共查询到18条相似文献,搜索用时 156 毫秒
1.
2.
生物医用纳米羟基磷灰石的研究进展 总被引:2,自引:0,他引:2
纳米羟基磷灰石既具有纳米材料的特性,又具有羟基磷灰石本身的特性,在生物医学领域具有非常广阔的应用前景.本文详细介绍了纳米羟基磷灰石的历史发展、制备方法、表面改性及其在生物医用材料领域的应用. 相似文献
3.
4.
纳米掺锶羟基磷灰石及其在牙膏中的应用研究 总被引:2,自引:0,他引:2
采用化学沉淀法以金属锶元素取代纳米羟基磷灰石中的部分钙元素。可制得纳米掺锶羟基磷灰石;通过XRD、FTIR、TEM等手段,对纳米掺锶羟基磷灰石进行了结构分析;掺锶后提高了纳米掺锶羟基磷灰石的生物性能和使用性能,将其应用于牙膏,可以提高牙膏的使用功效作用,具有广阔的应用前景。 相似文献
5.
介绍了纳米羟基磷灰石的制备方法,纳米羟基磷灰石在牙齿再矿化、牙齿脱敏和牙齿美白方面的性能及纳米羟基磷灰石在牙膏中的应用。 相似文献
7.
主要研究纳米级羟基磷灰石(Nano-HAP)在牙膏中的应用。通过抑菌试验与再矿化试验,分别研究其抗菌效果和对人工龋的再矿化效果。结果表明,纳米级羟基磷灰石(Nano-HAP)质量分数为5%时具有非常显著的抑制变形链球菌生长作用(P<0.01),含纳米级羟基磷灰石(Nano-HAP)质量分数为5%的牙膏对人工龋进行再矿化10 d后,牙釉质的显微硬度值得到非常显著的提高(P<0.01),对牙齿脱矿区有较好的再矿化作用。含纳米级羟基磷灰石(Nano-HAP)质量分数为5%的牙膏具有防龋效果。 相似文献
8.
9.
殷宪国 《硫磷设计与粉体工程》2012,(2):36-40,52
介绍了纳米羟基磷灰石制备和掺杂技术,以及纳米羟基磷灰石复合材料,包括它们在组织工程支架材料、缓控释药物载体、靶向药物传递及环境功能材料等方面的制备技术和应用,显示纳米羟基磷灰石及其复合材料在生物医学领域将会有良好发展前景。 相似文献
10.
羟基磷灰石生物医用陶瓷材料的研究与发展 总被引:8,自引:0,他引:8
自然骨的主要无机矿物成分为纳米羟基磷灰石[Ca10(PO4)6(OH)2,HAP]针状晶体。人工合成的羟基磷灰石材料具有与自然矿物相似的结构,形态,成分,表现出良好的生物相容性和生物活性,广泛应用于医药和牙科领域。对近年来羟基磷灰石生物材料的制备和应用进行了综述。 相似文献
11.
12.
13.
In this study, vascular stents were fabricated from poly (lactide-ɛ-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-by-layer self-assembly technique. In addition, nano-composite scaffolds of poly (lactic-co-glycolic acid)/polycaprolactone/nano-hydroxyapatite (PLGA/PCL/nHA) loaded with the vascular stents were prepared by thermoforming-particle leaching and their basic performance and osteogenesis were tested in vitro and in vivo. The results show that the PLCL/Col/nHA stents and PLGA/PCL/nHA nano-composite scaffolds had good surface structures, mechanical properties, biocompatibility and could guide bone regeneration. These may provide a new way to build vascularized-tissue engineered bone to repair large bone defects in bone tissue engineering. 相似文献
14.
简要介绍了羟基磷灰石的结晶结构和其理化性质,综合论述了纳米羟基磷灰石的制备工艺及其原理。同时,对常用制备方法进行了比较,指出了目前纳米羟基磷灰石粉体制备存在的问题及今后的发展方向。 相似文献
15.
Zhang D Tian A Xue X Wang M Qiu B Wu A 《International journal of molecular sciences》2012,13(1):1109-1125
In this study, we investigated the effects of temozolomide (TMZ)/Poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite microspheres on the behavior of U87 glioma cells. The microspheres were fabricated by the "Solid/Water/Oil" method, and they were characterized by using X-Ray diffraction, scanning electron microscopy and differential scanning calorimetry. The proliferation, apoptosis and invasion of glioma cells were evaluated by MTT, flow cytometry assay and Transwell assay. The presence of the key invasive gene, α(V)β3 integrin, was detected by the RT-PCR and Western blot method. It was found that the temozolomide/PLGA/nano-hydroxyapatite microspheres have a significantly diminished initial burst of drug release, compared to the TMZ laden PLGA microspheres. Our results suggest they can significantly inhibit the proliferation and invasion of glioma cells, and induce their apoptosis. Additionally, α(V)β3 integrin was also reduced by the microspheres. These data suggest that by inhibiting the biological behavior of glioma cells in vitro, the newly designed temozolomide/PLGA/nano-hydroxyapatite microspheres, as controlled drug release carriers, have promising potential in treating glioma. 相似文献
16.
17.
《Ceramics International》2016,42(14):15559-15567
The objective of this study was to combine titanium doped nano-hydroxyapatite with chitosan and calcium sulfate to obtain cement-type materials with improved cohesion and handling properties. It was proven that the presence of nano-TiHA influenced setting, hardening, microstructure and bioactivity of the cement samples. In the developed composites chitosan played a role of the cohesion promotor and created homogenous organic layers on the materials surfaces. Application of chitosan in acetic acid solution favorably delayed setting process of calcium sulfate dihydrate. The polymer combined with nano-TiHA and calcium sulfate improved handling and workability of the cements without diminishing their mechanical properties. It was suggested that the resorption rate of materials based on calcium sulfate can be optimized by addition of both titanium doped nano-hydroxyapatite and chitosan. 相似文献