共查询到20条相似文献,搜索用时 15 毫秒
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E Ejima JD Rosenblatt M Massari E Quan D Stephens CA Rosen D Prager 《Canadian Metallurgical Quarterly》1993,81(4):1017-1024
The human T-cell leukemia virus type I (HTLV-I) and HTLV-II Tax proteins are potent transactivators of viral and cellular gene expression. Using deletion mutants, the downstream parathyroid hormone-related protein (PTHrP) promoter is shown to be responsive to both HTLV-I and HTLV-II Tax as well as the AP1/c-jun proto-oncogene. Transactivation of PTHrP by Tax was seen in T cells but not in B-cell lines or fibroblasts. A carboxy terminal Tax deletion mutant was deficient in transactivation of both the PTHrP and IL2R alpha promoters but not the HTLV-I long terminal repeat (LTR). Exogenous provision of NFkB rescued IL2R alpha expression but not the PTHrP promoter. Thus, HTLV-I Tax, HTLV-II Tax, and c-jun transactivate PTHrP and may contribute to the pathogenesis of hypercalcemia in adult T-cell leukemia. 相似文献
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H Hirai T Suzuki J Fujisawa J Inoue M Yoshida 《Canadian Metallurgical Quarterly》1994,91(9):3584-3588
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T Yamagata K Mitani H Ueno Y Kanda Y Yazaki H Hirai 《Canadian Metallurgical Quarterly》1997,17(8):4272-4281
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