Targetry of MoO3 on a copper substrate for the no-carrier-added ^94mTC production via ^94Mo（p,n）^94mTc reaction

94mTc was produced via natMo(p,xn)94mTc reaction.Deposition of MoO3 on Cu substrate was carried out via two special sedimentation methods for the production of 94mTc.The 533 mg of MoO3,600 μL of collodium (nitrocellulose) and 3 mL of acetone were used to prepare a MoO3 layer of 11.69 cm2 and 45.81 mg.cm-2.Also,a MoO3 layer was prepared by 533 mg of MoO3,71.188 mg of methylcellulose and 4 mL of water.The targets were checked by SEM and thermal shock test.     

Biodistribution and pharmacokinetics of ^99mTc—CQDO and ^99mTc—CQDO—MeB for new myocardial imaging agent

A comparison of ~(99m)Tc- CQDO and ~(99m)Tc-CQDO-MeB has been made for biodistribution and pharmacokinetics. ~(99m)Tc-CQDO and its adducts of methaneboronic acid ~(99m)Tc-CQDO-MeB were prepared by the reduction of Na~(99m)TcO_4 with SnCl_2·2H_2O in aqueous solution. Radiochemical purity of ~(99m)Tc-CQDO and ~(99m)Tc-CQDO-MeB determined by TLC were over 95% after extraction. Biodistributions of ~(99m)Tc-CQDO and ~(99m)Tc-CQDO-MeB in mice demonstrated that both of them could be easily absorbed by myocardium, and the peak uptake of each were 10.83±2.2% ID/g and 11.84±1.69%ID/g, respectively. ~(99m)Tc-CQDO showed rapid clearance from myocardial tissue while ~(99m)Tc-CQDO-MeB had long retention in heart muscle. The myocardial uptake of ~(99m)Tc-CQDO was only 5.88±1.66%ID/g at 10 min. and the uptake of ~(99m)Tc-CQDO-MeB was 7.42±0.17%ID/g at 60 min. The elimination of each from blood has a biexponential pattern, the first T_(1/2) is 1.38 and 1.5 min, respectively. The partition coefficient of ~(99m)Tc-CQD     

Effect of some factors on direct ^99mTc monoclonal antibody labelling efficiency

This study is focused in the influence of some experimental factors on direct ^99mTc monoclonal antibody labelling method.The factors include weak ligands,reducing agent content and reduction time used in labelling.Biodistribution and scintigraphic imaging of animals are also performed.Finally,optimal parameters are supposed.     

^99mTc—ECD brain SPECT imaging in patients with acquired immunodeficiency syndromes

In order to investigate the changes of regional cerebral blood flow (rCBF) in patients with acquired immunodeficiency syndromes (AIDS), 99mTc-ECD brain SPECT imaging was performed in 5 patients with AIDS and 16 sex and age matched normal controls, and the rCBF percentages compared to the cerebellum were calculated using a semi-quantitative processing software. Hypoperfusions in the right and left frontal, temporal, porietal lobe, basal ganglia and left thalamus were seen in 1 patient with dementia. Hypoperfusions in the right and left frontal and temporal lobe were seen in 4 asymptomatic patients. The rCBF in the right and left frontal, temporal, porietal lobe, basal ganglia and thalamus, front and pons were decreased significantly in patients with AIDS than those of the control subjects (p <0.005). It is concluded that there exists reduced cortico-subcortical rCBF in AIDS patients.     

Evaluation of suspected local recurrence in lung cancer and head ＆ neck cancer： A comparison between ^99mTc-HL91 SPECT and CT for biopsy proven lesions

CT has rather low accuracy for the follow-up of tumors after therapy. This study was to determine whether the diagnostic accuracy can be improved with ^99mTc-HL91 SPECT in comparison with parallel results of CT imaging. Thirty patients of lung cancer or head ＆ neck cancer, suspected of recurrences on clinical symptoms and CT during clinical follow-up after therapy, underwent ^99mTc-HL91 SPECT. The radioactivity ratios of tumor to normal tissues （T/NT） were calculated using the region of interest technique. Results of ^99mTc-HL91 SPECT were verified by histopathology. The ^99mTc-HL91 average uptake ratios of T/NT in the group of recurrent lesions and non-recurrent lesions were 1.58±0.16 and 1.18±0.14, respectively. A significant difference was found between T/NT data of the two phases （t=4.87, P〈0.001）. The ^99mTc-HL91 SPECT shows sensitivity of 72.73%, specificity of 89.47% and accuracy of 83.83% for differentiating recurrent lesion, while the CT shows sensitivity of 63.63%, specificity of 84.21% and accuracy of 76.67%. A combination of ^99mTc-HL91 SPECT and CT for 21 patients with lung cancers or head ＆ neck cancers with congruent results shows sensitivity of 100%, specificity of 94.12% and accuracy of 95.23%. It is concluded that ^99mTc-HL91 SPECT may play a role in differentiating recurrent lesions in patients with lung cancer and head ＆ neck cancer. Furthermore, the combination of CT and ^99mTc-HL91 SPECT is a more effective method for diagnosing recurrence of lung cancer and head ＆ neck cancer.     

Evaluation of some ratio effects in ~(99m)Tc-MIBI imaging of breast tumors

1 INTRODUCTIONUse of the radionuclide jmaging is attracting attention for detection'in breast can-cer.l1~4] It plays an imPortant role to ear1y diagnose, discover akillary lymPh node metas-tasis and evaluate the multidrug-resistant of the breast cancer. At pIesent, most authorsuse tumor/normal value to express the radionuclide uptake in a t.mo..I5~6l Ih this study,we comPared the tumr/normal ratio with some other ratios.2 MATERIALS AND METHODSOne hUndred patients with a histolog…     

含服硝苯吡啶对99mTc-MIBI心肌显像的影响

为观察硝苯吡啶对＾９９ｍＴｃ－ＭＩＢＩ心肌断层显像的影响,把３５例冠心病患者分成硝苯吡啶组和硝酸甘油组,隔日行介入心肌断层显像,静注＾９９ｍＴｃ－ＭＩＢＩ后１ｈ和５ｈ时分别采集图象,分析结果显示硝苯吡啶组虽有４０．０％的心肌节段摄取较用药前改善,但１ｈ显像有３３个节段出现逆向性摄取减少,其中２９个节段５ｈ显像又恢复正常。硝酸甘油组有６９．５％心肌节段较用药前摄取改善,１ｈ显像未见有逆向性摄取减少,     

99mTc-MIBI显像对甲状腺癌及术后随访的临床价值

４６例甲状腺原发肿块（恶性病变１８例,良性病变２８例）及２４例甲状腺癌术后复发或转移患者,应用＾９９ｍＴｃ－ＭＩＢＩ显像。结果１８例甲状腺癌中１４例原发灶有效射性填充。而２８例良性病变中仅９例原发灶有放射性填充。２４例甲状腺癌术后复发或转移患者有１９例呈阳性显示,其阳性率明显高于＾１３１Ｉ显像。＾９９ｍＴｃ－ＭＩＢＩ显像对甲状腺癌尤其是术后复发、转移的早期诊断具有较高的临床价值。     

Mammography and 99mTc-MIBI scintimammography in breast cancer diagnosis

The aim of this work has been to evaluate whether a diagnostic protocol based on the joint use of mammography and ^99mTc-MIBI scintimammography can help to distinguish the lesions and to reduce the number of biopsies required in patients with suspected breast cancer,A total of 58 women were evaluated by palpation ,mammography,scintimammography,Twenty-four patints were scintimammographed with ^99mTc-MIBI at 10 min after injection.Thirty-four patients were taken doublepase scintimammography with ^99mTc-MIBI 10min and 60-90 min fater injection. Based on mammography,the supicion degrees of malignancy were rated,and 30 results of malignancy were confirmed by histopatology,Based on mammography,18 lesion were considered to be most probably benign (of which 3 were histopathologically breast cancer),19 as indeterminate(of which 9 were histopatologically breast cancer),and 21 as malignant (of which 18 were histopathologically breast cancer),The results of early and delayed phases ^99mTc-MIBI scintimammography were the same.The sensitivity,specificity and accuracy of scintimammography were 74.29%,86.96% and 79.31%,respectively,Scintimammography gave 16 correct diagnosis in 19 mammogram indeterminate (84.2%) and demonstrated 5 out of 8 cases axillary lymph nodes metastasis (72.5%),These studies show that ^99mTc-MIBI scintimammography used as a complementary testing technique to mammography is useful in the examination of patients with suspected breast cancer,The adoption of a joint mammography-scintimammography diagnostic protocol could considerably reduce the number of biopsies performed in patients with lesion of indeterminate mammographic suspicion of malignancy.     

Joint imaging of 99mTcO4- and 99mTc-MIBI for thyroid carcinoma recurrence and cervical metastases

In this paper, the joint imaging of 99mTcO4- and 99mTc-methoxy isobutyl isonitrile was compared with neck Color Doppler Ultrasonography (CDU) to identify its value in thyroid carcinoma, postoperative recurrence or cervical metastases. Thyroid carcinoma patients (150 operated and 21 re-operated with suspected postoperative recurrence or cervical metastases) were retrospectively analyzed. Taking the pathological result as the gold standard, the thyroid foci (437 cases), the thyroid foci of ≥1-cm diameter (215 cases) and the suspected postoperative recurrence or cervical metastases (87 cases) were compared by diagnostic results of the joint imaging and the neck CDU. The sensitivity, specificity and accuracy of the joint imaging were 64.18%, 80.00% and 67.82%, and 44.78%, 40.00% and 43.68%, respectively, for the cases with suspected postoperative recurrence or cervical metastases. For thyroid carcinoma of ≥1-cm diameter, the sensitivity of the joint imaging was 97.75%, and the neck CDU was 89.89%, but both specificity and accuracy was similar for thyroid carcinoma independence on their diameter. For thyroid carcinoma, the sensitivity of the joint imaging was 81.99%, and the neck CDU was 89.10%. The results show that the joint imaging is sensitive for large diameter thyroid carcinoma.     

99mTc-MDP骨显像在监测带肌蒂骨移植中的价值

选用成熟体健家犬9条，随机分为4组，采用自身对照法，动物左侧为实验侧，切取带缝匠肌的髂骨块，右侧为对照侧，将骨瓣游离后用医用硅胶膜包裹，固定于大腿外侧，术后2、4、6、8周从右侧切取与实验侧大小一样的骨块，以放射性核素骨显像，组织学检查等方法，观察肌蒂移植骨存活范围和成骨活形形式，探讨带蒂移植骨在治疗股骨头缺血性坏死方面的价值。结果显示：（1）带缝匠肌髂骨瓣为一部分存活骨，在6距离1.2-1.7cm处开始出现骨组织坏死，（2）带缝匠肌髂骨瓣成骨活动有两种方式，存活骨在机械性刺激和血供减少的情况下，骨髓组织被纤维肉芽组织和新生毛细管替代，远端死骨则是由近端存活骨向其爬行替代。（3）组织学检查2周时死骨内有少许纤维肉芽组织和新生毛细血管，6周时出现原始骨小梁，8周时部分骨小梁恢复正常形态，骨母细胞明显减少。（4）带肌蒂骨瓣存活范围与肌蒂宽度成正比关系，由此可见，带缝匠肌髂骨瓣是一块血供欠佳的骨髓，对股骨头坏死和塌陷的修复是有限的，放射核素骨显像能早期判断带蒂移植骨的成活情况。     

^99mTc—EHIDA肝胆显像对肝门局部冷冻损伤的评价

对实验动物小猪第一肝门冷冻后１，２周以及对照组进行ＳＰＥＣＴ肝胆动态显像，结果发现肝门冷区放射性分布稀疏或缺损样改变，而肠道出现放射性的时间明显延工，与对照组比较差异显著，结果提示，胆道系统受损，对肝门区进行直接深低温冷冻治疗时，应该对胆道系统加以保护，避免产生严重并发症。     

99mTc-tetrofosmin SPECT显像在肺癌和纵膈淋巴结转移的临床研究

对３２例手术病理证实的肺癌和肺结核病人（其中鳞状上皮癌１６例,腺癌８例,小细胞肺癌４例,肺转移癌２例,肺结核２例）,进行＾９９ｍＴｃ－ＴＦ ＳＰＥＣＴ显像和ＣＴ检查,将结果直接与手术结果对比,来评价肺和纵膈淋巴结病变。结果在肺癌原发灶,＾９９ｍＴｃ－ＴＦ ＳＰＥＣＴ显像具有较高的灵敏度（９３％,２８／３０）,但２例肺结核病灶也显示＾９９ｍＴｃ－ＴＦ的摄取增高。有５例手术证实伴有肿瘤中心坏死的肺癌病     

99mTc-MIBI 测定门静脉压力分析肝硬化病情及评价疗效

采用