Cancer prevention--behavior changes: the short and the long of it

BACKGROUND: Behavioral factors play an important role in the adoption and maintenance of nutritional modifications, delivered either through chemopreventive regimens or through dietary adaptation. A body of research supports a protective role of fruits and vegetables, dietary fiber, and eating a low-fat diet in reducing cancer risk. There is only limited knowledge, however, about the cancer-preventing properties of specific micronutrients, apart from beta-carotene; about optimal levels of intake of differing micronutrients; and about patterns of food intake associated with reduced cancer risk. Thus, it would seem preferable, overall, to be able to recommend cancer prevention through dietary modification rather than through the administration of individual agents. METHODS: Studies of dietary adherence in cancer prevention have yielded varying success rates, but are generally quite promising. We have developed a model that encompasses the range of behavioral, psychological, social, and systemic variables thought to influence adherence to nutritional regimens. RESULTS: The model is being utilized to influence the form and content of nutritional regimens and to promote short-term change which can then be sustained as long-term lifestyle modification. The model can also be applied to evaluate adherence to nutritional or other behavioral modifications and to determine the factors predictive of success.     

The long and the short of it: developmental genetics of the skeletal dysplasias

The skeletal dysplasias are a large heterogeneous group of genetic conditions characterized by abnormal shape, growth, or integrity of bones. Often, there may be prominent features associated with other organ systems as part of a more encompassing skeletal malformation syndrome. Tremendous advances have been made in the clinical and molecular delineation of these conditions over the past 20-30 years. We have progressed from initial broad clinical classifications of these conditions in the first two-thirds of this century, to extensive delineation based on radiographic features in the 1970s and 1980s, to the present reconsideration and grouping of these conditions according to their molecular pathogenesis. This has in part been spurred on by advances in the understanding of the developmental pathways which govern skeletal development, as well as by the human genome sequencing effort, which has provided a plethora of positional candidate genes for many of these conditions. The pathogenetic correlations derived from such studies are often based on parallels between the human phenotype and mouse models of the human condition, and have sometimes revealed novel developmental functions.     

Aging and negative priming in a location suppression task: The long and the short of it.

The role of temporal parameters in aging and inhibitory function was examined using negative priming (NP) and repetition priming (RP) in a task involving a series of visually presented prime-probe sets; responses were made on the basis of the location of a target stimulus. Preparatory intervals (PI) preceding prime-probe sets were 3,000 ms or 1,500 ms. The longer PI resulted in less NP in older adults than did the shorter PI. Further analyses suggest that older adults may be less prepared to inhibit the distractor following the longer PI. The longer PI also produced more RP than did the shorter PI for both age groups, indicating a greater emphasis on facilitatory processes in this condition. In addition, evidence was obtained to suggest that an inverse relationship between NP and RP exists for both young and old adults. These data suggest that individuals or task conditions may emphasize either facilitation or inhibition in selection. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The long and the short of memory.

Reviews and evaluates evidence regarding the number of dynamically different memory traces mediating human retention. Persistence of sensation and adaptational (fatigue) "memories" are ignored. Most of the evidence supporting the distinction between short- and long-term memory traces (primary and secondary memory) is regarded as equally consistent with a single-trace hypothesis. However, 3 phenomena are considered to support the dual-trace theory over the single-trace theory. There appears to be no evidence to justify splitting long-term memory into components such as intermediate-term memory and long-term memory. Attention is directed particularly toward phenomena that are truly relevant for deciding such issues. (65 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The short of it: Abbreviating the temporal discounting procedure.

A typical temporal discounting procedure determines the present, subjective value (indifference point) of a delayed outcome at 5 to 8 different delays to that outcome. These indifference points are used to determine a single index of discounting called a discounting rate. One concern that remains in the collection of this data is the high number of trials or choices, resulting in participant fatigue or other factors that may affect the validity of the data. In this report, we propose an abbreviated alternative to the more comprehensive and time-consuming discounting procedure. Specifically, we propose that fewer indifference points can be used to determine statistically equivalent discount rates with no loss in data sensitivity. We reanalyzed temporal discounting data obtained with 7 indifference points, and estimated discount rates from all combinations of 2, 3, and 4 of the 7 indifference points. Results indicate that valid and sensitive discounting indices can be obtained with fewer indifference points, and the most appropriate sets of indifference points are highlighted. The proposed abbreviated procedure is likely to be particularly useful when time constraints or participant fatigue is a concern as well as in repeated-measures contexts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Transdermal nicotine on sleep and PGO spikes

There is conflicting evidence for the role of nicotine in sleep regulation. This study was undertaken to determine the effects of transdermal nicotine at doses of 17.5, 35 and 52.5 mg on sleep and PGO spike activity. Minor effects were observed on sleep with a general increase in waking. PGO spike activity was abolished by all patches. The results are discussed in terms of the mechanisms involved in the disappearance of PGO spikes as a result of nicotine.     

The long and short of semantic priming effects in lexical decision.

Unlike other forms of priming, semantic priming appears only to occur at short lags. In apparent contrast to this, S. Becker, M. Moscovitch, M. Behrmann, and S. Joordens (1997) described a theory of priming that predicts long-term effects for all forms of relatedness. This prediction is reconciled with previous failures to observe long-term semantic priming on the basis of 2 claims: (a) that previously used pairs share few semantic features and (b) that tasks typically used to study priming are not especially sensitive to semantic influences. The present experiments provide further support for these claims by demonstrating long-term semantic priming in the lexical-decision task when the stimuli and task are modified in a way that increases semantic involvement. However, the findings suggest that in addition to the mechanism advocated by Becker et al., a second mechanism is necessary to provide a complete account of semantic priming effects. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The sucking reflex: The effects of long feeding vs. short feeding on the behavior of a human infant.

"In order to investigate the effects of long feeding time and short feeding time on non-nutritive sucking and other behavioral variables in the newborn infant, a three-week-old child was given a series of long feedings and short feedings over a period of approximately 30 days… . It was found that more non-nutritive sucking occurred during the long feeding sessions. In addition, more crying, more general restlessness, and more difficulty in sleeping occurred during the long feeding periods… . The hypothesis that nonnutritive sucking results from inadequate use of the sucking response was not supported by the data in this study." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Retinal processing: amacrine cells keep it short and sweet

A recent study suggests a neuronal circuit in the retina by which amacrine cells contribute to the generation of transient responses in ganglion cells, thereby enabling the visual system to detect changes in light intensity.     

The factorial structure of the Dutch translation of the Inventory of Interpersonal Problems: A test of the long and short versions.

In this article, the authors study the factorial structure of 2 versions (64 items and 32 items) of the Dutch translation of the Inventory of Interpersonal Problems (IIP; L. M. Horowitz, L. E. Alden, J. S. Wiggins, & A. L. Pincus, 2000) in both a clinical sample (n = 382) and a student sample (n = 287). First, the authors test whether both inventories are constituted by correlated uni-dimensional subscales, and they conclude that this is true only for the short version. Second, the authors study whether the correlations between the subscales follow a circumplex pattern. This proves to be true for both versions. Coefficients alpha and correlations between the IIP-64 and IIP-32 subscales are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Crack deflection: Implications for the growth of long and short fatigue cracks

The influences of crack deflection on the growth rates ofnominally Mode I fatigue cracks are examined. Previous theoretical analyses of stress intensity solutions for kinked elastic cracks are reviewed. Simple elastic deflection models are developed to estimate the growth rates of nonlinear fatigue cracks subjected to various degrees of deflection, by incorporating changes in the effective driving force and in the apparent propagation rates. Experimental data are presented for intermediate-quenched and step-quenched conditions of Fe/2Si/0.1C ferrite-martensite dual phase steel, where variations in crack morphology alone influence considerably the fatigue crack propagation rates and threshold stress intensity range values. Such results are found to be in good quantitative agreement with the deflection model predictions of propagation rates for nonlinear cracks. Experimental information on crack deflection, induced by variable amplitude loading, is also provided for 2020-T651 aluminum alloy. It is demonstrated with the aid of elastic analyses and experiments that crack deflection models offer a physically-appealing rationale for the apparently slower growth rates of long fatigue cracks subjected to constant and variable amplitude loading and for the apparent deceleration and/or arrest of short cracks. The changes in the propagation rates of deflected fatigue cracks are discussed in terms of thelocal mode of crack advance, microstructure, effective driving force, growth mechanisms, mean stress, slip characteristics, and crack closure.     

The role of the cerebellar interpositus nucleus in short and long term memory for trace eyeblink conditioning.

In previous studies the cerebellar interpositus (IP) nucleus, but not the hippocampus, was shown to be necessary both for initial learning and retention and for long-term retention of the standard delay eyeblink conditioned response (CR). However, in the trace eyeblink CR procedure, the hippocampus is also necessary for initial learning and retention, but not for long-term retention. Here the authors evaluate the role of the IP nucleus in both initial learning and retention, and in long-term retention of the trace eyeblink CR, using muscimol infusion to reversibly inactivate the IP nucleus. For the short-term study, there were two subgroups, the first sequentially passed through acquisition, inactivation, and reacquisition phases, whereas the second subgroup went through inactivation, acquisition, and inactivation phases. For the long-term study, the rabbits acquired the CR and then rested for a month. Next, they were distributed into two subgroups: with or without retention training, and finally went through inactivation and reacquisition phases. The results showed that the prelearning IP nucleus inactivation prevented the acquisition of the trace CR, whereas the postlearning inactivation reversibly abolished the expression of both the short- and long-term CR. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of nicotine on the rate and strength of long bone fracture healing

Empirical clinical observation suggests that cigarette smoking had an inhibitory effect on long bone fracture healing, but this has not been proven scientifically. Forty female New Zealand White rabbits had midshaft tibial osteotomies performed and plated. These were divided randomly into two groups receiving either systemic nicotine or saline (placebo). Lateral radiographs were taken at 4, 6, and 8 weeks that showed a 17.2% average difference in callus formation between the two groups and a significant lag in formation of cortical continuity in the nicotine group. The rabbits were sacrificed 8 weeks after fracture, and healing was compared biomechanically. Three (13%) fractures showed no clinical evidence of union in the nicotine group, whereas all fractures in the control group healed. Biomechanical testing showed the nicotine exposed bones to be 26% weaker in three-point bending than were those exposed to placebo.     

Distributed memory for both short and long term

The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were systemically given and the elicited behaviors were quantitatively assessed. Systemic administration of haloperidol, but not SCH23390, dose-dependently induced contraversive dystonic posturing in unilateral GP-lesioned rats. On the other hand, systemic administration of quinpirole, but not SKF38393, induced ipsiversive circling. MK-801, only when given at a high dose, unilateral GP-lesioned rat, the D2 receptor agonist and antagonist caused ipsiversive and contraversive posturing or circling, respectively. Since the rotational behavior is induced on the basis of asymmetry of the basal ganglia output activity, there must be a marked difference between the GP ablation and the administration of D2 receptor blockade on the basal ganglia output activity, supporting a speculation that overactivity of the basal ganglia under dopamine depletion is not solely a result of the disinhibition from the inhibitory GP efferents. The present unilateral GP-lesion model appears to be a useful one for the pharmacobehavioral investigation of D2-mediated mechanisms.     

Detection of unexpected tones with short and long durations

The detectability of short and long unexpected tones masked by a continuous wideband noise was assessed using a probe-signal method. This method leads the listener to expect a target frequency by presenting the signal most often at that frequency, and only occasionally at other unexpected probe frequencies. The probe-signal contour (percent correct as a function of probe frequency) was considerably broader with 5-ms than with 295-ms signals. However, auditory filter shapes measured using the notched-noise technique were very similar for those two signal durations, indicating that the results obtained in the probe-signal conditions do not simply reflect peripheral frequency selectivity. Further supporting this interpretation, probe tones having the same frequency but a different duration from the target were poorly detected. It is proposed that the subject listens through a time-frequency window whose location and shape in the time-frequency plane is determined by the duration and frequency of the target.