共查询到19条相似文献,搜索用时 133 毫秒
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取代芳(硫)醚氨基化合物是重要的制药中间体,本文采用FeCl3.6H2O/C催化下水合肼还原取代芳(硫)醚硝基物,高收率、高纯度制得取代芳(硫)醚氨基化合物.该工艺具有操作方便、后处理简单等特点,反应过程易操控,对设备要求不高,安全可靠,对环境污染小,更适合于工业化生产.4个实例产物收率为85.0%~95.3%,GC纯... 相似文献
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镍基复合催化剂催化邻硝基苯胺加氢合成邻苯二胺 总被引:1,自引:0,他引:1
采用镍基复合催化剂,分别以水、乙醇为溶剂,邻硝基苯胺氢化合成邻苯二胺。实验结果表明,在水中,温度85-105℃、压力1.5MPa下收率为72%-78%(以邻硝基苯胺计);在乙醇中,温度45℃、压力0.8~1.5MPa下收率为82%-91%(以邻硝基苯胺计)。以乙醇为溶剂镍基复合催化剂催化加氢法与传统的硫化碱还原或铁粉还原工艺相比,在减少废水和降低成本等方面有较大的优势。 相似文献
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冰乙酸为催化剂,2,5-二肼基-1,3,4-噻二唑与取代吲哚-3-甲醛在乙醇中缩合反应,得到了4种新型含吲哚基的1,3,4-噻二唑类双腙化合物,其结构经IR,1 H NMR所证实。最佳反应条件为:反应温度90℃,n(2,5-二肼基-1,3,4-噻二唑)∶n(取代吲哚-3-甲醛)=1.0∶2.4,反应时间4h,收率75.5%~81.0%。 相似文献
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文中阐述了由邻硝基苯胺经过卤化、还原和闭环三步合成5-碘-2-甲基苯并咪唑的新的反应工艺,并对工艺进行了优化。考察了碘化中I2和氧化剂H2O2的用量,还原阶段中催化剂Raney Ni的使用量、反应中压力的影响,以及闭环阶段催化剂醋酸的用量、反应时间、反应温度对反应收率的影响。通过研究,获得了最优工艺条件,在优化条件下总收率达到75.1%。 相似文献
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《Journal of Sulfur Chemistry》2013,34(3):276-283
In this work, we have studied the reaction of substituted 2-thiocyanoacetophenone and hydrazine hydrate as a novel and simple pathway for the preparation of the substituted 1,4,5-thiodiazepine ring system. The mechanism of this reaction revealed that in the initial step condensation of hydrazine with carbonyl groups of substituted 2-thiocyanoacetophenons 2a–2f gives the corresponding substituted aromatic dithiocyano azide intermediates which in turn undergo cyclization to1,4,5-thiadiazepines in the presence of hydrazine. This cyclization is a novel method for the preparation of sulfide bond from the reaction of hydrazine and a dithiocyano intermediate. An account of the reaction mechanism is given. 相似文献
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采用自制廉价催化剂、水合肼为清洁还原剂研究了不同结构芳硝基物的水合肼催化氢转移还原反应,发现取代基的性质及位置对水合肼还原反应均有影响,苯环上吸电子基的存在有利于硝基还原;水合肼还原法不还原蒽醌结构中的醌式羰基。在水合肼用量接近理论量的前提下,N-甲基-4-硝基苯胺、N-甲基-N-(4'-硝基苄基)-4-甲基苯磺酰胺、4,4'-二硝基二苯砜的水合肼还原产品收率分别达到99%、97%、92%。实验中以高效液相色谱对还原反应过程进行跟踪分析,分别采用大气压离子化质谱(APCI-MS)、核磁共振谱及红外光谱对还原产物的结构进行了表征。 相似文献
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D. D. Rajadhyaksha D. W. Rangnekar 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1986,36(7):300-304
Synthesis of pyrazolo[4′,3′ :-5,6′pyrido]1,2-a benzimidazoles was achieved by the condensation of 1-chloro-2-formyl-3-methyl pyrido[1,2-a]benzimidazole-4-carbonitrile and 1-chloro-3-methyl pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile with hydrazine hydrate and phenyl hydrazine. The fluorescence properties of the resulting compounds were studied. Some of the compounds when applied on polyester fibres as fluorescent brighteners gave excellent results. 相似文献
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2,2-二(3-氨基-4-羟基)苯基丙烷的合成与结构表征 总被引:4,自引:0,他引:4
分别在Pd/C、FeOOH和FeCl3·6H2O/C三种不同催化剂存在下,由水合肼还原2,2 二(4 羟基 3 硝基)苯基丙烷(1)合成了2,2 二(3 氨基 4 羟基)苯基丙烷,筛选出成本低、收率高的理想催化剂为FeCl3·6H2O/C。当物料配比n(水合肼):n(1)=5:1,反应起始温度为70℃,反应时间为80min时,收率为93 0%。产物经重结晶纯化后,由元素分析、红外光谱、核磁共振谱和质谱对其结构进行了表征,确证了产物的结构。 相似文献
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Norman O. V. Sonntag 《Journal of the American Oil Chemists' Society》1968,45(8):571-574
The acylation of hydrazine hydrate with a series of saturated fatty acid chlorides containing from eight to 18 carbon atoms
was studied under a variety of conditions in order to obtain the desirable fatty acid monohydrazides. Optimum yields were
obtained (ranging from 31.5% to 75% as the series ascended from C-8 to C-18) for the even-numbered monohydrazide members through
the use of a large excess of hydrazine hydrate in several organic solvents. Diethyl ether was found to be suitable if the
acid chloride is dissolved in it and added slowly to a cold mixture of hydrazine hydrate in ether. The Schotten-Baumann technique
was found suitable for the preparation of the symmetrically substituted fatty acid dihydrazides in better than 82% yields
when one mole of hydrazine hydrate was acylated with two of acid chlorides. Physical and chemical properties of both series
of fatty nitrogen derivatives are briefly treated. Stearic monohydrazide was condensed with acetonylacetone to give a substituted
pyrrole. An unsymmetrical dihydrazide was prepared by the acylation of myristic monohydrazide with lauroyl chloride. Stearic
dimethylhydrazide was prepared by the acylation of dimethylhydrazine with stearoyl chloride. Two quaternizations of this product
were carried out.
Part I. JAOCS31, 151 ({dy1954}).
Presented at the AOCS Meeting, New York, October 1960. 相似文献
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以NaOH溶液快速沉淀CuC l2和A lC l3的混合溶液制备了催化剂CuO-A l2O3,当n(CuO)∶n(A l2O3)=1∶2时所得催化剂性能最好。在水中,以邻硝基甲苯为底物,考察了几种因素对反应的影响。较优的反应条件为:4.11 g(30 mmol)邻硝基甲苯,3.53 g(60 mmol)水合肼,0.45 g CuO-A l2O3,80℃反应50 m in。在此条件下邻甲基苯胺的收率达到98%。在同样的条件下,CuO-A l2O3催化水合肼,几种还原芳香族硝基化合物得到相应的芳胺,收率90%~99%。 相似文献
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Copper nanowires were synthesized by the wet chemical reduction method using copper sulfate as the copper precursor, aliphatic amines (methylamine, ethanediamine, 1,2-propanediamine) as the inducing reagents, and hydrazine hydrate as the reductant through the aging and reduction processes. The high-resolution transmission electron microscopy (HRTEM) images reveal that the copper nanowires were synthesized by coalescing extremely small-sized copper nanoparticles with the particle sizes of 1–6 nm in copper complex micelles. A longer aging time period favored the coalescing of the copper nanoparticles to form thinner copper nanowires in the following reduction process. The coalescing extent of copper nanoparticles in copper nanowires was highly enhanced by ethanediamine and 1,2-propanediamine as compared with that by methylamine. The copper nanowire-filled polyester films had higher electrical conductivity than the copper nanoparticle-filled ones. 相似文献