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Kai Han Qi Lei Shi‐Bo Wang Jing‐Jing Hu Wen‐Xiu Qiu Jing‐Yi Zhu Wei‐Na Yin Xu Luo Xian‐Zheng Zhang 《Advanced functional materials》2015,25(20):2961-2971
In this paper, a self‐delivery system PpIX‐PEG‐(KLAKLAK)2 (designated as PPK) is fabricated to realize mitochondria‐targeted photodynamic tumor therapy. It is found that the PPK self‐delivery system exhibited high drug loading efficacy as well as novel capacity in generation of intracellular reactive oxygen species (ROS). This study also indicated that the photochemical internalization effect of the photosensitizer protoporphyrin IX (PpIX) under a short time light irradiation improved the cellular internalization of PPK. On the contrary, PPK could target to the subcellular organelle mitochondria due to the presence of proapoptosis (KLAKLAK)2 peptide. Importantly, the in situ generation of ROS in mitochondria enhanced the photodynamic therapy efficacy under another long time irradiation, leading to significant cell death with decreased mitochondrial membrane potential. Besides, relative high tumor accumulation, minimal systemic cytotoxicity and efficacious long‐term tumor inhibition in vivo are also confirmed by using a murine model. All these results demonstrated the self‐delivery system PPK with a dual‐stage light irradiation strategy is a promising nanoplatform for tumor treatment. 相似文献
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A Tumor Targeted Chimeric Peptide for Synergistic Endosomal Escape and Therapy by Dual‐Stage Light Manipulation 下载免费PDF全文
Kai Han Qi Lei Hui‐Zhen Jia Shi‐Bo Wang Wei‐Na Yin Wei‐Hai Chen Si‐Xue Cheng Xian‐Zheng Zhang 《Advanced functional materials》2015,25(8):1248-1257
In this study, a pH sensitive chimeric peptide is developed to codeliver a photosensitizer, protoporphyrin IX (PpIX), and plasmid DNA simultaneously. In the presence of matrix metalloproteinase‐2 (MMP‐2), the chimeric peptide undergoes the process of hydrolysis of PLGVR peptide sequence, exfoliation of PEG, and increase of positive charges. As a result, the chimeric peptide can be preferentially uptaken by MMP‐2 rich tumor cells. To realize synergistic effect of drug and gene delivery, a dual‐stage light irradiation strategy is developed, i.e., the short time light irradiation can efficiently enhance the endosomal escape of the chimeric peptide/PpIX/DNA complexes by the formation the reactive oxygen species (ROS), resulting in synergistic endosomal escape and improved DNA expression. In addition, due to the screened phototoxicity of PpIX, short time light irradiation does not lead to detectable changes in the cell viability. After the gene transfection, the screened phototoxicity of PpIX is subsequently stimulated by long time irradiation to achieve high synergistic efficacy of photodynamic and gene therapies. Both in vitro and in vivo studies confirm the chimeric peptide‐based nanocarrier with a good synergistic effect is a promising nanoplatform for tumor treatments. 相似文献
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Cancer Phototherapy: Mitochondria‐Targeted Small‐Molecule Fluorophores for Dual Modal Cancer Phototherapy (Adv. Funct. Mater. 17/2016) 下载免费PDF全文
Shenglin Luo Xu Tan Shengtao Fang Yu Wang Tao Liu Xin Wang Yi Yuan Huiqin Sun Qingrong Qi Chunmeng Shi 《Advanced functional materials》2016,26(17):2975-2975
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Antimicrobial Surfaces: Dual‐Mechanism Antimicrobial Polymer–ZnO Nanoparticle and Crystal Violet‐Encapsulated Silicone (Adv. Funct. Mater. 9/2015) 下载免费PDF全文
Sacha Noimark Jonathan Weiner Nuruzzaman Noor Elaine Allan Charlotte K. Williams Milo S. P. Shaffer Ivan P. Parkin 《Advanced functional materials》2015,25(9):1366-1366
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Chao Wang Liang Cheng Yumeng Liu Xiaojing Wang Xinxing Ma Zhaoyi Deng Yonggang Li Zhuang Liu 《Advanced functional materials》2013,23(24):3018-3018
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Photodynamic Therapy: Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo (Adv. Funct. Mater. 37/2014) 下载免费PDF全文
Yuri Choi Seongchan Kim Myung‐Ho Choi Soo‐Ryoon Ryoo Jongnam Park Dal‐Hee Min Byeong‐Su Kim 《Advanced functional materials》2014,24(37):5774-5774
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Photodynamic Therapy: Porous Porphyrin‐Based Organosilica Nanoparticles for NIR Two‐Photon Photodynamic Therapy and Gene Delivery in Zebrafish (Adv. Funct. Mater. 21/2018) 下载免费PDF全文
Chiara Mauriello Jimenez Dina Aggad Jonas G. Croissant Karen Tresfield Danielle Laurencin Dorothée Berthomieu Nicolas Cubedo Mireille Rossel Shahad Alsaiari Dalaver H. Anjum Rachid Sougrat Manuel A. Roldan‐Gutierrez Sébastien Richeter Erwan Oliviero Laurence Raehm Clarence Charnay Xavier Cattoën Sébastien Clément Michel Wong Chi Man Marie Maynadier Vincent Chaleix Vincent Sol Marcel Garcia Magali Gary‐Bobo Niveen M. Khashab Nadir Bettache Jean‐Olivier Durand 《Advanced functional materials》2018,28(21)
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Photodynamic Therapy: Light‐Up Probe for Targeted and Activatable Photodynamic Therapy with Real‐Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses (Adv. Funct. Mater. 42/2015) 下载免费PDF全文
Youyong Yuan Chong‐Jing Zhang Ryan T. K. Kwok Shidang Xu Ruoyu Zhang Jien Wu Ben Zhong Tang Bin Liu 《Advanced functional materials》2015,25(42):6691-6691
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Cancer Therapy: Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer (Adv. Funct. Mater. 20/2017) 下载免费PDF全文
Fangyuan Zhou Bing Feng Tingting Wang Dangge Wang Qingshuo Meng Jianfeng Zeng Zhiwen Zhang Siling Wang Haijun Yu Yaping Li 《Advanced functional materials》2017,27(20)
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Cancer Therapy: Nucleus‐Targeting Gold Nanoclusters for Simultaneous In Vivo Fluorescence Imaging,Gene Delivery,and NIR‐Light Activated Photodynamic Therapy (Adv. Funct. Mater. 37/2015) 下载免费PDF全文
Raviraj Vankayala Chien‐Lin Kuo Karthik Nuthalapati Chi‐Shiun Chiang Kuo Chu Hwang 《Advanced functional materials》2015,25(37):5933-5933
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Cancer Therapy: A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy (Adv. Funct. Mater. 45/2017) 下载免费PDF全文
Wei Cheng Junpeng Nie Nansha Gao Gan Liu Wei Tao Xiaojun Xiao Lijuan Jiang Zhigang Liu Xiaowei Zeng Lin Mei 《Advanced functional materials》2017,27(45)