Lumbar disk prolapse surgery with or without free fat transplantation. A prospective triple-blind randomized study

The aim of this prospective triple-blind randomized study was to determine if a free fat transplant used in operation in lumbar disc herniation could reduce the degree of intraspinal scar tissue and to evaluate whether the scar tissue could lead to symptoms. Ninety-nine patients were subsequently examined after median 376 days. The clinical outcome was scored using the Low Back Pain Rating Scale. Enhanced CT-scanning was assessed regarding the degree of scar tissue and survival of the fat transplant. There was no difference in the clinical outcome between the two groups. Significantly fewer had dural scarring in the group who had a free fat transplantation, but there was no difference regarding the degree of radicular scarring. The transplant was shown on CT-scan at the follow-up examination in 66% of the patients who had a fat transplantation. Free fat transplantation can reduce the degree of dural scar tissue after operation for lumbal disc herniation, but does not result in a clinically better outcome.     

Lumbar intervertebral disk herniation in children

A consecutive series of 16 children from 9 to 18 years old, with lumbar intervertebral disc herniation who were treated surgically in Department of Neurosurgery Medical Academy in Poznań, between 1978-1992, was analysed. The clinical symptoms, X-ray assessment, type of operation and outcome are reviewed. In our analysis characteristic features of disc herniation in children are: the onset of pain due to violent injury in relation to lifting, bilateral neurological symptoms and radiculography imaging central intervertebral disc herniation.     

Lumbar disk herniation combined with epidural hematoma. A case report

We examined the protective effect of nicotine against neuronal cell death in the model system of serum- and nerve growth factor (NGF)-free cultures of PC12 cells. Serum deprivation induced massive death of undifferentiated PC12 cells, which was inhibited by the addition of NGF, but not by the addition nicotine (100 microM). Even after PC12 cells had been differentiated by the treatment with NGF, serum and NGF deprivation induced rapid and massive death of these cells. The addition of nicotine (1-100 microM) to the deprivation system prevented such cell death almost completely. The protective effect of nicotine was abolished by hexamethonium or mecamylamine, inhibitors of nicotinic acetylcholine (nACh) receptors. Treatment with reserpine to deplete intracellular catecholamines did not influence the effect. The results suggest that the protective effect of nicotine against neuronal cell death is exerted through nACh receptors.     

Alcohol, tobacco and recreational drug use and the risk of non-Hodgkin's lymphoma

A population based case-control study was conducted to determine whether risk of non-Hodgkin's lymphoma (NHL) in the absence of HIV infection is related to the previous use of tobacco, alcohol or recreational drugs. A total of 378 residents of Los Angeles County who were diagnosed with high- or intermediate-grade NHL were compared with individually age-, race- and sex-matched neighbourhood control subjects with regard to history of use of tobacco products, alcohol and ten specific recreational drugs. Risk of NHL among women decreased with increased consumption of alcoholic beverages (trend P = 0.03), with risk 50% lower among those consuming five or more drinks per week than among non-drinkers. Cocaine, amphetamines, Quaaludes and lysergic acid diethylamide (LSD) were each associated with a significantly increased risk of NHL in men with risk greater among those with more frequent use of these drugs. Confounding factors could not be excluded in these findings. The use of multiple types of drugs was also associated with a significantly increased risk of NHL in men (trend P = 0.005) with risk greatest among those using five or more types of drugs (odds ratio = 5.8, 95% confidence limits = 1.2-28.4); among these drugs, cocaine use appeared to account for the elevated risk of NHL among men based on multivariable analyses.     

Lumbar disk prolapses and radiological spinal intervention. What do the randomized controlled trials say?

We searched the Medline database and examined 11 randomized controlled trials to evaluate the efficacy of treating lumbar herniated discs by injection with chymopapain or by automated percutaneous discectomy. Our findings show that chemonucleolysis with chymopapain is a documented treatment which is better than placebo, but consistently inferior to surgical discectomy. The two randomized controlled trials to evaluate automated percutaneous discectomy fail to show efficacy that is any better than would be expected from a placebo response. We conclude that surgical discectomy is the best treatment option for a herniated disc when conservative efforts have failed.     

Alcohol and tobacco cessation in alcohol-dependent smokers: Analysis of real-time reports.

Alcohol-tobacco interactions and relapse precipitants were examined among alcohol-dependent smokers in a trial of concurrent alcohol and tobacco treatment. After discharge from treatment, participants completed 14 days of electronic diary (ED) assessments of mood, self-efficacy, urges to drink or smoke, and drinking and smoking behavior. ED data revealed an increase in frequency of alcohol urges after smoking episodes. Drinking relapse episodes were predicted by prior ED ratings of low self-efficacy to resist drinking and high urge to smoke. Smoking relapse episodes were predicted by high urge to smoke and high negative, high arousal mood. Results support a cross-substance cue reactivity model of multiple substance use and a limited-strength model, but not a cross-substance coping model. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol, sexual arousal, and self-control.

Investigated the effects of alcohol on self-regulation using delay of gratification for viewing time for an erotic film as the primary dependent measure. Other measures included reflection–impulsivity, locus of control, sexual-guilt scores, and continuous recording of Ss' penile tumescence. Using a balanced placebo design with 50 undergraduate men, Ss were led to believe that they had consumed an alcoholic or a nonalcoholic beverage, and half of each of these 2 groups received either alcohol or tonic water. In addition, the effects of 3 doses of alcohol (placebo, low dose, high dose) were investigated. Instructional set, regardless of drink content, resulted in longer delay times and increased thoughts with sexual content. Although there was no significant relation between increasing dose of alcohol and delay time, there was an interaction between scores on Rotter's Internal–External Locus of Control Scale and alcohol dose. Externalizers showed an inverse linear relation between increasing dose of alcohol and delay time. Internalizers showed the opposite trend. Results support other research showing that expectations about drinking can be more potent predictors of behavior than the pharmacological impact of alcohol. Implications for the self-regulation of sexual behavior under the influence of alcohol are discussed. (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Gender, Alcohol Consumption, and Differing Alcohol Expectancy Dimensions in College Drinkers.

Examinations of gender differences in alcohol expectancies among college drinkers typically have used self-report measures to assess single expectancy dimensions and often have been confounded by drinking level. This study examined gender differences in alcohol expectancies using 2 assessment methods. College students (N = 88) completed self-report questionnaires, including expectancy likelihood and subjective evaluation endorsements of expectancies, and a computerized expectancy accessibility task. Expectancy accessibility and endorsement were modestly correlated, with higher alcohol consumption and female gender linked to greater accessibility and endorsement of social enhancement expectancies. Gender moderated the relation between consumption and sociability expectancy accessibility; among men, heavier drinking was associated with more rapid activation of expectancies. Findings suggest complexity in associations among these variables and underscore the need to capture the multidimensionality of the expectancy construct and its relationship to alcohol use. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structure of the stacked disk aggregate of tobacco mosaic virus protein

The coat protein of tobacco mosaic virus is known to form three different classes of aggregate, depending on environmental conditions, namely helical, disk, and A-protein. Among the disk aggregates, there are four-layer, six-layer, and long stacks, which can be obtained by varying the ionic strength and temperature conditions during the association process. The four-layer aggregate has been crystallized, and its structure solved to atomic resolution. The stacked disk aggregate had been presumed to be built of a polar two-layer disk related to the crystalline A and B rings. A study using monoclonal antibodies specific to the bottom surface of TMV protein demonstrated that the stacked disk aggregate is bipolar, and suggested that the repeating two-layer unit might be similar to the dihedrally symmetrical A-ring pair in the disk crystal. In this paper we present a three-dimensional reconstruction of the stacked disk aggregate obtained by electron microscopy of ice-embedded samples. After modeling of the structure, we found the ring pairs to have the same quaternary structure as the A-ring pair of the four-layer aggregate. The resolution achieved in the image processing of the electron micrographs is on the order of 9 A in the meridional direction and 12 A in the equatorial. The identification of the structure of the stacked disk with the A-ring pair of the disk crystal provides an explanation of the observation that the axial periodicity of the disk pair, which is approximately 53 A when fully hydrated, can shrink to approximately 43 A in the dry state.     

Alcohol, customary drinking behavior, and pain.

Tested the hypothesis that the reduction of experimentally induced pain is a joint function of alcohol and customary drinking habits. 51 male college students (all of whom were experienced drinkers) were administered a drinking history inventory assessing where, when, with whom, and how much they customarily drank. Pain thresholds and self-reports of pain intensity were measured following pain induced by pressure applied to a finger and cold applied to a hand. Both stimuli were administered before and after alcohol dosage to 3 independent groups. The drinking history data were factor analyzed, and factor scores reflecting the several dimensions of customary drinking behavior were entered into a multiple regression analysis of the experimental results. These analyses produced numerous significant interaction effects of alcohol and customary drinking behavior. Four factors accounted for 68.2% of the overall variance: (a) Times (33%), (b) Context (14.6%), (c) Amount (11.3%), and (d) Sickness (8.9%). Among other findings, results show that the higher dosage of alcohol led to pain reduction in solitary barroom drinkers but increased pain in drinkers who customarily drank at home with family or friends, and suggest that susceptibility to alcohol analgesia seems to be a behavioral characteristic of problem drinkers. (38 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Lumbar phlebography: methodological choice and reliability in the radiographic study of lumbar disk hernias

Lumbar epidural venography was used as the examination of choice in the investigation of suspected disc herniation in 270 patients. Compression or occlusion of an epidural and/or radicular vein at the disc level is the most significant venographic abnormality. In 110 patients operated on, the reliability of lumbar epidural venography was equal to 97.2%.     

Alcohol, expectancy, cognitive labeling, and mirth.

Investigated the role of alcohol, expectancy, and cognitive labeling in producing positive emotional changes following moderate alcohol consumption. In a 2–3 factorial design, 96 male normal drinkers (undergraduates) were (a) given either an alcoholic (.45 g ethanol/kg) or a nonalcoholic beverage, (b) instructed that they were receiving either an alcoholic or a nonalcoholic beverage, and (c) either informed or not informed of common physical sensations that result from a moderate dose of alcohol. Ss were then exposed to humorous stimuli, and their laughter and self-reports of mood were measured. Hypotheses based on extensions to alcohol intoxication of the cognitive-attributional components of S. Schachter's (1964) theory of emotion were not supported. Although both instructing Ss that they had received alcohol and actually administering alcohol increased Ss' reports of positive affect, only the beverage content instruction influenced Ss' laughter. Implications for current conceptualizations of the emotional and behavioral effects of alcohol consumption are discussed. (35 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol primes, expectancies, and the working self-concept.

Previous research has shown that alcohol consumption can lead to momentary changes in the self-concept (e.g., Steele & Josephs, 1990). In two studies (n = 150), we examined whether the implicit activation of alcohol expectancies (i.e., sociability-related expectancies) would also lead to changes in self-perception. To test this idea, participants first completed a measure of sociability-related alcohol expectancies. In a subsequent laboratory session, participants were exposed to either alcohol-related primes (i.e., pictures or words associated with alcohol) or neutral primes. After the priming task, participants completed an ostensibly unrelated self-concept survey that contained words related to sociability (e.g., “outgoing”) and nonsociability related words (e.g., “clever”). For both studies, results revealed that sociability-related alcohol expectancies were positively associated with sociability-related self-concept ratings for participants exposed to alcohol primes, but not for participants exposed to the neutral primes. Implications for the role implicit self-concept activation may have on drinking behaviors are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol, sexual arousal, and the transfer of excitation.

Investigations of the alcohol-related disinhibition of responses to deviant sexual stimuli suggest that the pharmacological actions of ethanol have little influence on the disinhibition process. The mere belief that alcohol is consumed is sufficient to induce increased sexual arousal. Studies with conventional stimuli, however, suggest that interactions occur between the pharmacological presence of ethanol and the psychological expectations of its presence. The present article examines the contribution of pharmacological, cognitive, and environmental variables to perceived sexual arousal. Pictures that elicited either a low or moderate level of self-reported sexual arousal were viewed and evaluated by 64 men and 64 women after completing their drinks. The evaluations and arousal measures suggested significant Instruction by Content by Arousal interactions. The strongest perceptions of arousal occurred among Ss who did not know they were drinking alcohol. When Ss were unaware of the alcohol intoxication, the pharmacological excitation induced by alcohol transferred to the perception and evaluation of the slides. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol consumption, water consumption, and emotionality in mice.

Tested 95 F2 mice for 1 mo. on a variety of tests of emotionality and activity. For a 2nd mo. Ss were given a choice of tap water of 10% ethanol for fluid consumption. 42 measures from emotionality testing were correlated with 30 readings of alcohol and 30 readings of water consumption. Abosolute consumption of alcohol and the relationship between emotionality and alcohol consumption increased over the 30-day period. 3 major shifts in the pattern of correlations over time were observed, suggesting a 3-stage theory of fluid consumption in the 2-choice situation. High alcohol consumption in the last stage, which accounted for most of the correlations, is related to a pattern of emotionality involving high activity, low freezing, and low emotional defecation. A construct of stress resistance is hypothesized to account for these relationships in conflict with classical drive-reduction theory. The 1st stage is considered to be more compatible with classical drive-reduction theory. An intermediate or transition stage is also involved with suggestions that this may be more complex for alcohol than water consumption. (27 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol, Tobacco, and Drug Use Disorders and Personality Disorder Symptoms.

In a nonclinical sample of 395 young adults, the authors evaluated the relations between major personality traits, Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV; American Psychiatric Association, 1994) personality disorder symptoms, and DSM-IV alcohol use disorders (AUDs). Consistent with previous findings, traits related to disinhibition and negative affectivity were consistently associated with AUDs, as were Cluster B personality disorder symptoms (especially antisocial and borderline disorder symptoms). Multivariate analyses revealed that Cluster B symptoms were significantly associated with AUDs above and beyond what was accounted for by personality traits. Further, the authors found differential patterns of relations between other substance use disorders (SUDs; i.e., tobacco dependence and drug use diagnoses) and personality disorder symptoms. Overall, these results suggest that personality disorder symptoms predict unique variance in SUDs that reflect maladaptive aspects of personality traits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alcohol and highway safety.

Recent statistics dealing with drinking driver and drinking pedestrian fatalities are reported. A world survey of counter-measures is undertaken, as is an evaluation of these measures. Counter-measures employed by the Federal (Canadian) Government are described, with implications for future evaluation of the program. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The European Alcohol Action Plan. The Alcohol, Drug and Tobacco Unit. Department of Lifestyles and Health, Regional Office for Europe. World Health Organization. Copenhagen, 1993

The translation to the Spanish language of the European Alcohol Action Plan, from the Regional Office for Europe of the World Health Organization, is presented as a support measure and promotion of its application. The European Alcohol Action Plan calls for a European movement to support actions at the local, national and international levels. The Action Plan calls for the participation of many partners in public, private and voluntary sectors. Its successful implementation will make a clearly recognizable contribution to improve Europeans' health and to prevent the harm done by the use of alcohol. Alcohol is a major public health problem throughout the European Region as a whole. In relation to alcohol, Member States hold two shared commitments. The first one is a commitment to the health policy for Europe, as expressed in the Targets for Health for All, and specifically the target 17 which calls for a 25% reduction in alcohol consumption between 1980 and 2000, with particular attention to reduce its harmful use. The second one is a commitment to the European Alcohol Action Plan which was strongly endorsed at the 1992 Regional Committee as a positive set of guidelines to be followed by the European Member States. Member States, nongovernmental organizations, the European Union, the Council of Europe and the Nordic Council are taking initiatives to reduce the harm produced by the use of alcohol.