Retention of response persistence in weanling and adolescent rats.

Two experiments (192 Sprague-Dawley rats) examined parameters affecting retention of continuously reinforced (CRF) and partially reinforced (PRF) runway training in weanling and adolescent Ss. In Exp I, weanling Ss were given CRF or PRF training and 12 hrs, 3 days, or 10 days later were given 8 CRF reacquisition trials followed by extinction. In Exp II, weanling and adolescent Ss were given CRF or PRF runway training and extinguished 10 days later following 0, 8, or 24 CRF reacquisition trials. Results suggest that (a) weanlings characteristically display a partial reinforcement extinction effect (PREE) of unusually large magnitude if extinguished within 12 hrs of training, (b) this large-magnitude PREE dissipates within 3 days of training regardless of the number of CRF reacquisition trials preceding extinction, (c) no PREE of any magnitude is seen in weanlings or adolescents following a 10-day interval unless CRF reacquisition trials precede extinction, and (d) retention of the PREE is poor or nonexistent in Ss trained as adolescents and extinguished 10 days later, even with CRF reacquisition preceding extinction. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Retention and durability of persistence acquired by young and infant rats.

Conducted 2 experiments in a runway apparatus with 72 young Holtzman rats. A classic partial reinforcement acquisition effect was obtained in Ss trained from 30 to 45 days of age but not in those trained from 18 to 25 days of age. In an immediate extinction test for half of the Ss, a partial reinforcement extinction effect (PREE) was found in both age groups, but there were differences in the extinction patterns. Following a 45-day retention interval and a continuous reinforcement reacquisition treatment for all groups, the PREE emerged clearly in adult Ss which had not undergone previous extinction. In those Ss which had previously been extinguished the PREE emerged again but was somewhat reduced. Results from the younger Ss suggest that relatively permanent persistence in approach to food can be formed in the days that normally immediately precede and follow weaning in laboratory rats. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of acute trimethyltin exposure on appetitive acquisition and extinction performance in the adult rat.

16 adult male Sprague-Dawley rats were given an intragastric infusion of 7 mg/kg of trimethyltin chloride (TMT), and 16 additional Ss (controls) received saline, to investigate TMT's effect on Ss' appetitive acquisition and extinction performance. Ss from each condition were divided into 2 equal groups and trained with either partial or continuous reinforcement (PRF or CRF) in a straight-alley maze 21 days after dosing. The acquisition training phase contained 40 trials (4 trials/day) and was followed by 20 trials of extinction training (4 trials/day). Analyses performed on total speed revealed that TMT Ss performed at lower levels during acquisition than controls, regardless of schedule condition. Also, the rate of resistance to extinction was significantly reduced for TMT Ss compared with that of controls, regardless of the training schedules used during acquisition. A PRF extinction effect was observed for both control and TMT Ss, independent of dose regimen. PRF training occasioned greater persistence during extinction than did CRF training. Findings are discussed in terms of issues relating to TMT-induced hippocampal lesions. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Persistence in the absence of primary motivation in the albino rat.

Trained 24 male Holtzman rats under either partial reinforcement (PRF) or continuous reinforcement (CRF). Ss were subsequently pre-fed their daily ration in the form of reward pellets and immediately run in the same task under a CRF schedule. Results reveal that PRF-trained Ss persisted in the satiated state relative to CRF controls. These results, termed the satiation effect, present difficulties to theories of persistence which address only extinction tests. An interpretation utilizing a modification of A. Amsel's (1962) frustration hypothesis is advanced. Implications of this proposal for a general theory of persistence and the methodological advantages of the satiation technique are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effects of acquisition training schedule on extinction and reinstatement of cocaine self-administration in male rats.

Partial reinforcement is known to increase resistance to extinction (Rn) relative to training with continuous reinforcement. This phenomenon, referred to as the partial reinforcement extinction effect, is one of the most robust in learning and conditioning studies. Experiment 1 investigated manipulations known to affect the partial reinforcement extinction effect and determined their possible relevance for drug use patterns. Male rats received intravenous cocaine self-administration training under partial reinforcement (FR-10) training or continuous reinforcement (FR-1) conditions with either a low (0.25 mg/kg infusion) or a high cocaine dose (1.00 mg/kg infusion). Animals were placed on an extinction (recurrent nonreward) schedule for 10 days (1-hr sessions) prior to being tested for cue-induced reinstatement (single 2-hr session). Experiment 2 involved acquisition of cocaine self-administration under FR-1 conditions of short training (15 days) or extended training (30 days) with a low dose (0.25 mg/kg infusion) or a medium dose (0.50 mg/kg infusion) of cocaine reward prior to extinction or reinstatement. Experiment 1 showed that rats trained with FR-10-high dose outcomes exhibited greater Rn than the remaining groups. Additionally, FR-10-high dose and FR-10-low dose rats were more likely to return to active drug seeking during the reinstatement test. In Experiment 2, rats trained under FR-1-medium dose conditions were more persistent during extinction following short acquisition training than comparable rats experiencing extended acquisition training. The reinstatement test was conducted following extinction, in which it was observed that overtraining under FR-1-medium dose reward schedules resulted in a decrease in the tendency to return to active drug seeking. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sparing of patterned alternation but not partial reinforcement extinction effect after prenatal chronic exposure to ethanol in infant rats.

The effects of in utero administration of ethanol on single patterned alternation (PA) and the partial reinforcement extinction effect (PREE) were studied in 15-day-old rat pups. This fetal-alcohol treatment had no effect on PA but eliminated the PREE by reducing persistence in extinction after partial reinforcement (PRF) training to its level after continuous reinforcement (CRF) training, which was not affected by the treatment. The results are discussed in terms of prenatal damage to the hippocampus and in relation to an earlier experiment (Lobaugh, Bootin, & Amsel, 1985), which found no effect of infant hippocampal lesions on PA but an elimination of the PREE, which, unlike the fetal-alcohol case, resulted from PRF-like persistence in extinction following CRF training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dissociations between medial prefrontal cortical subregions in the modulation of learning and action.

The medial prefrontal cortex (mPFC) has been implicated in various attentional functions. This experiment examined the involvement of mPFC subregions in the allocation of attention in learning and action as a function of the predictive accuracy of cues. Rats with dorsal (encompassing anterior cingulate, prelimbic, and infralimbic cortices) or ventral (encompassing mainly infralimbic and dorsopeduncular cortices and tenia tecta) mPFC lesions were trained in a multiple-choice discrimination task in which operant nosepoke responses to some visual cues were consistently (100%) reinforced (CRF) with food, whereas responses to other visual cues were partially (50%) reinforced (PRF). In challenge tests designed to assess attention in the control of action, responding was directed more to CRF cues than to PRF cues in sham and dorsal mPFC-lesioned rats, but ventral mPFC-lesioned rats showed similar levels of responding to both CRF and PRF cues. Nevertheless, when given a choice between simultaneously presented CRF and PRF cues in a cue competition test, all groups responded more to CRF cues. In a subsequent Pavlovian overshadowing phase designed to assess attention in the acquisition of new learning, previously trained CRF cues overshadowed conditioning to novel auditory cues more than did PRF cues in dorsal mPFC-lesioned rats, whereas the opposite pattern was observed in sham and ventral mPFC-lesioned rats. These results suggest a dissociation within the mPFC in the use of reinforcement prediction information to allocate attention for new learning and for the control of action. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Evidence for a transitional period for development of persistence in infant rats.

Conducted 4 experiments with a total of 188 rat pups to test the hypothesis that rat pups can learn persistence at age 11 days but cannot express this learning in their behavior until they are a few days older. Exp I used a space-trial procedure to investigate the relative reinforcing effects of milk suckling, dry suckling, and contact without suckling at ages 11 and 14 days. Exp II used the Exp I procedure, manipulating schedule of reward at 2 ages and under 2 of the reward conditions. Exp III manipulated the dry suckling reward schedule in 11- and 14-day-old pups. Exp IV manipulated partial and continuous reinforcement on Day 11 but tested for persistence on Day 14. Results suggest the existence of a traditional period in neonatal rats for the learning of persistence. Partial reinforcement training with suckling on an anesthetized dam as reward induced greater persistence in extinction of the approach response than did continuous reinforcement in rat pups 14 days old but not in 11-day-old pups. Other aspects of this period of development are discussed. (26 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Extinction of persistence in a within-subject partial reinforcement experiment.

Male albino Wistar rats (N = 96) served as Ss in 2 within-S partial reinforcement experiments, designed to lessen generalization in acquisition as a means of eliminating the generalized partial reinforcement effect in extinction. When the use of a separate-phase mode of training alone proved to be unsuccessful for this purpose, a phase of extinction was interpolated between the continuously and partially reinforced acquisition phases. This manipulation was successful and Ss receiving the training sequence of partial reinforcement-extinction followed by continuous reinforcement-extinction did not show the generalized partial reinforcement effect in the final extinction phase. It is suggested that during the phase of interpolated extinction avoidance responses were counterconditioned to the stimulus complex which included nonreward. (French summary) (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Habituation to shock and learned persistence in preweanling, juvenile, and adult rats.

In Exp I, a prolonged shock-habituation treatment given between runway acquisition and simple extinction promoted persistence in both preweanling and juvenile Holtzman rats. Exp II showed even stronger persistence effects in a punished-extinction test given after shock treatment, the effects being stronger in preweanlings than in juveniles. Exp III demonstrated that shock treatment at infant-to-preweanling age resulted in increased persistence that survived a 42-day retention interval in a nonreward extinction test. Exp IV demonstrated habituation to shock in preweanlings and juveniles in terms of recovery of suppression of milk intake in the shock situation and, compared with controls, in terms of reduced latency to eat in a punished-reward test at several retention intervals. Exp V showed that the strength of persistence to approach in a runway reflected the presumed degree of habituation in 70-day-old Ss. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The signal-generated partial reinforcement extinction effect.

The five experiments reported here distinguish between memory of the reinforcement event just experienced on a preceding trial, called event-generated memory, and a reinforcement event memory activated by a signal associated with the memory, called signal-generated memory. In each experiment, a group of rats received discrimination training in Phase 1 to establish some stimulus as a signal for nonreward (N) and then consistent reinforcement (CRF) in Phase 2, in which the signal for N was presented on selected rewarded (R) trials. I hypothesized that this treatment would activate a memory of nonreward, S{N} and that this signal-generated S{N} would become a signal for reward much like event-generated S{N} does during conventional partial reinforcement (PRF) training. Rats that received this training had substantially higher resistance to extinction than did CRF and nonsignaled control groups, an effect named the signal-generated partial reinforcement extinction effect (PREE). The effect was shown to be due to presenting a signal associated with N in the CRF context and not to intrinsic properties of the signal or other characteristics of the training experience; the effect was also shown to be as large as the conventional PREE. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Persistence of runway performance after septal lesions in rats.

Assigned 32 male Wistar albino rats to groups receiving bilateral septal lesions or control operations. Septal lesions prevented the partial reinforcement extinction effect after 48 acquisition trials. Septal Ss showed increased resistance to extinction following continuous reinforcement but decreased resistance to extinction following partial reinforcement. Analysis of the acquisition data indicated that the lesions retarded the development of approach-avoidance conflicts associated with reward and nonreward. In a 2nd study, 16 septal and 16 control Ss received 96 acquisition trials. Extended training allowed the development of conflict responses under partial reinforcement, and the Ss with lesions were indistinguishable from controls during extinction. Following continuous reinforcement, septal lesions produced slower extinction of response. It is concluded that the lesions interfered with the development of feedback from frustration, approach-avoidance conflicts, and frustration tolerance. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Durability and generalizability of persistence training.

40 male and 40 female college students experienced either partial reinforcement (persistence training) or continuous reinforcement on either of 2 instrumental tasks (finger shuttle or button press) as therapy for failure-induced depression and subsequently were exposed to protracted failure (extinction). Following this initial extinction phase all Ss received continuous reinforcement on a common instrumental task (button press) as therapy and then encountered extinction (consecutive failure trials) for a 2nd time. Results show that increased persistence occasioned by partial-reinforcement therapy was able to survive interpolated periods of extinction and continuous reinforcement; that is, durable persistence training effects were shown. Furthermore, persistence training effects were shown to be generalizable (the persistence advantage associated with partial-reinforcement therapy transferred across topographically different responses), but the generalization process was not a complete one. The results are discussed within the frameworks of frustration theory and alternative cognitive theories. (35 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Invasiveness of 2 selected strains of Toxoplasma gondii with respect to mice, rats and rabbits

In Experiment I, groups of 22-and 140+-day rats were trained in acquisition and extinction of 1-way avoidance with a CS that consisted of the opening of a guilotine door 5 sec before US onset or a combination of door-opening plus a tonal signal that remained on until the occurrence of the motor response. Under both CS conditions, avoidance acquistion was similar at each age level. The extinction date indicated comparable performance for the young subjects but differential performance and greater resistance to extinction for the adult subjects. Adults trained with the door-opening CS persisted in responding for an entire series of 100 extinction trials, whereas the adults trained with the compound CS extinguished well within the 100-trial, whereas the adults trained with the compound CS extinguished well within the 100-trial limit. A 2nd experiment included 10 pre-exposures of the simple or compound CS's prior to avoidance training. Although the pups were insensitive to pre-exposure effects, the adults that were pre-exposed and trained with identical CS's showed evidence of pre-exposure effects. Results of both experiments were interpreted as indicative of differential cue saliency between ages.     

Transfer across delayed discriminations: II. Differences in the substitutability of initial versus test stimuli.

In 2 experiments, pigeons were trained on, and then transferred to, delayed simple discriminations in which the initial stimuli signalled reinforcement versus extinction following a retention interval. Experiment 1 showed that discriminative responding on the retention test transferred to novel test stimuli that had appeared in another delayed simple discrimination but not to stimuli having the same reinforcement history off-baseline. By contrast, Experiment 2 showed that performances transferred to novel initial stimuli whether they had been trained on-baseline or off-baseline. These results suggest that the test stimuli in delayed simple discriminations acquire control over responding only in the memory task itself. On the other hand, control by the initial stimuli, if coded as outcome expectancies, does not require such task-specific training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral and neuroanatomical effects of prenatal, postnatal, or combined exposure to ethanol in weanling rats.

Separate and combined effects of prenatal and postnatal exposure to ethanol on activity, emotionality, learning, and hippocampal neuroanatomy were examined in infant rats. Neonatal rats from mothers that were fed either a liquid ethanol (E) or control (C) diet were artificially reared on either 3% ethanol (E) or isocaloric maltose/dextrin (C). Pups in 4 treatment groups (EE, EC, CE, and CC) were compared. Differences in activity and emotionality were slight. Ethanol affected both the partial reinforcement acquisition effect and the partial reinforcement extinction effect. Hippocampal cell density (compared with Group CC) showed a 12% reduction in CA1 pyramidal cells and an 11% reduction in mature granule cells in Groups EC and EE; the CA4 area (compared with Group CC) was significantly larger after postnatal exposure (Groups CE and EE). Significant positive correlations were found between rate of extinction after partial reinforcement (PRF) training and CA1 pyramidal cell density in Groups CC and CE. A significant negative correlation was found between extinction rate after PRF training and CA4 area in Group EE. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Resistance to extinction in the goldfish (Carassius auratus).

Examined resistance to extinction of 180 goldfish in a trials-equated alley situation. A reverse partial reinforcement effect (100% vs. 57% reinforcement) was found following brief acquisition training, while a conventional partial reinforcement effect was obtained after extended acquisition training. Extended acquisition training with a partial reinforcement sequence that had N lengths of 3 (an N length is the number of consecutive nonreinforcements before at least 1 reinforced trial) produced greater resistance to extinction than training with a sequence that had N lengths of 1. After brief acquisition training Ss with the shorter N length produced greater resistance to extinction. (15 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Context extinction following conditioning with delayed reward enhances subsequent instrumental responding.

In Experiment 1, delayed reward generated low response rates relative to immediate reward delivered with the same frequency. Lister rats exposed to delayed reward subsequently responded at a higher rate in extinction if they received nonreinforced exposure to the conditioned context after instrumental training and prior to test, compared with animals that received home cage exposure. In Experiment 2, a signaled delay of reinforcement resulted in higher rates than an unsignaled delay. Nonreinforced exposure to the conditioning context elevated response rate for subjects in the unsignaled condition relative to a home cage group, but had no effect on response rates for subjects that had received the signaled delay. In Experiment 3, following an unsignaled reinforcement delay, groups receiving either no event or signaled food in the context responded faster in extinction than groups receiving no context exposure or unsignaled food. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Impulsive choice as a predictor of acquisition of IV cocaine self- administration and reinstatement of cocaine-seeking behavior in male and female rats.

Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice predicted the rate of acquisition of IV cocaine self-administration. The objectives of the present experiments were to: (a) compare impulsive choice in males and females, (b) extend previous research on impulsive choice and acquisition of cocaine self-administration to males, and (c) compare males and females during maintenance, extinction, and reinstatement of cocaine-seeking behavior. Male and female rats were trained on an adjusting delay task in which a response on one of two levers yielded one food pellet immediately, and a response on the other resulted in three pellets after an adjusting delay that decreased after responses on the immediate lever and increased after responses on the delay lever. A mean adjusted delay (MAD) was used as the quantitative measure of impulsivity. In Experiment 1, MADs were analyzed for sex differences. In Experiment 2, acquisition of cocaine self-administration was examined in rats selected for high (HiI; MADs ≤9 seconds) or low (LoI; MADs ≥13 seconds) impulsivity. In Experiment 3, HiI and LoI groups were compared on maintenance and extinction of cocaine self-administration and cocaine-primed reinstatement of drug-seeking behavior. There were no sex differences in impulsive choice; however, HiI male and female rats acquired cocaine self-administration faster than their LoI counterparts. LoI females responded more on a cocaine-associated lever during maintenance and extinction than HiI females, but HiI females showed greater reinstatement of cocaine-seeking behavior than all other groups at the highest dose tested (15 mg/kg). Thus, individual differences in impulsive choice were associated with differences in cocaine-seeking behavior. Impulsive choice and sex may be additive vulnerability factors in certain phases of drug abuse. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Instrumental response persistence following induction of hippocampal theta frequency during fixed-ratio responding in rats.

Four groups of 6 male albino rats (24 Ss) were used to investigate the relationship between hippocampal theta and instrumental response persistence. All Ss were first trained on a discrete-trial FR-10 schedule of reinforcement. In Phase 2, hippocampal theta was induced via electrical stimulation of medial septal pacemaker cells through implanted electrodes at the beginning of 50% of the 8 daily FR-10 trials for experimental Ss, while stimulated-control Ss received 200-Hz medial septal stimulation which does not induce theta. The 2 remaining control groups continued as in the training phase. In Phase 3, FR-10 responding was extinguished in all Ss. Induction of hippocampal theta depressed responding and led to greater resistance to extinction in the experimental group compared with the other groups. (PsycINFO Database Record (c) 2010 APA, all rights reserved)