Functional radiology of the liver: magnetic resonance imaging

Magnetic Resonance (MR) images sensitive to the flowing blood are defined as images of MR angiography. Proton movement within a magnetic field modifies both the intensity and the phase of Nuclear Magnetic Resonance (NMR) signal; two techniques of MR angiography are thus distinguished: (TOF) the "time of flight" (intensity) and the "phase-contrast" (phase) technique. In the time of flight MR angiography the blood may appear as hypointense or hyperintense compared to stationary tissues. Blood hypointensity in vessels is due to the flow void phenomenon while hyperintensity is due to the phenomenon of flow-related enhancement. In phase contrast MR angiography, protons moving within a magnetic field modify their phase directly proportional to the displacement velocity and gradient intensity. Moreover, MRI allows noninvasive measurement of blood flow. Flow velocity is measured with TOF sequences or phase-contrast sequences. In TOF sequences quantitative measurement is performed with the bolus tracking procedure. In contrast-phase sequences the velocity is measured based on the extent of signal phase modification induced by the proton displacement velocity. The recent use of liver-specific contrast media supplies information on parenchymal liver function.     

Combined MRI and CFD analysis of fully developed steady and pulsatile laminar flow through a bend

A combined MR and computational fluid dynamics (CFD) study is made of flow in a simple phantom laboratory flow rig consisting of a 180 degree bend with straight entry and exit sections. The aim was to investigate the potential of the use of MRI-linked CFD simulations for in vivo use. To this end, the experiment was set up for both steady and pulsatile laminar flow conditions, with Reynolds and Dean numbers and Womersley pulsatility parameter representative of resting flow in the human aorta. The geometrical images of the pipe and the velocity images at entry to the bend were used as boundary conditions for CFD simulations of the flow. The CFD results for both steady and pulsatile cases compared favorably with velocity images obtained at exit from the bend. Additional information such as pressure and wall shear stress, which either could not be measured adequately via MRI, or could not be measured at all, was also extracted from the simulation. Overall, the results were sufficiently promising to justify pursuing subsequent in vivo studies.     

Psychoeducational family treatment in schizophrenia--a popular concept? A critical evaluation of different treatment models

Magnetic resonance angiography (MRA) refers to a collection of imaging techniques which accentuate the signal intensity of flowing blood and suppress the signal intensity of stationary tissues. The resulting images are processed to resemble conventional catheter angiograms but carry fundamentally different information which is derived from flow rather than anatomy. All MRA techniques are subject to a variety of artifacts can stimulate pathology. A knowledge of the techniques used to produce and display MR angiographic images is essential for their accurate interpretation.     

Use of three-dimensional segmented FLASH sequence with magnetization transfer contrast to improve Gd-DTPA-enhanced intrahepatic MR portography

Twenty healthy volunteers underwent gadopentetate dimeglumine (gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA))-enhanced MR angiography (MRA) using three-dimensional-segmented fast low angle shot images (FLASH) with magnetization transfer contrast (MTC) pulses. MRA was obtained at 75 seconds (early phase) and 135 seconds (late phase) after bolus injection of Gd-DTPA (MTC+ group) during one period of breath-holding. Within 1 week. MRA without MTC was performed under the same scanning conditions. Visualization of intrahepatic portal branches with these methods was compared in both phases. Portal vein-liver contrast-to-noise ratios were significantly higher in the MTC+ group in both phases. For third- and fourth-order portal branches, visualization was significantly better in the MTC+ group in both phases. Use of three-dimensional-segmented FLASH shortened acquisition time and facilitated imaging during breath-holding and also reduced whole-body average specific absorption rate values. Visualization of intrahepatic portal vein branches was improved by MTC pulses, and effective imaging time was prolonged.     

移动床固体颗粒绕流顺排圆管的过程

工业中常用带埋管的移动床来加热或冷却固体颗粒物料,其过程涉及颗粒流与管壁间的复杂传热,而颗粒绕流圆管的流动过程对其传热效果起着决定性作用.为简化描述颗粒的流动过程,通过分析颗粒绕流圆管的特性,建立了拟漏斗流模型,并给出了模型所需颗粒绕流圆管描述参数的取值范围,模型可用以求取颗粒绕流圆管的速度场和时长等参数.建立了埋管移动床实验系统,考察了颗粒绕流顺排管束的过程;同时利用离散单元法(DEM)对该过程进行数值模拟,获得了颗粒绕流圆管的流动过程,并利用移动床实验结果对比验证了离散单元法数值模拟结果;最后,对比了基于拟漏斗流模型的计算结果和离散单元法数值模拟结果,并根据此结果对拟漏斗流模型的描述参数进行了确定.     

Vortex Plate for Enhancing Particle Settling

The feasibility of enhancing suspended solids settling by using the newly proposed vortex plates in clarifiers, instead of conventional smooth lamellae, was studied using computational fluid dynamics (CFD) modeling and laboratory experiments in which suspended particles were mimicked by crushed walnut shells and glass beads. The vortex plate was formed by attaching perpendicular ribs to the plate, forming slots of 25×25?mm (depth×width) and placing the plate parallel to the longitudinal clarifier axis at an angle of 60° from the horizontal. Rib walls were placed either in vertical planes, perpendicular to the clarifier longitudinal axis, or were slightly sloping in the main flow direction (20° about the vertical). Three hydraulic concepts were explored with respect to enhancing suspended particle settling: (1) the use of flow energy to generate steady vortices inside the slots and thereby entrain particles into the slots, where they would be sheltered from the fast horizontal flow and could settle without much hindrance; (2) enhancing the particle settling by increasing the contact surface area and thereby reducing the length of travel of settling particles; the same principle is used in conventional lamellar settlers but the surface area of a vortex plate is three times that of a smooth lamella; and (3) increasing the particle collision frequency within the swirling flow inside slots to prompt particle flocculation. The CFD modeling and experimental observations confirmed the formation of strong vortices in the parallel slots of the vortex plate. Such vortices entrained the passing by particles and retained some of them in slots, which provided a quiescent settling zone. Both the simulation and measured results indicated that the vortex plate contributed to a slightly improved removal of suspended particles. A CFD particle tracking model was applied to clarifiers with two vortex plates or two smooth plates and indicated that the vortex plate removed about 8% more particles than the smooth plate. In laboratory tests with plate arrays, the vortex plate array also contributed to better particle removals, especially for slower settling particles and larger inflow rates (by up to 26%).     

Comparison of Computation Fluid Dynamics Simulation against Tracer Data from a Scale Model and Full-Sized Waste Stabilization Pond

The use of computation fluid dynamics (CFD) for waste stabilization pond design is becoming increasingly common but there is a large gap in the literature with regard to validating CFD pond models against experimental flow data. This paper assesses a CFD model against tracer studies undertaken on a full-sized field pond and then on a 1:5 scale model of the same pond operated under controlled conditions in the laboratory. While the CFD tracer simulation had some discrepancies with the field data, comparison to the laboratory model data was excellent. The issue is, therefore, not in the way the model solves the problem, for example, the choice of turbulence model or differencing scheme, but rather with how accurately the physical conditions in the field are defined. Extensive survey of the sludge layer and transient input of changing flow rates, wind velocities, and temperature could allow closer alignment of CFD simulations to field data. However, in the practical application of CFD where a modification such as baffle installation results in a large change, then a simple pragmatic model, while not exact, can still provide valuable design insight.     

Magnetic resonance angiography and magnetic resonance tomography in dissection of the vertebral artery

Vertebral artery dissection (VAD) is an important cause of posterior circulation stroke in young adults. Initial symptoms are often non-specific and diagnostic arteriography is not performed until neurological deficits are obvious. Since magnetic resonance tomography (MRT) is superior in the diagnosis of vertebrobasilar ischemia, we retrospectively analyzed the role of MRT and MR angiography (MRA) in the detection of dissections of the vertebral artery. Between 1989 and 1995 we identified 24 patients with a vertebral artery dissection and 1 patient with a basilar artery dissection (8 females and 17 males, 23-60 years of age, mean 41.2 years). The diagnosis of VAD (14 left VAD, 9 right VAD, 1 bilateral VAD, 1 basilar artery dissection) was established by specific arteriographical findings (DSA) or clinical and neuroradiological course. All patients underwent a combined MRT/MRA examination protocol at 1.5T that consisted of spin-echo imaging and time of flight MRA of the intra- and extracranial arteries using 2D Flash and 3D Fisp sequences. The MRT/MRA findings were correlated to DSA and ultrasound results. During the acute and subacute stage, MRT/MRA revealed abnormal findings in 21 of 22 dissected vessels (95.5%). There was one false-negative MRT/MRA in a patient with a V1 dissection (intimal flap without peripheral flow disturbances). In 7/22 VAD the MRT/MRA findings were rated specific (double lumen n = 1, mural hematoma n = 4, pseudoaneurysm n = 2). DAS was sensitive in 100% and ultrasound in 77.3%. Specific results were obtained by DSA in 8/ 22 VAD (36.4%) and in 7/22 VAD (30.4%) by MRT/MRA. When MRT/MRA and DSA results were combined, the specific findings increased to 43.5%. Follow-up examinations revealed recanalization in 52% of initially stenosed or occluded vertebral arteries; four patients developed a pseudoaneurysm, and two of them underwent ligation of the VAD. With this retrospective approach, we were able to show a high sensitivity of MRT/ MRA for the presence of disturbed flow in the dissected vertebral artery. The MRA projections tended to overestimate stenosis and were inferior to DSA in the appreciation of irregularities of the vessel wall. Identification of high-grade stenosis, especially in the presence of distal occlusion, was improved on the MRA source images. During the acute and subacute stage, the diagnosis of luminal thrombus can be difficult, because signal ambiguities exist between hemoglobin breakdown products and flow effects and adjacent fat tissues. The differentiation between luminal thrombus and mural hematoma requires interpretation of MRA source images, together with flow compensated spin-echo images. Additional fat suppressed images and flow presaturation may be required at the appropriate levels. The identification of mural hematoma is important, because this finding is considered specific and cannot be obtained with DSA. There is a complementary role of MRT/MRA and DSA for an improved overall specificity for vertebral artery dissection. A negative MRT/MRA result in a patient with appropriate symptoms, however, cannot exclude a dissection and should prompt DSA. On the other hand, a suggestive MRT/MRA result in the appropriate clinical context can replace DSA. The advantage of MRT/MRA is that the method offers a simultaneous diagnosis of posterior fossa ischemia and vertebral artery abnormalities. Therefore, MRT/MRA should be recommended in patients with suspected VAD and especially in those who have no definite neurological deficit. These patients will benefit greatly from early diagnosis and therapy. The fact that all our patients were diagnosed after neurological symptoms and that 64% of them have residual deficits gives an ethical and economical rationale for advocating early MRT/MRA in these patients.     

Use of Stereoscopy for Dam Break Flow Measurement

This investigation explored the applicability of video stereoscopy for the measurement of unsteady open channel flows. Specifically, the three-dimensional water surface profile and flow velocities associated with scale model dam break events were considered. Stereo images of the unsteady flow event were obtained using three, time-synchronized, video cameras situated above the tank such that, at all times, the area of interest was captured by at least two of the three cameras. To establish a point of reference from image to image, floating plastic tracking particles were placed on the water surface. The three-dimensional coordinates of the particles were then calculated using the camera positions and the locations of the individual plastic particles in the stereo images. Particle velocities were also deduced from the analysis of consecutive images. Based on this preliminary investigation we conclude that video stereoscopy is a promising method for measuring highly dynamic flows.     

Intracranial black-blood MR angiography with high-resolution 3D fast spin echo

Three-dimensional fast spin-echo (3DFSE) techniques are promising for black-blood imaging of cerebral vessels. In this study, flow-related signal dephasing was demonstrated as the primary mechanism for blood signal attenuation. Parameter optimization of TR (1500 to 3000 ms), receiver bandwidth (25 to 31.25 kHz), effective TE (25.7 to 30.1 ms), and ETL (7 to 8) was accomplished by making measurements of vessel-to-tissue contrast-to-noise ratios on vessels. A comparison of high-resolution 3DFSE and 3DTOF magnetic resonance angiography demonstrated that 3DFSE can generate images with equivalent or better small vessel detail than conventional techniques. 3DFSE black-blood techniques may provide improved sensitivity of small arteries and veins with slow or in-plane flow and immunity to flow-related distortions. Future studies with optimized parameters will determine the clinical efficacy of this technique.     

Contrast-enhanced 3D-TOF MRA of peripheral vessels: intravascular versus extracellular MR contrast media

MR contrast media have been used to improve MR angiography (MRA). Their effect has been particularly beneficial for extracranial MRA. This study evaluated the efficacy of a new formulation of ultrasmall superparamagnetic iron oxide particles (USPIO) on three-dimensional (3D) time of flight (TOF) MRA in the pelvis and lower limb circulation. Each of six dogs received 3 mg/kg of USPIO and .2 mmol/kg of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) bis-methylamide (BMA) by intravenous infusion on separate examinations. Precontrast and postcontrast 3D-TOF MRA images of the lower extremities were acquired over the course of 45 minutes postinjection. Signal intensity (SI) was measured on axial views along the external iliac, femoral, and popliteal arteries. USPIO provided clear demarcation of the major primary, secondary, and tertiary vessels and the improved contrast-to-noise ratio (CNR) was maintained for 45 minutes. Gd-DTPA-BMA provided less signal enhancement than USPIO. The increase in CNR with this agent had significantly declined by 15 minutes after injection. The major vessels could no longer be visualized at 30 and 45 minutes after injection of Gd-DTPA-BMA This study demonstrates the efficacy of USPIO as a contrast medium for 3D-TOF MRA. It was concluded that USPIO provided effective and persistent enhancement of the peripheral vessels.     

Three-dimensional numerical prediction of stress loading of blood particles in a centrifugal pump

The successful use of centrifugal pumps as temporary cardiac assist devices strongly depends on their degree of blood trauma. The mechanical stress loading experienced by cellular components on their passage through the pump is a major cause of blood trauma. Prediction of the mechanical stresses will assist optimization of pump design to minimize hemolysis and platelet activation. As a theoretical approach to this task., the determination of the complete three-dimensional (3D) flow field including all regions of high shear stress is therefore required. A computational fluid dynamics (CFD) software package, TASCflow, was used to model flow within a commercially available pump, the Aries Medical Isoflow Pump. This pump was selected in order to demonstrate the ability of the CFD software to handle complex impeller geometries. A turbulence model was included, and the Newtonian as well as the Reynolds stress tensor calculated for each nodal point. A novel aspect was the assignment of scalar stress values to streaklines representing particle paths through the pump. Scalar stress values were obtained by formulating a theory that enables the comparison of a three-dimensional state of stress with a uniaxial stress as applied in all mechanical blood damage tests. Stress loading-time functions for fluid particles passing inlet, impeller, and outlet domains of the pump were obtained. These showed that particles undergo a complex, irregularly fluctuating stress loading. Future blood damage theories would have to consider an unsteady stress loading regime that realistically reflects the flow conditions occurring within the pump.(ABSTRACT TRUNCATED AT 250 WORDS)     

Solute Transport Modeling for Urban Drainage Structures

Solute transport and dispersion processes affect the performance of a wide range of water engineering structures. Some urban drainage network models transport the pollutants by advection only, whereas others also account for the effects of dispersion, although there is only limited knowledge regarding appropriate values for dispersion parameters. Computational fluid dynamics (CFD)-based software tools enable engineers to simulate flow patterns and associated pollutant transport mechanisms within both natural and engineered hydraulic structures. It is feasible to use CFD to represent solute transport using two contrasting approaches, an unsteady species (scalar) transport model or a discrete phase (Lagrangian particle tracking) model. This paper outlines these two approaches, using the example of a storage tank to demonstrate, compare, and validate the two approaches, and to explore a number of issues associated with interpretation of the simulation outputs. It is concluded that both CFD-based approaches may be usefully utilized for the design and modeling of urban drainage systems.     

Physical and Numerical Simulation of Fluid Flow and Solidification at the Twin‐Roll Strip Casting Process

The fluid flow in a twin‐roll strip caster is investigated by physical and numerical simulation on a 1:1‐scale water model. A laser‐optical measurement technique (Laser Doppler Anemometry ‐ LDA) is used to validate the numerical results for the water flow. The numerical simulations are then transferred to the melt flow in the strip caster. The investigations are focused on different SEN concepts (submerged entry nozzle), a single‐nozzle system with two outlet ports and a double‐nozzle system with one outlet port each. The Influence of these concepts on the velocity, turbulence, and temperature distribution inside the liquid pool between the casting rolls and on the solidification and growth of the strip shells are investigated by numerical simulations (Computational Fluid Dynamics ‐ CFD). The non‐isothermal melt flow is calculated considering the solidification enthalpy as well as the behaviour of the solidifying melt. In addition to the numerical simulations of the melt flow inside the pool the temperature distribution in the cast strip is simulated. The SEN concept directly correlates with the temperature distribution Inside the strip. Furthermore, the surface temperature of the strip below the outlet of the roll gap is measured using a line‐scanner and is compared with the CFD simulation. In order to simulate the shape of the free surface in the liquid pool, CFD simulations of the water flow in the physical model are carried out using a Volume of Fluid model (VoF). This two‐phase model is able to reproduce free surface waves.     

Priming and induction of eosinophil trafficking in guinea-pig cutaneous inflammation by tumour necrosis factor alpha

This work addresses the fundamental limits imposed by the MRI process on the accuracy with which vessel diameters and cross-sectional areas can be derived from time-of-flight (TOF) and phase-contrast (PC) MR source images. By means of simulations and in vitro experiments, it is demonstrated that, even in the absence of flow-related artifacts, severe inaccuracies in the determination of diameters or cross-sectional areas may occur solely because of the physical process of the MR image acquisition. Resolution and intraluminal saturation have strong effects on the vessel appearance and thus on the diameter estimation error. It is shown that low resolution leads to diameter overestimation or even underestimation and that intraluminal saturation causes severe underestimation, even for relatively low flip angles. Velocity and velocity encoding do not have a major influence on lumen appearance in PC images. Accurate diameter estimations can be attained only if lumen diameters constitute at least three pixels for both TOF and PC acquisitions, provided that intraluminal saturation is suppressed or avoided. Additionally, since the constitution of TOF and PC images is dissimilar, lumina should be analyzed differently to obtain accurate diameters and cross-sectional areas.     

Numerical simulation of froth formation in aerated slurry coupled with population balance modelling

A computational fluid dynamic (CFD) model has been developed to incorporate pulp and froth zones into one model. In the present research, froth was considered as a separate phase comprised of a mixture of gas, liquid and solids. Considering the froth phase as a separate phase, allowed the incorporation of pulp and froth zones into one model by tracking the formation and destruction of the froth phase due to mass exchange between the pulp and froth. Bubble break-up and coalescence were taken into account in the pulp zone, by employing user functions, written using FORTRAN. The effect of bubble coalescence process due to ?lm rupture was considered in the froth phase. The variation in the concentration of attached particles due to attachment and detachment processes were also taken into account. The CFD model predicted the height of froth layer, the concentration of different bubble sizes in both pulp and froth zones, and finally the multiphase ?ow phenomena in the slurry column. Froth height was found to increase with the increase of gas flow rate while increasing solid concentration decreased froth height.     

Bed Shear Stress Boundary Condition for Storage Tank Sedimentation

Computational fluid dynamics-based (CFD) software tools enable engineers to simulate flow patterns and sediment transport in ancillary structures of sewer systems. Lagrangian particle tracking represents a computationally efficient technique for modeling sediment transport. In order to represent the process of sedimentation in storage tanks, careful consideration must be given to the boundary condition at the bottom of the tanks. None of the boundary conditions currently available in the FLUENT CFD software appears to represent the observed behavior of sediment particles, which may become resuspended after first contact with the bed if the local flow velocity is sufficiently high. In this study, a boundary condition based on bed shear stress has been implemented in FLUENT and evaluated against laboratory data. A particle is trapped if the local bed shear stress is below the critical bed shear stress; otherwise, the particle is resuspended. The approach gives satisfactory agreement with measured sedimentation efficiency data, and the simulated spatial distribution is very similar to the sediment distribution observed in a laboratory tank.     

The Effects of Sample Position and Gas Flow Pattern on the Sintering of a 7xxx Aluminum Alloy

The effects of sample position and gas flow pattern on the sintering of a 7xxx aluminum alloy Al-7Zn-2.5Mg-1Cu in flowing nitrogen have been investigated both experimentally and numerically. The near-surface pore distribution and sintered density of the samples show a strong dependency on the sample separation distance over the range from 2?mm to 40?mm. The open porosity in each sample increases with increasing separation distance while the closed porosity remains essentially unchanged. A two-dimensional computational fluid dynamics (CFD) model has been developed to analyze the gas flow behavior near the sample surfaces during isothermal sintering. The streamlines, velocity profile, and volume flow rate in the cavity between each two samples are presented as a function of the sample separation distance at a fixed nitrogen flow rate of 6?L/min. The CFD modeling results provide essential details for understanding the near-surface pore distribution and density of the sintered samples. It is proposed that the different gas flow patterns near the sample surfaces result in variations of the oxygen content from the incoming nitrogen flow in the local sintering atmosphere, which affects the self-gettering process of the aluminum compacts during sintering. This leads to the development of different near-surface pore distributions and sintered densities.     

Particle Image Velocimetry System with Self-Organized Feature Map Algorithm

Self-organized feature map algorithm and the classical particle tracking technique have been adopted together to analyze the single-exposure double-frame particle images for flow measurement. Similar to the normal correlation technique in particle image velocimetry, the whole region is divided into many small interrogation spots. Instead of applying the correlation algorithm to each of these spots to obtain their rigid translation, the self-organized feature map algorithm is used to compress the information such that every spot is represented by three coded equivalent particles. After tracking these three particles, a linear distributed velocity function can be obtained at every spot. The spot can contain not only translation, but also rotation, shear, and expansion while there is only rigid translation in the spot assumed in the commonly used correlation method. In addition to the theoretical explanation, the suggested method has been verified by a number of digital flow fields which have randomly distributed synthetic particles.     

Cardiac-gated MR angiography of pulsatile flow: k-space strategies

Signal strength in time-of-flight magnetic resonance (MR) angiography of pulsatile flow is modulated by the time-varying intraluminal magnetization strength. The specific appearance of MR angiographic images therefore depends on the relationship of different phase-encoding steps to the pulsatile flow waveform. Cardiac-phase gating can be applied with phase-encoding reordering to acquire different regions of k-space during the desired phases of the cardiac cycle. The authors have developed a simulation program for evaluating the merits of different encoding strategies for pulsatile flow. The model was validated with phantom studies. High signal intensity relative to that in conventional MR angiographic studies can be attained with strategies that impose relatively small penalties in total acquisition time.