类氨基酸基载药水凝胶敷料的制备与性能

为制备一种具有良好生物相容性、可控缓释的物理交联的水凝胶敷料,选用类氨基酸单体N-丙烯酰基甘氨酰胺(NAGA)与生物发酵产物衣康酸(IA)为单体,在紫外光(254 nm)下,通过自由基聚合,在不需要外加任何交联剂条件下即可形成水凝胶聚(N-丙烯酰基甘氨酰胺-衣康酸)〔P(NAGA-IA)〕.其中,由NAGA与IA物质的...     

医用水胶体敷料的制备、性能及伤口应用效果

针对传统敷料易粘附伤口,无法为创伤部位提供保护,无法抵抗外部细菌感染,进而导致组织再次损伤的问题,提出一种生物降解的抗菌医用水凝胶敷料,用于伤口愈合.首先通过化学改性法制备海藻酸钠(OAlg),利用席夫碱交联反应制备水凝胶OAlg/CMCS;再利用乳化交联法制备载盐酸四环素明胶微球(TH/GMs).在水凝胶中加入不同浓...     

聚N-丙烯酰基甘氨酸水凝胶的合成及溶胀性能

以N-丙烯酰基甘氨酸（Acgly）为单体、过硫酸铵（APS）为引发剂、亚甲基双丙烯酰胺（MBA）为交联剂,通过溶液自由基聚合得到含有不同交联剂用量的水凝胶,并进行红外光谱表征．实验中对合成的水凝胶在不同pH条件下的平衡溶胀比和溶胀收缩可逆性进行测试．结果表明：随着交联剂质量分数从0.5％增大至7％,水凝胶外观由无色透明变为白色不透明,同时水凝胶由软变硬,弹性变小,硬度增加;在2．8〈pH〈3．8范围内水凝胶的平衡溶胀比随溶液的pH增大迅速增大,水凝胶表现出较好的pH敏感性;在pH=1．0和pH=6．8条件下的水凝胶具有很好的收缩溶胀可逆性．     

医用银离子抗菌水凝胶敷料的制备及性能研究

将纳米银与水凝胶两者性能结合,制备医用银离子抗菌水凝胶敷料,并对其性能进行研究。不使用分散剂,采用水凝胶的纳米孔吸附银离子的方式制备纳米银,使用壳聚糖、冰醋酸、纳米银、泊洛沙姆、碳酸氨、甘油六种试剂制备纳米银抗菌凝胶,并采用类似的方式制备纳米银抗菌凝胶敷料。分别对制备得到的水凝胶敷料进行UV-vis分析,并测试其抗菌性、溶胀性和生物相容性。实验结果表明,在不添加分散剂和还原剂的条件下,硝酸银可以被还原成纳米银,表明纳米银制备方法可行;水凝胶对大肠杆菌的最大抑菌圈为4.20mm左右,对葡萄球杆菌的最大抑菌圈为3.52 mm左右,均具有良好的抗菌效果,且纳米银的添加,更加增强了水凝胶的抗菌性;相较于其他甘油含量的水凝胶敷料,添加2%甘油的敷料具有更好的溶胀性;银离子抗菌水凝胶敷料具有较好的生物相容性,在促进细胞增殖分化方面具有无可比拟的优势。     

新型水凝胶基伤口敷料的研究进展

从结构特点、制备方法和性能效果等方面,综述了具有应用潜力的水凝胶基伤口敷料在近年来的国内外研究进展,包括海藻酸盐、壳聚糖、明胶、纤维素、羧甲基纤维素、聚乙烯醇和聚乙二醇,并对水凝胶基敷料的未来发展进行了展望。     

活性氧响应海藻酸钠/聚乙烯醇水凝胶敷料的制备及性能

负载活性药物的水凝胶敷料能够通过药物的控制释放,防止细菌感染、消除炎症,从而有效促进伤口愈合,其性能与水凝胶的组成、制备方法以及药物负载过程有关。将3-氨基苯硼酸接枝的海藻酸钠（Alg-PBA）与聚乙烯醇（PVA）交联制备了水凝胶,研究了水凝胶的形成机理,考察了各组分质量比及PVA分子量对水凝胶形貌结构和流变行为的影响,并通过超临界溶液浸渍法将盐酸多西环素负载到水凝胶中。结果表明：Alg-PBA与PVA质量比为2:1、PVA分子量为77kDa时,可制备机械性能良好的水凝胶,载药水凝胶在体外药物释放中表现出了明显的活性氧（ROS）响应性,为新型水凝胶伤口敷料的制备提供了参考。     

水胶体医用敷料的制备与性能研究

以SIS热熔压敏胶为橡胶基材,羧甲基纤维素钠(CMC)、交联羧甲基纤维素钠(X-CMC)为水胶体制备水胶体医用敷料。利用正交试验确定SIS热熔压敏胶各成分含量,讨论CMC和X-CMC用量对水胶体敷料吸水性、完整性的影响。通过实验,确定最佳配方:橡胶相质量分数为60%,各组分的份数为SIS:100;S-100:wingtack98=1:1;树脂总用量:160;环烷油:80;亲水胶体质量分数为40%,其中CMC含量为30-15%,X-CMC含量为10-25%。用以上配方做的水胶体敷料,有较好的粘性、吸水性和柔软性,吸水后有较好的完整性。     

水凝胶的制备研究进展

简要介绍了水凝胶的结构、性质及应用情况,从化学交联、物理交联两个方面阐述了水凝胶的制备方法。详细介绍了由自由基聚合、辐射聚合、水溶性高分子的交联和互穿聚合物网络4种化学交联方法,以及通过离子间相互作用、结晶交联作用、氢键作用、疏水缔合作用4种相互作用力来实现物理交联的方法。并对水凝胶未来的研究方向及应用前景进行了展望。     

魔芋葡甘聚糖基敷料的研究及其应用进展

魔芋葡甘聚糖因具有良好的生物相容性、吸水性及凝胶性而被广泛应用于医用敷料领域,且魔芋葡甘聚糖含量丰富,又可生物降解,以魔芋葡甘聚糖为基底的医用敷料的部分性能较传统类型敷料有其独特优势,同时通过物理和化学等改性,可以研究出各种性能不同的新型敷料。本文总结了魔芋葡甘聚糖的近年来的研究,和其在敷料领域的应用。最后对魔芋葡甘聚糖敷料的发展做出展望。     

Degradation behavior of hydrogel based on crosslinked poly(aspartic acid)

The degradation behavior of hydrogel based on poly(aspartic acid) (PASP) which crosslinked by 1, 6‐hexamethylene diamine (HD) was studied in α‐chymotrypsin solution. The degradation behaviors of PASP under different crosslinking levels were evaluated as a function of biodegradation time by monitoring the changes of crosslinking density, molecular weight, rheological behavior, interior morphology, mass loss, and swelling ratio. It was found that the degradation behaviors relied heavily on the crosslinking density which calculated from the Flory‐Rehner equation. A pseudo first‐kinetic equation was proposed to model the mass loss behavior and the degradation rate constant was calculated under different crosslinking levels. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010     

聚丙烯酸水凝胶的制备研究

以丙烯酸为单体,N,N＇-亚甲基双丙烯酰胺为交联剂,过硫酸铵为引发剂,通过自由基聚合制备了聚丙烯酸水凝胶.考察了交联剂、引发剂、单体中和度、聚合温度以及盐溶液对水凝胶溶胀性能的影响.结果表明,引发剂为单体质量的0.6％,交联剂为0.8％,单体的中和度为70％时,凝胶的溶胀性能最佳,吸水率达到了3 000％以上,聚丙烯酸水凝胶的溶胀性能随着盐溶液浓度的增大而降低.     

改性聚乳酸载药微球的制备及性能

以尼莫地平为模型药物,聚乳酸(PLA)为载体材料,采用溶剂蒸发萃取法制备了N-乙烯基吡咯烷酮(NVP)接枝聚乳酸共聚物(PLA-g-PVP)微球,考察了聚乳酸质量分数、乳化剂质量分数、转速和投药质量比对微球的影响。采用红外光谱、差式扫描量热分析表征药物与载体的相互作用,扫描电镜观察微球表面形态,对不同接枝率共聚物微球的粒径、载药量、包封率及体外释放性能进行研究。结果表明,当w(PLA)=4%,w(乳化剂)=3%,转速9 000 r/min,投药质量比为2∶3时,不同接枝率改性聚乳酸微球形态圆整,平均粒径小于10μm,粒径分布窄,微球可连续释放14 d以上,释放速率随着接枝率增大而增大。     

Superabsorbent hydrogel of acrylic acid/potassium acrylate copolymers by ultraviolet photopolymerization: Synthesis and properties

Synthesis of superabsorbent hydrogel (SAHG) of acrylic acid‐potassium acrylate copolymer by direct Ultraviolet (UV) photopolymerization is a new method. The effects of degree of neutralization of acrylic acid (AA), photoinitiators, crosslinking agents, and exposure time of UV light on water absorbent properties were investigated. The results showed that the water absorbency (Q) and the salt solution (NaCl, 0.9%) absorbency (Qs) of SAHG, based on Irgacure 651, are high, reaching about 1400 and 130 mL/g, respectively. UV absorption spectrum proved that peak of UV absorption of Irgacure 651 matched the UV light source we used. Among the crosslinking agents, N,N′‐methylene bisacrylamide is more efficient than others, because of its very small content and high Q. ¹³C NMR spectrometry was used to identify the mechanism of crosslinking reaction through esterification of hydroxyethyl acrylate (HEA) and 2‐hydroxypropyl acrylate (HPA) with carboxylic acid group in acrylic acid‐ammonium acrylate copolymerization, but efficiency of crosslinking reaction by esterification was lower than that of copolymerization of vinyl group in crosslinking agent. The Q of acrylic acid‐potassium acrylate copolymer of SAHG reaches 1592 mL/g under the following conditions: degree of neutralization of acrylic acid is 80%, content of Irgacure 651 is 0.25 wt %, content of HEA is 0.2 wt %, and exposure time is 10 min. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 1181–1187, 2006     

聚天冬氨酸水凝胶合成及其应用于药物控释的研究进展

聚天冬氨酸是一种新型的聚合氨基酸材料,具有很好的生物相容性、生物降解性。本文综述了聚天冬氨酸及其衍生物水凝胶的研究现状,介绍了化学交联、光交联、γ射线交联3种交联方法合成的聚天冬氨酸及其衍生物水凝胶,以及近年来聚天冬氨酸基凝胶对大分子蛋白药物、小分子抗炎性药物、抗癌和基因药物控释的研究进展,并对该凝胶在药物控释领域的发展方向进行了预测。     

Preparation and swelling properties of a starch-g-poly(acrylic acid)/organo-mordenite hydrogel composite

A novel hydrogel composite was prepared via inverse suspension polymerization using starch, acrylic acid and organo-mordenite micropowder with the crosslinker, N,N′-methylenebisacrylamide and the initiator, potassium persulfate. Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy, scanning electron microscopy, and energy dispersive spectroscopy confirmed that the acrylic acid was grafted onto the backbone of the corn starch, that the organo-mordenite participated in the polymerization, and that the addition of organo-mordenite improved the surface morphology of the hydrogel composite. The swelling capacity of the hydrogel composite was evaluated in distilled water, and solutions with different pH values, and various salt solutions. It was found that the incorporation of 10 wt-% organo-mordenite enhanced the water absorbency by 144% (from 268 to 655 g·g⁻¹) and swelling was extremely sensitive to the pH values, the concentration of the salt solution and cation type. Swelling kinetics and water diffusion mechanism of the hydrogel composite in distilled water were also discussed. Moreover, the hydrogel composite showed excellent reversibility of water absorption even after five repetitive cycles and the hydrogel composite exhibited significant environmental-responsiveness by changing the swelling medium from distilled water to 0.1 mol·L⁻¹ NaCl solution. In addition, the loading and release of urea by the hydrogel composite were tested and the nutrient-slow-release capability of this material was found to be suitable for many potential applications.     

聚天冬氨酸凝胶的制备及生物降解性

以丙三醇三缩水甘油醚为交联剂制备聚天冬氨酸凝胶,考察了凝胶的热性能和黏弹性,并采用平板培养和液体培养法考察了凝胶的生物降解性。结果表明:丙三醇三缩水甘油醚交联凝胶具有良好的吸水保水性,且耐热性和黏弹性更优,平板试验证明凝胶也具有良好的生物降解性,液体培养法证明交联剂的种类和用量对凝胶的降解有较大影响,交联度均为60%的凝胶,交联剂为丙三醇三缩水甘油醚时第9天降解率为49.3%,较交联剂为乙二醇二缩水甘油醚制备的凝胶低9.2%,说明在相同交联度下丙三醇三缩水甘油醚形成的网络结构更致密;交联剂均为丙三醇三缩水甘油醚时,交联度为40%的第9天降解率为59.8%,较交联度为60%的凝胶提高了17.5%,交联度增加,降解速率降低。     

室温交联PVA水凝胶的制备与性能研究

以环氧氯丙烷为交联剂,采用室温化学交联法制备了聚乙烯醇(PVA)水凝胶,研究了交联温度和交联时间对PVA溶胀性能和力学性能的影响,借助差示扫描量热法(DSC)和扫描电子显微镜(SEM)对PVA水凝胶进行分析表征。结果表明,当交联时间为3d且交联温度为50℃时PVA水凝胶的综合性能最佳。PVA的玻璃化转变温度为-54.50℃,PVA水凝胶中包含有自由水、束缚水和非冷冻水。     

聚（反丁烯二酸丁二醇-CO-衣康酸丁二醇）酯的合成及性能研究

用不饱和脂肪族二元酸反丁烯二酸（FA）、衣康酸（IA）和1,4-丁二醇（BD）为原料,用熔融缩聚法合成了舍有c=c双键的聚（反丁烯二酸丁二醇-co-衣康酸丁二醇）酯（PFBI）,并采用红外光谱（FT—IR）、DSC、羟值、酸值及特性黏度测定对其进行结构和性能的表征,在37℃下,用含有脂肪酶的磷酸缓冲溶液对PFBI的生物降解性进行了研究,讨论了各组分对其性能的影响。