated into subjects and as a general orientation is discussed. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-monitoring and blood pressure.

Examined the association between self-monitoring (regulation and control of nonverbal and expressive behavior) and blood pressure (BP) among 594 municipal employees. For Ss not taking antihypertensive medication, scores on an acting/extraversion scale were mildly positively associated with resting BP among Whites in general, blue collar, clerical, and professional groups. Stronger positive correlations were obtained for attorneys and customer-service representatives. Results are contrasted with slightly negative associations for Blacks in general, 1st-level supervisors, and a group of previously studied union stewards. An interactive effect was also obtained between acting/extraversion and relative participation in work vs nonwork groups and activities; acting/extraversion and systolic BP were inversely related for Ss more active in extrawork groups. Differential consequences of greater or lesser interpersonal involvement and emotional regulation in different jobs are considered. (40 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Development and validation of a projective measure of power motivation.

In an attempt to develop a valid measure of power motivation, 34 Ss aroused by cues relevant to power motivation and 34 control Ss wrote stories in response to 5 pictures. A scoring system was applied to the data which succeeded in differentiating the 2 groups. High n power scorers of the control group differed from low n power scorers of the same group on a number of other factors relevant to power motivation. The results support the validity of this projective method of measuring power motivation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Acute blood pressure elevations with caffeine in men with borderline systemic hypertension

It has been shown that the problem of nosocomial infections is different in each specialist hospital division, and it is important to be aware of the local situation and to identify the specific problems. In order to set up an effective prevention programme and in the setting of a general system of control of nosocomial infection, we studied the incidence of infections and correlated the pathogenic organisms appearing during hospitalization in patients admitted to our Pneumology Division and Intermediate Intensive Care Unit over a period of 12 months. A nosocomial infections incidence of 13% was observed and 75% of these were respiratory, 21% urinary and 4% other infections. Seventy two percent of pathogenic agents were Gram-negative bacilli and 28% Gram-positive cocci. The site-specific rates of infections observed are related to intrinsic (host dependent) and extrinsic (non-host-dependent) risk factors that have not been exhaustively evaluated in the present study. However, the data so far collected will allow us to redirect the resources used in the control of nosocomial infections by targeting efforts at the surveillance of better defined groups of patients and by achieving data more suitable for comparisons between hospitals.     

Inverse relation of dietary protein markers with blood pressure. Findings for 10,020 men and women in the INTERSALT Study. INTERSALT Cooperative Research Group. INTERnational study of SALT and blood pressure

BACKGROUND: The purpose of this study was to assess relations to blood pressure (BP) in individuals of markers of dietary protein in their 24-hour urine collections. METHODS AND RESULTS: INTERSALT (INTERnational study of SALT and blood pressure) was a cross-sectional study of 10020 men and women aged 20 to 59 years in 52 population-based samples in 32 countries worldwide, with quality-controlled standardized procedures and assessment of multiple possible confounders. Three measurements of dietary protein in 24-hour urine of each individual participant were studied: total nitrogen and urea as indexes of total protein intake, and sulfate as an index of sulfur-containing dietary amino acids. Repeat examination was performed in a random 8% of participants to assess reliability and to correct for regression-dilution bias. Significant independent inverse relationships were found between BP (systolic and diastolic) and both 24-hour urinary total nitrogen and urea nitrogen, with adjustment for age, sex, alcohol intake, body mass, and 24-hour urinary sodium, potassium, calcium, and magnesium. With adjustment for regression-dilution bias, it was estimated that systolic and diastolic BP were on average 3.0 and 2.5 mm Hg lower, respectively, for persons with dietary total protein intake 30% above the overall mean than for those whose dietary protein intake was 30% below the overall mean (12.94 versus 6.96 g/d urinary total nitrogen, equivalent to 81 versus 44 g/d dietary protein, respectively). For the association of these markers with diastolic BP, results were similar for younger (20- to 39-year-old) and older (40- to 59-year-old) persons and for women and men. For their relation to systolic BP, regression coefficients were larger both for those aged 40 to 59 years than for those aged 20 to 39 years and for women than for men. Nonsignificant inverse relations were recorded for urinary sulfate and BP. CONCLUSIONS: These INTERSALT findings lend support to the hypothesis that higher dietary protein intake has favorable influences on BP.     

Effects of mental state on heart rate and blood pressure variability in men and women

The effect of different mental states on autonomic modulation of the cardiovascular system was assessed in healthy, normotensive men (n = 18) and women (n = 12). Heart rate variability (HRV), systolic blood pressure variability (BPV) and arterial baroreflex function were assessed during 4 tests at rest ((10 min + 5 min recovery) x 4): (1) Control (spontaneous breathing, (SB) (2) Mental distraction (SB + word puzzle) (3) Conscious control of breathing (paced at SB rate) and (4) Mental stress (SB + computer quiz). There were no significant gender differences in the responses to the interventions in terms of arterial (spontaneous) baroreflex (SPBX) control of HR, and indices of time and frequency domains of HRV and BPV, with the exception of the sympathetic indicator of HRV (low frequency power/total power; P < 0.01) which was lower in women during control and mental stress tests. Conscious control of breathing at SB did not alter HRV, BPV or SPBX in either men or women. Mental distraction and mental stress led to decreases in indices of time and frequency domains of HRV and BPV in all subjects, as well as increases in HR during distraction and in systolic BP during stress. These findings suggest that in studies of cardiovascular control: (1) Paced breathing at SB can be used for individuals with irregular breathing patterns (2) The extent of mental stress achieved is intervention-specific and for the most part, independent of gender and (3) Resting assessment of HRV, BPV and SPBX can be made by having subjects sit quietly without interventions in a controlled laboratory setting.